GREMLIN Database
SYP - Proline--tRNA ligase
UniProt: Q9UWX2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 481 (363)
Sequences: 8159 (3634)
Seq/√Len: 190.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_K253_D5.5511.00
307_V355_P3.3991.00
313_E317_M2.9971.00
380_E383_N2.9311.00
74_E78_R2.8781.00
310_Y313_E2.6921.00
57_F60_S2.6301.00
313_E361_G2.6131.00
315_C319_N2.6091.00
249_D253_D2.4451.00
362_T375_T2.4101.00
57_F186_K2.3521.00
292_V342_W2.3521.00
374_Y384_K2.3511.00
174_Q221_D2.3461.00
293_V315_C2.3381.00
317_M382_I2.3321.00
24_E40_M2.3161.00
331_T341_I2.2471.00
377_R380_E2.2421.00
315_C325_C2.2381.00
175_K179_E2.2371.00
24_E123_W2.2321.00
247_K251_S2.2251.00
315_C327_T2.2211.00
48_Q51_I2.2131.00
291_V323_I2.1971.00
321_N386_K2.1421.00
74_E105_K2.1421.00
244_K252_L2.1181.00
189_D195_Y2.1141.00
172_D175_K2.1051.00
362_T377_R2.0931.00
55_R65_E2.0801.00
49_N324_T2.0241.00
66_V119_M1.9701.00
182_E186_K1.9681.00
95_T105_K1.9431.00
355_P359_I1.9281.00
309_K313_E1.9271.00
167_H172_D1.9261.00
383_N387_E1.9141.00
52_G56_N1.9031.00
312_I316_E1.8891.00
46_L267_V1.8791.00
185_K189_D1.8781.00
317_M379_E1.8611.00
27_D40_M1.8581.00
290_K324_T1.8331.00
80_E121_N1.8311.00
235_Q239_K1.8141.00
174_Q232_H1.8011.00
66_V116_I1.7711.00
209_A212_T1.7451.00
310_Y358_L1.7421.00
289_I326_L1.7321.00
312_I315_C1.7271.00
71_L141_F1.7231.00
186_K190_T1.7181.00
75_D78_R1.7171.00
367_R370_N1.7151.00
271_I282_L1.7081.00
294_I335_P1.7061.00
169_T172_D1.6931.00
386_K390_N1.6541.00
323_I386_K1.6471.00
59_D135_Y1.6461.00
384_K388_L1.6271.00
356_R359_I1.6051.00
42_Y345_K1.5901.00
39_W267_V1.5871.00
361_G379_E1.5841.00
316_E320_K1.5791.00
270_V286_V1.5681.00
235_Q256_H1.5601.00
293_V311_S1.5571.00
384_K387_E1.5481.00
365_I381_A1.5451.00
178_E182_E1.5441.00
60_S319_N1.5431.00
49_N52_G1.5371.00
309_K312_I1.5041.00
312_I327_T1.4841.00
317_M378_K1.4681.00
45_K324_T1.4521.00
310_Y353_I1.4461.00
56_N190_T1.4431.00
380_E384_K1.4241.00
335_P339_F1.4211.00
72_I115_A1.4191.00
167_H176_Q1.4081.00
18_W22_E1.4081.00
53_I190_T1.3841.00
57_F61_T1.3831.00
232_H256_H1.3721.00
294_I350_R1.3661.00
296_I335_P1.3651.00
382_I386_K1.3611.00
356_R360_S1.3541.00
185_K195_Y1.3531.00
48_Q52_G1.3411.00
245_I253_D1.3371.00
299_K355_P1.3341.00
291_V351_L1.3201.00
297_P307_V1.3131.00
117_T243_F1.3091.00
176_Q179_E1.3061.00
351_L381_A1.3021.00
323_I385_I1.2981.00
174_Q178_E1.2951.00
317_M321_N1.2841.00
202_E206_F1.2831.00
63_H133_K1.2781.00
48_Q59_D1.2741.00
217_T220_P1.2671.00
33_I36_M1.2601.00
295_P327_T1.2541.00
182_E185_K1.2461.00
84_I107_A1.2421.00
44_F48_Q1.2361.00
349_I367_R1.2361.00
327_T330_D1.2331.00
307_V358_L1.2301.00
314_I378_K1.2301.00
284_P349_I1.2211.00
206_F210_L1.2121.00
246_Q252_L1.2121.00
196_V224_A1.2071.00
343_E350_R1.1981.00
20_L25_F1.1911.00
42_Y289_I1.1801.00
45_K49_N1.1791.00
284_P388_L1.1761.00
71_L94_V1.1731.00
78_R85_K1.1701.00
71_L108_L1.1681.00
349_I385_I1.1681.00
365_I376_V1.1601.00
86_G236_N1.1601.00
334_T337_E1.1551.00
47_R159_T1.1551.00
364_F375_T1.1521.00
74_E84_I1.1501.00
281_V346_G1.1461.00
11_N14_E1.1441.00
311_S327_T1.1361.00
349_I365_I1.1361.00
298_A308_M1.1211.00
292_V347_V1.1201.00
173_A232_H1.1161.00
342_W347_V1.1151.00
133_K176_Q1.1111.00
365_I384_K1.1091.00
284_P290_K1.1081.00
342_W350_R1.1031.00
281_V369_D1.1001.00
61_T183_I1.0981.00
80_E241_L1.0981.00
9_S12_F1.0961.00
8_W18_W1.0961.00
308_M312_I1.0951.00
185_K197_L1.0951.00
383_N386_K1.0941.00
207_A236_N1.0941.00
360_S375_T1.0931.00
349_I388_L1.0881.00
343_E346_G1.0801.00
321_N382_I1.0731.00
64_E326_L1.0691.00
60_S186_K1.0631.00
42_Y326_L1.0631.00
284_P389_L1.0601.00
317_M361_G1.0601.00
57_F190_T1.0561.00
70_L141_F1.0561.00
27_D122_L1.0531.00
54_I58_L1.0491.00
317_M320_K1.0491.00
61_T179_E1.0491.00
154_L264_D1.0451.00
295_P311_S1.0441.00
312_I330_D1.0371.00
172_D176_Q1.0361.00
245_I255_P1.0321.00
53_I186_K1.0291.00
291_V318_F1.0251.00
217_T221_D1.0241.00
351_L365_I1.0211.00
293_V314_I1.0161.00
313_E316_E1.0131.00
363_V378_K1.0111.00
45_K59_D1.0101.00
292_V326_L1.0101.00
109_R112_S1.0091.00
56_N60_S1.0081.00
56_N322_N1.0041.00
351_L363_V1.0021.00
54_I187_I0.9910.99
48_Q65_E0.9910.99
186_K189_D0.9880.99
328_D338_K0.9870.99
44_F67_L0.9810.99
177_V213_Y0.9780.99
381_A385_I0.9770.99
284_P385_I0.9760.99
343_E366_K0.9720.99
367_R388_L0.9720.99
175_K178_E0.9710.99
63_H176_Q0.9700.99
376_V384_K0.9680.99
293_V353_I0.9650.99
238_S255_P0.9590.99
66_V134_Y0.9540.99
357_E375_T0.9530.99
133_K179_E0.9510.99
170_Y256_H0.9490.99
206_F209_A0.9460.99
357_E360_S0.9450.99
361_G378_K0.9450.99
50_I266_A0.9400.99
210_L214_A0.9400.99
163_A180_A0.9370.99
243_F255_P0.9360.99
275_G281_V0.9350.99
244_K254_Y0.9350.99
378_K382_I0.9340.99
293_V327_T0.9340.99
292_V345_K0.9290.99
328_D331_T0.9270.99
139_S156_E0.9250.99
326_L347_V0.9220.99
20_L151_M0.9170.99
319_N325_C0.9090.99
121_N242_D0.9080.99
112_S136_Q0.9080.99
281_V368_R0.9070.99
370_N374_Y0.9070.99
118_T121_N0.9040.99
313_E378_K0.8940.99
32_P38_V0.8930.99
61_T186_K0.8890.99
117_T254_Y0.8890.99
333_K337_E0.8850.99
290_K323_I0.8840.99
117_T166_V0.8830.99
370_N373_S0.8780.99
51_I67_L0.8720.99
239_K254_Y0.8710.99
215_F219_M0.8700.99
70_L139_S0.8690.99
291_V385_I0.8680.99
181_I197_L0.8630.99
330_D333_K0.8600.98
297_P355_P0.8600.98
47_R67_L0.8590.98
323_I389_L0.8500.98
337_E341_I0.8470.98
352_E364_F0.8460.98
363_V381_A0.8450.98
202_E205_R0.8440.98
63_H163_A0.8420.98
19_V23_G0.8410.98
195_Y199_E0.8360.98
376_V380_E0.8360.98
60_S320_K0.8340.98
90_E93_W0.8300.98
108_L141_F0.8260.98
308_M330_D0.8260.98
316_E319_N0.8240.98
98_G104_V0.8240.98
47_R264_D0.8130.98
53_I57_F0.8110.98
151_M154_L0.8050.98
49_N290_K0.8050.98
39_W43_G0.8050.98
201_P204_D0.8020.98
310_Y357_E0.8000.98
295_P307_V0.7990.98
235_Q238_S0.7940.97
39_W264_D0.7920.97
179_E182_E0.7890.97
55_R59_D0.7880.97
318_F382_I0.7880.97
366_K373_S0.7870.97
166_V255_P0.7850.97
361_G377_R0.7830.97
318_F323_I0.7810.97
173_A233_L0.7810.97
211_H232_H0.7760.97
188_F215_F0.7750.97
154_L157_I0.7750.97
70_L108_L0.7750.97
310_Y378_K0.7740.97
64_E132_K0.7730.97
314_I317_M0.7720.97
291_V325_C0.7700.97
59_D319_N0.7690.97
97_G143_Y0.7680.97
199_E211_H0.7680.97
376_V381_A0.7660.97
311_S353_I0.7640.97
86_G205_R0.7580.97
40_M119_M0.7580.97
310_Y361_G0.7570.97
181_I230_V0.7570.97
27_D123_W0.7550.97
274_H281_V0.7520.97
165_T180_A0.7510.96
68_F116_I0.7500.96
344_I368_R0.7480.96
120_E134_Y0.7470.96
24_E27_D0.7470.96
13_S17_D0.7470.96
181_I213_Y0.7450.96
73_P104_V0.7450.96
295_P308_M0.7410.96
9_S13_S0.7400.96
75_D104_V0.7350.96
218_I222_G0.7330.96
50_I267_V0.7320.96
374_Y380_E0.7300.96
87_F207_A0.7280.96
371_F374_Y0.7230.96
321_N383_N0.7210.96
170_Y174_Q0.7200.96
80_E242_D0.7190.95
294_I342_W0.7190.95
387_E390_N0.7180.95
191_L286_V0.7180.95
13_S275_G0.7150.95
206_F214_A0.7130.95
165_T176_Q0.7120.95
357_E362_T0.7120.95
95_T98_G0.7100.95
238_S254_Y0.7090.95
298_A312_I0.7080.95
208_G212_T0.7070.95
139_S159_T0.7060.95
61_T133_K0.7060.95
353_I363_V0.7050.95
46_L282_L0.7040.95
179_E183_I0.7030.95
234_G238_S0.7020.95
61_T182_E0.7010.95
238_S241_L0.6990.95
271_I274_H0.6980.95
363_V376_V0.6980.95
61_T180_A0.6970.95
238_S243_F0.6960.95
157_I262_I0.6960.95
75_D80_E0.6900.94
314_I318_F0.6870.94
235_Q254_Y0.6860.94
20_L26_Y0.6850.94
48_Q55_R0.6830.94
32_P118_T0.6800.94
52_G55_R0.6800.94
15_W275_G0.6790.94
191_L266_A0.6780.94
123_W129_Q0.6770.94
10_K13_S0.6760.94
58_L180_A0.6750.94
215_F222_G0.6750.94
180_A183_I0.6720.94
219_M222_G0.6710.94
93_W107_A0.6700.93
78_R84_I0.6640.93
236_N240_A0.6640.93
323_I382_I0.6630.93
22_E344_I0.6630.93
58_L163_A0.6620.93
59_D65_E0.6610.93
25_F271_I0.6610.93
195_Y198_S0.6600.93
379_E383_N0.6590.93
262_I266_A0.6580.93
92_F143_Y0.6560.93
284_P381_A0.6550.93
125_K129_Q0.6550.93
54_I264_D0.6550.93
38_V119_M0.6510.92
71_L92_F0.6500.92
216_D219_M0.6490.92
295_P338_K0.6480.92
353_I357_E0.6460.92
289_I292_V0.6440.92
84_I105_K0.6440.92
19_V22_E0.6440.92
335_P343_E0.6410.92
58_L135_Y0.6410.92
31_Y36_M0.6380.92
247_K252_L0.6380.92
50_I286_V0.6350.92
169_T175_K0.6320.91
62_G319_N0.6310.91
36_M71_L0.6310.91
364_F373_S0.6310.91
195_Y200_R0.6310.91
214_A217_T0.6300.91
169_T248_K0.6280.91
24_E345_K0.6270.91
54_I137_I0.6260.91
333_K341_I0.6260.91
364_F372_K0.6250.91
356_R375_T0.6250.91
125_K132_K0.6240.91
160_F258_T0.6240.91
33_I106_L0.6240.91
352_E373_S0.6210.91
28_Y37_G0.6210.91
184_Y260_Y0.6210.91
337_E340_Y0.6210.91
212_T236_N0.6200.91
367_R374_Y0.6190.90
215_F227_I0.6180.90
295_P298_A0.6170.90
152_I268_A0.6160.90
193_I269_S0.6160.90
355_P358_L0.6140.90
25_F46_L0.6120.90
298_A332_E0.6120.90
212_T229_T0.6110.90
287_A348_P0.6100.90
367_R371_F0.6070.90
218_I233_L0.6070.90
200_R229_T0.6070.90
236_N239_K0.6070.90
178_E181_I0.6050.89
276_D368_R0.6040.89
121_N241_L0.6030.89
68_F115_A0.6030.89
188_F266_A0.6020.89
117_T257_Q0.5970.89
92_F108_L0.5960.89
202_E210_L0.5960.89
198_S216_D0.5950.89
71_L106_L0.5950.89
25_F282_L0.5950.89
295_P335_P0.5930.89
118_T122_L0.5920.88
51_I55_R0.5920.88
87_F206_F0.5920.88
171_D174_Q0.5910.88
53_I285_S0.5900.88
96_K99_S0.5880.88
310_Y314_I0.5880.88
76_L118_T0.5880.88
15_W18_W0.5870.88
77_L115_A0.5860.88
54_I262_I0.5850.88
149_R152_I0.5850.88
270_V274_H0.5850.88
6_E13_S0.5820.88
189_D194_P0.5820.88
74_E107_A0.5790.87
39_W47_R0.5770.87
159_T264_D0.5770.87
140_V160_F0.5770.87
96_K105_K0.5750.87
294_I338_K0.5730.87
20_L271_I0.5730.87
123_W134_Y0.5720.87
120_E255_P0.5700.87
299_K307_V0.5690.86
225_M269_S0.5690.86
116_I134_Y0.5690.86
196_V199_E0.5680.86
294_I352_E0.5680.86
386_K389_L0.5660.86
210_L256_H0.5660.86
23_G345_K0.5650.86
205_R208_G0.5630.86
196_V200_R0.5610.86
219_M225_M0.5600.86
296_I336_G0.5590.85
350_R373_S0.5570.85
24_E42_Y0.5570.85
184_Y188_F0.5570.85
122_L125_K0.5560.85
25_F151_M0.5560.85
81_S87_F0.5550.85
202_E212_T0.5540.85
177_V230_V0.5530.85
202_E209_A0.5520.85
44_F51_I0.5520.85
205_R212_T0.5520.85
331_T334_T0.5520.85
199_E213_Y0.5510.85
226_Q229_T0.5510.85
58_L137_I0.5500.85
334_T338_K0.5480.84
95_T99_S0.5480.84
274_H369_D0.5470.84
367_R372_K0.5470.84
309_K316_E0.5460.84
318_F381_A0.5460.84
58_L260_Y0.5450.84
51_I137_I0.5450.84
44_F47_R0.5450.84
187_I258_T0.5440.84
32_P115_A0.5440.84
52_G59_D0.5420.84
362_T380_E0.5420.84
133_K163_A0.5410.84
140_V260_Y0.5380.83
284_P367_R0.5380.83
184_Y259_S0.5380.83
94_V97_G0.5360.83
27_D119_M0.5340.83
374_Y378_K0.5320.83
58_L183_I0.5310.82
246_Q251_S0.5300.82
164_H226_Q0.5270.82
170_Y253_D0.5260.82
112_S138_V0.5250.82
50_I260_Y0.5240.82
16_F271_I0.5240.82
170_Y210_L0.5230.82
239_K242_D0.5220.81
32_P73_P0.5200.81
58_L161_K0.5190.81
174_Q211_H0.5190.81
374_Y388_L0.5180.81
205_R209_A0.5180.81
77_L91_V0.5180.81
53_I191_L0.5170.81
308_M327_T0.5150.81
281_V343_E0.5120.80
53_I286_V0.5120.80
282_L287_A0.5120.80
322_N386_K0.5120.80
14_E18_W0.5110.80
226_Q258_T0.5090.80
96_K143_Y0.5090.80
343_E369_D0.5080.80
33_I72_I0.5070.80
133_K180_A0.5070.80
381_A386_K0.5060.79
124_L252_L0.5050.79
46_L49_N0.5050.79
23_G344_I0.5030.79
373_S376_V0.5020.79
296_I307_V0.5010.79
311_S315_C0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ncxA 2 0.9085 100 0.195 Contact Map
3ialA 2 0.9917 100 0.196 Contact Map
1hc7A 2 0.9563 100 0.206 Contact Map
1nj1A 2 0.9626 100 0.215 Contact Map
4hvcA 2 0.9792 100 0.219 Contact Map
1nj8A 2 0.9418 100 0.231 Contact Map
1qf6A 1 0.7838 100 0.459 Contact Map
1nyrA 2 0.7838 100 0.466 Contact Map
2i4lA 2 0.7692 100 0.472 Contact Map
2j3lA 2 0.7838 100 0.494 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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