GREMLIN Database
XYLS - Alpha-xylosidase
UniProt: Q9P999 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 731 (655)
Sequences: 4124 (2772)
Seq/√Len: 108.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_R281_D4.9381.00
243_E247_R4.8951.00
287_H348_D4.2251.00
249_I514_I4.0851.00
242_K246_E3.8791.00
208_R213_D3.8771.00
243_E246_E3.8221.00
238_T285_E3.8131.00
657_D660_T3.6311.00
473_E574_S3.5811.00
284_E288_K3.4361.00
164_L415_A3.2591.00
392_K396_E3.1031.00
549_D581_Y3.0761.00
280_K284_E3.0721.00
209_K213_D3.0451.00
404_K659_I3.0411.00
542_L558_Q2.9951.00
248_K515_R2.9491.00
546_F560_M2.9471.00
524_I561_F2.9251.00
564_Y620_A2.9061.00
458_T482_S2.8361.00
579_E604_D2.7931.00
310_D338_Y2.7751.00
557_E578_K2.7671.00
587_Y596_K2.7561.00
314_K330_E2.7351.00
202_D205_K2.7221.00
309_K313_S2.7151.00
199_S202_D2.6671.00
65_D76_K2.6311.00
590_D593_T2.6211.00
577_E604_D2.5731.00
558_Q566_L2.5221.00
529_W533_S2.4761.00
114_V155_I2.4711.00
568_S580_V2.4251.00
248_K511_L2.4221.00
467_E573_P2.3951.00
280_K345_L2.3521.00
242_K289_M2.3451.00
251_L291_A2.3401.00
333_E337_S2.3101.00
336_W400_R2.2811.00
587_Y598_E2.2791.00
509_V513_Y2.2731.00
244_F499_P2.2561.00
605_V615_F2.2501.00
247_R507_Q2.2411.00
49_S68_T2.2141.00
201_D545_D2.2141.00
409_L422_A2.2091.00
608_T611_T2.1681.00
530_M534_I2.1601.00
154_F162_G2.1411.00
218_P221_A2.1321.00
241_V251_L2.1271.00
623_P641_L2.1151.00
437_R572_L2.1021.00
582_L603_M2.0711.00
113_R125_G2.0681.00
650_Y672_P2.0671.00
316_C319_L2.0231.00
479_F510_I2.0131.00
63_S76_K1.9891.00
166_D191_D1.9871.00
590_D611_T1.9831.00
19_R191_D1.9781.00
195_I206_G1.9621.00
582_L615_F1.9581.00
135_D138_G1.9541.00
340_K400_R1.9511.00
512_K610_D1.9481.00
166_D193_Y1.9401.00
308_F323_A1.9361.00
587_Y618_S1.9301.00
413_A417_Q1.9161.00
511_L515_R1.9111.00
579_E602_M1.9001.00
18_V64_V1.8871.00
258_W296_S1.8861.00
281_D285_E1.8831.00
340_K344_D1.8741.00
200_I547_R1.8711.00
447_S541_P1.8681.00
551_N602_M1.8521.00
577_E606_K1.8351.00
568_S578_K1.8201.00
328_K331_C1.8191.00
330_E333_E1.8121.00
222_Y528_A1.8001.00
271_F279_P1.7971.00
568_S615_F1.7891.00
540_R545_D1.7881.00
458_T488_L1.7831.00
132_Y135_D1.7551.00
572_L575_I1.7401.00
530_M563_P1.7321.00
325_N331_C1.7221.00
256_L293_L1.7221.00
234_Q238_T1.7201.00
616_V644_Y1.7071.00
504_R508_E1.7031.00
552_V581_Y1.7001.00
476_V506_Y1.6881.00
77_D81_G1.6791.00
567_I614_L1.6781.00
591_F614_L1.6701.00
565_I622_L1.6591.00
310_D314_K1.6551.00
205_K534_I1.6491.00
591_F624_L1.6391.00
508_E511_L1.6151.00
582_L605_V1.6091.00
54_I65_D1.6001.00
242_K285_E1.5901.00
207_Y415_A1.5891.00
234_Q278_R1.5831.00
260_Y342_F1.5801.00
597_L615_F1.5801.00
237_I256_L1.5791.00
241_V291_A1.5711.00
162_G203_V1.5691.00
114_V157_S1.5681.00
456_T485_C1.5571.00
570_V578_K1.5451.00
513_Y612_I1.5411.00
234_Q282_M1.5341.00
200_I543_V1.5301.00
565_I616_V1.5261.00
677_E680_Q1.5251.00
465_N495_F1.5191.00
484_F614_L1.5041.00
65_D74_I1.5001.00
481_W559_Y1.4871.00
333_E400_R1.4861.00
235_D239_S1.4861.00
560_M588_W1.4831.00
311_M323_A1.4811.00
244_F251_L1.4791.00
652_E670_I1.4751.00
520_L565_I1.4741.00
529_W670_I1.4721.00
248_K629_V1.4671.00
440_I571_T1.4661.00
536_Y544_M1.4621.00
64_V73_L1.4611.00
13_I17_I1.4581.00
217_L222_Y1.4451.00
552_V555_F1.4441.00
16_N206_G1.4421.00
283_V293_L1.4411.00
20_V192_Y1.4411.00
61_S78_N1.4411.00
621_V643_V1.4391.00
443_G454_W1.4381.00
505_E508_E1.4381.00
80_G83_V1.4281.00
519_K640_D1.4231.00
476_V609_L1.4181.00
624_L642_R1.4181.00
591_F616_V1.4161.00
476_V509_V1.4071.00
304_E309_K1.4001.00
580_V605_V1.3961.00
336_W397_G1.3921.00
590_D595_E1.3871.00
272_D275_D1.3861.00
389_M392_K1.3771.00
526_S651_F1.3751.00
528_A538_I1.3711.00
485_C559_Y1.3681.00
224_Y244_F1.3661.00
109_S159_K1.3611.00
241_V286_I1.3581.00
295_I347_I1.3561.00
392_K420_H1.3531.00
542_L560_M1.3531.00
564_Y617_R1.3531.00
82_I85_K1.3331.00
399_R661_Y1.3320.99
473_E609_L1.3320.99
156_V200_I1.3270.99
197_G202_D1.3270.99
476_V480_Q1.3230.99
662_E665_K1.3210.99
232_K236_E1.3180.99
332_R393_A1.3170.99
225_W255_V1.3140.99
252_D518_Y1.3110.99
340_K401_I1.3050.99
527_L530_M1.3050.99
309_K312_E1.3010.99
17_I195_I1.2950.99
530_M536_Y1.2930.99
205_K536_Y1.2890.99
226_Q231_Y1.2850.99
195_I210_L1.2840.99
58_S63_S1.2830.99
433_W473_E1.2830.99
426_S442_A1.2820.99
19_R193_Y1.2730.99
368_P373_D1.2670.99
16_N61_S1.2620.99
292_K348_D1.2560.99
241_V254_I1.2530.99
294_A349_A1.2470.99
443_G456_T1.2400.99
106_F181_K1.2360.99
530_M652_E1.2330.99
357_P379_G1.2320.99
62_L196_Y1.2320.99
396_E399_R1.2230.99
370_H373_D1.2230.99
565_I614_L1.2210.99
542_L555_F1.2190.99
281_D284_E1.2170.99
641_L673_I1.2170.99
234_Q277_P1.2120.99
249_I507_Q1.2110.99
150_I413_A1.2080.99
545_D617_R1.2080.99
519_K624_L1.2080.99
338_Y341_G1.2070.99
395_Y399_R1.2050.99
18_V75_M1.2000.99
607_V611_T1.1980.99
388_L417_Q1.1960.99
650_Y674_T1.1940.99
231_Y498_E1.1920.99
92_K95_E1.1870.99
76_K82_I1.1860.99
263_K267_N1.1850.99
220_W349_A1.1840.99
201_D536_Y1.1820.99
211_T418_Q1.1740.99
108_L114_V1.1720.99
332_R336_W1.1710.99
66_I73_L1.1670.99
512_K611_T1.1670.99
302_G305_T1.1660.99
198_D206_G1.1650.99
503_P506_Y1.1640.99
506_Y510_I1.1600.99
433_W573_P1.1510.99
20_V75_M1.1490.98
74_I82_I1.1480.98
236_E239_S1.1450.98
452_P531_T1.1370.98
245_R289_M1.1340.98
475_F490_V1.1330.98
90_D93_F1.1320.98
515_R627_K1.1220.98
329_D333_E1.1210.98
580_V615_F1.1200.98
34_L37_L1.1200.98
473_E573_P1.1180.98
318_I324_F1.1170.98
545_D560_M1.1150.98
589_Y618_S1.1150.98
224_Y490_V1.1140.98
283_V347_I1.1130.98
546_F617_R1.1110.98
227_S255_V1.1090.98
50_T54_I1.1080.98
329_D374_L1.1080.98
50_T53_S1.1070.98
197_G203_V1.1070.98
154_F203_V1.1040.98
490_V497_K1.1020.98
267_N304_E1.1010.98
523_Y623_P1.0980.98
131_A135_D1.0980.98
55_I68_T1.0960.98
18_V57_F1.0910.98
74_I85_K1.0880.98
113_R554_D1.0870.98
592_W611_T1.0870.98
241_V289_M1.0860.98
253_V292_K1.0840.98
224_Y488_L1.0830.98
315_G318_I1.0830.98
222_Y524_I1.0820.98
297_I339_V1.0800.98
238_T289_M1.0790.98
337_S340_K1.0760.98
541_P544_M1.0760.98
436_L481_W1.0760.98
503_P507_Q1.0740.98
237_I254_I1.0700.98
9_E21_L1.0690.98
545_D563_P1.0680.98
559_Y567_I1.0680.98
56_S63_S1.0660.98
165_W185_E1.0610.97
152_I415_A1.0590.97
219_K525_Y1.0540.97
301_F311_M1.0530.97
339_V350_Y1.0510.97
53_S68_T1.0510.97
388_L420_H1.0510.97
425_W428_D1.0480.97
226_Q244_F1.0480.97
9_E23_Y1.0450.97
245_R291_A1.0450.97
332_R392_K1.0420.97
484_F612_I1.0420.97
500_W503_P1.0290.97
217_L528_A1.0290.97
443_G539_M1.0290.97
12_F18_V1.0270.97
67_N72_E1.0260.97
597_L603_M1.0260.97
33_S36_V1.0260.97
662_E667_K1.0220.97
89_R92_K1.0220.97
15_D61_S1.0200.97
509_V610_D1.0160.97
513_Y592_W1.0150.97
479_F490_V1.0150.97
283_V345_L1.0050.96
411_R425_W1.0050.96
262_G267_N1.0040.96
117_L175_L1.0030.96
155_I175_L1.0010.96
472_A503_P1.0000.96
616_V622_L0.9960.96
353_D428_D0.9950.96
378_K381_E0.9880.96
237_I293_L0.9870.96
630_N633_E0.9870.96
75_M194_V0.9860.96
484_F516_L0.9850.96
332_R396_E0.9820.96
475_F510_I0.9820.96
208_R535_G0.9780.96
171_G185_E0.9740.96
235_D238_T0.9730.96
296_S351_W0.9720.96
484_F567_I0.9720.96
229_E259_R0.9700.96
236_E496_P0.9680.96
239_S243_E0.9670.96
85_K107_E0.9660.96
208_R452_P0.9660.96
426_S446_F0.9640.96
314_K337_S0.9640.96
373_D376_I0.9610.95
432_D435_T0.9600.95
86_E91_L0.9590.95
10_I64_V0.9580.95
424_S446_F0.9570.95
48_E58_S0.9550.95
467_E472_A0.9540.95
227_S491_H0.9500.95
225_W253_V0.9480.95
645_P675_W0.9470.95
560_M564_Y0.9460.95
527_L538_I0.9440.95
21_L189_K0.9430.95
90_D94_N0.9410.95
527_L651_F0.9370.95
117_L155_I0.9330.95
263_K274_T0.9310.95
216_L528_A0.9300.95
436_L571_T0.9300.95
444_L539_M0.9280.95
268_A301_F0.9260.94
405_R656_D0.9250.94
284_E287_H0.9210.94
499_P510_I0.9210.94
411_R428_D0.9200.94
213_D535_G0.9200.94
379_G383_L0.9190.94
67_N74_I0.9180.94
229_E296_S0.9180.94
135_D140_S0.9180.94
290_G633_E0.9180.94
10_I66_I0.9170.94
45_I57_F0.9160.94
403_N662_E0.9150.94
285_E288_K0.9140.94
67_N70_N0.9120.94
439_Q485_C0.9100.94
214_A452_P0.9100.94
299_P386_Y0.9100.94
245_R252_D0.9070.94
196_Y206_G0.9070.94
433_W436_L0.9050.94
354_A358_E0.9050.94
262_G273_E0.9010.94
9_E28_A0.8990.94
523_Y562_G0.8980.94
256_L276_F0.8970.93
531_T538_I0.8970.93
133_K138_G0.8970.93
391_T421_S0.8960.93
485_C539_M0.8950.93
483_T513_Y0.8950.93
310_D313_S0.8940.93
344_D401_I0.8930.93
47_G50_T0.8920.93
165_W171_G0.8920.93
426_S454_W0.8900.93
234_Q281_D0.8890.93
257_D428_D0.8890.93
286_I291_A0.8860.93
204_I544_M0.8860.93
77_D196_Y0.8840.93
564_Y622_L0.8830.93
476_V510_I0.8830.93
317_I323_A0.8780.93
14_A17_I0.8750.93
368_P371_D0.8720.93
472_A506_Y0.8700.92
169_S187_G0.8690.92
15_D60_E0.8680.92
459_G475_F0.8680.92
84_V87_K0.8640.92
307_V311_M0.8610.92
240_V500_W0.8590.92
233_S275_D0.8590.92
448_I543_V0.8570.92
372_V376_I0.8560.92
607_V615_F0.8560.92
590_D594_G0.8550.92
570_V608_T0.8540.92
133_K137_S0.8530.92
193_Y210_L0.8530.92
222_Y453_Y0.8510.92
201_D544_M0.8460.91
444_L541_P0.8440.91
122_G126_L0.8400.91
410_T424_S0.8390.91
639_I655_D0.8370.91
160_G198_D0.8360.91
374_L377_G0.8350.91
306_E310_D0.8350.91
298_W354_A0.8340.91
12_F59_S0.8330.91
428_D491_H0.8300.91
217_L453_Y0.8290.90
80_G84_V0.8290.90
427_G461_F0.8280.90
508_E512_K0.8260.90
36_V193_Y0.8260.90
333_E336_W0.8260.90
258_W298_W0.8250.90
233_S236_E0.8250.90
353_D411_R0.8240.90
17_I206_G0.8230.90
570_V575_I0.8170.90
336_W396_E0.8160.90
251_L254_I0.8150.90
512_K515_R0.8150.90
307_V338_Y0.8150.90
286_I293_L0.8140.90
510_I514_I0.8140.90
526_S653_L0.8140.90
167_N171_G0.8110.90
509_V609_L0.8090.89
50_T56_S0.8080.89
482_S488_L0.8070.89
521_L631_N0.8060.89
219_K655_D0.8040.89
56_S65_D0.8030.89
226_Q498_E0.8030.89
105_E182_V0.8010.89
63_S80_G0.8010.89
368_P372_V0.8010.89
64_V75_M0.8010.89
8_V71_G0.7980.89
81_G84_V0.7970.89
229_E298_W0.7970.89
629_V633_E0.7960.89
326_P329_D0.7960.89
505_E610_D0.7940.89
205_K213_D0.7920.88
255_V487_I0.7890.88
425_W491_H0.7890.88
261_W298_W0.7870.88
307_V310_D0.7850.88
311_M317_I0.7850.88
624_L640_D0.7850.88
673_I682_L0.7840.88
417_Q421_S0.7840.88
158_S553_Y0.7830.88
106_F192_Y0.7830.88
447_S537_T0.7820.88
395_Y661_Y0.7820.88
113_R553_Y0.7820.88
244_F500_W0.7810.88
417_Q451_I0.7810.88
48_E56_S0.7800.88
87_K93_F0.7780.87
135_D139_L0.7780.87
29_I32_N0.7770.87
257_D489_R0.7770.87
457_D489_R0.7760.87
549_D584_S0.7760.87
316_C331_C0.7760.87
504_R507_Q0.7750.87
507_Q511_L0.7750.87
247_R500_W0.7750.87
448_I541_P0.7750.87
425_W461_F0.7700.87
11_E19_R0.7680.87
280_K344_D0.7670.87
258_W354_A0.7670.87
222_Y538_I0.7660.87
373_D379_G0.7650.87
591_F642_R0.7650.87
417_Q424_S0.7650.87
617_R620_A0.7650.87
453_Y528_A0.7640.87
311_M334_L0.7630.86
350_Y398_Q0.7600.86
527_L563_P0.7590.86
216_L529_W0.7590.86
343_Y346_G0.7570.86
216_L525_Y0.7560.86
399_R406_V0.7560.86
83_V196_Y0.7550.86
527_L531_T0.7550.86
570_V607_V0.7550.86
398_Q406_V0.7550.86
252_D631_N0.7540.86
84_V88_R0.7520.86
152_I211_T0.7520.86
680_Q684_I0.7510.86
519_K627_K0.7500.86
626_G640_D0.7490.85
388_L419_R0.7480.85
652_E672_P0.7480.85
165_W173_I0.7470.85
477_R480_Q0.7450.85
354_A360_G0.7430.85
152_I451_I0.7420.85
673_I680_Q0.7420.85
242_K245_R0.7400.85
270_K306_E0.7380.85
226_Q254_I0.7370.85
623_P653_L0.7370.85
16_N202_D0.7360.84
10_I18_V0.7360.84
245_R630_N0.7350.84
229_E258_W0.7350.84
119_Q149_D0.7340.84
150_I424_S0.7340.84
337_S341_G0.7340.84
531_T534_I0.7340.84
237_I286_I0.7330.84
230_R259_R0.7320.84
102_V190_I0.7310.84
217_L221_A0.7290.84
328_K374_L0.7270.84
90_D95_E0.7270.84
335_F390_E0.7250.84
657_D662_E0.7250.84
155_I181_K0.7230.83
220_W292_K0.7230.83
353_D491_H0.7230.83
303_K321_T0.7220.83
483_T488_L0.7210.83
310_D337_S0.7210.83
560_M583_P0.7200.83
551_N581_Y0.7200.83
10_I20_V0.7200.83
167_N187_G0.7190.83
88_R91_L0.7180.83
555_F558_Q0.7150.83
630_N634_E0.7150.83
370_H374_L0.7140.83
120_H126_L0.7140.83
244_F248_K0.7130.83
134_L138_G0.7090.82
426_S443_G0.7090.82
607_V612_I0.7090.82
653_L673_I0.7080.82
665_K668_Y0.7080.82
207_Y211_T0.7050.82
399_R403_N0.7050.82
557_E571_T0.7040.82
167_N188_K0.7030.82
91_L95_E0.7030.82
228_K257_D0.7030.82
481_W485_C0.7030.82
124_N543_V0.7020.82
433_W474_I0.7010.81
249_I511_L0.7010.81
93_F96_E0.7010.81
239_S246_E0.6990.81
488_L514_I0.6990.81
44_S47_G0.6990.81
620_A623_P0.6980.81
211_T415_A0.6980.81
208_R537_T0.6980.81
149_D427_G0.6970.81
37_L40_L0.6970.81
89_R95_E0.6950.81
607_V613_P0.6940.81
477_R570_V0.6930.81
584_S600_G0.6920.81
72_E87_K0.6920.81
297_I342_F0.6900.80
312_E323_A0.6890.80
290_G632_A0.6890.80
674_T683_T0.6890.80
443_G485_C0.6880.80
45_I49_S0.6860.80
578_K605_V0.6850.80
240_V244_F0.6850.80
515_R629_V0.6850.80
232_K275_D0.6840.80
154_F164_L0.6830.80
34_L39_N0.6820.80
231_Y240_V0.6820.80
493_T497_K0.6820.80
219_K625_L0.6820.80
226_Q240_V0.6820.80
594_G642_R0.6800.79
35_V38_P0.6800.79
387_P412_S0.6790.79
592_W614_L0.6780.79
426_S429_V0.6780.79
575_I578_K0.6780.79
410_T421_S0.6770.79
234_Q285_E0.6770.79
480_Q512_K0.6760.79
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224_Y514_I0.6750.79
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21_L31_D0.6740.79
355_S410_T0.6720.79
431_G497_K0.6710.79
155_I161_Y0.6700.78
542_L583_P0.6700.78
63_S78_N0.6700.78
258_W261_W0.6690.78
261_W264_Y0.6680.78
26_R309_K0.6680.78
341_G344_D0.6680.78
335_F394_V0.6680.78
585_K588_W0.6680.78
398_Q408_I0.6660.78
287_H292_K0.6660.78
546_F564_Y0.6660.78
413_A451_I0.6660.78
394_V408_I0.6650.78
675_W682_L0.6650.78
343_Y398_Q0.6650.78
154_F207_Y0.6640.78
525_Y656_D0.6640.78
542_L552_V0.6630.78
255_V294_A0.6630.78
224_Y510_I0.6620.78
391_T410_T0.6620.78
662_E666_G0.6600.77
583_P588_W0.6600.77
461_F491_H0.6570.77
216_L532_Y0.6570.77
397_G400_R0.6560.77
542_L568_S0.6560.77
634_E637_D0.6560.77
641_L651_F0.6560.77
132_Y137_S0.6550.77
369_I374_L0.6540.77
480_Q608_T0.6540.77
89_R94_N0.6540.77
10_I73_L0.6530.77
119_Q442_A0.6530.77
457_D461_F0.6530.77
329_D375_E0.6510.76
518_Y521_L0.6510.76
229_E461_F0.6500.76
428_D461_F0.6500.76
157_S160_G0.6500.76
589_Y596_K0.6490.76
155_I163_I0.6480.76
447_S539_M0.6470.76
83_V86_E0.6460.76
133_K139_L0.6440.76
136_Y140_S0.6420.75
433_W477_R0.6420.75
547_R552_V0.6410.75
84_V92_K0.6410.75
243_E507_Q0.6390.75
38_P209_K0.6390.75
356_E425_W0.6380.75
475_F479_F0.6380.75
285_E289_M0.6370.75
117_L173_I0.6370.75
589_Y644_Y0.6370.75
263_K304_E0.6360.75
499_P514_I0.6330.74
164_L207_Y0.6330.74
186_A380_Y0.6320.74
351_W491_H0.6300.74
240_V498_E0.6300.74
661_Y666_G0.6290.74
59_S62_L0.6280.74
353_D461_F0.6270.74
183_W190_I0.6240.73
257_D491_H0.6240.73
479_F514_I0.6220.73
428_D457_D0.6220.73
151_G384_N0.6210.73
18_V45_I0.6210.73
424_S451_I0.6210.73
87_K91_L0.6190.73
228_K498_E0.6190.73
558_Q568_S0.6170.73
108_L176_R0.6170.73
103_E184_F0.6170.73
590_D615_F0.6160.72
238_T286_I0.6160.72
411_R461_F0.6140.72
407_V422_A0.6140.72
102_V187_G0.6130.72
549_D552_V0.6110.72
516_L614_L0.6110.72
260_Y297_I0.6100.72
621_V651_F0.6090.72
452_P538_I0.6090.72
405_R525_Y0.6090.72
219_K658_G0.6080.71
160_G203_V0.6070.71
295_I350_Y0.6070.71
197_G206_G0.6050.71
540_R560_M0.6050.71
220_W327_F0.6050.71
89_R93_F0.6040.71
53_S67_N0.6040.71
305_T309_K0.6020.71
251_L500_W0.6020.71
82_I94_N0.6010.71
298_W317_I0.6000.70
480_Q612_I0.6000.70
21_L166_D0.5990.70
229_E354_A0.5980.70
585_K599_G0.5980.70
257_D411_R0.5970.70
551_N600_G0.5970.70
339_V347_I0.5970.70
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530_M540_R0.5960.70
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681_E684_I0.5940.70
85_K90_D0.5940.70
526_S529_W0.5930.70
235_D242_K0.5930.70
287_H293_L0.5920.69
149_D354_A0.5920.69
238_T282_M0.5920.69
311_M325_N0.5910.69
314_K334_L0.5910.69
447_S452_P0.5910.69
445_N449_S0.5910.69
82_I88_R0.5900.69
185_E188_K0.5900.69
560_M617_R0.5900.69
244_F498_E0.5890.69
252_D525_Y0.5890.69
201_D563_P0.5880.69
518_Y525_Y0.5880.69
621_V641_L0.5880.69
351_W428_D0.5870.69
527_L560_M0.5860.69
85_K93_F0.5860.69
516_L592_W0.5860.69
86_E92_K0.5850.69
546_F549_D0.5840.68
430_L462_F0.5840.68
208_R536_Y0.5830.68
597_L601_R0.5830.68
457_D460_G0.5820.68
134_L137_S0.5810.68
156_V203_V0.5800.68
411_R491_H0.5790.68
86_E90_D0.5790.68
152_I207_Y0.5780.68
460_G478_W0.5780.68
91_L94_N0.5780.68
23_Y28_A0.5760.67
88_R93_F0.5760.67
228_K231_Y0.5760.67
224_Y499_P0.5760.67
561_F567_I0.5750.67
584_S601_R0.5750.67
80_G86_E0.5750.67
253_V294_A0.5740.67
596_K617_R0.5740.67
625_L628_N0.5740.67
8_V64_V0.5730.67
591_F595_E0.5720.67
271_F345_L0.5720.67
507_Q514_I0.5720.67
466_P474_I0.5720.67
156_V204_I0.5710.67
327_F393_A0.5700.67
539_M559_Y0.5690.66
595_E615_F0.5690.66
317_I322_T0.5680.66
411_R427_G0.5680.66
44_S50_T0.5670.66
136_Y151_G0.5660.66
237_I282_M0.5650.66
543_V553_Y0.5650.66
354_A487_I0.5640.66
516_L591_F0.5640.66
648_N676_D0.5640.66
488_L517_R0.5630.66
529_W532_Y0.5630.66
44_S61_S0.5620.65
258_W294_A0.5620.65
238_T242_K0.5620.65
427_G457_D0.5610.65
261_W300_T0.5610.65
205_K208_R0.5610.65
10_I55_I0.5600.65
57_F64_V0.5600.65
628_N633_E0.5590.65
437_R556_D0.5590.65
43_L46_K0.5590.65
152_I449_S0.5590.65
551_N554_D0.5590.65
239_S242_K0.5580.65
12_F45_I0.5580.65
327_F386_Y0.5570.65
514_I518_Y0.5570.65
298_W355_S0.5560.65
440_I559_Y0.5560.65
104_Q192_Y0.5560.65
85_K88_R0.5560.65
570_V613_P0.5560.65
393_A397_G0.5540.64
479_F488_L0.5530.64
119_Q150_I0.5520.64
83_V88_R0.5520.64
428_D460_G0.5520.64
306_E341_G0.5520.64
372_V375_E0.5520.64
325_N393_A0.5510.64
368_P374_L0.5500.64
369_I377_G0.5500.64
570_V574_S0.5500.64
36_V419_R0.5500.64
666_G673_I0.5500.64
92_K96_E0.5490.64
508_E610_D0.5490.64
204_I448_I0.5480.64
21_L191_D0.5480.64
672_P681_E0.5480.64
308_F312_E0.5450.63
339_V394_V0.5440.63
35_V40_L0.5440.63
676_D679_K0.5440.63
133_K140_S0.5440.63
168_Y414_F0.5440.63
225_W453_Y0.5440.63
57_F75_M0.5440.63
83_V89_R0.5430.63
441_P445_N0.5420.63
578_K607_V0.5420.63
297_I350_Y0.5420.63
225_W487_I0.5410.63
646_G651_F0.5410.63
490_V499_P0.5410.63
327_F335_F0.5410.63
149_D461_F0.5410.63
371_D377_G0.5400.62
261_W268_A0.5400.62
61_S202_D0.5400.62
639_I653_L0.5400.62
220_W253_V0.5390.62
590_D597_L0.5390.62
86_E93_F0.5390.62
484_F561_F0.5390.62
264_Y300_T0.5390.62
371_D376_I0.5390.62
356_E457_D0.5380.62
340_K397_G0.5380.62
112_E161_Y0.5380.62
618_S644_Y0.5370.62
82_I93_F0.5360.62
205_K209_K0.5360.62
457_D491_H0.5360.62
259_R354_A0.5350.62
349_A407_V0.5340.62
43_L49_S0.5340.62
33_S37_L0.5340.62
12_F15_D0.5330.61
368_P376_I0.5330.61
229_E487_I0.5330.61
46_K58_S0.5310.61
502_F510_I0.5300.61
229_E257_D0.5290.61
123_G556_D0.5290.61
229_E493_T0.5280.61
318_I360_G0.5270.61
84_V89_R0.5270.61
8_V22_Y0.5250.60
111_G550_Q0.5250.60
86_E89_R0.5250.60
567_I612_I0.5250.60
546_F585_K0.5240.60
639_I673_I0.5240.60
234_Q276_F0.5240.60
298_W319_L0.5240.60
576_I607_V0.5230.60
298_W351_W0.5230.60
17_I209_K0.5230.60
55_I58_S0.5230.60
224_Y479_F0.5220.60
152_I418_Q0.5220.60
81_G88_R0.5220.60
520_L524_I0.5210.60
566_L582_L0.5210.60
47_G55_I0.5200.60
23_Y26_R0.5200.60
120_H146_R0.5200.60
88_R95_E0.5200.60
618_S646_G0.5200.60
331_C334_L0.5190.59
18_V62_L0.5190.59
13_I193_Y0.5190.59
369_I373_D0.5190.59
268_A390_E0.5190.59
369_I376_I0.5180.59
88_R92_K0.5180.59
536_Y563_P0.5180.59
410_T422_A0.5170.59
46_K49_S0.5170.59
133_K136_Y0.5170.59
300_T324_F0.5170.59
573_P576_I0.5170.59
653_L669_Y0.5170.59
548_D667_K0.5170.59
354_A357_P0.5170.59
44_S48_E0.5160.59
429_V439_Q0.5150.59
24_Y29_I0.5140.59
131_A138_G0.5140.59
54_I68_T0.5140.59
429_V435_T0.5140.59
557_E572_L0.5140.59
393_A396_E0.5140.59
150_I354_A0.5130.59
625_L629_V0.5130.59
371_D375_E0.5130.59
257_D425_W0.5130.59
580_V602_M0.5120.58
214_A424_S0.5120.58
231_Y425_W0.5120.58
447_S536_Y0.5120.58
169_S380_Y0.5110.58
337_S400_R0.5110.58
437_R557_E0.5110.58
627_K637_D0.5100.58
665_K672_P0.5100.58
568_S571_T0.5100.58
675_W680_Q0.5090.58
84_V94_N0.5090.58
54_I610_D0.5080.58
411_R460_G0.5080.58
208_R450_G0.5070.58
549_D600_G0.5060.58
81_G87_K0.5060.58
369_I372_V0.5050.57
132_Y138_G0.5040.57
466_P495_F0.5030.57
325_N334_L0.5030.57
351_W461_F0.5030.57
352_L394_V0.5030.57
458_T479_F0.5020.57
322_T359_T0.5020.57
125_G128_Q0.5010.57
388_L416_G0.5010.57
154_F195_I0.5000.57
377_G382_Y0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lppA 3 0.9603 100 0.124 Contact Map
4ba0A 2 0.9603 100 0.127 Contact Map
3l4yA 1 0.9562 100 0.128 Contact Map
3topA 1 0.9603 100 0.129 Contact Map
3weoA 1 0.9549 100 0.131 Contact Map
2xvlA 1 0.9836 100 0.14 Contact Map
4kmqA 1 0.9466 100 0.194 Contact Map
4amwA 1 0.9863 100 0.202 Contact Map
2f2hA 4 0.9535 100 0.202 Contact Map
3nsxA 2 0.8167 100 0.218 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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