GREMLIN Database
GLYA - Serine hydroxymethyltransferase
UniProt: Q9UWT5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (398)
Sequences: 4038 (1801)
Seq/√Len: 90.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
156_I189_A4.2311.00
184_A188_H4.2111.00
160_E189_A3.3421.00
72_T76_E3.3041.00
177_P211_S3.0381.00
105_L220_I3.0341.00
288_R374_E2.9441.00
154_K157_K2.8711.00
78_M236_A2.8401.00
111_K137_Q2.8221.00
148_I303_K2.7761.00
223_V236_A2.7451.00
17_Q69_E2.7421.00
150_V155_A2.7411.00
156_I160_E2.6861.00
144_D147_N2.6841.00
373_K376_E2.6051.00
156_I182_E2.5871.00
330_I388_I2.4961.00
273_I276_K2.4871.00
181_K185_Q2.4151.00
157_K161_E2.4031.00
26_L367_M2.4001.00
295_E299_E2.3421.00
284_N288_R2.3341.00
158_M162_V2.3001.00
285_Q373_K2.2981.00
13_I69_E2.2941.00
207_G283_A2.2691.00
111_K162_V2.2291.00
209_V287_L2.1731.00
300_R382_E2.1441.00
285_Q374_E2.0881.00
72_T75_M2.0821.00
300_R385_K2.0751.00
196_Y218_A2.0571.00
296_A381_A2.0571.00
176_F313_K2.0491.00
87_C238_F2.0421.00
379_E400_E2.0201.00
139_I162_V2.0101.00
296_A299_E2.0091.00
155_A183_L1.9801.00
302_F385_K1.9711.00
296_A378_E1.9521.00
112_A138_H1.9461.00
78_M223_V1.9441.00
372_M380_I1.9411.00
296_A382_E1.9371.00
367_M377_M1.9331.00
341_V362_I1.9321.00
43_Y264_R1.9141.00
13_I70_I1.9061.00
106_A166_F1.8791.00
86_D239_S1.8641.00
86_D249_S1.8221.00
175_L304_V1.7981.00
76_E80_E1.7581.00
239_S245_F1.7511.00
154_K158_M1.7331.00
325_G352_E1.7271.00
17_Q66_Y1.7241.00
201_V210_W1.7171.00
111_K139_I1.7011.00
390_D393_D1.6951.00
387_V397_V1.6571.00
183_L194_L1.6511.00
386_K400_E1.6351.00
66_Y69_E1.6251.00
36_S274_E1.5961.00
292_A296_A1.5791.00
43_Y267_A1.5701.00
10_V70_I1.5691.00
86_D245_F1.5671.00
169_L183_L1.5661.00
285_Q288_R1.5531.00
152_V182_E1.5501.00
28_L367_M1.5451.00
19_V23_T1.5331.00
209_V284_N1.5321.00
379_E383_L1.5231.00
375_G378_E1.5141.00
322_R352_E1.5111.00
289_N368_T1.5071.00
95_T124_S1.5041.00
293_L381_A1.5031.00
333_L391_K1.4991.00
293_L377_M1.4991.00
209_V283_A1.4981.00
102_F168_V1.4841.00
219_D240_D1.4791.00
385_K389_I1.4781.00
280_E284_N1.4741.00
99_A131_L1.4711.00
85_K240_D1.4691.00
290_S312_T1.4620.99
20_W24_Q1.4590.99
10_V270_V1.4510.99
80_E275_M1.4400.99
383_L397_V1.4390.99
376_E408_F1.4160.99
12_E17_Q1.4050.99
294_A317_V1.4000.99
245_F249_S1.3930.99
118_Q345_L1.3910.99
25_T335_E1.3900.99
296_A300_R1.3800.99
105_L244_V1.3570.99
84_S214_L1.3560.99
324_F389_I1.3490.99
337_A387_V1.3490.99
13_I66_Y1.3440.99
303_K320_D1.3430.99
166_F195_V1.3140.99
144_D151_D1.3070.99
212_N215_K1.3040.99
210_W314_S1.3040.99
281_S284_N1.2980.99
47_F70_I1.2980.99
302_F324_F1.2960.99
201_V314_S1.2900.99
244_V247_Q1.2860.99
303_K323_Q1.2700.99
295_E378_E1.2600.98
25_T338_N1.2500.98
145_E348_Y1.2480.98
47_F67_T1.2470.98
402_I406_R1.2380.98
87_C236_A1.2330.98
100_A252_I1.2310.98
57_Y72_T1.2210.98
294_A304_V1.2180.98
52_A262_L1.2140.98
367_M380_I1.2110.98
106_A110_D1.2110.98
78_M272_A1.2090.98
372_M377_M1.2080.98
138_H168_V1.2030.98
101_V220_I1.2010.98
182_E185_Q1.1900.98
292_A378_E1.1880.98
110_D165_K1.1860.98
223_V272_A1.1850.98
300_R386_K1.1830.98
208_K280_E1.1830.98
379_E382_E1.1780.98
198_A238_F1.1770.98
11_L15_K1.1730.98
144_D154_K1.1720.98
293_L297_L1.1690.98
74_T269_A1.1620.97
195_V222_T1.1570.97
27_N340_I1.1570.97
143_F348_Y1.1550.97
6_E273_I1.1530.97
169_L196_Y1.1500.97
180_T210_W1.1440.97
62_Q331_A1.1400.97
382_E386_K1.1390.97
86_D240_D1.1340.97
107_E110_D1.1260.97
19_V46_D1.1250.97
291_K295_E1.1220.97
105_L193_K1.1210.97
336_D394_V1.1130.97
345_L349_D1.1120.97
383_L400_E1.1110.97
153_D182_E1.1100.97
139_I158_M1.1030.96
35_M40_E1.1020.96
298_A310_G1.1000.96
219_D244_V1.0920.96
107_E165_K1.0900.96
171_G178_H1.0890.96
156_I185_Q1.0880.96
379_E407_N1.0780.96
300_R378_E1.0780.96
116_P140_E1.0700.96
333_L387_V1.0700.96
188_H219_D1.0660.96
84_S238_F1.0660.96
4_P11_L1.0660.96
297_L385_K1.0620.96
352_E356_D1.0570.96
106_A112_A1.0570.96
181_K217_G1.0530.95
86_D248_V1.0480.95
240_D244_V1.0470.95
169_L194_L1.0450.95
193_K244_V1.0430.95
26_L372_M1.0340.95
67_T262_L1.0320.95
198_A205_I1.0310.95
341_V360_L1.0210.95
177_P210_W1.0180.94
396_E400_E1.0140.94
326_G352_E1.0130.94
324_F385_K1.0120.94
99_A256_F1.0100.94
184_A219_D1.0050.94
295_E298_A1.0030.94
303_K310_G1.0030.94
114_I124_S1.0010.94
115_A142_P0.9980.94
387_V394_V0.9950.94
288_R373_K0.9900.94
116_P119_A0.9900.94
334_L341_V0.9900.94
52_A64_T0.9850.93
114_I140_E0.9840.93
232_P267_A0.9810.93
113_L139_I0.9740.93
103_R136_I0.9710.93
300_R389_I0.9700.93
152_V155_A0.9690.93
104_V251_T0.9670.93
131_L135_G0.9670.93
102_F112_A0.9650.93
338_N402_I0.9640.93
230_P369_R0.9590.93
290_S365_Q0.9580.92
83_N208_K0.9530.92
137_Q162_V0.9520.92
10_V13_I0.9520.92
14_T42_V0.9510.92
400_E403_E0.9510.92
8_E12_E0.9500.92
252_I256_F0.9490.92
85_K239_S0.9480.92
7_L77_L0.9470.92
173_L318_A0.9440.92
337_A383_L0.9400.92
332_K336_D0.9380.92
10_V47_F0.9350.92
317_V362_I0.9330.91
171_G201_V0.9270.91
24_Q402_I0.9240.91
74_T89_L0.9230.91
152_V183_L0.9220.91
372_M404_M0.9210.91
349_D352_E0.9200.91
144_D348_Y0.9190.91
160_E190_V0.9170.91
159_I167_V0.9160.91
9_K273_I0.9130.91
160_E163_K0.9120.91
243_E247_Q0.9090.90
304_V317_V0.9090.90
299_E378_E0.9060.90
15_K19_V0.9050.90
42_V270_V0.9030.90
290_S317_V0.9020.90
292_A374_E0.9000.90
107_E134_L0.8980.90
220_I244_V0.8950.90
176_F311_Y0.8890.89
193_K220_I0.8870.89
302_F319_V0.8840.89
96_I99_A0.8780.89
236_A272_A0.8760.89
9_K12_E0.8730.89
158_M161_E0.8720.88
401_V404_M0.8690.88
394_V397_V0.8680.88
171_G314_S0.8650.88
102_F138_H0.8620.88
283_A286_I0.8610.88
178_H183_L0.8580.88
395_N398_K0.8570.88
119_A145_E0.8570.88
329_K333_L0.8560.88
326_G329_K0.8500.87
37_P41_S0.8490.87
281_S285_Q0.8460.87
337_A394_V0.8440.87
399_K403_E0.8410.87
318_A344_N0.8400.87
303_K346_L0.8390.86
150_V178_H0.8390.86
242_S245_F0.8380.86
298_A304_V0.8380.86
8_E11_L0.8330.86
69_E72_T0.8320.86
39_A271_T0.8290.86
85_K242_S0.8260.86
78_M238_F0.8250.86
395_N399_K0.8240.85
383_L404_M0.8230.85
329_K392_K0.8210.85
76_E79_N0.8200.85
239_S249_S0.8190.85
51_Y226_H0.8180.85
157_K160_E0.8160.85
222_T237_I0.8160.85
167_V183_L0.8120.85
181_K184_A0.8090.84
101_V106_A0.8090.84
3_L14_T0.8050.84
376_E407_N0.8030.84
10_V273_I0.8010.84
6_E38_L0.8000.84
376_E404_M0.7940.83
118_Q349_D0.7910.83
169_L198_A0.7890.83
101_V222_T0.7850.83
386_K396_E0.7840.83
373_K408_F0.7820.82
337_A397_V0.7820.82
349_D353_D0.7800.82
92_T96_I0.7800.82
239_S248_V0.7800.82
10_V73_L0.7780.82
101_V195_V0.7760.82
155_A186_H0.7720.82
201_V205_I0.7690.81
180_T201_V0.7660.81
372_M376_E0.7660.81
387_V391_K0.7640.81
175_L317_V0.7620.81
397_V400_E0.7620.81
14_T47_F0.7600.81
338_N398_K0.7600.81
78_M87_C0.7590.80
169_L218_A0.7580.80
297_L381_A0.7560.80
79_N87_C0.7540.80
113_L159_I0.7520.80
20_W23_T0.7510.80
24_Q338_N0.7500.80
329_K391_K0.7500.80
333_L390_D0.7470.79
85_K244_V0.7470.79
128_F138_H0.7450.79
214_L221_M0.7440.79
372_M408_F0.7420.79
112_A166_F0.7410.79
116_P142_P0.7340.78
145_E148_I0.7340.78
115_A178_H0.7340.78
230_P282_Y0.7330.78
329_K352_E0.7320.78
287_L291_K0.7280.78
328_N355_S0.7270.78
296_A385_K0.7270.78
321_V324_F0.7270.78
379_E403_E0.7260.77
61_Y226_H0.7260.77
381_A385_K0.7240.77
317_V364_V0.7230.77
378_E382_E0.7230.77
247_Q250_K0.7210.77
279_G283_A0.7190.77
333_L336_D0.7170.77
8_E38_L0.7170.77
331_A335_E0.7160.76
403_E406_R0.7160.76
187_V194_L0.7150.76
244_V248_V0.7140.76
404_M408_F0.7130.76
184_A194_L0.7130.76
103_R251_T0.7120.76
391_K394_V0.7110.76
108_P135_G0.7110.76
84_S212_N0.7090.76
194_L218_A0.7070.76
70_I262_L0.7060.75
215_K221_M0.7050.75
106_A195_V0.7010.75
207_G284_N0.7010.75
75_M79_N0.7010.75
3_L41_S0.7010.75
168_V195_V0.6990.75
51_Y61_Y0.6990.75
13_I17_Q0.6980.75
181_K215_K0.6970.75
113_L162_V0.6970.75
95_T252_I0.6960.74
198_A206_E0.6950.74
131_L136_I0.6930.74
103_R256_F0.6920.74
78_M82_T0.6900.74
239_S244_V0.6900.74
283_A365_Q0.6890.74
177_P212_N0.6870.73
293_L362_I0.6870.73
102_F166_F0.6860.73
326_G356_D0.6850.73
333_L337_A0.6850.73
155_A158_M0.6820.73
300_R381_A0.6820.73
383_L386_K0.6810.73
153_D157_K0.6780.72
155_A169_L0.6770.72
232_P271_T0.6770.72
113_L138_H0.6770.72
279_G286_I0.6770.72
364_V377_M0.6770.72
403_E407_N0.6760.72
240_D245_F0.6750.72
135_G251_T0.6750.72
398_K402_I0.6750.72
24_Q406_R0.6690.71
202_Y228_T0.6680.71
353_D356_D0.6670.71
59_R68_D0.6660.71
75_M249_S0.6650.71
34_V366_E0.6640.71
128_F355_S0.6620.71
335_E338_N0.6620.71
204_L287_L0.6550.70
383_L387_V0.6550.70
6_E276_K0.6550.70
129_G250_K0.6550.70
292_A295_E0.6540.70
405_R408_F0.6540.70
205_I210_W0.6530.70
84_S221_M0.6510.69
92_T261_H0.6510.69
304_V319_V0.6490.69
240_D243_E0.6490.69
397_V401_V0.6470.69
85_K245_F0.6440.69
401_V408_F0.6430.68
40_E49_S0.6420.68
362_I384_F0.6410.68
298_A303_K0.6370.68
17_Q20_W0.6340.67
207_G280_E0.6330.67
65_K335_E0.6320.67
151_D154_K0.6320.67
297_L304_V0.6310.67
231_G271_T0.6310.67
278_F281_S0.6300.67
51_Y259_N0.6300.67
283_A287_L0.6300.67
107_E137_Q0.6270.67
232_P264_R0.6260.66
115_A152_V0.6250.66
156_I186_H0.6250.66
335_E340_I0.6250.66
332_K335_E0.6230.66
105_L166_F0.6220.66
32_E51_Y0.6210.66
91_P252_I0.6170.65
291_K313_K0.6130.65
154_K162_V0.6120.65
95_T130_T0.6120.65
9_K80_E0.6120.65
153_D156_I0.6120.65
143_F345_L0.6100.64
103_R135_G0.6100.64
81_I272_A0.6090.64
287_L364_V0.6080.64
214_L238_F0.6070.64
80_E83_N0.6070.64
345_L353_D0.6050.64
187_V192_A0.6040.64
153_D189_A0.6040.64
319_V341_V0.6020.63
84_S240_D0.6010.63
285_Q368_T0.6000.63
11_L41_S0.6000.63
169_L178_H0.5990.63
390_D394_V0.5990.63
99_A130_T0.5980.63
302_F389_I0.5970.63
230_P274_E0.5960.63
401_V405_R0.5950.63
175_L306_G0.5930.62
214_L217_G0.5930.62
321_V346_L0.5930.62
180_T205_I0.5920.62
292_A377_M0.5920.62
73_L273_I0.5920.62
296_A377_M0.5910.62
215_K240_D0.5890.62
98_N222_T0.5880.62
274_E282_Y0.5880.62
13_I47_F0.5870.61
288_R291_K0.5870.61
386_K397_V0.5870.61
367_M372_M0.5870.61
287_L290_S0.5860.61
321_V325_G0.5850.61
35_M39_A0.5840.61
399_K402_I0.5830.61
175_L316_Q0.5830.61
95_T99_A0.5820.61
111_K158_M0.5810.61
74_T272_A0.5810.61
95_T102_F0.5800.61
3_L38_L0.5790.60
302_F384_F0.5790.60
225_T236_A0.5780.60
35_M267_A0.5780.60
14_T46_D0.5770.60
251_T256_F0.5750.60
219_D245_F0.5740.60
114_I138_H0.5740.60
35_M48_M0.5730.60
246_K250_K0.5720.60
375_G382_E0.5720.60
79_N84_S0.5720.60
377_M380_I0.5710.59
286_I364_V0.5700.59
207_G212_N0.5700.59
305_I321_V0.5690.59
261_H264_R0.5680.59
43_Y263_H0.5670.59
99_A103_R0.5670.59
25_T65_K0.5640.58
319_V324_F0.5640.58
152_V178_H0.5640.58
205_I314_S0.5620.58
329_K395_N0.5610.58
185_Q189_A0.5610.58
326_G357_P0.5600.58
144_D149_N0.5600.58
394_V398_K0.5600.58
239_S242_S0.5600.58
334_L360_L0.5580.58
85_K243_E0.5570.58
302_F323_Q0.5570.58
101_V166_F0.5570.58
177_P287_L0.5570.58
43_Y46_D0.5550.57
92_T95_T0.5540.57
345_L355_S0.5540.57
9_K69_E0.5530.57
239_S247_Q0.5530.57
116_P138_H0.5530.57
25_T34_V0.5530.57
72_T262_L0.5520.57
181_K188_H0.5490.56
27_N366_E0.5480.56
73_L77_L0.5480.56
14_T45_S0.5450.56
334_L384_F0.5440.56
277_Y281_S0.5440.56
268_T272_A0.5430.56
40_E46_D0.5430.56
276_K281_S0.5420.55
113_L140_E0.5410.55
32_E226_H0.5400.55
79_N85_K0.5400.55
382_E400_E0.5400.55
62_Q335_E0.5400.55
119_A142_P0.5390.55
148_I346_L0.5370.55
172_S199_A0.5360.55
119_A348_Y0.5360.55
103_R131_L0.5360.55
58_K355_S0.5360.55
262_L265_L0.5350.55
376_E379_E0.5350.55
106_A165_K0.5330.54
242_S246_K0.5320.54
179_P182_E0.5300.54
99_A135_G0.5290.54
82_T202_Y0.5290.54
104_V248_V0.5280.54
196_Y201_V0.5280.54
199_A222_T0.5280.54
209_V288_R0.5270.53
202_Y223_V0.5240.53
330_I360_L0.5240.53
228_T365_Q0.5230.53
9_K73_L0.5220.53
240_D247_Q0.5210.53
225_T234_G0.5210.53
106_A193_K0.5210.53
159_I186_H0.5200.52
293_L296_A0.5200.52
127_K140_E0.5190.52
226_H259_N0.5190.52
167_V186_H0.5190.52
148_I302_F0.5180.52
10_V66_Y0.5160.52
112_A140_E0.5160.52
77_L270_V0.5130.52
324_F388_I0.5130.52
149_N176_F0.5120.51
286_I290_S0.5110.51
62_Q340_I0.5100.51
349_D355_S0.5090.51
64_T268_T0.5090.51
92_T268_T0.5090.51
339_I383_L0.5080.51
376_E380_I0.5070.51
302_F388_I0.5060.51
288_R292_A0.5040.50
62_Q343_K0.5030.50
140_E158_M0.5030.50
207_G287_L0.5030.50
302_F381_A0.5030.50
112_A165_K0.5020.50
66_Y70_I0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rv3A 3 0.9838 100 0.495 Contact Map
3ou5A 2 0.9053 100 0.517 Contact Map
3h7fA 2 0.9584 100 0.617 Contact Map
4wxgA 2 0.933 100 0.63 Contact Map
3n0lA 2 0.9076 100 0.65 Contact Map
3ecdA 2 0.8614 100 0.657 Contact Map
2dkjA 2 0.9238 100 0.664 Contact Map
3gbxA 2 0.8684 100 0.664 Contact Map
4bhdA 2 0.9492 100 0.67 Contact Map
4tn4A 2 0.9746 100 0.672 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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