GREMLIN Database
PDXS - Pyridoxal biosynthesis lyase PdxS
UniProt: Q9UWX3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (291)
Sequences: 889 (231)
Seq/√Len: 13.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_L306_V5.8671.00
171_A209_I4.6631.00
133_K268_W4.1401.00
110_E311_K3.9991.00
182_S225_V3.8250.99
104_A108_I3.7650.99
194_A333_L3.4860.99
206_M271_A3.3030.98
198_N324_I3.1610.98
173_N212_E3.0970.98
250_V273_G3.0860.97
284_Q320_M3.0380.97
159_N162_E2.9220.96
240_L244_I2.8890.96
70_V111_E2.8570.96
216_L238_V2.8340.96
190_T251_N2.8010.95
48_T52_K2.6670.94
78_E287_D2.5900.93
104_A334_Q2.5880.93
332_L335_V2.5680.93
216_L242_A2.5320.92
198_N323_D2.3850.90
49_T53_H2.3290.88
306_V309_A2.3080.88
107_K312_M2.3060.88
69_N111_E2.2990.88
113_M139_G2.1590.84
227_K231_Y2.1590.84
55_F59_Q2.1170.83
225_V235_Y2.0970.82
130_Y264_A2.0580.81
107_K311_K1.9640.78
206_M266_M1.9410.77
305_I309_A1.9370.77
284_Q315_E1.9110.76
136_E164_S1.8940.75
246_R272_D1.8690.74
198_N201_E1.8540.74
257_I297_A1.8420.73
219_M227_K1.7780.70
329_P335_V1.7710.70
199_V257_I1.7710.70
295_L308_E1.7540.69
198_N204_K1.7520.69
55_F142_M1.7450.69
129_Y268_W1.7320.68
201_E204_K1.7300.68
178_L237_I1.6880.66
250_V271_A1.6850.66
182_S235_Y1.6800.66
154_E200_S1.6540.65
47_G51_V1.6500.64
113_M140_V1.6320.63
320_M323_D1.6310.63
304_E308_E1.6240.63
274_L297_A1.6200.63
93_D282_K1.6140.63
107_K111_E1.5450.59
295_L299_C1.5300.58
129_Y133_K1.5160.58
173_N208_I1.5020.57
105_D313_I1.4800.56
54_A58_F1.4640.55
250_V272_D1.4250.53
59_Q142_M1.4130.52
221_E239_E1.4050.52
154_E204_K1.4030.52
154_E198_N1.4020.52
216_L227_K1.3780.50
214_R223_D1.3650.50
58_F298_A1.3640.50
190_T253_A1.3560.49
48_T54_A1.3490.49
155_E211_S1.3310.48
57_I273_G1.3210.47
49_T186_S1.3170.47
241_T244_I1.3150.47
233_V238_V1.3140.47
130_Y133_K1.3100.47
240_L243_K1.3080.47
94_V99_G1.3060.46
181_T188_I1.2910.46
172_R251_N1.2810.45
284_Q323_D1.2800.45
92_Y320_M1.2780.45
52_K186_S1.2760.45
53_H186_S1.2650.44
57_I142_M1.2650.44
208_I212_E1.2490.43
201_E324_I1.2370.43
288_E312_M1.2240.42
307_L311_K1.2190.42
235_Y239_E1.2100.41
159_N171_A1.2060.41
210_N214_R1.2000.41
253_A271_A1.1780.40
129_Y158_I1.1670.39
182_S233_V1.1670.39
173_N232_Q1.1350.38
182_S234_P1.1330.37
92_Y96_K1.1330.37
101_A201_E1.1220.37
172_R190_T1.1210.37
250_V253_A1.1210.37
178_L241_T1.1210.37
241_T246_R1.1190.37
323_D326_S1.1180.37
208_I334_Q1.1130.36
328_K331_E1.1080.36
228_A237_I1.0910.35
51_V54_A1.0900.35
47_G52_K1.0830.35
78_E117_T1.0830.35
284_Q322_I1.0820.35
227_K242_A1.0760.35
172_R265_L1.0700.34
244_I272_D1.0700.34
74_Q77_E1.0660.34
107_K110_E1.0500.33
188_I199_V1.0470.33
200_S207_K1.0440.33
138_L307_L1.0390.33
225_V229_R1.0380.33
289_R315_E1.0350.33
92_Y284_Q1.0270.32
89_K104_A1.0140.32
74_Q78_E1.0040.31
57_I250_V1.0020.31
171_A188_I0.9990.31
330_E335_V0.9960.31
217_I245_K0.9890.31
211_S238_V0.9880.31
211_S219_M0.9850.30
68_T72_Q0.9830.30
299_C302_Y0.9830.30
105_D314_S0.9790.30
129_Y289_R0.9700.30
223_D229_R0.9690.30
124_V158_I0.9690.30
134_L261_A0.9680.30
109_I194_A0.9670.30
206_M210_N0.9650.30
97_S104_A0.9640.29
223_D233_V0.9630.29
283_S286_P0.9600.29
162_E221_E0.9580.29
54_A72_Q0.9460.29
90_L94_V0.9400.28
54_A140_V0.9390.28
108_I111_E0.9370.28
52_K140_V0.9260.28
53_H59_Q0.9240.28
240_L246_R0.9210.28
112_V186_S0.9170.27
47_G53_H0.9160.27
94_V101_A0.9150.27
158_I163_F0.9120.27
219_M229_R0.9030.27
219_M231_Y0.9010.27
272_D327_L0.8970.27
198_N322_I0.8960.27
142_M250_V0.8950.27
266_M307_L0.8940.26
214_R233_V0.8920.26
134_L309_A0.8850.26
263_A293_V0.8790.26
90_L138_L0.8770.26
187_M250_V0.8740.26
245_K302_Y0.8740.26
198_N326_S0.8590.25
49_T59_Q0.8580.25
216_L241_T0.8570.25
132_A158_I0.8520.25
212_E215_S0.8510.25
305_I308_E0.8510.25
211_S220_S0.8470.25
150_T331_E0.8430.24
68_T172_R0.8390.24
48_T51_V0.8390.24
56_P60_K0.8320.24
210_N218_S0.8300.24
215_S218_S0.8270.24
196_T199_V0.8230.24
156_H232_Q0.8220.24
57_I110_E0.8190.23
82_V298_A0.8140.23
253_A272_D0.8120.23
130_Y306_V0.8090.23
101_A150_T0.8070.23
289_R320_M0.8030.23
268_W300_W0.8020.23
110_E114_S0.7990.23
97_S194_A0.7960.23
70_V138_L0.7910.22
322_I328_K0.7890.22
50_R53_H0.7890.22
331_E335_V0.7870.22
209_I253_A0.7860.22
97_S334_Q0.7850.22
70_V108_I0.7830.22
212_E219_M0.7800.22
227_K271_A0.7740.22
130_Y268_W0.7740.22
315_E320_M0.7730.22
47_G54_A0.7720.22
324_I333_L0.7720.22
221_E242_A0.7710.22
88_D94_V0.7670.22
68_T190_T0.7670.22
108_I334_Q0.7640.21
124_V172_R0.7630.21
201_E325_K0.7620.21
326_S332_L0.7600.21
242_A246_R0.7570.21
53_H250_V0.7560.21
72_Q96_K0.7520.21
297_A309_A0.7480.21
117_T324_I0.7480.21
133_K303_P0.7480.21
68_T104_A0.7470.21
97_S333_L0.7430.21
109_I334_Q0.7400.21
187_M273_G0.7400.21
100_V196_T0.7400.21
130_Y289_R0.7390.21
101_A198_N0.7390.21
104_A109_I0.7380.21
199_V289_R0.7380.21
92_Y268_W0.7360.20
225_V233_V0.7350.20
226_K232_Q0.7330.20
214_R245_K0.7290.20
234_P237_I0.7280.20
217_I242_A0.7270.20
227_K238_V0.7240.20
203_V265_L0.7190.20
285_D331_E0.7170.20
232_Q299_C0.7160.20
274_L287_D0.7130.20
169_N310_Q0.7120.20
284_Q312_M0.7120.20
94_V318_S0.7120.20
49_T54_A0.7110.20
199_V266_M0.7100.20
229_R232_Q0.7090.20
53_H161_W0.7080.19
218_S222_E0.7070.19
133_K300_W0.7050.19
52_K58_F0.7040.19
113_M138_L0.7030.19
59_Q272_D0.7000.19
206_M209_I0.6990.19
194_A209_I0.6960.19
257_I263_A0.6950.19
52_K56_P0.6950.19
203_V253_A0.6950.19
154_E172_R0.6940.19
78_E299_C0.6910.19
133_K158_I0.6900.19
172_R253_A0.6850.19
110_E199_V0.6830.19
216_L224_R0.6810.19
324_I327_L0.6810.19
271_A332_L0.6810.19
219_M242_A0.6800.19
178_L228_A0.6770.18
219_M246_R0.6750.18
88_D169_N0.6730.18
63_V263_A0.6720.18
78_E304_E0.6710.18
326_S330_E0.6700.18
220_S225_V0.6670.18
320_M325_K0.6660.18
303_P311_K0.6620.18
53_H240_L0.6600.18
295_L309_A0.6600.18
199_V324_I0.6590.18
208_I234_P0.6580.18
105_D309_A0.6580.18
238_V242_A0.6520.18
110_E240_L0.6520.18
57_I60_K0.6520.18
172_R194_A0.6520.18
257_I293_V0.6510.18
172_R203_V0.6500.18
226_K233_V0.6490.18
86_V94_V0.6470.18
68_T251_N0.6450.17
246_R295_L0.6430.17
213_I241_T0.6430.17
246_R273_G0.6400.17
213_I244_I0.6380.17
129_Y163_F0.6380.17
61_G64_V0.6370.17
285_D314_S0.6370.17
209_I271_A0.6360.17
284_Q289_R0.6350.17
49_T52_K0.6340.17
53_H273_G0.6320.17
107_K164_S0.6300.17
253_A267_M0.6280.17
50_R54_A0.6270.17
89_K94_V0.6260.17
63_V264_A0.6260.17
282_K315_E0.6250.17
142_M297_A0.6240.17
63_V293_V0.6230.17
59_Q133_K0.6230.17
60_K298_A0.6220.17
215_S227_K0.6200.17
224_R234_P0.6190.17
49_T55_F0.6110.16
51_V58_F0.6110.16
113_M299_C0.6100.16
130_Y312_M0.6090.16
92_Y156_H0.6090.16
222_E300_W0.6020.16
257_I264_A0.6010.16
111_E331_E0.6010.16
105_D285_D0.5980.16
216_L231_Y0.5950.16
310_Q314_S0.5930.16
96_K113_M0.5920.16
225_V232_Q0.5910.16
178_L238_V0.5910.16
74_Q288_E0.5900.16
217_I271_A0.5890.16
207_K223_D0.5880.16
97_S108_I0.5880.16
86_V90_L0.5870.16
103_M265_L0.5870.16
82_V323_D0.5860.16
139_G304_E0.5860.16
56_P298_A0.5850.16
156_H220_S0.5850.16
274_L324_I0.5840.16
182_S220_S0.5830.16
263_A271_A0.5820.16
55_F164_S0.5800.16
198_N209_I0.5780.16
48_T165_V0.5770.15
267_M272_D0.5760.15
326_S335_V0.5760.15
201_E286_P0.5750.15
285_D288_E0.5750.15
297_A306_V0.5740.15
46_T53_H0.5730.15
108_I138_L0.5710.15
113_M198_N0.5700.15
113_M143_I0.5680.15
208_I237_I0.5660.15
156_H200_S0.5620.15
227_K241_T0.5610.15
236_Q326_S0.5600.15
65_M87_L0.5600.15
232_Q238_V0.5590.15
113_M142_M0.5580.15
90_L124_V0.5570.15
74_Q117_T0.5570.15
68_T230_E0.5560.15
47_G250_V0.5560.15
210_N244_I0.5560.15
124_V297_A0.5550.15
97_S324_I0.5510.15
188_I247_L0.5510.15
235_Y238_V0.5480.15
154_E325_K0.5470.15
286_P313_I0.5460.15
264_A293_V0.5450.15
100_V150_T0.5450.15
207_K233_V0.5450.15
173_N233_V0.5440.15
92_Y182_S0.5440.15
285_D306_V0.5440.15
66_D126_I0.5430.15
58_F252_F0.5420.15
137_A329_P0.5400.14
333_L337_G0.5400.14
257_I266_M0.5380.14
124_V307_L0.5370.14
51_V117_T0.5370.14
78_E110_E0.5370.14
156_H229_R0.5360.14
87_L191_K0.5350.14
90_L169_N0.5350.14
92_Y257_I0.5350.14
190_T209_I0.5340.14
140_V165_V0.5310.14
124_V143_I0.5290.14
47_G59_Q0.5280.14
97_S101_A0.5270.14
320_M334_Q0.5270.14
325_K332_L0.5270.14
312_M328_K0.5260.14
202_A279_G0.5240.14
155_E204_K0.5230.14
123_K191_K0.5220.14
224_R242_A0.5220.14
209_I300_W0.5190.14
198_N333_L0.5170.14
50_R232_Q0.5170.14
87_L279_G0.5170.14
246_R274_L0.5170.14
101_A327_L0.5160.14
90_L97_S0.5160.14
130_Y272_D0.5160.14
287_D291_K0.5140.14
101_A204_K0.5130.14
65_M85_M0.5130.14
257_I322_I0.5130.14
199_V227_K0.5120.14
201_E326_S0.5110.14
114_S161_W0.5110.14
58_F299_C0.5110.14
200_S265_L0.5100.14
216_L219_M0.5090.14
221_E243_K0.5090.14
178_L213_I0.5090.14
97_S109_I0.5090.14
163_F167_F0.5090.14
217_I241_T0.5090.14
207_K232_Q0.5080.14
85_M279_G0.5080.14
77_E187_M0.5070.14
132_A286_P0.5070.14
65_M279_G0.5060.14
191_K279_G0.5040.14
206_M257_I0.5040.14
246_R250_V0.5030.14
45_H142_M0.5030.14
156_H226_K0.5020.13
59_Q229_R0.5020.13
182_S232_Q0.5010.13
163_F188_I0.5000.13
333_L336_R0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yzrA 5 0.8077 100 0.721 Contact Map
2nv1A 5 0.7663 100 0.784 Contact Map
2zbtA 5 0.8225 100 0.789 Contact Map
3o07A 3 0.7633 100 0.806 Contact Map
4adtA 5 0.8077 100 0.81 Contact Map
4qccA 6 0.6538 99.6 0.906 Contact Map
2htmA 3 0.5799 99.5 0.909 Contact Map
3qjaA 1 0.7278 99.5 0.911 Contact Map
1wv2A 3 0.5503 99.5 0.911 Contact Map
1y0eA 2 0.574 99.4 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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