GREMLIN Database
ILVC1 - Ketol-acid reductoisomerase 1
UniProt: Q9UWX9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 335 (326)
Sequences: 1923 (662)
Seq/√Len: 36.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_I44_L4.6141.00
102_K105_A4.1491.00
152_A177_A3.9581.00
210_M242_V3.1891.00
22_R45_N3.0301.00
103_K125_D2.9331.00
251_L262_G2.8881.00
106_D129_Y2.8111.00
84_V92_L2.7901.00
35_W110_A2.7631.00
154_V165_L2.7621.00
178_T182_V2.6781.00
310_S314_N2.5781.00
123_P126_S2.5751.00
259_K309_L2.5071.00
210_M235_L2.5011.00
206_I235_L2.4401.00
189_E223_Q2.4291.00
143_Y146_A2.4211.00
94_L98_Q2.3681.00
58_E61_K2.3641.00
91_T95_E2.3611.00
277_R280_E2.2930.99
271_D274_V2.2800.99
87_M256_D2.2250.99
245_K249_G2.1760.99
13_A178_T2.1670.99
142_E244_E2.1570.99
265_V281_A2.1420.99
40_R65_I2.0900.99
268_F284_R2.0270.99
108_V129_Y2.0200.99
82_F97_V1.9780.98
274_V277_R1.9560.98
91_T299_G1.9470.98
106_D167_K1.9360.98
211_R312_V1.9200.98
52_R69_H1.8980.98
173_K178_T1.8890.98
106_D127_D1.8890.98
57_W61_K1.8870.98
265_V293_E1.8390.97
18_I170_A1.8260.97
39_L174_G1.8260.97
265_V284_R1.8160.97
300_R303_P1.7930.97
48_V65_I1.7730.97
159_D166_H1.7500.96
71_K96_S1.7420.96
28_Y63_D1.7410.96
70_T96_S1.7330.96
271_D277_R1.7170.96
127_D164_A1.6910.96
16_D19_K1.6790.96
24_A73_A1.6560.95
165_L184_P1.6530.95
273_S276_K1.6230.95
81_I110_A1.6150.94
68_L76_D1.6090.94
50_L54_G1.6020.94
80_I105_A1.6020.94
223_Q226_V1.5910.94
135_G177_A1.5880.94
26_L82_F1.5810.94
210_M232_I1.5720.94
57_W69_H1.5600.93
113_F291_A1.5600.93
61_K66_T1.5480.93
66_T76_D1.5400.93
35_W81_I1.5310.93
125_D160_V1.5290.93
139_T142_E1.5280.93
47_V76_D1.5120.92
26_L49_G1.4980.92
47_V68_L1.4920.92
127_D163_T1.4900.92
298_Y302_M1.4790.91
207_M262_G1.4750.91
319_K323_Q1.4750.91
10_D178_T1.4600.91
206_I210_M1.4450.90
81_I108_V1.4430.90
283_Q287_S1.4270.90
183_I226_V1.4090.89
296_E300_R1.4070.89
22_R47_V1.4010.89
143_Y148_G1.3920.89
296_E299_G1.3870.88
52_R57_W1.3830.88
293_E304_T1.3820.88
207_M247_I1.3740.88
74_V105_A1.3670.88
268_F277_R1.3620.87
265_V269_V1.3620.87
264_T293_E1.3470.87
208_E275_R1.3390.87
294_W297_E1.3350.86
22_R76_D1.3280.86
264_T284_R1.3260.86
74_V100_Y1.3240.86
259_K263_M1.3210.86
256_D302_M1.3190.86
280_E284_R1.3140.85
215_E275_R1.3080.85
75_K100_Y1.2970.85
138_P253_A1.2900.84
210_M317_E1.2880.84
263_M309_L1.2880.84
207_M251_L1.2880.84
232_I242_V1.2710.84
37_Q65_I1.2680.83
208_E211_R1.2660.83
214_F316_L1.2580.83
89_Q114_N1.2560.83
307_N311_N1.2560.83
13_A182_V1.2530.83
8_Y165_L1.2450.82
58_E62_S1.2440.82
208_E212_A1.2430.82
116_H188_K1.2400.82
106_D161_S1.2120.80
219_E279_K1.2120.80
105_A126_S1.2010.80
219_E275_R1.2000.80
74_V80_I1.1960.80
218_V316_L1.1960.80
305_V309_L1.1940.79
294_W302_M1.1850.79
140_V150_V1.1830.79
269_V281_A1.1830.79
292_E296_E1.1770.78
129_Y164_A1.1750.78
127_D160_V1.1690.78
51_E55_K1.1680.78
23_I174_G1.1660.78
69_H72_D1.1570.77
42_S144_Y1.1440.76
45_N66_T1.1410.76
294_W298_Y1.1380.76
54_G65_I1.1330.76
26_L84_V1.1310.76
289_K293_E1.1270.75
172_A182_V1.1250.75
263_M308_G1.1250.75
257_T290_F1.1130.74
119_L295_V1.1080.74
54_G57_W1.0990.73
232_I317_E1.0970.73
90_R94_L1.0950.73
13_A173_K1.0910.73
254_V262_G1.0900.73
14_N17_L1.0860.73
163_T166_H1.0840.72
33_R253_A1.0840.72
127_D161_S1.0820.72
114_N120_I1.0770.72
215_E315_S1.0710.72
200_V213_A1.0700.71
212_A216_T1.0570.70
277_R284_R1.0490.70
125_D158_Q1.0470.70
15_L173_K1.0440.70
101_M126_S1.0390.69
284_R289_K1.0340.69
70_T74_V1.0340.69
308_G312_V1.0300.68
244_E249_G1.0280.68
295_V300_R1.0240.68
100_Y105_A1.0210.68
296_E307_N1.0200.68
189_E226_V1.0140.67
50_L56_S1.0130.67
206_I242_V1.0110.67
113_F119_L1.0060.67
272_E276_K1.0010.66
269_V274_V0.9940.66
310_S313_Q0.9940.66
160_V164_A0.9890.65
105_A123_P0.9840.65
10_D173_K0.9820.65
201_I213_A0.9810.65
71_K100_Y0.9760.64
6_K184_P0.9690.64
135_G150_V0.9680.64
65_I68_L0.9630.63
302_M306_V0.9610.63
122_P125_D0.9550.63
33_R138_P0.9480.62
307_N310_S0.9460.62
45_N76_D0.9370.61
17_L170_A0.9360.61
56_S67_P0.9280.60
106_D164_A0.9270.60
25_V171_I0.9260.60
272_E275_R0.9180.59
80_I123_P0.9150.59
200_V269_V0.9070.59
14_N166_H0.9020.58
47_V80_I0.9020.58
326_D329_Q0.9010.58
294_W305_V0.9000.58
264_T308_G0.8900.57
276_K279_K0.8860.57
108_V171_I0.8860.57
208_E267_K0.8750.56
69_H74_V0.8750.56
249_G252_K0.8730.56
59_L63_D0.8690.55
281_A284_R0.8680.55
25_V39_L0.8610.55
118_K121_D0.8590.54
248_S313_Q0.8580.54
269_V277_R0.8530.54
37_Q63_D0.8490.53
302_M305_V0.8490.53
131_I172_A0.8460.53
135_G152_A0.8460.53
148_G330_K0.8410.53
90_R299_G0.8370.52
115_I130_M0.8360.52
101_M123_P0.8320.52
44_L174_G0.8310.52
25_V36_A0.8290.52
256_D294_W0.8290.52
50_L67_P0.8270.52
251_L312_V0.8270.52
78_D105_A0.8260.51
129_Y154_V0.8250.51
165_L169_L0.8230.51
328_V331_G0.8230.51
26_L74_V0.8180.51
51_E57_W0.8140.50
148_G331_G0.8130.50
26_L70_T0.8080.50
6_K11_N0.8030.49
139_T243_Y0.8030.49
24_A47_V0.8020.49
93_W107_L0.8000.49
89_Q120_I0.7930.49
248_S318_E0.7890.48
216_T275_R0.7890.48
68_L72_D0.7880.48
18_I174_G0.7880.48
304_T308_G0.7870.48
113_F191_T0.7870.48
79_I129_Y0.7810.48
49_G56_S0.7790.47
273_S277_R0.7760.47
89_Q109_F0.7720.47
296_E311_N0.7710.47
324_L328_V0.7690.46
304_T307_N0.7680.46
88_V92_L0.7650.46
105_A125_D0.7630.46
143_Y243_Y0.7610.46
232_I247_I0.7600.46
40_R54_G0.7590.46
208_E251_L0.7540.45
265_V277_R0.7530.45
119_L296_E0.7490.45
82_F92_L0.7470.45
152_A175_I0.7460.44
152_A182_V0.7440.44
167_K170_A0.7410.44
59_L62_S0.7380.44
103_K160_V0.7370.44
284_R293_E0.7350.44
78_D102_K0.7250.43
210_M239_V0.7230.42
40_R63_D0.7190.42
46_V49_G0.7180.42
119_L298_Y0.7150.42
220_E282_L0.7130.42
135_G142_E0.7110.41
113_F295_V0.7090.41
56_S59_L0.7080.41
313_Q316_L0.7060.41
154_V168_A0.7060.41
20_G170_A0.7030.41
30_S138_P0.7030.41
39_L171_I0.7030.41
17_L167_K0.7020.41
296_E310_S0.7020.41
9_T327_L0.7000.41
142_E145_K0.7000.41
296_E304_T0.6990.40
183_I330_K0.6960.40
37_Q56_S0.6960.40
247_I312_V0.6930.40
143_Y329_Q0.6910.40
235_L242_V0.6880.40
242_V247_I0.6880.40
90_R295_V0.6870.39
319_K322_N0.6860.39
128_V158_Q0.6830.39
79_I170_A0.6820.39
117_Y191_T0.6790.39
260_Y293_E0.6770.39
270_I274_V0.6760.39
284_R287_S0.6750.38
148_G243_Y0.6750.38
51_E54_G0.6750.38
138_P252_K0.6750.38
280_E283_Q0.6740.38
33_R63_D0.6710.38
280_E289_K0.6700.38
165_L168_A0.6690.38
173_K182_V0.6630.37
60_A67_P0.6610.37
108_V167_K0.6590.37
84_V88_V0.6590.37
205_G209_L0.6590.37
75_K102_K0.6590.37
260_Y330_K0.6580.37
305_V308_G0.6570.37
159_D162_G0.6550.37
208_E262_G0.6540.37
135_G139_T0.6540.37
263_M293_E0.6520.37
118_K157_H0.6490.36
200_V281_A0.6480.36
57_W67_P0.6480.36
15_L44_L0.6470.36
37_Q41_D0.6460.36
40_R52_R0.6450.36
323_Q326_D0.6440.36
72_D76_D0.6440.36
8_Y184_P0.6430.36
153_L184_P0.6430.36
24_A49_G0.6430.36
130_M152_A0.6420.36
148_G329_Q0.6420.36
60_A65_I0.6400.36
21_K167_K0.6390.35
281_A293_E0.6360.35
50_L57_W0.6350.35
142_E249_G0.6340.35
248_S322_N0.6340.35
183_I223_Q0.6270.35
289_K292_E0.6240.34
102_K126_S0.6240.34
116_H157_H0.6240.34
35_W108_V0.6220.34
103_K126_S0.6200.34
51_E88_V0.6200.34
81_I171_I0.6190.34
309_L313_Q0.6190.34
296_E303_P0.6190.34
293_E296_E0.6180.34
51_E70_T0.6170.34
76_D170_A0.6160.34
54_G67_P0.6140.34
74_V82_F0.6130.33
87_M331_G0.6120.33
87_M254_V0.6110.33
293_E308_G0.6090.33
26_L97_V0.6090.33
196_F282_L0.6090.33
87_M259_K0.6070.33
135_G179_R0.6070.33
264_T277_R0.6060.33
220_E286_K0.6060.33
208_E285_I0.6040.33
191_T291_A0.6020.33
311_N314_N0.6010.32
251_L254_V0.5990.32
11_N173_K0.5980.32
247_I317_E0.5980.32
139_T331_G0.5960.32
265_V280_E0.5940.32
80_I126_S0.5940.32
188_K226_V0.5940.32
56_S60_A0.5920.32
24_A80_I0.5910.32
142_E146_A0.5870.31
33_R37_Q0.5860.31
72_D75_K0.5860.31
7_I26_L0.5860.31
98_Q123_P0.5850.31
10_D15_L0.5850.31
192_E286_K0.5820.31
75_K269_V0.5820.31
211_R247_I0.5820.31
139_T143_Y0.5820.31
127_D167_K0.5790.31
61_K67_P0.5760.31
8_Y12_D0.5740.30
309_L312_V0.5730.30
215_E267_K0.5710.30
103_K123_P0.5710.30
322_N326_D0.5690.30
129_Y168_A0.5690.30
120_I257_T0.5680.30
13_A17_L0.5680.30
121_D306_V0.5670.30
15_L40_R0.5660.30
265_V268_F0.5650.30
308_G311_N0.5640.30
236_K240_D0.5640.30
154_V226_V0.5640.30
214_F219_E0.5640.30
143_Y177_A0.5630.30
181_G229_F0.5630.30
260_Y265_V0.5630.30
40_R68_L0.5630.30
256_D309_L0.5620.30
69_H96_S0.5620.30
192_E222_Y0.5620.30
106_D163_T0.5600.29
314_N319_K0.5600.29
264_T281_A0.5590.29
140_V177_A0.5580.29
139_T328_V0.5580.29
281_A289_K0.5580.29
303_P306_V0.5580.29
76_D105_A0.5570.29
70_T84_V0.5530.29
68_L73_A0.5530.29
48_V68_L0.5510.29
118_K301_G0.5500.29
203_V254_V0.5500.29
33_R252_K0.5480.29
167_K292_E0.5480.29
36_A295_V0.5470.28
24_A77_A0.5460.28
256_D305_V0.5440.28
21_K78_D0.5430.28
117_Y287_S0.5420.28
214_F223_Q0.5400.28
25_V110_A0.5400.28
265_V308_G0.5390.28
117_Y257_T0.5390.28
321_G325_R0.5380.28
119_L299_G0.5380.28
74_V97_V0.5380.28
272_E279_K0.5370.28
234_E261_G0.5370.28
256_D259_K0.5370.28
262_G312_V0.5360.28
7_I143_Y0.5360.28
268_F280_E0.5350.28
254_V258_A0.5330.27
208_E215_E0.5330.27
18_I76_D0.5330.27
145_K148_G0.5330.27
129_Y167_K0.5320.27
119_L291_A0.5310.27
47_V77_A0.5310.27
200_V235_L0.5300.27
49_G80_I0.5300.27
264_T269_V0.5300.27
177_A330_K0.5300.27
40_R45_N0.5250.27
289_K304_T0.5240.27
7_I223_Q0.5240.27
119_L301_G0.5230.27
33_R36_A0.5230.27
208_E269_V0.5220.27
279_K283_Q0.5200.27
215_E218_V0.5190.27
84_V96_S0.5190.27
50_L61_K0.5180.26
37_Q40_R0.5160.26
44_L170_A0.5160.26
37_Q59_L0.5140.26
271_D276_K0.5130.26
135_G254_V0.5120.26
28_Y62_S0.5110.26
121_D166_H0.5100.26
152_A226_V0.5100.26
264_T280_E0.5100.26
55_K58_E0.5080.26
7_I329_Q0.5070.26
319_K326_D0.5070.26
110_A235_L0.5070.26
292_E304_T0.5060.26
84_V87_M0.5040.26
85_P92_L0.5040.26
268_F281_A0.5020.25
297_E302_M0.5020.25
16_D58_E0.5020.25
47_V170_A0.5020.25
74_V77_A0.5020.25
6_K280_E0.5020.25
287_S292_E0.5010.25
10_D41_D0.5000.25
118_K306_V0.5000.25
210_M247_I0.5000.25
7_I323_Q0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ulkA 3 0.9731 100 0.497 Contact Map
4xdyA 2 0.9731 100 0.503 Contact Map
4xdzA 2 0.9821 100 0.505 Contact Map
4tskA 3 0.9851 100 0.531 Contact Map
3fr7A 2 0.9761 100 0.576 Contact Map
1np3A 4 0.9761 100 0.582 Contact Map
4kqwA 2 0.9731 100 0.599 Contact Map
4yt2A 2 0.8985 99.9 0.834 Contact Map
3ggoA 2 0.7881 99.7 0.879 Contact Map
3c24A 2 0.7761 99.4 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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