ILVC1 - SULSO - GREMLIN Contacts

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ILVC1 - Ketol-acid reductoisomerase 1

UniProt:	Q9UWX9	Sequences: MKCTSKIYTDNDANLDLIKGKRIAVLGYGSQGRAWAQNLRDSGLNVVVGLEREGKSWELAKSDGITPLHTKDAVKDADIIIFLVPDMVQRTLWLESVQPYMKKGADLVFAHGFNIHYKLIDPPKDSDVYMIAPKGPGPTVREYYKAGGGVPALVAVHQDVSGTALHKALAIAKGIGATRAGVIPTTFKEETETDLFGEQVILVGGIMELMRAAFETLVEEGYQPEVAYFETINELKMLVDLVYEKGISGMLKAVSDTAKYGGMTVGKFVIDESVRKRMKEALQRIKSGKFAEEWVEEYGRGMPTVVNGLSNVQNSLEEKIGNQLRDLVQKGKPKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	335 (326)
Sequences:	1923 (662)
Seq/√Len:	36.7

ECOLI - ILVC
BACSU - ILVC
SULSO - ILVC1 ILVC3 ILVC2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
23_I	44_L	4.614	1.00
102_K	105_A	4.149	1.00
152_A	177_A	3.958	1.00
210_M	242_V	3.189	1.00
22_R	45_N	3.030	1.00
103_K	125_D	2.933	1.00
251_L	262_G	2.888	1.00
106_D	129_Y	2.811	1.00
84_V	92_L	2.790	1.00
35_W	110_A	2.763	1.00
154_V	165_L	2.762	1.00
178_T	182_V	2.678	1.00
310_S	314_N	2.578	1.00
123_P	126_S	2.575	1.00
259_K	309_L	2.507	1.00
210_M	235_L	2.501	1.00
206_I	235_L	2.440	1.00
189_E	223_Q	2.429	1.00
143_Y	146_A	2.421	1.00
94_L	98_Q	2.368	1.00
58_E	61_K	2.364	1.00
91_T	95_E	2.361	1.00
277_R	280_E	2.293	0.99
271_D	274_V	2.280	0.99
87_M	256_D	2.225	0.99
245_K	249_G	2.176	0.99
13_A	178_T	2.167	0.99
142_E	244_E	2.157	0.99
265_V	281_A	2.142	0.99
40_R	65_I	2.090	0.99
268_F	284_R	2.027	0.99
108_V	129_Y	2.020	0.99
82_F	97_V	1.978	0.98
274_V	277_R	1.956	0.98
91_T	299_G	1.947	0.98
106_D	167_K	1.936	0.98
211_R	312_V	1.920	0.98
52_R	69_H	1.898	0.98
173_K	178_T	1.889	0.98
106_D	127_D	1.889	0.98
57_W	61_K	1.887	0.98
265_V	293_E	1.839	0.97
18_I	170_A	1.826	0.97
39_L	174_G	1.826	0.97
265_V	284_R	1.816	0.97
300_R	303_P	1.793	0.97
48_V	65_I	1.773	0.97
159_D	166_H	1.750	0.96
71_K	96_S	1.742	0.96
28_Y	63_D	1.741	0.96
70_T	96_S	1.733	0.96
271_D	277_R	1.717	0.96
127_D	164_A	1.691	0.96
16_D	19_K	1.679	0.96
24_A	73_A	1.656	0.95
165_L	184_P	1.653	0.95
273_S	276_K	1.623	0.95
81_I	110_A	1.615	0.94
68_L	76_D	1.609	0.94
50_L	54_G	1.602	0.94
80_I	105_A	1.602	0.94
223_Q	226_V	1.591	0.94
135_G	177_A	1.588	0.94
26_L	82_F	1.581	0.94
210_M	232_I	1.572	0.94
57_W	69_H	1.560	0.93
113_F	291_A	1.560	0.93
61_K	66_T	1.548	0.93
66_T	76_D	1.540	0.93
35_W	81_I	1.531	0.93
125_D	160_V	1.529	0.93
139_T	142_E	1.528	0.93
47_V	76_D	1.512	0.92
26_L	49_G	1.498	0.92
47_V	68_L	1.492	0.92
127_D	163_T	1.490	0.92
298_Y	302_M	1.479	0.91
207_M	262_G	1.475	0.91
319_K	323_Q	1.475	0.91
10_D	178_T	1.460	0.91
206_I	210_M	1.445	0.90
81_I	108_V	1.443	0.90
283_Q	287_S	1.427	0.90
183_I	226_V	1.409	0.89
296_E	300_R	1.407	0.89
22_R	47_V	1.401	0.89
143_Y	148_G	1.392	0.89
296_E	299_G	1.387	0.88
52_R	57_W	1.383	0.88
293_E	304_T	1.382	0.88
207_M	247_I	1.374	0.88
74_V	105_A	1.367	0.88
268_F	277_R	1.362	0.87
265_V	269_V	1.362	0.87
264_T	293_E	1.347	0.87
208_E	275_R	1.339	0.87
294_W	297_E	1.335	0.86
22_R	76_D	1.328	0.86
264_T	284_R	1.326	0.86
74_V	100_Y	1.324	0.86
259_K	263_M	1.321	0.86
256_D	302_M	1.319	0.86
280_E	284_R	1.314	0.85
215_E	275_R	1.308	0.85
75_K	100_Y	1.297	0.85
138_P	253_A	1.290	0.84
210_M	317_E	1.288	0.84
263_M	309_L	1.288	0.84
207_M	251_L	1.288	0.84
232_I	242_V	1.271	0.84
37_Q	65_I	1.268	0.83
208_E	211_R	1.266	0.83
214_F	316_L	1.258	0.83
89_Q	114_N	1.256	0.83
307_N	311_N	1.256	0.83
13_A	182_V	1.253	0.83
8_Y	165_L	1.245	0.82
58_E	62_S	1.244	0.82
208_E	212_A	1.243	0.82
116_H	188_K	1.240	0.82
106_D	161_S	1.212	0.80
219_E	279_K	1.212	0.80
105_A	126_S	1.201	0.80
219_E	275_R	1.200	0.80
74_V	80_I	1.196	0.80
218_V	316_L	1.196	0.80
305_V	309_L	1.194	0.79
294_W	302_M	1.185	0.79
140_V	150_V	1.183	0.79
269_V	281_A	1.183	0.79
292_E	296_E	1.177	0.78
129_Y	164_A	1.175	0.78
127_D	160_V	1.169	0.78
51_E	55_K	1.168	0.78
23_I	174_G	1.166	0.78
69_H	72_D	1.157	0.77
42_S	144_Y	1.144	0.76
45_N	66_T	1.141	0.76
294_W	298_Y	1.138	0.76
54_G	65_I	1.133	0.76
26_L	84_V	1.131	0.76
289_K	293_E	1.127	0.75
172_A	182_V	1.125	0.75
263_M	308_G	1.125	0.75
257_T	290_F	1.113	0.74
119_L	295_V	1.108	0.74
54_G	57_W	1.099	0.73
232_I	317_E	1.097	0.73
90_R	94_L	1.095	0.73
13_A	173_K	1.091	0.73
254_V	262_G	1.090	0.73
14_N	17_L	1.086	0.73
163_T	166_H	1.084	0.72
33_R	253_A	1.084	0.72
127_D	161_S	1.082	0.72
114_N	120_I	1.077	0.72
215_E	315_S	1.071	0.72
200_V	213_A	1.070	0.71
212_A	216_T	1.057	0.70
277_R	284_R	1.049	0.70
125_D	158_Q	1.047	0.70
15_L	173_K	1.044	0.70
101_M	126_S	1.039	0.69
284_R	289_K	1.034	0.69
70_T	74_V	1.034	0.69
308_G	312_V	1.030	0.68
244_E	249_G	1.028	0.68
295_V	300_R	1.024	0.68
100_Y	105_A	1.021	0.68
296_E	307_N	1.020	0.68
189_E	226_V	1.014	0.67
50_L	56_S	1.013	0.67
206_I	242_V	1.011	0.67
113_F	119_L	1.006	0.67
272_E	276_K	1.001	0.66
269_V	274_V	0.994	0.66
310_S	313_Q	0.994	0.66
160_V	164_A	0.989	0.65
105_A	123_P	0.984	0.65
10_D	173_K	0.982	0.65
201_I	213_A	0.981	0.65
71_K	100_Y	0.976	0.64
6_K	184_P	0.969	0.64
135_G	150_V	0.968	0.64
65_I	68_L	0.963	0.63
302_M	306_V	0.961	0.63
122_P	125_D	0.955	0.63
33_R	138_P	0.948	0.62
307_N	310_S	0.946	0.62
45_N	76_D	0.937	0.61
17_L	170_A	0.936	0.61
56_S	67_P	0.928	0.60
106_D	164_A	0.927	0.60
25_V	171_I	0.926	0.60
272_E	275_R	0.918	0.59
80_I	123_P	0.915	0.59
200_V	269_V	0.907	0.59
14_N	166_H	0.902	0.58
47_V	80_I	0.902	0.58
326_D	329_Q	0.901	0.58
294_W	305_V	0.900	0.58
264_T	308_G	0.890	0.57
276_K	279_K	0.886	0.57
108_V	171_I	0.886	0.57
208_E	267_K	0.875	0.56
69_H	74_V	0.875	0.56
249_G	252_K	0.873	0.56
59_L	63_D	0.869	0.55
281_A	284_R	0.868	0.55
25_V	39_L	0.861	0.55
118_K	121_D	0.859	0.54
248_S	313_Q	0.858	0.54
269_V	277_R	0.853	0.54
37_Q	63_D	0.849	0.53
302_M	305_V	0.849	0.53
131_I	172_A	0.846	0.53
135_G	152_A	0.846	0.53
148_G	330_K	0.841	0.53
90_R	299_G	0.837	0.52
115_I	130_M	0.836	0.52
101_M	123_P	0.832	0.52
44_L	174_G	0.831	0.52
25_V	36_A	0.829	0.52
256_D	294_W	0.829	0.52
50_L	67_P	0.827	0.52
251_L	312_V	0.827	0.52
78_D	105_A	0.826	0.51
129_Y	154_V	0.825	0.51
165_L	169_L	0.823	0.51
328_V	331_G	0.823	0.51
26_L	74_V	0.818	0.51
51_E	57_W	0.814	0.50
148_G	331_G	0.813	0.50
26_L	70_T	0.808	0.50
6_K	11_N	0.803	0.49
139_T	243_Y	0.803	0.49
24_A	47_V	0.802	0.49
93_W	107_L	0.800	0.49
89_Q	120_I	0.793	0.49
248_S	318_E	0.789	0.48
216_T	275_R	0.789	0.48
68_L	72_D	0.788	0.48
18_I	174_G	0.788	0.48
304_T	308_G	0.787	0.48
113_F	191_T	0.787	0.48
79_I	129_Y	0.781	0.48
49_G	56_S	0.779	0.47
273_S	277_R	0.776	0.47
89_Q	109_F	0.772	0.47
296_E	311_N	0.771	0.47
324_L	328_V	0.769	0.46
304_T	307_N	0.768	0.46
88_V	92_L	0.765	0.46
105_A	125_D	0.763	0.46
143_Y	243_Y	0.761	0.46
232_I	247_I	0.760	0.46
40_R	54_G	0.759	0.46
208_E	251_L	0.754	0.45
265_V	277_R	0.753	0.45
119_L	296_E	0.749	0.45
82_F	92_L	0.747	0.45
152_A	175_I	0.746	0.44
152_A	182_V	0.744	0.44
167_K	170_A	0.741	0.44
59_L	62_S	0.738	0.44
103_K	160_V	0.737	0.44
284_R	293_E	0.735	0.44
78_D	102_K	0.725	0.43
210_M	239_V	0.723	0.42
40_R	63_D	0.719	0.42
46_V	49_G	0.718	0.42
119_L	298_Y	0.715	0.42
220_E	282_L	0.713	0.42
135_G	142_E	0.711	0.41
113_F	295_V	0.709	0.41
56_S	59_L	0.708	0.41
313_Q	316_L	0.706	0.41
154_V	168_A	0.706	0.41
20_G	170_A	0.703	0.41
30_S	138_P	0.703	0.41
39_L	171_I	0.703	0.41
17_L	167_K	0.702	0.41
296_E	310_S	0.702	0.41
9_T	327_L	0.700	0.41
142_E	145_K	0.700	0.41
296_E	304_T	0.699	0.40
183_I	330_K	0.696	0.40
37_Q	56_S	0.696	0.40
247_I	312_V	0.693	0.40
143_Y	329_Q	0.691	0.40
235_L	242_V	0.688	0.40
242_V	247_I	0.688	0.40
90_R	295_V	0.687	0.39
319_K	322_N	0.686	0.39
128_V	158_Q	0.683	0.39
79_I	170_A	0.682	0.39
117_Y	191_T	0.679	0.39
260_Y	293_E	0.677	0.39
270_I	274_V	0.676	0.39
284_R	287_S	0.675	0.38
148_G	243_Y	0.675	0.38
51_E	54_G	0.675	0.38
138_P	252_K	0.675	0.38
280_E	283_Q	0.674	0.38
33_R	63_D	0.671	0.38
280_E	289_K	0.670	0.38
165_L	168_A	0.669	0.38
173_K	182_V	0.663	0.37
60_A	67_P	0.661	0.37
108_V	167_K	0.659	0.37
84_V	88_V	0.659	0.37
205_G	209_L	0.659	0.37
75_K	102_K	0.659	0.37
260_Y	330_K	0.658	0.37
305_V	308_G	0.657	0.37
159_D	162_G	0.655	0.37
208_E	262_G	0.654	0.37
135_G	139_T	0.654	0.37
263_M	293_E	0.652	0.37
118_K	157_H	0.649	0.36
200_V	281_A	0.648	0.36
57_W	67_P	0.648	0.36
15_L	44_L	0.647	0.36
37_Q	41_D	0.646	0.36
40_R	52_R	0.645	0.36
323_Q	326_D	0.644	0.36
72_D	76_D	0.644	0.36
8_Y	184_P	0.643	0.36
153_L	184_P	0.643	0.36
24_A	49_G	0.643	0.36
130_M	152_A	0.642	0.36
148_G	329_Q	0.642	0.36
60_A	65_I	0.640	0.36
21_K	167_K	0.639	0.35
281_A	293_E	0.636	0.35
50_L	57_W	0.635	0.35
142_E	249_G	0.634	0.35
248_S	322_N	0.634	0.35
183_I	223_Q	0.627	0.35
289_K	292_E	0.624	0.34
102_K	126_S	0.624	0.34
116_H	157_H	0.624	0.34
35_W	108_V	0.622	0.34
103_K	126_S	0.620	0.34
51_E	88_V	0.620	0.34
81_I	171_I	0.619	0.34
309_L	313_Q	0.619	0.34
296_E	303_P	0.619	0.34
293_E	296_E	0.618	0.34
51_E	70_T	0.617	0.34
76_D	170_A	0.616	0.34
54_G	67_P	0.614	0.34
74_V	82_F	0.613	0.33
87_M	331_G	0.612	0.33
87_M	254_V	0.611	0.33
293_E	308_G	0.609	0.33
26_L	97_V	0.609	0.33
196_F	282_L	0.609	0.33
87_M	259_K	0.607	0.33
135_G	179_R	0.607	0.33
264_T	277_R	0.606	0.33
220_E	286_K	0.606	0.33
208_E	285_I	0.604	0.33
191_T	291_A	0.602	0.33
311_N	314_N	0.601	0.32
251_L	254_V	0.599	0.32
11_N	173_K	0.598	0.32
247_I	317_E	0.598	0.32
139_T	331_G	0.596	0.32
265_V	280_E	0.594	0.32
80_I	126_S	0.594	0.32
188_K	226_V	0.594	0.32
56_S	60_A	0.592	0.32
24_A	80_I	0.591	0.32
142_E	146_A	0.587	0.31
33_R	37_Q	0.586	0.31
72_D	75_K	0.586	0.31
7_I	26_L	0.586	0.31
98_Q	123_P	0.585	0.31
10_D	15_L	0.585	0.31
192_E	286_K	0.582	0.31
75_K	269_V	0.582	0.31
211_R	247_I	0.582	0.31
139_T	143_Y	0.582	0.31
127_D	167_K	0.579	0.31
61_K	67_P	0.576	0.31
8_Y	12_D	0.574	0.30
309_L	312_V	0.573	0.30
215_E	267_K	0.571	0.30
103_K	123_P	0.571	0.30
322_N	326_D	0.569	0.30
129_Y	168_A	0.569	0.30
120_I	257_T	0.568	0.30
13_A	17_L	0.568	0.30
121_D	306_V	0.567	0.30
15_L	40_R	0.566	0.30
265_V	268_F	0.565	0.30
308_G	311_N	0.564	0.30
236_K	240_D	0.564	0.30
154_V	226_V	0.564	0.30
214_F	219_E	0.564	0.30
143_Y	177_A	0.563	0.30
181_G	229_F	0.563	0.30
260_Y	265_V	0.563	0.30
40_R	68_L	0.563	0.30
256_D	309_L	0.562	0.30
69_H	96_S	0.562	0.30
192_E	222_Y	0.562	0.30
106_D	163_T	0.560	0.29
314_N	319_K	0.560	0.29
264_T	281_A	0.559	0.29
140_V	177_A	0.558	0.29
139_T	328_V	0.558	0.29
281_A	289_K	0.558	0.29
303_P	306_V	0.558	0.29
76_D	105_A	0.557	0.29
70_T	84_V	0.553	0.29
68_L	73_A	0.553	0.29
48_V	68_L	0.551	0.29
118_K	301_G	0.550	0.29
203_V	254_V	0.550	0.29
33_R	252_K	0.548	0.29
167_K	292_E	0.548	0.29
36_A	295_V	0.547	0.28
24_A	77_A	0.546	0.28
256_D	305_V	0.544	0.28
21_K	78_D	0.543	0.28
117_Y	287_S	0.542	0.28
214_F	223_Q	0.540	0.28
25_V	110_A	0.540	0.28
265_V	308_G	0.539	0.28
117_Y	257_T	0.539	0.28
321_G	325_R	0.538	0.28
119_L	299_G	0.538	0.28
74_V	97_V	0.538	0.28
272_E	279_K	0.537	0.28
234_E	261_G	0.537	0.28
256_D	259_K	0.537	0.28
262_G	312_V	0.536	0.28
7_I	143_Y	0.536	0.28
268_F	280_E	0.535	0.28
254_V	258_A	0.533	0.27
208_E	215_E	0.533	0.27
18_I	76_D	0.533	0.27
145_K	148_G	0.533	0.27
129_Y	167_K	0.532	0.27
119_L	291_A	0.531	0.27
47_V	77_A	0.531	0.27
200_V	235_L	0.530	0.27
49_G	80_I	0.530	0.27
264_T	269_V	0.530	0.27
177_A	330_K	0.530	0.27
40_R	45_N	0.525	0.27
289_K	304_T	0.524	0.27
7_I	223_Q	0.524	0.27
119_L	301_G	0.523	0.27
33_R	36_A	0.523	0.27
208_E	269_V	0.522	0.27
279_K	283_Q	0.520	0.27
215_E	218_V	0.519	0.27
84_V	96_S	0.519	0.27
50_L	61_K	0.518	0.26
37_Q	40_R	0.516	0.26
44_L	170_A	0.516	0.26
37_Q	59_L	0.514	0.26
271_D	276_K	0.513	0.26
135_G	254_V	0.512	0.26
28_Y	62_S	0.511	0.26
121_D	166_H	0.510	0.26
152_A	226_V	0.510	0.26
264_T	280_E	0.510	0.26
55_K	58_E	0.508	0.26
7_I	329_Q	0.507	0.26
319_K	326_D	0.507	0.26
110_A	235_L	0.507	0.26
292_E	304_T	0.506	0.26
84_V	87_M	0.504	0.26
85_P	92_L	0.504	0.26
268_F	281_A	0.502	0.25
297_E	302_M	0.502	0.25
16_D	58_E	0.502	0.25
47_V	170_A	0.502	0.25
74_V	77_A	0.502	0.25
6_K	280_E	0.502	0.25
287_S	292_E	0.501	0.25
10_D	41_D	0.500	0.25
118_K	306_V	0.500	0.25
210_M	247_I	0.500	0.25
7_I	323_Q	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ulkA	3	0.9731	100	0.497	Contact Map
4xdyA	2	0.9731	100	0.503	Contact Map
4xdzA	2	0.9821	100	0.505	Contact Map
4tskA	3	0.9851	100	0.531	Contact Map
3fr7A	2	0.9761	100	0.576	Contact Map
1np3A	4	0.9761	100	0.582	Contact Map
4kqwA	2	0.9731	100	0.599	Contact Map
4yt2A	2	0.8985	99.9	0.834	Contact Map
3ggoA	2	0.7881	99.7	0.879	Contact Map
3c24A	2	0.7761	99.4	0.896	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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