GREMLIN Database
ARGDC - Arginine decarboxylase proenzyme
UniProt: Q9UWU1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 134 (112)
Sequences: 884 (577)
Seq/√Len: 54.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_D120_N3.1041.00
43_L119_L2.9541.00
51_V58_L2.8561.00
63_A75_V2.7411.00
31_D122_K2.6341.00
61_I77_A2.4031.00
74_S79_V2.3481.00
109_Q128_Y2.2901.00
44_E48_L2.1561.00
96_T100_Y2.1421.00
46_L115_I2.1111.00
27_G112_F2.1071.00
40_K44_E1.9631.00
45_K49_E1.9121.00
49_E53_I1.8981.00
89_W96_T1.8720.99
58_L77_A1.8220.99
36_R42_F1.8060.99
38_N70_K1.7900.99
31_D123_R1.7860.99
43_L73_V1.7330.99
86_L97_L1.7320.99
39_D42_F1.7060.99
67_G70_K1.6580.99
26_F129_A1.6560.99
31_D121_P1.6260.98
49_E52_D1.5570.98
81_E102_C1.5420.98
29_L115_I1.4200.96
42_F46_L1.4100.96
55_H107_D1.3590.95
63_A77_A1.3120.94
86_L95_A1.2960.94
48_L61_I1.2930.94
46_L118_A1.2830.94
109_Q113_A1.2450.93
66_F91_E1.2420.92
43_L86_L1.2090.91
27_G99_V1.1550.89
30_Y123_R1.1500.89
91_E102_C1.1300.88
44_E61_I1.1220.88
35_E117_N1.1200.88
65_S71_G1.1190.88
40_K65_S1.0860.86
74_S85_A1.0780.86
66_F102_C1.0630.85
76_I85_A1.0470.84
40_K73_V1.0350.84
116_V124_Y1.0320.83
54_A101_T1.0280.83
63_A76_I1.0130.82
21_I92_Y1.0050.82
113_A116_V1.0050.82
51_V77_A1.0040.82
36_R120_N0.9920.81
59_V80_E0.9910.81
22_G82_S0.9900.81
32_I121_P0.9880.81
47_V84_I0.9880.81
44_E63_A0.9450.78
20_I100_Y0.9360.77
70_K101_T0.9360.77
24_H98_D0.9350.77
49_E114_H0.9220.76
56_M103_G0.9220.76
25_V126_M0.9150.75
48_L58_L0.9030.74
57_K81_E0.9010.74
41_E117_N0.8960.74
56_M96_T0.8920.73
25_V112_F0.8900.73
79_V101_T0.8710.72
97_L100_Y0.8630.71
50_A103_G0.8590.70
75_V89_W0.8440.69
49_E88_T0.8390.69
50_A114_H0.8250.67
49_E118_A0.8190.67
57_K107_D0.8160.66
124_Y130_D0.8110.66
70_K93_N0.8090.66
42_F124_Y0.8060.66
66_F70_K0.8010.65
42_F120_N0.7950.64
45_K123_R0.7880.64
40_K63_A0.7780.63
125_Q129_A0.7740.62
25_V29_L0.7720.62
53_I117_N0.7710.62
35_E118_A0.7670.62
27_G126_M0.7670.62
29_L125_Q0.7650.61
30_Y112_F0.7530.60
19_R129_A0.7530.60
50_A54_A0.7500.60
29_L116_V0.7500.60
84_I115_I0.7430.59
107_D113_A0.7400.59
36_R46_L0.7400.59
64_W73_V0.7340.58
76_I89_W0.7310.58
127_F130_D0.7190.57
53_I110_S0.7180.57
45_K110_S0.7120.56
72_G82_S0.7060.55
50_A56_M0.7060.55
28_N132_S0.7050.55
32_I78_L0.7040.55
41_E53_I0.6910.54
51_V95_A0.6900.54
60_E77_A0.6750.52
99_V116_V0.6660.51
98_D131_R0.6600.50
89_W92_Y0.6590.50
95_A121_P0.6580.50
50_A111_A0.6470.49
49_E110_S0.6460.49
97_L121_P0.6420.49
43_L97_L0.6290.47
46_L86_L0.6250.47
43_L75_V0.6220.46
40_K74_S0.6190.46
51_V84_I0.6160.46
74_S89_W0.6120.45
75_V132_S0.6100.45
113_A117_N0.6080.45
42_F118_A0.6060.45
35_E38_N0.6050.45
28_N65_S0.6050.45
27_G115_I0.5990.44
29_L124_Y0.5930.43
64_W80_E0.5910.43
28_N71_G0.5900.43
58_L63_A0.5900.43
46_L119_L0.5820.42
70_K90_N0.5810.42
38_N65_S0.5790.42
104_E120_N0.5780.42
100_Y116_V0.5740.41
56_M106_S0.5720.41
36_R39_D0.5710.41
45_K128_Y0.5710.41
61_I75_V0.5680.41
56_M100_Y0.5670.41
21_I89_W0.5640.40
48_L77_A0.5590.40
103_G108_P0.5560.39
51_V111_A0.5530.39
48_L52_D0.5460.38
47_V112_F0.5450.38
52_D113_A0.5430.38
124_Y127_F0.5420.38
59_V89_W0.5410.38
125_Q130_D0.5410.38
89_W94_Y0.5360.37
110_S120_N0.5350.37
39_D49_E0.5220.36
52_D63_A0.5220.36
84_I96_T0.5210.36
21_I59_V0.5200.36
84_I101_T0.5200.36
28_N127_F0.5080.35
75_V86_L0.5080.35
107_D110_S0.5070.35
42_F45_K0.5020.34
23_K107_D0.5010.34
38_N78_L0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iiiA 2 0.8507 100 0.17 Contact Map
1vr7A 2 0.8582 100 0.184 Contact Map
1mhmA 1 0.8955 91.2 0.884 Contact Map
1jl0A 2 0.806 81.1 0.9 Contact Map
3c6kA 2 0.7612 41.8 0.923 Contact Map
2qmxA 3 0.4627 12.7 0.94 Contact Map
3ifvA 3 0.6642 10.3 0.943 Contact Map
1plqA 3 0.6866 9.6 0.944 Contact Map
4hnzA 5 0.9328 9 0.944 Contact Map
4lubA 2 0.4552 9 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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