GREMLIN Database
TSR3 - Probable ribosome biogenesis protein SSO0551
UniProt: Q9UWV6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 166 (160)
Sequences: 500 (320)
Seq/√Len: 25.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_T102_S4.0161.00
104_I124_S3.4121.00
15_R93_I3.1121.00
54_V114_V3.1041.00
90_G136_L3.0391.00
68_N71_Q2.9981.00
61_I103_S2.9931.00
147_K151_D2.5960.99
46_L110_T2.4970.99
3_V107_L2.2000.97
94_H100_K2.1760.97
111_L119_E2.1600.97
131_H135_E2.1310.97
104_I127_V2.0960.96
3_V111_L2.0810.96
5_I18_G2.0620.96
45_T153_K2.0190.95
39_D62_V1.9140.94
148_T151_D1.8870.93
12_D15_R1.7850.91
142_E145_K1.7550.90
59_I110_T1.7550.90
37_V79_G1.7110.89
141_L145_K1.6950.89
112_Y117_V1.6750.88
108_I124_S1.6740.88
118_E150_E1.6700.88
158_E162_K1.6490.87
30_T60_T1.5940.85
39_D42_A1.5890.85
11_D16_C1.5530.84
59_I107_L1.5480.84
132_T135_E1.5480.84
4_Y30_T1.5210.83
32_V77_I1.4200.78
154_K158_E1.3870.76
27_A107_L1.3840.76
117_V142_E1.3790.76
83_R103_S1.3730.76
45_T156_E1.3550.75
120_A134_I1.3420.74
153_K156_E1.3370.74
50_D82_R1.3250.73
20_K126_V1.3060.72
63_D128_K1.3050.72
112_Y141_L1.3030.72
6_I30_T1.2780.70
131_H138_K1.2610.69
11_D18_G1.2500.68
86_I99_Y1.2430.68
88_F97_I1.2400.68
126_V131_H1.2300.67
104_I126_V1.2150.66
6_I11_D1.2060.65
3_V129_W1.1940.65
36_V152_I1.1880.64
20_K104_I1.1880.64
20_K23_K1.1690.63
20_K24_L1.1610.62
7_D35_G1.1550.62
10_K68_N1.1390.61
60_T103_S1.1380.61
77_I97_I1.1370.61
138_K154_K1.1350.61
69_T74_F1.1130.59
45_T149_E1.1030.58
51_K55_R1.1010.58
122_K126_V1.0950.58
117_V145_K1.0910.58
44_I49_K1.0900.58
7_D18_G1.0810.57
131_H136_L1.0780.57
48_N51_K1.0730.56
112_Y134_I1.0580.55
59_I143_A1.0520.55
49_K148_T1.0520.55
35_G103_S1.0400.54
19_K63_D1.0090.52
92_P129_W1.0080.52
157_R161_E1.0060.51
16_C63_D1.0020.51
47_S149_E0.9930.51
55_R160_I0.9890.50
64_T156_E0.9800.50
55_R116_E0.9800.50
27_A103_S0.9550.48
11_D103_S0.9540.48
16_C64_T0.9510.47
5_I27_A0.9400.47
38_L78_R0.9370.46
97_I135_E0.9370.46
92_P126_V0.9330.46
38_L63_D0.9260.46
17_T76_N0.9250.46
8_Y32_V0.9190.45
5_I11_D0.9120.45
138_K159_I0.9070.44
138_K147_K0.9050.44
21_L107_L0.9030.44
93_I100_K0.9000.44
138_K142_E0.8990.44
39_D103_S0.8970.44
52_D55_R0.8880.43
11_D27_A0.8860.43
35_G60_T0.8860.43
36_V99_Y0.8790.42
37_V95_Y0.8700.42
142_E150_E0.8650.41
150_E153_K0.8620.41
104_I123_L0.8590.41
51_K116_E0.8580.41
3_V123_L0.8560.41
108_I129_W0.8540.40
114_V123_L0.8480.40
7_D11_D0.8430.40
87_L113_I0.8410.40
153_K157_R0.8380.39
46_L59_I0.8370.39
89_A130_G0.8320.39
53_I57_I0.8250.38
21_L108_I0.8250.38
112_Y158_E0.8220.38
154_K157_R0.8100.37
24_L126_V0.8030.37
45_T83_R0.7970.37
52_D146_N0.7920.36
139_E162_K0.7910.36
49_K102_S0.7880.36
8_Y35_G0.7710.35
48_N148_T0.7700.35
86_I149_E0.7680.35
42_A52_D0.7600.34
150_E161_E0.7590.34
18_G39_D0.7580.34
86_I98_A0.7560.34
71_Q93_I0.7540.34
64_T69_T0.7540.34
10_K72_S0.7390.33
143_A155_I0.7370.33
45_T102_S0.7360.33
18_G103_S0.7350.32
146_N155_I0.7290.32
4_Y62_V0.7230.32
108_I152_I0.7190.31
150_E156_E0.7170.31
143_A159_I0.7160.31
22_V27_A0.7130.31
39_D160_I0.7120.31
26_I126_V0.7120.31
64_T103_S0.7060.31
23_K52_D0.7040.31
149_E153_K0.7030.30
17_T38_L0.7010.30
83_R156_E0.7000.30
80_E102_S0.6970.30
115_D145_K0.6960.30
88_F160_I0.6960.30
47_S152_I0.6920.30
97_I121_I0.6910.30
37_V157_R0.6820.29
114_V134_I0.6790.29
35_G58_G0.6780.29
99_Y160_I0.6780.29
5_I103_S0.6760.29
136_L158_E0.6750.29
6_I10_K0.6740.29
40_P63_D0.6740.29
124_S151_D0.6640.28
31_R92_P0.6560.28
90_G124_S0.6520.27
22_V62_V0.6510.27
90_G132_T0.6510.27
26_I104_I0.6510.27
7_D62_V0.6510.27
70_S158_E0.6440.27
38_L59_I0.6440.27
13_P48_N0.6430.27
61_I69_T0.6400.27
127_V130_G0.6290.26
23_K125_N0.6290.26
11_D83_R0.6290.26
36_V159_I0.6280.26
51_K145_K0.6280.26
93_I140_L0.6250.26
104_I130_G0.6230.26
7_D16_C0.6170.25
128_K140_L0.6070.25
10_K75_K0.5990.24
69_T73_E0.5970.24
16_C40_P0.5890.24
17_T129_W0.5880.24
58_G68_N0.5820.24
63_D153_K0.5800.23
21_L152_I0.5800.23
78_R148_T0.5800.23
20_K77_I0.5780.23
62_V68_N0.5770.23
21_L130_G0.5740.23
36_V148_T0.5740.23
149_E156_E0.5700.23
90_G131_H0.5700.23
42_A136_L0.5690.23
15_R107_L0.5660.23
125_N162_K0.5600.22
48_N156_E0.5570.22
128_K157_R0.5570.22
129_W132_T0.5560.22
25_K68_N0.5540.22
146_N152_I0.5480.22
99_Y119_E0.5480.22
46_L55_R0.5480.22
36_V162_K0.5420.22
7_D103_S0.5420.22
104_I115_D0.5390.21
63_D77_I0.5370.21
19_K22_V0.5340.21
46_L117_V0.5340.21
87_L109_A0.5340.21
9_H79_G0.5330.21
107_L110_T0.5300.21
20_K162_K0.5300.21
44_I149_E0.5240.21
141_L147_K0.5240.21
92_P128_K0.5230.21
27_A33_G0.5220.21
149_E152_I0.5200.20
18_G58_G0.5180.20
21_L62_V0.5150.20
36_V135_E0.5150.20
6_I18_G0.5150.20
51_K114_V0.5130.20
98_A156_E0.5100.20
63_D72_S0.5100.20
121_I131_H0.5070.20
20_K124_S0.5070.20
83_R95_Y0.5060.20
11_D15_R0.5060.20
8_Y72_S0.5030.20
64_T82_R0.5000.20
142_E147_K0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j16B 1 0.6807 36.3 0.955 Contact Map
1yrtA 1 0.512 17.4 0.962 Contact Map
3bk7A 1 0.9157 14.5 0.963 Contact Map
2yyvA 2 0.3253 11.9 0.964 Contact Map
2d28C 1 0.6988 11.2 0.965 Contact Map
4uerb 1 0.1807 7.6 0.967 Contact Map
1zlpA 4 0.8795 7.6 0.967 Contact Map
4gvfA 1 0.759 6.5 0.968 Contact Map
2nugA 2 0.6988 5.8 0.969 Contact Map
2p8tA 1 0.8494 5.1 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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