GREMLIN Database
PRIL - DNA primase large subunit PriL
UniProt: Q9UWW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (287)
Sequences: 165 (134)
Seq/√Len: 7.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_T283_M3.6530.95
44_R90_E3.5940.95
246_S261_E3.3580.92
239_I268_R3.1350.89
228_E262_D2.9360.86
230_E288_L2.9210.86
228_E231_I2.7360.82
228_E263_L2.5670.77
228_E252_M2.5650.77
262_D266_K2.5540.77
228_E255_Y2.5420.76
228_E266_K2.4950.75
263_L266_K2.4330.73
231_I260_V2.4320.73
213_I237_F2.3750.71
255_Y266_K2.3570.70
225_K231_I2.3030.69
255_Y267_Y2.2690.67
228_E269_G2.2030.65
161_Q174_Q2.1890.64
266_K269_G2.1590.63
280_C289_C2.1260.62
218_E227_N2.1220.62
257_V261_E2.1160.62
231_I263_L2.1050.61
92_K180_A2.0970.61
231_I252_M2.0640.60
252_M262_D2.0430.59
228_E260_V2.0090.57
255_Y269_G1.9990.57
40_Q63_P1.9460.55
180_A238_Y1.9450.55
235_I252_M1.9220.54
225_K228_E1.8910.53
231_I262_D1.8620.52
37_L41_A1.8390.51
255_Y262_D1.8350.50
231_I266_K1.8140.50
68_Y191_I1.8080.49
252_M255_Y1.7450.47
225_K263_L1.7250.46
206_L211_G1.7220.46
252_M263_L1.7140.46
92_K177_G1.6940.45
225_K252_M1.6850.44
174_Q278_Y1.6810.44
6_K156_W1.6490.43
88_Y177_G1.6450.43
231_I269_G1.6440.43
232_R238_Y1.6400.43
231_I255_Y1.6390.42
14_L234_L1.6110.41
116_K208_E1.5910.41
239_I248_I1.5850.40
262_D269_G1.5820.40
289_C293_C1.5730.40
24_G138_F1.5680.40
255_Y263_L1.5680.40
252_M266_K1.5620.39
280_C293_C1.5610.39
196_L199_I1.5450.39
260_V266_K1.5340.38
196_L203_L1.5300.38
225_K262_D1.5190.38
278_Y282_K1.5010.37
278_Y301_L1.4940.37
217_I283_M1.4900.37
248_I268_R1.4900.37
27_L41_A1.4820.36
263_L269_G1.4750.36
8_Y101_E1.4690.36
241_I273_T1.4510.35
228_E275_Y1.4500.35
252_M264_Y1.4440.35
245_L268_R1.4390.35
145_Y161_Q1.4290.34
256_N259_N1.4120.34
95_R180_A1.4020.33
267_Y283_M1.3930.33
70_T90_E1.3710.32
27_L287_G1.3630.32
260_V263_L1.3300.31
217_I234_L1.3260.31
280_C298_P1.3240.31
90_E178_L1.3210.31
40_Q74_L1.3140.30
262_D275_Y1.3100.30
258_S297_N1.2950.30
236_T256_N1.2940.30
289_C298_P1.2900.29
281_A284_K1.2840.29
225_K255_Y1.2760.29
266_K275_Y1.2680.29
196_L206_L1.2610.29
240_D277_V1.2560.28
228_E257_V1.2540.28
221_L230_E1.2530.28
68_Y86_Y1.2400.28
233_T282_K1.2330.28
255_Y260_V1.2240.27
216_C289_C1.2190.27
228_E267_Y1.2180.27
243_K300_Q1.2180.27
46_Q82_L1.2130.27
179_I189_E1.2110.27
220_I226_L1.2110.27
30_L217_I1.2060.27
260_V269_G1.2050.27
63_P66_V1.2030.27
249_V255_Y1.1950.26
225_K266_K1.1880.26
261_E265_R1.1800.26
206_L209_R1.1790.26
297_N302_Y1.1780.26
216_C280_C1.1750.26
88_Y219_N1.1730.26
227_N230_E1.1720.26
231_I275_Y1.1670.25
237_F272_G1.1670.25
44_R178_L1.1640.25
115_L217_I1.1520.25
39_D203_L1.1510.25
41_A69_T1.1440.25
239_I245_L1.1350.25
213_I302_Y1.1330.24
241_I302_Y1.1310.24
236_T297_N1.1250.24
48_T70_T1.1230.24
140_V217_I1.1140.24
201_E236_T1.1130.24
196_L210_R1.1090.24
18_L213_I1.1080.24
45_I290_V1.1040.24
168_V242_G1.1000.23
249_V260_V1.0960.23
226_L238_Y1.0940.23
294_N305_S1.0850.23
17_E187_I1.0840.23
45_I73_S1.0700.23
67_F191_I1.0680.23
257_V263_L1.0680.23
90_E146_L1.0650.22
75_A233_T1.0630.22
225_K269_G1.0590.22
252_M269_G1.0570.22
93_Q178_L1.0460.22
68_Y278_Y1.0400.22
80_V170_L1.0330.22
224_E236_T1.0320.22
235_I267_Y1.0310.22
236_T277_V1.0140.21
252_M260_V1.0060.21
235_I259_N1.0030.21
249_V261_E0.9980.21
30_L57_Y0.9950.21
217_I274_R0.9930.20
296_K300_Q0.9900.20
207_I211_G0.9810.20
246_S257_V0.9800.20
235_I249_V0.9750.20
25_I30_L0.9740.20
225_K260_V0.9720.20
168_V179_I0.9630.20
203_L211_G0.9540.19
71_L191_I0.9450.19
248_I296_K0.9410.19
20_K203_L0.9380.19
66_V70_T0.9340.19
29_D115_L0.9320.19
48_T174_Q0.9290.19
231_I257_V0.9280.19
237_F302_Y0.9230.19
67_F74_L0.9120.18
67_F301_L0.9040.18
85_R183_I0.9020.18
8_Y13_S0.9010.18
84_R261_E0.9010.18
48_T97_L0.8950.18
38_I224_E0.8920.18
182_S187_I0.8900.18
260_V271_K0.8890.18
215_P280_C0.8880.18
165_K199_I0.8880.18
45_I74_L0.8840.18
16_D247_G0.8750.18
221_L231_I0.8700.17
68_Y186_K0.8670.17
223_K267_Y0.8620.17
75_A192_R0.8620.17
87_A187_I0.8540.17
245_L265_R0.8500.17
237_F243_K0.8490.17
94_F150_K0.8470.17
216_C293_C0.8440.17
77_L295_V0.8410.17
201_E206_L0.8370.17
269_G275_Y0.8360.17
152_L172_K0.8350.17
199_I203_L0.8340.17
63_P94_F0.8250.16
215_P298_P0.8220.16
195_N200_P0.8220.16
142_F163_L0.8210.16
293_C298_P0.8160.16
149_T261_E0.8110.16
144_D157_K0.8080.16
37_L208_E0.8050.16
191_I277_V0.7970.16
263_L267_Y0.7960.16
81_K303_F0.7950.16
215_P293_C0.7940.16
166_G216_C0.7920.16
49_K219_N0.7920.16
71_L75_A0.7910.16
99_H217_I0.7890.16
89_A186_K0.7870.16
295_V301_L0.7850.16
34_S197_K0.7780.15
26_T272_G0.7760.15
166_G214_P0.7760.15
145_Y178_L0.7740.15
240_D270_D0.7720.15
260_V270_D0.7710.15
217_I229_E0.7710.15
29_D106_L0.7710.15
142_F227_N0.7700.15
232_R278_Y0.7680.15
156_W233_T0.7680.15
8_Y158_L0.7670.15
253_K257_V0.7650.15
91_A174_Q0.7580.15
180_A270_D0.7580.15
257_V271_K0.7580.15
245_L274_R0.7550.15
93_Q108_E0.7540.15
75_A184_K0.7540.15
88_Y252_M0.7500.15
71_L192_R0.7500.15
67_F71_L0.7470.15
30_L36_T0.7460.15
203_L207_I0.7440.15
78_N208_E0.7430.15
196_L200_P0.7430.15
48_T89_A0.7400.15
156_W161_Q0.7380.15
40_Q91_A0.7370.15
269_G285_Q0.7360.14
102_N202_K0.7350.14
177_G268_R0.7340.14
81_K150_K0.7330.14
64_V68_Y0.7330.14
260_V278_Y0.7330.14
33_N115_L0.7300.14
59_S140_V0.7280.14
44_R70_T0.7270.14
163_L297_N0.7210.14
53_E144_D0.7210.14
215_P289_C0.7200.14
260_V275_Y0.7190.14
24_G92_K0.7180.14
142_F157_K0.7140.14
41_A146_L0.7140.14
195_N199_I0.7120.14
38_I52_D0.7110.14
243_K277_V0.7100.14
86_Y163_L0.7080.14
205_S221_L0.7080.14
213_I297_N0.7050.14
219_N290_V0.7030.14
242_G299_L0.7010.14
257_V262_D0.7010.14
236_T252_M0.6970.14
13_S24_G0.6960.14
73_S167_Y0.6890.14
45_I174_Q0.6890.14
161_Q278_Y0.6880.14
164_H208_E0.6880.14
284_K292_S0.6870.14
283_M293_C0.6860.14
140_V218_E0.6850.13
101_E206_L0.6850.13
138_F271_K0.6840.13
18_L281_A0.6830.13
93_Q97_L0.6810.13
196_L211_G0.6800.13
258_S286_L0.6750.13
170_L201_E0.6740.13
106_L110_S0.6740.13
73_S220_I0.6740.13
88_Y157_K0.6710.13
257_V266_K0.6710.13
48_T90_E0.6700.13
98_L248_I0.6640.13
26_T98_L0.6640.13
228_E235_I0.6630.13
234_L250_S0.6620.13
14_L286_L0.6610.13
5_V173_N0.6600.13
7_K101_E0.6600.13
67_F300_Q0.6590.13
253_K261_E0.6580.13
45_I282_K0.6570.13
174_Q184_K0.6560.13
82_L277_V0.6530.13
256_N272_G0.6510.13
159_S163_L0.6510.13
65_L210_R0.6490.13
31_L104_E0.6440.13
29_D33_N0.6390.13
113_L288_L0.6390.13
248_I260_V0.6380.13
158_L236_T0.6350.13
18_L45_I0.6340.13
98_L229_E0.6320.13
166_G298_P0.6320.13
45_I78_N0.6300.12
262_D267_Y0.6290.12
287_G302_Y0.6250.12
265_R272_G0.6230.12
152_L181_E0.6190.12
228_E271_K0.6180.12
290_V293_C0.6180.12
288_L293_C0.6150.12
12_K185_S0.6130.12
66_V90_E0.6120.12
30_L41_A0.6100.12
70_T156_W0.6090.12
145_Y156_W0.6070.12
39_D54_L0.6060.12
99_H173_N0.6050.12
191_I237_F0.6050.12
201_E205_S0.6040.12
64_V89_A0.6040.12
48_T69_T0.6040.12
44_R156_W0.6040.12
70_T73_S0.6030.12
203_L209_R0.6000.12
77_L230_E0.5990.12
232_R263_L0.5990.12
223_K230_E0.5970.12
20_K140_V0.5970.12
232_R262_D0.5940.12
45_I235_I0.5940.12
252_M257_V0.5940.12
5_V13_S0.5900.12
28_T241_I0.5890.12
235_I281_A0.5830.12
28_T45_I0.5830.12
181_E228_E0.5830.12
235_I264_Y0.5800.12
220_I230_E0.5790.12
91_A145_Y0.5790.12
95_R271_K0.5780.12
11_I180_A0.5760.12
51_G173_N0.5730.11
40_Q65_L0.5720.11
206_L210_R0.5710.11
166_G215_P0.5700.11
111_K241_I0.5690.11
14_L66_V0.5680.11
45_I209_R0.5680.11
82_L269_G0.5680.11
44_R66_V0.5650.11
214_P275_Y0.5650.11
18_L67_F0.5620.11
185_S197_K0.5620.11
91_A177_G0.5620.11
193_P196_L0.5610.11
84_R260_V0.5590.11
142_F258_S0.5590.11
46_Q206_L0.5590.11
186_K192_R0.5570.11
77_L197_K0.5570.11
155_D246_S0.5570.11
86_Y91_A0.5550.11
148_Y183_I0.5500.11
29_D217_I0.5480.11
145_Y183_I0.5480.11
18_L206_L0.5480.11
18_L68_Y0.5480.11
274_R301_L0.5470.11
172_K176_I0.5430.11
294_N297_N0.5430.11
94_F237_F0.5410.11
135_Q143_I0.5410.11
172_K205_S0.5400.11
19_K171_D0.5400.11
30_L60_Y0.5400.11
44_R91_A0.5400.11
101_E114_D0.5390.11
165_K200_P0.5390.11
51_G149_T0.5360.11
57_Y238_Y0.5360.11
44_R192_R0.5360.11
91_A183_I0.5340.11
67_F182_S0.5340.11
65_L74_L0.5300.11
66_V91_A0.5300.11
141_H187_I0.5290.11
180_A188_V0.5290.11
43_D85_R0.5280.11
228_E261_E0.5250.11
91_A156_W0.5240.11
213_I238_Y0.5240.11
89_A94_F0.5230.11
284_K296_K0.5230.11
66_V156_W0.5210.11
78_N83_I0.5200.11
237_F297_N0.5200.11
99_H230_E0.5170.11
181_E293_C0.5170.11
166_G289_C0.5160.11
295_V299_L0.5160.11
225_K230_E0.5150.11
6_K74_L0.5140.11
83_I290_V0.5130.11
36_T283_M0.5130.11
19_K59_S0.5130.11
68_Y142_F0.5120.11
59_S173_N0.5100.10
35_T114_D0.5090.10
263_L275_Y0.5090.10
31_L101_E0.5090.10
66_V73_S0.5070.10
230_E278_Y0.5050.10
248_I274_R0.5040.10
19_K58_V0.5030.10
91_A160_G0.5020.10
86_Y90_E0.5020.10
75_A191_I0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zt2B 2 0.6645 100 0.578 Contact Map
4rr2B 1 0.9283 100 0.646 Contact Map
3lgbA 1 0.3616 99.9 0.761 Contact Map
3l9qA 3 0.342 99.9 0.777 Contact Map
2dlaA 2 0.6743 96.9 0.933 Contact Map
4bpxB 1 0.6026 93.2 0.947 Contact Map
1aihA 2 0.5407 23.5 0.971 Contact Map
4gtnA 2 0.2997 20.2 0.972 Contact Map
2dsjA 2 0.2932 19.5 0.972 Contact Map
4eadA 2 0.342 13.8 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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