GREMLIN Database
VATE - V-type ATP synthase subunit E
UniProt: Q9UWW5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (187)
Sequences: 973 (742)
Seq/√Len: 54.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_K101_E3.1431.00
24_K28_E3.0711.00
17_E20_T3.0541.00
103_K136_K3.0291.00
126_C134_I2.7841.00
13_K17_E2.6031.00
14_V18_I2.6011.00
77_E80_Y2.5791.00
15_R19_K2.5521.00
88_R91_G2.5061.00
30_I34_N2.4941.00
131_K135_E2.4491.00
152_M170_S2.4151.00
113_E158_I2.3691.00
37_H41_V2.2661.00
105_A109_I2.1971.00
26_L30_I2.1121.00
93_I171_L2.0591.00
92_K95_E2.0491.00
83_N87_E2.0271.00
102_Y171_L1.9671.00
138_V141_N1.9171.00
22_L26_L1.8981.00
28_E31_K1.8960.99
104_D107_E1.8460.99
124_I156_I1.8150.99
19_K23_S1.8020.99
169_F174_I1.7840.99
107_E140_N1.7590.99
50_E54_K1.7400.99
121_K143_N1.7190.99
34_N38_N1.7030.99
114_I144_V1.6750.99
51_L55_T1.6140.98
126_C156_I1.5830.98
61_G68_V1.5740.98
132_L135_E1.5680.98
8_D11_L1.5640.98
93_I133_M1.5570.98
9_K13_K1.5440.98
27_D31_K1.5160.98
110_I124_I1.4970.97
27_D30_I1.4960.97
185_K188_D1.4570.97
10_S14_V1.4550.97
88_R92_K1.4360.97
7_L11_L1.4330.96
86_Y179_F1.4080.96
25_S29_A1.3850.96
17_E21_E1.3760.96
130_D154_G1.3750.96
134_I137_I1.3580.95
133_M137_I1.3490.95
38_N41_V1.3240.95
84_K88_R1.3220.94
23_S27_D1.3200.94
49_N53_V1.3130.94
87_E91_G1.2930.94
11_L15_R1.2930.94
173_L176_D1.2920.94
44_Y48_I1.2860.94
65_R69_E1.2590.93
68_V171_L1.2360.92
59_I63_K1.2320.92
77_E81_W1.2180.92
33_L37_H1.2130.91
35_E39_K1.1880.91
6_L10_S1.1880.91
79_E102_Y1.1820.90
12_N15_R1.1750.90
125_Y147_K1.1680.90
110_I156_I1.1650.90
91_G95_E1.1570.89
102_Y130_D1.1510.89
43_E47_R1.1500.89
50_E71_K1.1450.89
85_V179_F1.1420.89
36_G40_I1.1270.88
14_V17_E1.1240.88
14_V25_S1.1170.88
89_V153_L1.1080.87
96_V99_T1.1080.87
29_A36_G1.1050.87
20_T24_K1.1050.87
160_F164_G1.0930.87
99_T136_K1.0660.85
125_Y159_Y1.0660.85
154_G170_S1.0460.84
15_R22_L1.0440.84
5_Q8_D1.0400.84
83_N164_G1.0380.84
156_I160_F1.0370.84
32_L43_E1.0260.83
34_N37_H1.0230.83
144_V158_I1.0170.82
123_T147_K1.0160.82
24_K27_D1.0150.82
168_D173_L1.0050.82
82_I86_Y1.0040.81
104_D108_N1.0030.81
13_K16_E0.9970.81
12_N16_E0.9970.81
153_L172_K0.9830.80
107_E111_S0.9810.80
6_L9_K0.9800.80
102_Y106_I0.9780.80
38_N45_S0.9780.80
16_E27_D0.9710.79
41_V45_S0.9630.79
152_M172_K0.9530.78
8_D12_N0.9500.78
95_E100_K0.9440.77
70_N169_F0.9170.75
121_K161_E0.9160.75
147_K150_E0.9100.75
184_G187_S0.9020.74
94_G139_G0.9010.74
182_M185_K0.8920.73
62_E66_L0.8760.72
15_R18_I0.8720.71
32_L36_G0.8650.71
91_G99_T0.8610.70
20_T130_D0.8580.70
40_I51_L0.8450.69
124_I185_K0.8400.69
112_K116_E0.8380.68
12_N29_A0.8350.68
111_S128_P0.8310.68
183_R187_S0.8290.68
138_V142_K0.8280.67
154_G172_K0.8250.67
23_S38_N0.8250.67
112_K174_I0.8210.67
84_K87_E0.8080.66
100_K132_L0.8060.65
31_K35_E0.7990.65
99_T129_N0.7980.65
63_K67_E0.7970.64
146_V149_D0.7890.64
28_E33_L0.7870.63
45_S48_I0.7840.63
124_I144_V0.7840.63
31_K37_H0.7790.63
21_E33_L0.7750.62
64_A80_Y0.7730.62
113_E169_F0.7690.62
11_L164_G0.7690.62
138_V146_V0.7660.61
113_E167_R0.7600.61
5_Q34_N0.7570.60
126_C130_D0.7570.60
131_K146_V0.7530.60
121_K145_T0.7500.60
18_I21_E0.7480.60
130_D170_S0.7430.59
35_E124_I0.7430.59
128_P150_E0.7410.59
156_I174_I0.7350.58
79_E183_R0.7320.58
43_E48_I0.7270.57
56_K60_E0.7270.57
135_E139_G0.7250.57
7_L178_V0.7240.57
22_L82_I0.7170.56
19_K22_L0.7150.56
127_S130_D0.7120.56
5_Q30_I0.7110.56
41_V44_Y0.7090.55
73_T76_V0.7090.55
33_L36_G0.7080.55
168_D181_S0.7070.55
63_K164_G0.7050.55
49_N52_I0.7040.55
35_E91_G0.7040.55
125_Y128_P0.7030.55
27_D93_I0.7010.55
72_R154_G0.7000.55
119_E190_L0.6990.54
113_E117_I0.6990.54
16_E19_K0.6970.54
11_L47_R0.6960.54
12_N23_S0.6950.54
27_D34_N0.6870.53
186_I190_L0.6760.52
29_A37_H0.6750.52
11_L21_E0.6740.52
90_L172_K0.6730.52
25_S28_E0.6720.52
107_E138_V0.6720.52
55_T63_K0.6690.51
29_A33_L0.6680.51
32_L40_I0.6600.50
134_I190_L0.6600.50
14_V21_E0.6570.50
86_Y89_V0.6560.50
70_N159_Y0.6550.50
128_P135_E0.6500.49
68_V187_S0.6500.49
10_S27_D0.6420.48
128_P149_D0.6390.48
17_E25_S0.6340.47
23_S26_L0.6310.47
80_Y84_K0.6290.47
52_I56_K0.6290.47
86_Y90_L0.6190.46
4_E7_L0.6180.46
61_G71_K0.6170.46
18_I29_A0.6150.45
109_I130_D0.6110.45
176_D179_F0.6100.45
102_Y159_Y0.6100.45
10_S21_E0.6090.45
26_L29_A0.6090.45
108_N188_D0.6090.45
46_Q50_E0.6080.45
32_L35_E0.6070.45
76_V80_Y0.6020.44
99_T104_D0.5940.43
104_D110_I0.5930.43
74_L92_K0.5920.43
112_K169_F0.5900.43
170_S181_S0.5890.43
64_A170_S0.5890.43
76_V186_I0.5850.42
169_F184_G0.5810.42
32_L51_L0.5800.42
136_K143_N0.5800.42
61_G183_R0.5800.42
9_K17_E0.5790.42
70_N81_W0.5770.41
126_C131_K0.5720.41
75_L79_E0.5710.41
7_L30_I0.5710.41
168_D179_F0.5670.40
69_E93_I0.5630.40
88_R100_K0.5610.40
8_D21_E0.5600.40
122_V156_I0.5570.39
87_E132_L0.5570.39
68_V72_R0.5560.39
84_K89_V0.5550.39
122_V172_K0.5520.39
128_P132_L0.5520.39
127_S152_M0.5500.39
74_L78_K0.5500.39
66_L182_M0.5470.38
69_E72_R0.5460.38
23_S121_K0.5440.38
146_V162_R0.5440.38
48_I52_I0.5430.38
132_L136_K0.5430.38
6_L82_I0.5420.38
6_L187_S0.5400.38
101_E108_N0.5400.38
29_A40_I0.5390.38
122_V158_I0.5380.38
124_I158_I0.5370.37
62_E69_E0.5350.37
137_I141_N0.5340.37
61_G72_R0.5310.37
11_L19_K0.5290.37
61_G187_S0.5280.37
124_I173_L0.5280.37
82_I186_I0.5230.36
79_E83_N0.5220.36
78_K191_F0.5210.36
15_R26_L0.5210.36
13_K37_H0.5180.36
106_I166_T0.5160.35
160_F184_G0.5160.35
110_I122_V0.5140.35
51_L81_W0.5060.34
40_I43_E0.5060.34
21_E75_L0.5050.34
179_F183_R0.5040.34
148_T152_M0.5030.34
168_D180_D0.5020.34
15_R99_T0.5010.34
186_I189_M0.5010.34
7_L18_I0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v6iA 1 0.9639 100 0.275 Contact Map
2dm9A 2 0.5773 100 0.282 Contact Map
4efaE 1 0.9742 100 0.312 Contact Map
3lg8A 1 0.4845 99.8 0.534 Contact Map
2kk7A 1 0.2423 96.7 0.829 Contact Map
1l2pA 1 0.3144 90.9 0.873 Contact Map
2wssS 1 0.7474 84 0.886 Contact Map
3v6iB 1 0.4536 64 0.904 Contact Map
4efaG 1 0.4897 54.8 0.909 Contact Map
3ghgA 2 0.634 19 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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