GREMLIN Database
SPEH - S-adenosylmethionine decarboxylase proenzyme
UniProt: Q9UWY8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (109)
Sequences: 892 (580)
Seq/√Len: 55.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_L108_L3.2091.00
25_D109_G3.2051.00
43_A50_I2.8571.00
55_S64_V2.7841.00
23_E111_K2.6321.00
63_S68_I2.5981.00
53_I66_A2.4251.00
98_L117_E2.3121.00
38_I104_I2.3051.00
36_E40_K2.2601.00
19_G101_F2.1701.00
32_T36_E2.0461.00
85_T89_Y2.0191.00
50_I66_A1.9821.00
78_W85_T1.9381.00
41_E45_I1.9201.00
31_D34_R1.8861.00
28_V34_R1.8811.00
37_Q41_E1.8500.99
18_Y118_A1.8300.99
23_E112_R1.7430.99
75_I86_V1.7340.99
41_E44_D1.6910.99
23_E110_A1.6060.98
35_L62_V1.5910.98
34_R38_I1.5220.98
70_E91_C1.4720.97
21_L104_I1.4430.97
98_L102_R1.4030.96
55_S66_A1.3220.95
35_L75_I1.3190.95
19_G88_V1.3110.95
36_E53_I1.2920.94
75_I84_A1.2660.94
40_K53_I1.2600.93
38_I107_K1.1920.91
39_I73_I1.1920.91
47_N96_S1.1880.91
32_T62_V1.1730.91
102_R105_V1.1700.90
22_Y112_R1.1610.90
32_T57_K1.1560.90
27_D106_E1.1340.89
105_V113_Y1.0990.87
12_V89_Y1.0790.87
58_I80_E1.0700.86
55_S65_V1.0650.86
46_G90_S1.0590.85
58_I91_C1.0480.85
32_T55_S1.0380.84
13_V81_Y1.0260.84
57_K60_E0.9960.82
63_S74_T0.9930.82
64_V78_W0.9930.82
48_M85_T0.9880.81
65_V74_T0.9840.81
16_Q87_D0.9660.80
43_A66_A0.9550.79
48_M92_G0.9410.78
51_L69_L0.9340.77
43_A84_A0.9210.76
17_V115_I0.9130.76
80_E91_C0.9080.75
41_E77_T0.8970.74
28_V109_G0.8920.74
14_G71_S0.8860.74
41_E103_Y0.8850.73
36_E55_S0.8850.73
40_K50_I0.8710.72
24_C110_A0.8630.72
61_G71_S0.8440.70
32_T63_S0.8360.69
21_L114_T0.8270.68
17_V101_F0.8270.68
20_S121_S0.8190.68
113_Y119_D0.8170.67
68_I90_S0.8110.67
22_Y101_F0.8100.67
30_K60_E0.8090.67
88_V105_V0.8030.66
114_T118_A0.8020.66
42_A103_Y0.7990.66
20_S60_E0.7990.66
19_G104_I0.7910.65
56_W62_V0.7870.64
49_N70_E0.7870.64
42_A46_G0.7830.64
42_A92_G0.7830.64
116_N119_D0.7800.64
38_I75_I0.7690.63
41_E107_K0.7560.61
28_V38_I0.7520.61
33_K106_E0.7400.60
40_K66_A0.7400.60
73_I104_I0.7310.59
60_E82_R0.7180.57
65_V78_W0.7030.56
49_N96_S0.7010.56
86_V89_Y0.6970.55
45_I99_N0.6960.55
24_C67_I0.6930.55
21_L113_Y0.6890.54
56_W69_L0.6800.53
17_V21_L0.6770.53
37_Q99_N0.6740.53
34_R113_Y0.6700.52
43_A73_I0.6570.51
51_L58_I0.6550.51
20_S54_K0.6550.51
21_L105_V0.6540.51
30_K59_G0.6520.50
92_G100_A0.6400.49
51_L78_W0.6390.49
34_R109_G0.6350.48
30_K57_K0.6350.48
71_S77_T0.6280.48
31_D41_E0.6260.47
20_S57_K0.6240.47
35_L64_V0.6210.47
27_D107_K0.6180.47
42_A48_M0.6010.45
20_S116_N0.6000.45
78_W81_Y0.5990.45
102_R106_E0.5960.44
41_E99_N0.5950.44
31_D96_S0.5900.44
52_D66_A0.5890.44
16_Q74_T0.5790.42
73_I85_T0.5770.42
44_D55_S0.5750.42
13_V51_L0.5730.42
12_V15_K0.5680.41
37_Q112_R0.5680.41
31_D44_D0.5650.41
67_I117_E0.5620.41
39_I101_F0.5580.40
35_L86_V0.5520.40
84_A110_A0.5510.40
89_Y105_V0.5500.39
76_H79_P0.5470.39
34_R107_K0.5430.39
27_D45_I0.5410.39
43_A100_A0.5410.39
27_D30_K0.5410.39
25_D38_I0.5360.38
53_I96_S0.5350.38
19_G115_I0.5340.38
114_T119_D0.5320.38
73_I90_S0.5320.38
93_P109_G0.5270.37
17_V103_Y0.5250.37
113_Y116_N0.5240.37
44_D102_R0.5230.37
39_I85_T0.5230.37
63_S67_I0.5200.36
29_L121_S0.5200.36
64_V121_S0.5180.36
33_K45_I0.5140.36
58_I70_E0.5140.36
13_V78_W0.5100.35
87_D120_R0.5040.35
90_S95_T0.5040.35
96_S102_R0.5030.35
45_I103_Y0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iiiA 2 0.9194 100 0.178 Contact Map
1vr7A 2 0.9274 100 0.183 Contact Map
3c6kA 2 0.8226 58.4 0.915 Contact Map
1mhmA 1 0.8871 55.7 0.917 Contact Map
1jl0A 2 0.879 19.9 0.935 Contact Map
4u3eA 2 0.7661 14.6 0.939 Contact Map
4adnA 2 0.3387 10.1 0.943 Contact Map
2od0A 2 0.3871 9.2 0.944 Contact Map
2yb5A 1 0.3387 8.6 0.945 Contact Map
1nq6A 1 0.7097 6.4 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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