GREMLIN Database
PDXT - Glutamine amidotransferase subunit PdxT
UniProt: Q9UWX4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 200 (185)
Sequences: 1643 (1119)
Seq/√Len: 82.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_K78_L3.6221.00
171_E197_L3.3451.00
170_A177_A3.2061.00
2_K31_E2.8901.00
87_A177_A2.7851.00
150_I170_A2.7041.00
74_I80_V2.6401.00
158_Q171_E2.4721.00
192_E196_H2.3421.00
93_E113_S2.3301.00
19_L48_I2.3171.00
110_M170_A2.2841.00
111_N172_E2.2221.00
169_F178_T2.1701.00
5_I16_F2.1281.00
149_A166_V2.1131.00
72_E76_S2.0331.00
129_I141_H2.0161.00
19_L30_G2.0041.00
81_L178_T2.0011.00
93_E152_K1.9971.00
115_I151_A1.9901.00
16_F34_S1.9411.00
110_M175_M1.9391.00
7_A34_S1.9361.00
16_F32_I1.9161.00
176_L197_L1.8171.00
2_K33_I1.8021.00
143_V185_S1.7951.00
169_F190_I1.7941.00
87_A150_I1.7721.00
3_I46_G1.7471.00
49_I89_M1.7161.00
92_K111_N1.6921.00
112_I177_A1.6881.00
32_I48_I1.6321.00
188_T192_E1.6111.00
95_S151_A1.5861.00
17_L20_K1.5731.00
67_L107_I1.5721.00
58_G105_P1.5591.00
94_V106_L1.5481.00
133_S158_Q1.5451.00
21_R188_T1.5381.00
67_L71_K1.5240.99
4_G44_V1.5240.99
87_A179_T1.5240.99
162_E165_G1.4750.99
109_T175_M1.4630.99
113_S152_K1.4560.99
129_I139_K1.4300.99
110_M177_A1.4230.99
119_Y179_T1.4200.99
118_Y149_A1.3940.99
58_G106_L1.3870.99
149_A179_T1.3840.99
74_I109_T1.3810.99
87_A114_V1.3430.99
130_V142_V1.3420.99
92_K109_T1.3320.99
97_A104_Q1.3270.99
58_G62_K1.3240.99
140_A189_S1.2820.98
33_I43_G1.2680.98
3_I195_L1.2530.98
159_S167_T1.2480.98
70_L73_K1.2380.98
153_V167_T1.2310.98
61_A89_M1.2190.97
16_F20_K1.2170.97
111_N154_W1.1980.97
91_A114_V1.1830.97
38_P65_G1.1800.97
95_S115_I1.1640.97
132_L190_I1.1630.97
71_K75_T1.1340.96
62_K67_L1.1240.96
171_E193_Y1.1210.96
18_Q188_T1.1200.96
127_E141_H1.1170.96
82_G178_T1.1080.96
2_K43_G1.1000.95
153_V159_S1.0970.95
12_F36_K1.0820.95
81_L190_I1.0410.94
28_L195_L1.0250.93
44_V79_P1.0240.93
162_E167_T1.0230.93
134_K158_Q1.0180.93
13_E17_L1.0150.93
20_K32_I0.9980.92
37_I40_D0.9940.92
139_K189_S0.9880.92
35_I44_V0.9870.92
33_I44_V0.9810.92
56_T60_V0.9720.91
154_W157_A0.9700.91
44_V73_K0.9660.91
176_L194_F0.9660.91
57_I89_M0.9610.91
66_L69_E0.9560.91
81_L176_L0.9560.91
127_E143_V0.9490.90
132_L140_A0.9390.90
81_L194_F0.9350.90
30_G48_I0.9320.89
68_D72_E0.9220.89
74_I175_M0.9100.88
38_P69_E0.9050.88
61_A107_I0.9020.88
35_I66_L0.9020.88
119_Y167_T0.9010.88
19_L191_H0.8970.87
130_V161_A0.8850.87
127_E185_S0.8840.87
3_I198_V0.8840.87
6_I47_V0.8710.86
41_L44_V0.8710.86
80_V109_T0.8650.86
20_K31_E0.8640.85
62_K105_P0.8620.85
132_L135_I0.8610.85
41_L70_L0.8580.85
160_L169_F0.8550.85
135_I139_K0.8550.85
132_L169_F0.8540.85
90_L175_M0.8530.85
18_Q191_H0.8450.84
41_L73_K0.8450.84
159_S162_E0.8360.84
157_A160_L0.8330.83
7_A12_F0.8280.83
58_G104_Q0.8240.83
18_Q21_R0.8230.83
110_M172_E0.8190.82
59_L63_R0.8130.82
48_I82_G0.8040.81
193_Y197_L0.7950.80
140_A190_I0.7930.80
40_D43_G0.7930.80
132_L161_A0.7870.80
176_L193_Y0.7800.79
12_F34_S0.7650.78
44_V78_L0.7580.77
34_S40_D0.7540.77
121_R190_I0.7520.77
131_D139_K0.7500.76
143_V184_L0.7470.76
8_Y60_V0.7430.76
70_L109_T0.7400.75
46_G78_L0.7300.74
133_S162_E0.7290.74
79_P174_N0.7280.74
166_V179_T0.7230.74
169_F176_L0.7220.74
133_S136_G0.7210.73
113_S151_A0.7190.73
140_A187_T0.7170.73
94_V97_A0.7150.73
28_L188_T0.7120.73
112_I150_I0.7120.73
105_P108_G0.7110.72
4_G41_L0.7100.72
13_E16_F0.7050.72
58_G103_S0.6990.71
150_I179_T0.6950.71
167_T170_A0.6950.71
135_I140_A0.6940.71
158_Q197_L0.6800.69
135_I190_I0.6800.69
119_Y142_V0.6790.69
163_L178_T0.6790.69
127_E130_V0.6750.69
104_Q108_G0.6750.69
40_D66_L0.6740.68
142_V161_A0.6730.68
90_L109_T0.6730.68
55_T126_F0.6710.68
118_Y166_V0.6700.68
58_G67_L0.6560.66
41_L66_L0.6520.66
60_V63_R0.6500.66
67_L105_P0.6490.65
167_T179_T0.6460.65
18_Q28_L0.6460.65
11_S184_L0.6400.64
115_I149_A0.6390.64
12_F16_F0.6360.64
92_K175_M0.6350.64
113_S154_W0.6340.64
19_L32_I0.6330.64
119_Y169_F0.6330.64
47_V70_L0.6330.64
35_I47_V0.6280.63
93_E155_G0.6250.63
11_S56_T0.6250.63
47_V80_V0.6230.62
12_F59_L0.6230.62
88_I150_I0.6200.62
156_K159_S0.6190.62
74_I107_I0.6180.62
194_F198_V0.6170.62
91_A112_I0.6140.61
60_V64_L0.6110.61
115_I118_Y0.6100.61
92_K112_I0.6090.61
119_Y123_K0.6080.60
70_L78_L0.6080.60
156_K172_E0.6060.60
136_G139_K0.6060.60
46_G195_L0.6050.60
57_I70_L0.5980.59
11_S149_A0.5980.59
119_Y130_V0.5950.59
58_G97_A0.5930.59
71_K109_T0.5920.58
12_F28_L0.5910.58
8_Y61_A0.5880.58
17_L21_R0.5880.58
163_L169_F0.5850.58
128_A142_V0.5820.57
134_K193_Y0.5790.57
185_S193_Y0.5780.57
38_P66_L0.5770.56
118_Y177_A0.5770.56
42_K69_E0.5770.56
174_N197_L0.5750.56
135_I189_S0.5750.56
82_G110_M0.5740.56
136_G192_E0.5710.56
163_L166_V0.5710.56
111_N156_K0.5690.55
173_N196_H0.5690.55
119_Y127_E0.5670.55
74_I90_L0.5660.55
140_A185_S0.5650.55
124_E163_L0.5640.55
30_G195_L0.5640.55
39_K42_K0.5620.55
60_V118_Y0.5560.54
5_I32_I0.5550.54
87_A149_A0.5540.54
92_K172_E0.5520.53
127_E142_V0.5500.53
60_V91_A0.5500.53
130_V168_V0.5460.52
4_G127_E0.5450.52
61_A74_I0.5420.52
36_K118_Y0.5410.52
140_A143_V0.5390.52
135_I141_H0.5370.51
41_L69_E0.5350.51
46_G194_F0.5320.51
40_D64_L0.5320.51
2_K45_D0.5300.50
72_E75_T0.5300.50
71_K195_L0.5290.50
5_I19_L0.5280.50
74_I79_P0.5280.50
11_S81_L0.5240.50
74_I174_N0.5240.50
7_A108_G0.5230.49
97_A106_L0.5230.49
37_I123_K0.5220.49
129_I140_A0.5210.49
97_A103_S0.5190.49
152_K179_T0.5150.48
128_A140_A0.5140.48
96_D104_Q0.5130.48
95_S113_S0.5110.48
8_Y41_L0.5090.48
118_Y191_H0.5090.48
138_D189_S0.5070.47
59_L62_K0.5070.47
129_I135_I0.5070.47
131_D138_D0.5050.47
151_A166_V0.5050.47
69_E72_E0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2issD 1 0.92 100 0.635 Contact Map
2nv0A 1 0.925 100 0.635 Contact Map
1q7rA 1 0.94 100 0.641 Contact Map
2abwA 1 0.97 100 0.642 Contact Map
3en0A 2 0.97 100 0.653 Contact Map
2ywdA 1 0.94 100 0.659 Contact Map
2ywjA 1 0.915 100 0.66 Contact Map
1jvnA 1 0.93 99.9 0.7 Contact Map
2vdjA 2 0.935 99.9 0.705 Contact Map
2h2wA 2 0.925 99.9 0.71 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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