Q981E3 - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q981E3 - Phosphomethylpyrimidine kinase (ThiD-1)

UniProt:	Q981E3	Sequences: MHTRPVVATIAGSDSGGGAGLQADLKTFSALGVFGTTIITGLTAQNTRTVTKVLEIPLDFIEAQFDAVCLDLHPTHAKTGMLASGKVVELVLRKIREYNIKLVLDPVMVAKSGSLLVTEDISEQIKKAMKEAIISTPNRYEAEIINKTKINSQDDVIKAAREIYSKYGNVVVKGFNGVDYAIIDGEEIELKGDYISTKNTHGSGDVFSASITAYLALGYKLKDALIRAKKFATMTVKYGLDLGGGYGPVDPFAPIESIVKREEGRNQLENLLWYLESNLNVILKLINDTSKVNVAYMTKYNDVLSLAGGLIKYLDKLKIDGPILNNVNNEITRIMRETPDEKIGILLPFTDKILDAAEKGKIKLNKSGINGDAILRDNMVLIIAKDKDELIRKLKEVAIG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	400 (362)
Sequences:	493 (391)
Seq/√Len:	20.6

ECOLI - THID
HALSA - Q9HMC6
SULSO - Q981E3 Q97W49

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
25_L	35_G	7.585	1.00
28_F	213_A	5.084	1.00
33_V	213_A	4.990	1.00
13_S	43_T	4.413	1.00
38_I	65_F	4.282	1.00
28_F	33_V	4.226	1.00
79_T	104_L	3.855	1.00
54_L	57_P	3.419	1.00
88_V	125_I	3.352	1.00
13_S	39_I	3.345	1.00
110_A	114_S	3.304	1.00
41_G	55_E	3.242	1.00
134_I	171_V	3.052	0.99
79_T	102_L	3.046	0.99
152_S	155_D	2.837	0.99
134_I	221_L	2.832	0.99
47_T	243_G	2.814	0.99
7_V	28_F	2.811	0.99
96_R	131_E	2.759	0.99
42_L	60_F	2.722	0.99
52_K	63_A	2.668	0.98
9_T	37_T	2.629	0.98
171_V	207_F	2.599	0.98
16_G	43_T	2.560	0.98
286_I	289_T	2.538	0.98
143_E	150_I	2.442	0.97
28_F	35_G	2.430	0.97
42_L	56_I	2.394	0.97
117_V	121_I	2.332	0.96
47_T	245_G	2.292	0.96
220_K	223_D	2.281	0.96
81_M	116_L	2.277	0.96
103_V	215_L	2.244	0.95
104_L	132_A	2.154	0.94
229_K	233_T	2.146	0.94
211_I	225_L	2.045	0.92
62_E	93_R	2.031	0.92
160_A	236_V	2.024	0.92
171_V	190_L	1.984	0.91
22_Q	37_T	1.971	0.91
51_T	67_A	1.967	0.91
148_T	162_E	1.943	0.90
17_G	23_A	1.914	0.89
283_L	287_N	1.905	0.89
31_L	214_Y	1.872	0.88
164_Y	170_V	1.829	0.87
200_T	236_V	1.820	0.87
143_E	159_A	1.819	0.87
13_S	22_Q	1.802	0.86
250_D	256_E	1.792	0.86
71_D	243_G	1.742	0.84
9_T	28_F	1.712	0.83
48_R	244_G	1.704	0.83
15_S	43_T	1.699	0.83
7_V	33_V	1.688	0.82
338_T	342_K	1.665	0.82
283_L	289_T	1.647	0.81
151_N	155_D	1.633	0.80
6_V	75_T	1.621	0.80
21_L	25_L	1.613	0.79
66_D	94_K	1.591	0.78
69_C	74_P	1.586	0.78
284_K	288_D	1.583	0.78
190_L	225_L	1.581	0.78
326_N	330_E	1.579	0.78
50_V	205_D	1.574	0.78
89_E	127_K	1.566	0.77
13_S	16_G	1.560	0.77
77_A	209_A	1.556	0.77
62_E	90_L	1.545	0.76
101_K	133_I	1.544	0.76
61_I	90_L	1.541	0.76
39_I	43_T	1.538	0.76
192_G	233_T	1.533	0.76
346_L	349_F	1.531	0.76
138_N	141_E	1.502	0.74
12_G	19_A	1.492	0.74
43_T	72_L	1.486	0.73
169_N	221_L	1.466	0.72
336_R	340_D	1.451	0.72
14_D	19_A	1.447	0.71
14_D	24_D	1.442	0.71
274_Y	278_N	1.438	0.71
77_A	102_L	1.420	0.70
9_T	25_L	1.409	0.69
362_I	366_K	1.374	0.67
71_D	245_G	1.364	0.67
243_G	248_P	1.357	0.66
129_M	163_I	1.357	0.66
46_N	208_S	1.340	0.65
283_L	286_I	1.339	0.65
215_L	218_G	1.338	0.65
363_K	366_K	1.337	0.65
57_P	146_N	1.323	0.64
22_Q	208_S	1.311	0.64
95_I	100_I	1.300	0.63
300_Y	340_D	1.299	0.63
38_I	64_Q	1.294	0.62
65_F	94_K	1.291	0.62
199_N	246_Y	1.282	0.62
51_T	70_L	1.273	0.61
7_V	216_A	1.265	0.61
199_N	247_G	1.257	0.60
105_D	137_P	1.232	0.59
41_G	109_V	1.229	0.58
12_G	24_D	1.217	0.58
267_Q	275_L	1.209	0.57
276_E	286_I	1.188	0.56
200_T	247_G	1.187	0.56
171_V	225_L	1.185	0.56
90_L	93_R	1.173	0.55
11_A	18_G	1.172	0.55
150_I	196_S	1.171	0.55
134_I	211_I	1.164	0.54
146_N	163_I	1.162	0.54
139_R	150_I	1.158	0.54
6_V	36_T	1.156	0.54
153_Q	157_I	1.155	0.54
26_K	46_N	1.151	0.53
22_Q	38_I	1.150	0.53
14_D	18_G	1.148	0.53
115_L	144_I	1.147	0.53
82_L	91_V	1.145	0.53
197_T	247_G	1.135	0.52
293_N	304_L	1.130	0.52
6_V	72_L	1.129	0.52
12_G	18_G	1.127	0.52
271_L	274_Y	1.115	0.51
58_L	90_L	1.111	0.51
11_A	25_L	1.110	0.51
215_L	221_L	1.102	0.50
18_G	24_D	1.098	0.50
106_P	137_P	1.091	0.49
103_V	134_I	1.090	0.49
22_Q	64_Q	1.087	0.49
293_N	297_M	1.082	0.49
330_E	333_R	1.081	0.49
289_T	330_E	1.079	0.49
315_D	318_K	1.075	0.48
300_Y	307_A	1.073	0.48
130_K	167_Y	1.069	0.48
47_T	71_D	1.069	0.48
214_Y	219_Y	1.068	0.48
24_D	78_K	1.059	0.47
181_A	190_L	1.054	0.47
160_A	183_I	1.052	0.47
271_L	275_L	1.046	0.46
115_L	122_S	1.034	0.46
93_R	209_A	1.032	0.46
16_G	72_L	1.023	0.45
300_Y	303_V	1.018	0.45
305_S	327_V	1.015	0.44
44_A	60_F	1.013	0.44
303_V	307_A	1.010	0.44
320_D	323_I	1.010	0.44
11_A	19_A	1.010	0.44
299_K	303_V	1.008	0.44
10_I	91_V	1.003	0.44
234_M	257_S	1.001	0.44
21_L	35_G	0.997	0.43
69_C	100_I	0.993	0.43
61_I	172_V	0.993	0.43
50_V	82_L	0.989	0.43
19_A	24_D	0.978	0.42
163_I	171_V	0.977	0.42
304_L	325_N	0.968	0.41
209_A	212_T	0.965	0.41
293_N	300_Y	0.963	0.41
284_K	287_N	0.962	0.41
26_K	231_F	0.961	0.41
12_G	20_G	0.952	0.40
86_K	186_E	0.951	0.40
225_L	228_A	0.947	0.40
284_K	289_T	0.947	0.40
163_I	170_V	0.945	0.40
126_K	145_I	0.943	0.40
307_A	323_I	0.940	0.40
97_E	224_A	0.935	0.39
105_D	136_T	0.932	0.39
6_V	73_H	0.931	0.39
21_L	39_I	0.929	0.39
236_V	246_Y	0.928	0.39
255_I	258_I	0.927	0.39
22_Q	25_L	0.925	0.39
181_A	216_A	0.925	0.39
283_L	288_D	0.924	0.39
240_L	249_V	0.924	0.39
157_I	187_E	0.924	0.39
347_L	351_D	0.922	0.39
192_G	229_K	0.920	0.38
215_L	230_K	0.920	0.38
137_P	141_E	0.920	0.38
141_E	203_S	0.917	0.38
165_S	184_D	0.917	0.38
31_L	227_R	0.911	0.38
64_Q	68_V	0.910	0.38
344_G	359_K	0.907	0.38
206_V	296_Y	0.906	0.38
61_I	87_V	0.903	0.37
83_A	108_M	0.903	0.37
89_E	128_A	0.902	0.37
19_A	138_N	0.901	0.37
102_L	209_A	0.900	0.37
223_D	226_I	0.896	0.37
161_R	244_G	0.894	0.37
74_P	104_L	0.894	0.37
15_S	44_A	0.893	0.37
10_I	123_E	0.892	0.37
76_H	212_T	0.891	0.37
30_A	210_S	0.884	0.36
116_L	245_G	0.884	0.36
151_N	196_S	0.884	0.36
147_K	298_T	0.883	0.36
50_V	112_S	0.881	0.36
284_K	305_S	0.880	0.36
46_N	243_G	0.878	0.36
53_V	134_I	0.875	0.36
293_N	307_A	0.872	0.35
359_K	363_K	0.872	0.35
299_K	304_L	0.862	0.35
28_F	132_A	0.857	0.35
145_I	172_V	0.857	0.35
184_D	196_S	0.853	0.34
113_G	141_E	0.853	0.34
353_I	356_A	0.852	0.34
19_A	50_V	0.848	0.34
172_V	275_L	0.845	0.34
55_E	83_A	0.840	0.34
163_I	217_L	0.838	0.33
153_Q	178_V	0.837	0.33
18_G	201_H	0.833	0.33
160_A	172_V	0.829	0.33
139_R	277_S	0.826	0.33
102_L	147_K	0.825	0.33
108_M	296_Y	0.824	0.33
86_K	322_P	0.821	0.32
285_L	346_L	0.819	0.32
171_V	181_A	0.818	0.32
66_D	163_I	0.817	0.32
72_L	75_T	0.816	0.32
154_D	157_I	0.816	0.32
92_L	130_K	0.815	0.32
20_G	24_D	0.813	0.32
75_T	121_I	0.813	0.32
9_T	35_G	0.804	0.31
15_S	142_A	0.803	0.31
224_A	291_K	0.800	0.31
272_L	278_N	0.799	0.31
284_K	346_L	0.798	0.31
76_H	194_Y	0.797	0.31
74_P	79_T	0.796	0.31
7_V	89_E	0.794	0.31
16_G	27_T	0.793	0.31
23_A	50_V	0.786	0.30
28_F	237_K	0.784	0.30
157_I	189_E	0.783	0.30
85_G	120_D	0.777	0.30
61_I	131_E	0.776	0.30
18_G	45_Q	0.775	0.30
138_N	203_S	0.774	0.30
118_T	208_S	0.772	0.30
197_T	236_V	0.772	0.30
310_L	314_L	0.771	0.30
313_Y	334_I	0.769	0.30
90_L	145_I	0.767	0.29
121_I	245_G	0.766	0.29
340_D	348_P	0.766	0.29
138_N	205_D	0.765	0.29
247_G	251_P	0.757	0.29
224_A	350_T	0.756	0.29
176_N	205_D	0.753	0.29
50_V	114_S	0.753	0.29
129_M	168_G	0.753	0.29
223_D	346_L	0.752	0.29
199_N	239_G	0.752	0.29
61_I	143_E	0.750	0.28
45_Q	201_H	0.750	0.28
34_F	251_P	0.749	0.28
313_Y	317_L	0.749	0.28
92_L	131_E	0.749	0.28
209_A	321_G	0.747	0.28
190_L	211_I	0.746	0.28
88_V	211_I	0.746	0.28
95_I	126_K	0.746	0.28
213_A	310_L	0.745	0.28
64_Q	117_V	0.743	0.28
300_Y	336_R	0.743	0.28
93_R	163_I	0.741	0.28
67_A	70_L	0.740	0.28
75_T	206_V	0.739	0.28
133_I	215_L	0.736	0.28
61_I	135_S	0.736	0.28
14_D	20_G	0.735	0.28
329_N	333_R	0.734	0.28
41_G	274_Y	0.734	0.28
41_G	83_A	0.731	0.27
10_I	40_T	0.729	0.27
119_E	318_K	0.728	0.27
109_V	251_P	0.727	0.27
150_I	159_A	0.718	0.27
323_I	331_I	0.718	0.27
134_I	181_A	0.717	0.27
36_T	91_V	0.716	0.27
171_V	250_D	0.716	0.27
154_D	196_S	0.716	0.27
31_L	208_S	0.716	0.27
53_V	98_Y	0.715	0.27
136_T	200_T	0.715	0.27
86_K	133_I	0.714	0.27
160_A	163_I	0.712	0.26
176_N	203_S	0.709	0.26
118_T	161_R	0.707	0.26
300_Y	362_I	0.705	0.26
299_K	307_A	0.704	0.26
85_G	130_K	0.703	0.26
44_A	47_T	0.702	0.26
25_L	28_F	0.701	0.26
164_Y	169_N	0.701	0.26
129_M	252_F	0.696	0.26
17_G	50_V	0.696	0.26
8_A	36_T	0.695	0.26
26_K	47_T	0.694	0.26
9_T	22_Q	0.694	0.26
210_S	228_A	0.694	0.26
188_I	226_I	0.693	0.26
142_A	172_V	0.692	0.25
304_L	307_A	0.692	0.25
93_R	184_D	0.692	0.25
9_T	21_L	0.689	0.25
308_G	330_E	0.688	0.25
178_V	181_A	0.687	0.25
172_V	186_E	0.687	0.25
25_L	37_T	0.684	0.25
184_D	325_N	0.684	0.25
16_G	34_F	0.682	0.25
35_G	323_I	0.681	0.25
293_N	299_K	0.680	0.25
11_A	138_N	0.679	0.25
87_V	179_D	0.677	0.25
108_M	144_I	0.672	0.25
18_G	81_M	0.671	0.24
84_S	233_T	0.671	0.24
155_D	250_D	0.669	0.24
31_L	211_I	0.669	0.24
227_R	230_K	0.668	0.24
158_K	187_E	0.667	0.24
29_S	34_F	0.667	0.24
340_D	359_K	0.667	0.24
45_Q	78_K	0.666	0.24
10_I	59_D	0.664	0.24
19_A	205_D	0.664	0.24
182_I	187_E	0.663	0.24
142_A	167_Y	0.662	0.24
23_A	27_T	0.660	0.24
186_E	237_K	0.659	0.24
12_G	201_H	0.659	0.24
103_V	132_A	0.657	0.24
86_K	223_D	0.656	0.24
127_K	158_K	0.655	0.24
59_D	196_S	0.654	0.24
102_L	150_I	0.651	0.23
101_K	169_N	0.651	0.23
234_M	254_P	0.651	0.23
69_C	94_K	0.650	0.23
43_T	52_K	0.649	0.23
157_I	161_R	0.649	0.23
134_I	255_I	0.647	0.23
168_G	249_V	0.647	0.23
134_I	225_L	0.644	0.23
12_G	45_Q	0.643	0.23
100_I	209_A	0.643	0.23
11_A	109_V	0.641	0.23
154_D	188_I	0.640	0.23
65_F	95_I	0.639	0.23
11_A	205_D	0.638	0.23
30_A	160_A	0.633	0.23
44_A	211_I	0.632	0.23
10_I	25_L	0.631	0.23
9_T	206_V	0.629	0.22
360_G	363_K	0.628	0.22
347_L	355_D	0.627	0.22
200_T	203_S	0.626	0.22
131_E	170_V	0.624	0.22
29_S	125_I	0.624	0.22
125_I	129_M	0.622	0.22
218_G	250_D	0.622	0.22
299_K	340_D	0.622	0.22
289_T	348_P	0.621	0.22
104_L	160_A	0.621	0.22
93_R	110_A	0.621	0.22
14_D	26_K	0.619	0.22
120_D	338_T	0.618	0.22
14_D	201_H	0.617	0.22
101_K	193_D	0.616	0.22
74_P	162_E	0.616	0.22
43_T	142_A	0.616	0.22
173_K	247_G	0.614	0.22
160_A	218_G	0.613	0.22
44_A	63_A	0.613	0.22
35_G	209_A	0.612	0.22
134_I	360_G	0.610	0.22
84_S	118_T	0.609	0.22
129_M	164_Y	0.609	0.22
83_A	319_I	0.608	0.22
132_A	135_S	0.608	0.22
337_E	347_L	0.607	0.21
286_I	330_E	0.606	0.21
199_N	248_P	0.603	0.21
41_G	237_K	0.602	0.21
206_V	248_P	0.602	0.21
169_N	224_A	0.601	0.21
308_G	312_K	0.600	0.21
171_V	211_I	0.600	0.21
109_V	247_G	0.596	0.21
110_A	344_G	0.596	0.21
327_V	331_I	0.596	0.21
130_K	142_A	0.593	0.21
13_S	72_L	0.591	0.21
79_T	249_V	0.591	0.21
36_T	68_V	0.589	0.21
158_K	165_S	0.588	0.21
14_D	45_Q	0.586	0.21
21_L	228_A	0.586	0.21
8_A	144_I	0.586	0.21
100_I	236_V	0.585	0.21
354_L	364_L	0.585	0.21
107_V	136_T	0.585	0.21
199_N	297_M	0.584	0.20
61_I	130_K	0.584	0.20
104_L	118_T	0.583	0.20
11_A	23_A	0.583	0.20
122_S	168_G	0.581	0.20
93_R	151_N	0.580	0.20
285_L	332_T	0.579	0.20
11_A	108_M	0.579	0.20
111_K	246_Y	0.579	0.20
112_S	176_N	0.577	0.20
285_L	289_T	0.576	0.20
11_A	176_N	0.576	0.20
35_G	71_D	0.576	0.20
14_D	78_K	0.576	0.20
102_L	109_V	0.575	0.20
233_T	253_A	0.575	0.20
219_Y	230_K	0.574	0.20
137_P	173_K	0.574	0.20
330_E	334_I	0.572	0.20
82_L	107_V	0.572	0.20
362_I	365_N	0.571	0.20
169_N	212_T	0.571	0.20
194_Y	232_A	0.570	0.20
209_A	273_W	0.569	0.20
130_K	228_A	0.567	0.20
183_I	249_V	0.566	0.20
158_K	162_E	0.566	0.20
37_T	69_C	0.565	0.20
9_T	39_I	0.565	0.20
93_R	356_A	0.564	0.20
326_N	332_T	0.564	0.20
127_K	162_E	0.564	0.20
54_L	210_S	0.564	0.20
264_G	325_N	0.564	0.20
113_G	116_L	0.562	0.20
110_A	304_L	0.562	0.20
19_A	106_P	0.558	0.19
24_D	45_Q	0.558	0.19
27_T	210_S	0.557	0.19
287_N	297_M	0.557	0.19
174_G	179_D	0.556	0.19
19_A	141_E	0.556	0.19
129_M	135_S	0.556	0.19
143_E	149_K	0.556	0.19
233_T	236_V	0.555	0.19
156_V	206_V	0.555	0.19
303_V	315_D	0.553	0.19
7_V	222_K	0.552	0.19
315_D	324_L	0.549	0.19
136_T	211_I	0.549	0.19
138_N	173_K	0.548	0.19
85_G	215_L	0.548	0.19
51_T	223_D	0.547	0.19
271_L	283_L	0.546	0.19
12_G	40_T	0.546	0.19
112_S	203_S	0.546	0.19
13_S	21_L	0.545	0.19
283_L	291_K	0.545	0.19
156_V	180_Y	0.543	0.19
7_V	75_T	0.542	0.19
115_L	242_L	0.542	0.19
125_I	248_P	0.542	0.19
249_V	312_K	0.541	0.19
76_H	134_I	0.539	0.19
76_H	185_G	0.537	0.19
165_S	244_G	0.536	0.18
70_L	122_S	0.536	0.18
5_P	229_K	0.534	0.18
64_Q	243_G	0.533	0.18
96_R	184_D	0.530	0.18
302_D	339_P	0.528	0.18
89_E	124_Q	0.528	0.18
111_K	251_P	0.528	0.18
282_I	289_T	0.527	0.18
151_N	186_E	0.526	0.18
11_A	203_S	0.525	0.18
208_S	321_G	0.525	0.18
303_V	362_I	0.524	0.18
149_K	152_S	0.523	0.18
160_A	331_I	0.523	0.18
173_K	203_S	0.521	0.18
311_I	330_E	0.520	0.18
149_K	223_D	0.519	0.18
183_I	188_I	0.519	0.18
42_L	68_V	0.519	0.18
200_T	248_P	0.518	0.18
74_P	154_D	0.518	0.18
300_Y	304_L	0.517	0.18
354_L	361_K	0.516	0.18
17_G	82_L	0.516	0.18
47_T	296_Y	0.515	0.18
54_L	60_F	0.514	0.18
121_I	125_I	0.514	0.18
11_A	35_G	0.512	0.18
25_L	134_I	0.512	0.18
116_L	121_I	0.511	0.18
77_A	134_I	0.511	0.18
27_T	174_G	0.510	0.17
77_A	212_T	0.509	0.17
40_T	280_N	0.509	0.17
173_K	207_F	0.509	0.17
109_V	315_D	0.508	0.17
107_V	138_N	0.507	0.17
37_T	167_Y	0.507	0.17
51_T	63_A	0.507	0.17
295_A	303_V	0.507	0.17
158_K	222_K	0.507	0.17
215_L	224_A	0.506	0.17
26_K	35_G	0.506	0.17
11_A	247_G	0.505	0.17
215_L	236_V	0.503	0.17
171_V	317_L	0.503	0.17
199_N	241_D	0.502	0.17
108_M	125_I	0.501	0.17
22_Q	128_A	0.500	0.17
72_L	125_I	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rm5A	2	0.9775	100	0.497	Contact Map
2i5bA	2	0.6475	100	0.586	Contact Map
1ub0A	2	0.6025	100	0.623	Contact Map
3h74A	2	0.665	100	0.635	Contact Map
4yl5A	2	0.5425	100	0.635	Contact Map
4c5kA	2	0.6625	100	0.637	Contact Map
1jxhA	2	0.6025	100	0.638	Contact Map
3mbhA	5	0.6725	100	0.648	Contact Map
2ddmA	2	0.6225	100	0.659	Contact Map
4jjpA	2	0.56	100	0.666	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.