GREMLIN Database
DGGGP - Digeranylgeranylglyceryl phosphate synthase
UniProt: Q9UWY6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (270)
Sequences: 10210 (7408)
Seq/√Len: 450.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_V81_V3.8871.00
62_V81_V3.8761.00
59_V85_K3.4321.00
5_S78_K3.3051.00
52_G92_F3.1691.00
80_S83_K2.9951.00
82_N86_A2.9951.00
200_N204_R2.8771.00
238_I242_I2.8461.00
238_I241_T2.8411.00
8_Q78_K2.8201.00
26_F39_I2.4911.00
49_I95_G2.2601.00
6_Y83_K2.2121.00
239_P242_I2.1411.00
183_N186_S2.1121.00
103_N106_A2.1031.00
201_K204_R2.0851.00
7_M12_I2.0631.00
100_I107_L1.9881.00
104_I108_V1.9601.00
100_I104_I1.9511.00
48_L94_I1.9501.00
55_V91_L1.9331.00
182_Y186_S1.9041.00
41_L98_L1.8781.00
86_A90_A1.8731.00
89_I93_I1.8441.00
6_Y87_L1.8411.00
64_I190_V1.8281.00
258_R262_K1.8061.00
250_T253_G1.7971.00
62_V66_K1.7871.00
237_F241_T1.7371.00
244_S247_Q1.7161.00
243_L246_I1.6991.00
204_R208_I1.6751.00
106_A148_L1.6721.00
194_A202_S1.6671.00
186_S195_T1.6661.00
10_V55_V1.6511.00
9_L55_V1.6451.00
74_I84_A1.6411.00
4_K8_Q1.6201.00
62_V74_I1.5991.00
41_L101_L1.5861.00
197_L201_K1.5811.00
35_E38_G1.5731.00
97_A101_L1.5531.00
229_Y233_L1.5521.00
66_K75_P1.5481.00
48_L91_L1.5221.00
214_L235_L1.5211.00
261_L265_A1.5151.00
79_I84_A1.5121.00
156_L159_I1.5041.00
108_V112_V1.5011.00
116_G138_T1.4951.00
182_Y199_I1.4921.00
48_L95_G1.4701.00
259_T263_I1.4651.00
55_V87_L1.4591.00
85_K89_I1.4401.00
10_V51_A1.4391.00
271_A275_G1.4151.00
259_T262_K1.4091.00
59_V84_A1.4031.00
45_V98_L1.3931.00
243_L247_Q1.3911.00
59_V88_S1.3901.00
22_A43_A1.3851.00
82_N85_K1.3841.00
253_G257_A1.3721.00
55_V88_S1.3701.00
105_Y109_I1.3661.00
263_I267_S1.3651.00
211_V215_I1.3531.00
10_V91_L1.3531.00
237_F240_F1.3341.00
199_I203_W1.3221.00
10_V87_L1.3181.00
17_G173_R1.3141.00
155_W159_I1.3111.00
124_L134_L1.3031.00
81_V85_K1.3021.00
25_G29_S1.2971.00
140_A167_F1.2781.00
51_A91_L1.2771.00
201_K205_I1.2711.00
119_Y134_L1.2671.00
49_I110_A1.2561.00
56_I88_S1.2501.00
221_F230_L1.2491.00
53_G117_L1.2361.00
9_L79_I1.2351.00
237_F242_I1.2301.00
262_K266_I1.2261.00
22_A46_V1.2251.00
262_K265_A1.2201.00
96_I100_I1.2121.00
226_N229_Y1.2081.00
7_M10_V1.1771.00
226_N275_G1.1721.00
124_L127_T1.1681.00
204_R207_K1.1541.00
99_S110_A1.1471.00
98_L102_L1.1321.00
200_N203_W1.1311.00
193_L197_L1.1301.00
168_F209_L1.1231.00
182_Y195_T1.1211.00
40_L44_L1.1111.00
63_E67_I1.1101.00
191_K196_T1.1061.00
251_I254_A1.1061.00
129_F196_T1.0991.00
258_R261_L1.0891.00
255_S259_T1.0881.00
68_N71_Y1.0771.00
220_P229_Y1.0771.00
203_W207_K1.0721.00
232_L271_A1.0721.00
160_I164_L1.0671.00
165_Y216_I1.0661.00
137_T163_T1.0631.00
67_I70_P1.0621.00
265_A268_G1.0511.00
251_I255_S1.0501.00
268_G271_A1.0491.00
61_D126_K1.0371.00
104_I107_L1.0341.00
59_V74_I1.0301.00
155_W160_I1.0271.00
131_G192_T1.0261.00
105_Y108_V1.0131.00
25_G28_V1.0101.00
17_G21_G1.0011.00
18_A47_G0.9941.00
115_I119_Y0.9811.00
252_E256_K0.9811.00
174_E178_G0.9771.00
73_P77_G0.9701.00
262_K269_I0.9691.00
26_F43_A0.9631.00
60_Y123_D0.9591.00
87_L91_L0.9561.00
36_L40_L0.9561.00
229_Y232_L0.9521.00
75_P84_A0.9511.00
12_I47_G0.9501.00
248_K251_I0.9491.00
265_A269_I0.9441.00
179_I201_K0.9441.00
114_A118_I0.9331.00
55_V79_I0.9311.00
9_L84_A0.9281.00
45_V99_S0.9281.00
44_L48_L0.9191.00
68_N184_G0.9151.00
231_I235_L0.9131.00
44_L98_L0.9111.00
99_S102_L0.9051.00
106_A145_Y0.9051.00
226_N230_L0.8921.00
207_K211_V0.8881.00
185_D192_T0.8881.00
61_D64_I0.8841.00
135_V174_E0.8801.00
183_N187_L0.8781.00
119_Y123_D0.8781.00
179_I202_S0.8771.00
92_F114_A0.8711.00
151_F154_N0.8691.00
83_K86_A0.8691.00
90_A94_I0.8681.00
50_A54_Y0.8601.00
37_K41_L0.8561.00
264_S268_G0.8551.00
148_L159_I0.8551.00
22_A26_F0.8531.00
64_I126_K0.8451.00
147_G151_F0.8441.00
30_S34_L0.8421.00
226_N233_L0.8391.00
172_I209_L0.8361.00
116_G134_L0.8341.00
72_R75_P0.8331.00
123_D128_G0.8331.00
181_D185_D0.8281.00
88_S92_F0.8271.00
156_L160_I0.8261.00
22_A42_S0.8231.00
256_K260_Y0.8191.00
107_L111_L0.8131.00
63_E66_K0.8111.00
61_D121_A0.8091.00
213_L217_S0.8071.00
96_I107_L0.8061.00
37_K40_L0.8061.00
130_Y133_L0.8051.00
157_L160_I0.8031.00
93_I97_A0.8021.00
259_T265_A0.8021.00
267_S271_A0.8011.00
198_G202_S0.8011.00
261_L264_S0.8001.00
256_K259_T0.7961.00
15_V47_G0.7961.00
32_W35_E0.7951.00
64_I67_I0.7941.00
164_L168_F0.7931.00
248_K253_G0.7931.00
23_I43_A0.7931.00
214_L217_S0.7921.00
136_A171_L0.7891.00
83_K87_L0.7871.00
175_I205_I0.7821.00
236_V239_P0.7821.00
234_I237_F0.7811.00
55_V84_A0.7811.00
221_F224_G0.7791.00
34_L39_I0.7791.00
6_Y79_I0.7791.00
228_I231_I0.7781.00
260_Y265_A0.7771.00
260_Y264_S0.7761.00
190_V196_T0.7721.00
241_T244_S0.7721.00
12_I51_A0.7711.00
242_I260_Y0.7711.00
212_L216_I0.7701.00
228_I232_L0.7681.00
205_I208_I0.7671.00
258_R264_S0.7631.00
85_K88_S0.7601.00
140_A170_T0.7561.00
132_N178_G0.7551.00
178_G194_A0.7551.00
132_N174_E0.7541.00
270_I274_L0.7541.00
261_L269_I0.7521.00
132_N175_I0.7491.00
103_N109_I0.7461.00
86_A89_I0.7461.00
220_P224_G0.7461.00
73_P78_K0.7451.00
253_G256_K0.7451.00
182_Y194_A0.7451.00
79_I87_L0.7441.00
8_Q13_H0.7431.00
249_E253_G0.7351.00
217_S220_P0.7341.00
172_I210_L0.7341.00
96_I99_S0.7331.00
132_N171_L0.7331.00
154_N158_R0.7331.00
255_S258_R0.7321.00
174_E177_K0.7321.00
257_A261_L0.7301.00
119_Y124_L0.7291.00
95_G99_S0.7281.00
124_L128_G0.7281.00
41_L102_L0.7271.00
193_L196_T0.7271.00
254_A257_A0.7251.00
94_I98_L0.7251.00
72_R77_G0.7231.00
42_S149_A0.7221.00
164_L216_I0.7191.00
111_L115_I0.7181.00
257_A260_Y0.7181.00
56_I118_I0.7141.00
227_L231_I0.7061.00
24_M28_V0.7051.00
139_T143_I0.7011.00
51_A87_L0.7001.00
59_V62_V0.7001.00
173_R177_K0.6911.00
214_L218_P0.6911.00
190_V195_T0.6881.00
30_S33_Y0.6881.00
79_I83_K0.6871.00
125_K128_G0.6851.00
113_T141_L0.6851.00
166_A170_T0.6841.00
262_K268_G0.6841.00
254_A258_R0.6801.00
233_L237_F0.6771.00
64_I188_N0.6771.00
51_A55_V0.6741.00
42_S46_V0.6731.00
18_A50_A0.6731.00
105_Y148_L0.6711.00
52_G91_L0.6691.00
261_L271_A0.6671.00
177_K180_E0.6651.00
67_I188_N0.6641.00
183_N199_I0.6611.00
229_Y235_L0.6581.00
261_L268_G0.6571.00
230_L234_I0.6561.00
144_F163_T0.6551.00
258_R271_A0.6541.00
17_G20_L0.6521.00
219_L223_I0.6501.00
218_P221_F0.6491.00
75_P78_K0.6491.00
161_I223_I0.6471.00
130_Y197_L0.6400.99
48_L98_L0.6360.99
210_L213_L0.6350.99
235_L238_I0.6330.99
179_I199_I0.6290.99
148_L152_S0.6250.99
266_I270_I0.6250.99
141_L145_Y0.6180.99
232_L235_L0.6160.99
61_D190_V0.6160.99
245_I257_A0.6160.99
38_G102_L0.6140.99
180_E255_S0.6140.99
63_E69_K0.6130.99
12_I15_V0.6110.99
62_V65_D0.6100.99
242_I245_I0.6100.99
260_Y263_I0.6090.99
146_G150_F0.6080.99
30_S35_E0.6080.99
15_V50_A0.6080.99
197_L205_I0.6070.99
139_T170_T0.6060.99
185_D189_N0.6050.99
33_Y37_K0.6050.99
236_V240_F0.6000.99
52_G118_I0.5970.99
145_Y163_T0.5940.99
258_R265_A0.5940.99
99_S107_L0.5940.99
261_L266_I0.5940.99
12_I18_A0.5920.99
126_K190_V0.5920.99
38_G150_F0.5900.99
53_G113_T0.5890.99
6_Y10_V0.5880.99
216_I219_L0.5860.99
136_A141_L0.5850.99
60_Y121_A0.5820.99
26_F42_S0.5810.99
261_L273_L0.5790.99
88_S118_I0.5780.99
209_L212_L0.5770.99
96_I111_L0.5750.99
52_G95_G0.5740.99
92_F96_I0.5710.99
26_F34_L0.5690.99
19_A22_A0.5680.99
58_D61_D0.5680.99
53_G121_A0.5670.99
140_A166_A0.5670.99
194_A197_L0.5650.99
191_K195_T0.5650.99
19_A47_G0.5640.99
248_K254_A0.5630.99
263_I266_I0.5600.99
218_P222_F0.5570.99
192_T196_T0.5570.99
13_H16_I0.5530.98
108_V111_L0.5530.98
257_A264_S0.5510.98
73_P76_S0.5500.98
171_L209_L0.5460.98
92_F95_G0.5450.98
158_R161_I0.5450.98
136_A170_T0.5440.98
144_F159_I0.5430.98
63_E81_V0.5410.98
158_R223_I0.5390.98
254_A261_L0.5390.98
154_N157_L0.5370.98
8_Q73_P0.5370.98
31_Q34_L0.5370.98
26_F151_F0.5360.98
49_I113_T0.5290.98
67_I71_Y0.5290.98
157_L161_I0.5280.98
45_V110_A0.5280.98
175_I178_G0.5250.98
52_G114_A0.5210.98
231_I234_I0.5210.98
57_N121_A0.5190.98
259_T266_I0.5180.98
135_V173_R0.5170.98
205_I209_L0.5160.98
52_G88_S0.5160.98
70_P184_G0.5150.98
15_V54_Y0.5140.98
116_G137_T0.5130.98
208_I212_L0.5110.97
257_A262_K0.5100.97
161_I219_L0.5090.97
141_L163_T0.5070.97
33_Y36_L0.5050.97
14_N50_A0.5050.97
163_T167_F0.5000.97
250_T255_S0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.9397 100 0.232 Contact Map
4tq3A 1 0.9645 100 0.298 Contact Map
2xq2A 2 0.805 42 0.934 Contact Map
1v4eA 3 0.8227 5.7 0.956 Contact Map
1rqjA 2 0.8404 4.5 0.958 Contact Map
3ne5A 3 0.4397 4 0.959 Contact Map
4xnjA 1 0.5887 3.8 0.96 Contact Map
3dh4A 3 0.7411 3.4 0.96 Contact Map
3m0gA 2 0.7695 3.2 0.961 Contact Map
4cz8A 2 0.9716 3.2 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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