GREMLIN Database
VATB - V-type ATP synthase beta chain
UniProt: Q9UWW8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (415)
Sequences: 7128 (2589)
Seq/√Len: 127.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_N97_D7.5811.00
145_R244_H4.6221.00
184_A230_A4.3391.00
332_D345_N3.9691.00
20_V56_V3.5421.00
136_A344_I3.2311.00
30_E74_M3.1341.00
90_R100_D2.8891.00
32_V56_V2.8321.00
85_E241_Q2.8061.00
77_R80_E2.6701.00
424_S427_T2.6481.00
26_A46_V2.6071.00
33_E73_R2.5551.00
44_G56_V2.5551.00
85_E243_M2.5331.00
33_E41_R2.4971.00
128_E145_R2.4961.00
372_N375_F2.4881.00
32_V72_I2.4851.00
182_V234_A2.4571.00
231_L304_P2.3841.00
143_L303_M2.2991.00
86_E108_G2.2431.00
80_E110_K2.1921.00
161_M419_F2.1841.00
92_F233_L2.1771.00
20_V72_I2.1491.00
234_A300_I2.1411.00
203_T207_N2.1131.00
135_S423_R2.1031.00
212_I233_L2.0701.00
55_I58_V2.0581.00
34_I44_G2.0371.00
313_I330_V2.0141.00
19_Y53_I2.0131.00
335_L340_I1.9981.00
194_L198_K1.9971.00
367_H371_S1.9881.00
368_K371_S1.9691.00
198_K201_E1.9441.00
378_Y381_A1.9421.00
180_A243_M1.9171.00
10_I65_V1.9081.00
111_R115_G1.8941.00
27_S30_E1.8571.00
102_G201_E1.8551.00
373_Q376_A1.8381.00
235_E289_R1.8091.00
143_L329_I1.7971.00
12_M19_Y1.7921.00
111_R232_T1.7521.00
236_Y241_Q1.7441.00
198_K202_E1.7391.00
111_R236_Y1.7351.00
204_G207_N1.7341.00
364_R368_K1.7281.00
365_D369_D1.7211.00
111_R240_E1.7181.00
364_R367_H1.7181.00
210_A233_L1.7161.00
7_F71_K1.7091.00
131_Q138_D1.7061.00
139_G428_T1.6991.00
180_A237_L1.6971.00
11_S21_Q1.6971.00
434_E437_S1.6961.00
375_F378_Y1.6961.00
340_I416_S1.6931.00
180_A210_A1.6821.00
197_R211_M1.6791.00
139_G414_F1.6761.00
30_E76_G1.6681.00
338_K411_E1.6411.00
371_S410_F1.6191.00
128_E292_K1.5831.00
306_L321_T1.5771.00
6_E74_M1.5741.00
364_R371_S1.5671.00
33_E43_R1.5581.00
340_I411_E1.5581.00
401_R405_L1.5581.00
405_L408_E1.5481.00
35_E41_R1.5361.00
385_R388_A1.5341.00
182_V233_L1.5131.00
35_E71_K1.5001.00
82_K110_K1.4881.00
142_A354_A1.4671.00
92_F212_I1.4571.00
364_R375_F1.4381.00
368_K372_N1.4211.00
375_F381_A1.4201.00
154_G157_L1.4171.00
81_V233_L1.4091.00
150_P325_T1.4071.00
90_R102_G1.4001.00
32_V44_G1.3981.00
20_V23_V1.3961.00
90_R103_P1.3891.00
244_H299_S1.3871.00
85_E236_Y1.3861.00
384_T388_A1.3821.00
10_I70_T1.3811.00
199_F356_D1.3811.00
9_N71_K1.3771.00
35_E73_R1.3711.00
87_M233_L1.3611.00
86_E107_K1.3561.00
186_I226_T1.3531.00
132_T143_L1.3491.00
79_L113_I1.3481.00
364_R378_Y1.3461.00
26_A54_A1.3371.00
90_R98_S1.3361.00
98_S103_P1.3351.00
184_A249_L1.3311.00
385_R390_I1.3291.00
93_N218_E1.3081.00
86_E106_I1.3051.00
227_P286_I1.3021.00
358_I365_D1.2881.00
33_E75_L1.2871.00
13_I65_V1.2831.00
201_E206_I1.2821.00
393_E404_L1.2781.00
245_V300_I1.2671.00
373_Q377_S1.2661.00
18_V44_G1.2571.00
62_T65_V1.2531.00
137_I166_I1.2521.00
81_V229_T1.2521.00
42_R60_E1.2511.00
418_G421_E1.2491.00
126_P144_L1.2441.00
406_F411_E1.2441.00
375_F379_A1.2411.00
122_A296_K1.2401.00
231_L290_A1.2401.00
287_Y324_I1.2391.00
315_H318_P1.2361.00
91_I197_R1.2180.99
259_L282_D1.2110.99
43_R97_D1.2100.99
132_T303_M1.2060.99
202_E205_A1.2030.99
371_S375_F1.2000.99
367_H370_V1.1990.99
185_A193_A1.1990.99
109_E240_E1.1980.99
427_T431_I1.1980.99
26_A32_V1.1960.99
77_R110_K1.1940.99
11_S53_I1.1910.99
413_K416_S1.1900.99
167_A209_V1.1870.99
242_D297_K1.1860.99
353_L357_G1.1850.99
141_N329_I1.1780.99
140_L374_L1.1780.99
283_L321_T1.1760.99
368_K375_F1.1720.99
88_L180_A1.1690.99
253_T257_E1.1640.99
115_G240_E1.1600.99
379_A382_V1.1550.99
21_Q53_I1.1520.99
340_I415_V1.1480.99
263_S271_G1.1440.99
178_N243_M1.1310.99
367_H375_F1.1290.99
94_P229_T1.1260.99
137_I329_I1.1250.99
161_M420_N1.1170.99
354_A358_I1.1080.99
308_M315_H1.1060.99
130_I170_A1.1000.99
364_R425_I1.0990.99
107_K110_K1.0970.99
252_M321_T1.0890.99
334_A337_N1.0870.99
88_L210_A1.0810.99
380_R383_D1.0780.99
241_Q245_V1.0780.99
82_K107_K1.0760.99
384_T390_I1.0700.99
231_L300_I1.0640.99
287_Y321_T1.0600.99
9_N21_Q1.0580.98
405_L409_L1.0550.98
387_L390_I1.0530.98
134_I137_I1.0490.98
184_A247_A1.0490.98
384_T389_A1.0460.98
97_D104_P1.0460.98
109_E236_Y1.0410.98
124_E127_E1.0390.98
383_D386_G1.0370.98
382_V386_G1.0330.98
35_E70_T1.0310.98
129_F357_G1.0270.98
60_E222_M1.0250.98
19_Y50_Q1.0220.98
154_G333_R1.0220.98
364_R372_N1.0180.98
54_A58_V1.0090.98
385_R389_A0.9980.98
370_V373_Q0.9950.98
143_L301_T0.9920.98
311_D333_R0.9880.98
131_Q425_I0.9870.98
134_I162_L0.9860.98
190_Y215_L0.9810.98
358_I368_K0.9790.97
218_E222_M0.9780.97
228_K282_D0.9760.97
370_V401_R0.9700.97
311_D314_T0.9690.97
381_A385_R0.9690.97
34_I70_T0.9670.97
365_D368_K0.9630.97
382_V385_R0.9620.97
386_G389_A0.9610.97
20_V32_V0.9590.97
122_A295_G0.9580.97
283_L324_I0.9540.97
252_M287_Y0.9530.97
367_H381_A0.9520.97
308_M318_P0.9520.97
90_R99_L0.9420.97
149_L303_M0.9390.97
186_I249_L0.9380.97
87_M92_F0.9360.97
66_S70_T0.9360.97
335_L416_S0.9350.97
167_A181_V0.9320.97
94_P218_E0.9220.96
100_D103_P0.9170.96
136_A415_V0.9160.96
31_L43_R0.9160.96
345_N348_M0.9100.96
7_F73_R0.9080.96
94_P99_L0.9050.96
223_K261_E0.9020.96
364_R381_A0.8990.96
376_A380_R0.8980.96
119_N122_A0.8960.96
87_M210_A0.8950.96
151_I163_A0.8950.96
143_L149_L0.8910.96
210_A237_L0.8840.95
30_E78_G0.8840.95
142_A425_I0.8840.95
38_N41_R0.8820.95
231_L247_A0.8820.95
283_L320_L0.8810.95
423_R431_I0.8790.95
94_P222_M0.8790.95
281_T284_A0.8780.95
181_V184_A0.8780.95
132_T138_D0.8780.95
318_P330_V0.8770.95
367_H379_A0.8770.95
84_S87_M0.8760.95
327_G352_R0.8760.95
313_I318_P0.8760.95
368_K379_A0.8740.95
364_R379_A0.8680.95
257_E275_Y0.8670.95
154_G311_D0.8640.95
365_D375_F0.8640.95
30_E138_D0.8620.95
365_D371_S0.8620.95
154_G319_D0.8620.95
35_E39_G0.8610.95
182_V210_A0.8600.95
238_A245_V0.8590.95
376_A381_A0.8590.95
339_G372_N0.8580.95
58_V62_T0.8580.95
383_D389_A0.8570.95
171_T244_H0.8570.95
167_A248_I0.8540.95
17_L266_R0.8530.94
406_F437_S0.8520.94
79_L225_L0.8500.94
205_A209_V0.8490.94
178_N244_H0.8470.94
230_A247_A0.8470.94
377_S381_A0.8460.94
31_L75_L0.8450.94
189_R192_D0.8450.94
257_E309_P0.8440.94
180_A245_V0.8410.94
197_R201_E0.8400.94
337_N348_M0.8380.94
384_T387_L0.8370.94
186_I227_P0.8360.94
124_E295_G0.8330.94
385_R403_Y0.8320.94
364_R370_V0.8320.94
255_Y286_I0.8310.94
92_F105_V0.8290.94
256_C283_L0.8270.94
102_G105_V0.8260.93
188_A192_D0.8250.93
128_E244_H0.8240.93
386_G396_L0.8230.93
167_A183_F0.8220.93
195_F356_D0.8210.93
50_Q55_I0.8200.93
139_G432_G0.8200.93
251_D305_I0.8190.93
144_L353_L0.8180.93
244_H292_K0.8180.93
367_H372_N0.8140.93
313_I348_M0.8130.93
13_I113_I0.8090.93
330_V333_R0.8090.93
409_L413_K0.8030.92
90_R104_P0.8020.92
374_L410_F0.8020.92
124_E292_K0.8000.92
90_R105_V0.8000.92
355_K375_F0.7990.92
18_V34_I0.7960.92
292_K299_S0.7950.92
404_L408_E0.7930.92
138_D428_T0.7920.92
32_V46_V0.7910.92
129_F142_A0.7870.92
368_K378_Y0.7870.92
60_E97_D0.7870.92
83_I232_T0.7850.92
17_L55_I0.7840.92
246_L303_M0.7840.92
367_H378_Y0.7740.91
369_D372_N0.7740.91
131_Q432_G0.7720.91
30_E75_L0.7700.91
398_E401_R0.7690.91
99_L213_V0.7690.91
353_L358_I0.7680.91
368_K376_A0.7660.91
85_E237_L0.7650.91
425_I429_L0.7610.90
290_A302_Q0.7610.90
168_K208_R0.7600.90
229_T232_T0.7570.90
142_A358_I0.7530.90
166_I246_L0.7510.90
60_E219_P0.7490.90
113_I229_T0.7450.89
377_S399_V0.7440.89
279_M282_D0.7400.89
404_L407_G0.7380.89
132_T137_I0.7370.89
109_E241_Q0.7370.89
20_V44_G0.7350.89
255_Y282_D0.7340.89
42_R65_V0.7330.89
145_R299_S0.7310.89
312_D319_D0.7290.88
367_H433_W0.7280.88
154_G312_D0.7270.88
398_E402_K0.7270.88
310_N315_H0.7260.88
371_S376_A0.7260.88
399_V403_Y0.7250.88
407_G411_E0.7250.88
348_M382_V0.7210.88
10_I18_V0.7200.88
364_R376_A0.7190.88
381_A388_A0.7180.88
366_D440_P0.7170.88
80_E112_D0.7170.88
205_A208_R0.7170.88
247_A290_A0.7160.87
130_I143_L0.7150.87
228_K255_Y0.7120.87
116_S285_T0.7120.87
180_A208_R0.7120.87
366_D370_V0.7110.87
154_G274_G0.7100.87
21_Q52_G0.7080.87
152_F318_P0.7070.87
245_V261_E0.7050.87
32_V54_A0.7050.87
49_S68_T0.7050.87
93_N99_L0.7040.87
249_L286_I0.7030.87
125_Y356_D0.7030.87
334_A382_V0.7010.86
79_L229_T0.7000.86
106_I109_E0.7000.86
168_K420_N0.6980.86
98_S104_P0.6970.86
423_R429_L0.6970.86
214_S218_E0.6960.86
49_S54_A0.6960.86
365_D372_N0.6950.86
137_I141_N0.6950.86
188_A254_N0.6930.86
79_L138_D0.6930.86
124_E297_K0.6930.86
226_T230_A0.6900.85
163_A248_I0.6900.85
45_L225_L0.6870.85
372_N381_A0.6840.85
371_S379_A0.6820.85
78_G112_D0.6820.85
370_V433_W0.6810.85
235_E238_A0.6800.85
105_V108_G0.6790.85
57_Q262_I0.6780.84
392_G395_S0.6770.84
396_L399_V0.6730.84
26_A74_M0.6720.84
45_L59_F0.6700.84
275_Y312_D0.6670.84
272_R320_L0.6650.83
423_R428_T0.6650.83
82_K108_G0.6630.83
99_L104_P0.6630.83
59_F222_M0.6630.83
224_T259_L0.6620.83
233_L237_L0.6620.83
364_R429_L0.6620.83
207_N210_A0.6610.83
330_V348_M0.6600.83
189_R254_N0.6600.83
386_G390_I0.6580.83
219_P222_M0.6570.83
141_N350_L0.6570.83
86_E109_E0.6550.82
126_P353_L0.6540.82
49_S55_I0.6540.82
193_A213_V0.6530.82
435_I439_L0.6520.82
202_E206_I0.6500.82
380_R384_T0.6490.82
92_F95_L0.6490.82
95_L98_S0.6480.82
129_F353_L0.6450.81
66_S69_G0.6430.81
91_I99_L0.6420.81
181_V209_V0.6420.81
54_A57_Q0.6410.81
102_G206_I0.6400.81
397_S400_D0.6390.81
90_R101_N0.6390.81
437_S440_P0.6390.81
332_D348_M0.6380.81
402_K409_L0.6380.81
224_T262_I0.6350.80
131_Q428_T0.6330.80
134_I419_F0.6310.80
201_E207_N0.6310.80
157_L333_R0.6300.80
169_Q422_N0.6290.80
181_V248_I0.6290.80
236_Y240_E0.6280.80
368_K381_A0.6270.80
151_I329_I0.6270.80
231_L249_L0.6260.79
371_S378_Y0.6250.79
319_D322_G0.6250.79
227_P249_L0.6240.79
22_G26_A0.6230.79
112_D232_T0.6230.79
88_L206_I0.6210.79
367_H429_L0.6190.79
135_S431_I0.6180.79
144_L352_R0.6170.79
141_N344_I0.6150.78
223_K235_E0.6130.78
372_N376_A0.6130.78
256_C317_I0.6110.78
431_I434_E0.6100.78
430_D434_E0.6090.78
109_E112_D0.6070.77
371_S381_A0.6070.77
354_A371_S0.6060.77
371_S380_R0.6040.77
248_I305_I0.6040.77
88_L243_M0.6040.77
31_L79_L0.6040.77
163_A305_I0.6020.77
99_L218_E0.6020.77
41_R73_R0.6020.77
129_F425_I0.6010.77
155_S324_I0.6000.77
314_T321_T0.5990.76
27_S66_S0.5990.76
257_E320_L0.5980.76
373_Q401_R0.5970.76
14_K17_L0.5950.76
426_E430_D0.5930.76
268_E291_G0.5900.75
339_G407_G0.5900.75
367_H425_I0.5900.75
132_T290_A0.5900.75
370_V375_F0.5890.75
323_Y350_L0.5880.75
158_P250_I0.5880.75
97_D110_K0.5860.75
168_K197_R0.5860.75
255_Y259_L0.5850.75
34_I72_I0.5840.75
10_I38_N0.5820.74
136_A346_V0.5820.74
164_A213_V0.5790.74
45_L79_L0.5760.74
81_V84_S0.5750.74
292_K295_G0.5750.74
115_G232_T0.5750.74
139_G142_A0.5740.73
372_N378_Y0.5730.73
75_L78_G0.5720.73
383_D388_A0.5720.73
132_T170_A0.5710.73
365_D370_V0.5710.73
378_Y382_V0.5700.73
427_T430_D0.5700.73
18_V62_T0.5690.73
149_L327_G0.5690.73
420_N431_I0.5690.73
159_A250_I0.5690.73
240_E300_I0.5680.73
252_M286_I0.5670.72
131_Q171_T0.5670.72
153_S165_Q0.5660.72
87_M107_K0.5640.72
433_W436_L0.5630.72
231_L235_E0.5610.72
132_T152_F0.5600.72
170_A244_H0.5600.72
152_F325_T0.5600.72
183_F193_A0.5590.71
358_I429_L0.5570.71
377_S403_Y0.5570.71
180_A241_Q0.5530.71
379_A383_D0.5520.70
20_V54_A0.5520.70
121_A345_N0.5510.70
10_I13_I0.5510.70
199_F232_T0.5500.70
124_E296_K0.5500.70
84_S107_K0.5490.70
45_L192_D0.5490.70
238_A300_I0.5480.70
14_K266_R0.5460.70
164_A196_F0.5460.70
369_D373_Q0.5440.69
398_E407_G0.5410.69
155_S257_E0.5410.69
200_F205_A0.5410.69
86_E105_V0.5400.69
6_E25_D0.5400.69
55_I266_R0.5370.68
29_N47_I0.5370.68
155_S322_G0.5370.68
423_R427_T0.5350.68
94_P98_S0.5330.68
59_F228_K0.5300.67
370_V439_L0.5280.67
184_A302_Q0.5270.67
364_R369_D0.5260.67
315_H319_D0.5260.67
151_I331_L0.5260.67
260_R317_I0.5250.67
129_F358_I0.5250.67
86_E103_P0.5250.67
149_L329_I0.5250.67
61_G64_G0.5230.66
76_G79_L0.5230.66
144_L357_G0.5220.66
338_K385_R0.5220.66
17_L167_A0.5220.66
48_D55_I0.5210.66
212_I229_T0.5200.66
310_N319_D0.5190.66
364_R377_S0.5190.66
204_G209_V0.5190.66
303_M339_G0.5190.66
365_D377_S0.5190.66
218_E276_P0.5190.66
374_L432_G0.5180.66
138_D169_Q0.5180.66
414_F431_I0.5180.66
355_K419_F0.5180.66
370_V374_L0.5170.66
418_G422_N0.5150.65
201_E209_V0.5150.65
98_S105_V0.5140.65
104_P108_G0.5140.65
365_D379_A0.5140.65
112_D115_G0.5130.65
155_S323_Y0.5120.65
374_L415_V0.5110.65
231_L234_A0.5110.65
312_D333_R0.5110.65
107_K236_Y0.5100.64
134_I165_Q0.5100.64
92_F229_T0.5100.64
42_R61_G0.5090.64
139_G371_S0.5080.64
199_F202_E0.5080.64
378_Y388_A0.5080.64
160_N250_I0.5060.64
19_Y48_D0.5060.64
85_E108_G0.5060.64
425_I428_T0.5050.64
228_K266_R0.5050.64
367_H380_R0.5050.64
378_Y410_F0.5030.63
168_K203_T0.5020.63
30_E79_L0.5020.63
414_F428_T0.5020.63
83_I87_M0.5020.63
103_P107_K0.5010.63
16_P57_Q0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c61A 2 0.9417 100 0.096 Contact Map
3vr4D 1 0.9762 100 0.103 Contact Map
3gqbB 1 0.9784 100 0.105 Contact Map
3j9tB 1 0.9676 100 0.122 Contact Map
3oaaA 2 0.9546 100 0.122 Contact Map
2qe7A 1 0.9482 100 0.125 Contact Map
2r9vA 1 0.9611 100 0.141 Contact Map
3mfyA 1 0.8035 100 0.145 Contact Map
2ck3A 1 0.9633 100 0.146 Contact Map
1fx0A 1 0.9546 100 0.151 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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