GREMLIN Database
Q981E3 - Phosphomethylpyrimidine kinase (ThiD-1)
UniProt: Q981E3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 400 (362)
Sequences: 493 (391)
Seq/√Len: 20.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_L35_G7.5851.00
28_F213_A5.0841.00
33_V213_A4.9901.00
13_S43_T4.4131.00
38_I65_F4.2821.00
28_F33_V4.2261.00
79_T104_L3.8551.00
54_L57_P3.4191.00
88_V125_I3.3521.00
13_S39_I3.3451.00
110_A114_S3.3041.00
41_G55_E3.2421.00
134_I171_V3.0520.99
79_T102_L3.0460.99
152_S155_D2.8370.99
134_I221_L2.8320.99
47_T243_G2.8140.99
7_V28_F2.8110.99
96_R131_E2.7590.99
42_L60_F2.7220.99
52_K63_A2.6680.98
9_T37_T2.6290.98
171_V207_F2.5990.98
16_G43_T2.5600.98
286_I289_T2.5380.98
143_E150_I2.4420.97
28_F35_G2.4300.97
42_L56_I2.3940.97
117_V121_I2.3320.96
47_T245_G2.2920.96
220_K223_D2.2810.96
81_M116_L2.2770.96
103_V215_L2.2440.95
104_L132_A2.1540.94
229_K233_T2.1460.94
211_I225_L2.0450.92
62_E93_R2.0310.92
160_A236_V2.0240.92
171_V190_L1.9840.91
22_Q37_T1.9710.91
51_T67_A1.9670.91
148_T162_E1.9430.90
17_G23_A1.9140.89
283_L287_N1.9050.89
31_L214_Y1.8720.88
164_Y170_V1.8290.87
200_T236_V1.8200.87
143_E159_A1.8190.87
13_S22_Q1.8020.86
250_D256_E1.7920.86
71_D243_G1.7420.84
9_T28_F1.7120.83
48_R244_G1.7040.83
15_S43_T1.6990.83
7_V33_V1.6880.82
338_T342_K1.6650.82
283_L289_T1.6470.81
151_N155_D1.6330.80
6_V75_T1.6210.80
21_L25_L1.6130.79
66_D94_K1.5910.78
69_C74_P1.5860.78
284_K288_D1.5830.78
190_L225_L1.5810.78
326_N330_E1.5790.78
50_V205_D1.5740.78
89_E127_K1.5660.77
13_S16_G1.5600.77
77_A209_A1.5560.77
62_E90_L1.5450.76
101_K133_I1.5440.76
61_I90_L1.5410.76
39_I43_T1.5380.76
192_G233_T1.5330.76
346_L349_F1.5310.76
138_N141_E1.5020.74
12_G19_A1.4920.74
43_T72_L1.4860.73
169_N221_L1.4660.72
336_R340_D1.4510.72
14_D19_A1.4470.71
14_D24_D1.4420.71
274_Y278_N1.4380.71
77_A102_L1.4200.70
9_T25_L1.4090.69
362_I366_K1.3740.67
71_D245_G1.3640.67
243_G248_P1.3570.66
129_M163_I1.3570.66
46_N208_S1.3400.65
283_L286_I1.3390.65
215_L218_G1.3380.65
363_K366_K1.3370.65
57_P146_N1.3230.64
22_Q208_S1.3110.64
95_I100_I1.3000.63
300_Y340_D1.2990.63
38_I64_Q1.2940.62
65_F94_K1.2910.62
199_N246_Y1.2820.62
51_T70_L1.2730.61
7_V216_A1.2650.61
199_N247_G1.2570.60
105_D137_P1.2320.59
41_G109_V1.2290.58
12_G24_D1.2170.58
267_Q275_L1.2090.57
276_E286_I1.1880.56
200_T247_G1.1870.56
171_V225_L1.1850.56
90_L93_R1.1730.55
11_A18_G1.1720.55
150_I196_S1.1710.55
134_I211_I1.1640.54
146_N163_I1.1620.54
139_R150_I1.1580.54
6_V36_T1.1560.54
153_Q157_I1.1550.54
26_K46_N1.1510.53
22_Q38_I1.1500.53
14_D18_G1.1480.53
115_L144_I1.1470.53
82_L91_V1.1450.53
197_T247_G1.1350.52
293_N304_L1.1300.52
6_V72_L1.1290.52
12_G18_G1.1270.52
271_L274_Y1.1150.51
58_L90_L1.1110.51
11_A25_L1.1100.51
215_L221_L1.1020.50
18_G24_D1.0980.50
106_P137_P1.0910.49
103_V134_I1.0900.49
22_Q64_Q1.0870.49
293_N297_M1.0820.49
330_E333_R1.0810.49
289_T330_E1.0790.49
315_D318_K1.0750.48
300_Y307_A1.0730.48
130_K167_Y1.0690.48
47_T71_D1.0690.48
214_Y219_Y1.0680.48
24_D78_K1.0590.47
181_A190_L1.0540.47
160_A183_I1.0520.47
271_L275_L1.0460.46
115_L122_S1.0340.46
93_R209_A1.0320.46
16_G72_L1.0230.45
300_Y303_V1.0180.45
305_S327_V1.0150.44
44_A60_F1.0130.44
303_V307_A1.0100.44
320_D323_I1.0100.44
11_A19_A1.0100.44
299_K303_V1.0080.44
10_I91_V1.0030.44
234_M257_S1.0010.44
21_L35_G0.9970.43
69_C100_I0.9930.43
61_I172_V0.9930.43
50_V82_L0.9890.43
19_A24_D0.9780.42
163_I171_V0.9770.42
304_L325_N0.9680.41
209_A212_T0.9650.41
293_N300_Y0.9630.41
284_K287_N0.9620.41
26_K231_F0.9610.41
12_G20_G0.9520.40
86_K186_E0.9510.40
225_L228_A0.9470.40
284_K289_T0.9470.40
163_I170_V0.9450.40
126_K145_I0.9430.40
307_A323_I0.9400.40
97_E224_A0.9350.39
105_D136_T0.9320.39
6_V73_H0.9310.39
21_L39_I0.9290.39
236_V246_Y0.9280.39
255_I258_I0.9270.39
22_Q25_L0.9250.39
181_A216_A0.9250.39
283_L288_D0.9240.39
240_L249_V0.9240.39
157_I187_E0.9240.39
347_L351_D0.9220.39
192_G229_K0.9200.38
215_L230_K0.9200.38
137_P141_E0.9200.38
141_E203_S0.9170.38
165_S184_D0.9170.38
31_L227_R0.9110.38
64_Q68_V0.9100.38
344_G359_K0.9070.38
206_V296_Y0.9060.38
61_I87_V0.9030.37
83_A108_M0.9030.37
89_E128_A0.9020.37
19_A138_N0.9010.37
102_L209_A0.9000.37
223_D226_I0.8960.37
161_R244_G0.8940.37
74_P104_L0.8940.37
15_S44_A0.8930.37
10_I123_E0.8920.37
76_H212_T0.8910.37
30_A210_S0.8840.36
116_L245_G0.8840.36
151_N196_S0.8840.36
147_K298_T0.8830.36
50_V112_S0.8810.36
284_K305_S0.8800.36
46_N243_G0.8780.36
53_V134_I0.8750.36
293_N307_A0.8720.35
359_K363_K0.8720.35
299_K304_L0.8620.35
28_F132_A0.8570.35
145_I172_V0.8570.35
184_D196_S0.8530.34
113_G141_E0.8530.34
353_I356_A0.8520.34
19_A50_V0.8480.34
172_V275_L0.8450.34
55_E83_A0.8400.34
163_I217_L0.8380.33
153_Q178_V0.8370.33
18_G201_H0.8330.33
160_A172_V0.8290.33
139_R277_S0.8260.33
102_L147_K0.8250.33
108_M296_Y0.8240.33
86_K322_P0.8210.32
285_L346_L0.8190.32
171_V181_A0.8180.32
66_D163_I0.8170.32
72_L75_T0.8160.32
154_D157_I0.8160.32
92_L130_K0.8150.32
20_G24_D0.8130.32
75_T121_I0.8130.32
9_T35_G0.8040.31
15_S142_A0.8030.31
224_A291_K0.8000.31
272_L278_N0.7990.31
284_K346_L0.7980.31
76_H194_Y0.7970.31
74_P79_T0.7960.31
7_V89_E0.7940.31
16_G27_T0.7930.31
23_A50_V0.7860.30
28_F237_K0.7840.30
157_I189_E0.7830.30
85_G120_D0.7770.30
61_I131_E0.7760.30
18_G45_Q0.7750.30
138_N203_S0.7740.30
118_T208_S0.7720.30
197_T236_V0.7720.30
310_L314_L0.7710.30
313_Y334_I0.7690.30
90_L145_I0.7670.29
121_I245_G0.7660.29
340_D348_P0.7660.29
138_N205_D0.7650.29
247_G251_P0.7570.29
224_A350_T0.7560.29
176_N205_D0.7530.29
50_V114_S0.7530.29
129_M168_G0.7530.29
223_D346_L0.7520.29
199_N239_G0.7520.29
61_I143_E0.7500.28
45_Q201_H0.7500.28
34_F251_P0.7490.28
313_Y317_L0.7490.28
92_L131_E0.7490.28
209_A321_G0.7470.28
190_L211_I0.7460.28
88_V211_I0.7460.28
95_I126_K0.7460.28
213_A310_L0.7450.28
64_Q117_V0.7430.28
300_Y336_R0.7430.28
93_R163_I0.7410.28
67_A70_L0.7400.28
75_T206_V0.7390.28
133_I215_L0.7360.28
61_I135_S0.7360.28
14_D20_G0.7350.28
329_N333_R0.7340.28
41_G274_Y0.7340.28
41_G83_A0.7310.27
10_I40_T0.7290.27
119_E318_K0.7280.27
109_V251_P0.7270.27
150_I159_A0.7180.27
323_I331_I0.7180.27
134_I181_A0.7170.27
36_T91_V0.7160.27
171_V250_D0.7160.27
154_D196_S0.7160.27
31_L208_S0.7160.27
53_V98_Y0.7150.27
136_T200_T0.7150.27
86_K133_I0.7140.27
160_A163_I0.7120.26
176_N203_S0.7090.26
118_T161_R0.7070.26
300_Y362_I0.7050.26
299_K307_A0.7040.26
85_G130_K0.7030.26
44_A47_T0.7020.26
25_L28_F0.7010.26
164_Y169_N0.7010.26
129_M252_F0.6960.26
17_G50_V0.6960.26
8_A36_T0.6950.26
26_K47_T0.6940.26
9_T22_Q0.6940.26
210_S228_A0.6940.26
188_I226_I0.6930.26
142_A172_V0.6920.25
304_L307_A0.6920.25
93_R184_D0.6920.25
9_T21_L0.6890.25
308_G330_E0.6880.25
178_V181_A0.6870.25
172_V186_E0.6870.25
25_L37_T0.6840.25
184_D325_N0.6840.25
16_G34_F0.6820.25
35_G323_I0.6810.25
293_N299_K0.6800.25
11_A138_N0.6790.25
87_V179_D0.6770.25
108_M144_I0.6720.25
18_G81_M0.6710.24
84_S233_T0.6710.24
155_D250_D0.6690.24
31_L211_I0.6690.24
227_R230_K0.6680.24
158_K187_E0.6670.24
29_S34_F0.6670.24
340_D359_K0.6670.24
45_Q78_K0.6660.24
10_I59_D0.6640.24
19_A205_D0.6640.24
182_I187_E0.6630.24
142_A167_Y0.6620.24
23_A27_T0.6600.24
186_E237_K0.6590.24
12_G201_H0.6590.24
103_V132_A0.6570.24
86_K223_D0.6560.24
127_K158_K0.6550.24
59_D196_S0.6540.24
102_L150_I0.6510.23
101_K169_N0.6510.23
234_M254_P0.6510.23
69_C94_K0.6500.23
43_T52_K0.6490.23
157_I161_R0.6490.23
134_I255_I0.6470.23
168_G249_V0.6470.23
134_I225_L0.6440.23
12_G45_Q0.6430.23
100_I209_A0.6430.23
11_A109_V0.6410.23
154_D188_I0.6400.23
65_F95_I0.6390.23
11_A205_D0.6380.23
30_A160_A0.6330.23
44_A211_I0.6320.23
10_I25_L0.6310.23
9_T206_V0.6290.22
360_G363_K0.6280.22
347_L355_D0.6270.22
200_T203_S0.6260.22
131_E170_V0.6240.22
29_S125_I0.6240.22
125_I129_M0.6220.22
218_G250_D0.6220.22
299_K340_D0.6220.22
289_T348_P0.6210.22
104_L160_A0.6210.22
93_R110_A0.6210.22
14_D26_K0.6190.22
120_D338_T0.6180.22
14_D201_H0.6170.22
101_K193_D0.6160.22
74_P162_E0.6160.22
43_T142_A0.6160.22
173_K247_G0.6140.22
160_A218_G0.6130.22
44_A63_A0.6130.22
35_G209_A0.6120.22
134_I360_G0.6100.22
84_S118_T0.6090.22
129_M164_Y0.6090.22
83_A319_I0.6080.22
132_A135_S0.6080.22
337_E347_L0.6070.21
286_I330_E0.6060.21
199_N248_P0.6030.21
41_G237_K0.6020.21
206_V248_P0.6020.21
169_N224_A0.6010.21
308_G312_K0.6000.21
171_V211_I0.6000.21
109_V247_G0.5960.21
110_A344_G0.5960.21
327_V331_I0.5960.21
130_K142_A0.5930.21
13_S72_L0.5910.21
79_T249_V0.5910.21
36_T68_V0.5890.21
158_K165_S0.5880.21
14_D45_Q0.5860.21
21_L228_A0.5860.21
8_A144_I0.5860.21
100_I236_V0.5850.21
354_L364_L0.5850.21
107_V136_T0.5850.21
199_N297_M0.5840.20
61_I130_K0.5840.20
104_L118_T0.5830.20
11_A23_A0.5830.20
122_S168_G0.5810.20
93_R151_N0.5800.20
285_L332_T0.5790.20
11_A108_M0.5790.20
111_K246_Y0.5790.20
112_S176_N0.5770.20
285_L289_T0.5760.20
11_A176_N0.5760.20
35_G71_D0.5760.20
14_D78_K0.5760.20
102_L109_V0.5750.20
233_T253_A0.5750.20
219_Y230_K0.5740.20
137_P173_K0.5740.20
330_E334_I0.5720.20
82_L107_V0.5720.20
362_I365_N0.5710.20
169_N212_T0.5710.20
194_Y232_A0.5700.20
209_A273_W0.5690.20
130_K228_A0.5670.20
183_I249_V0.5660.20
158_K162_E0.5660.20
37_T69_C0.5650.20
9_T39_I0.5650.20
93_R356_A0.5640.20
326_N332_T0.5640.20
127_K162_E0.5640.20
54_L210_S0.5640.20
264_G325_N0.5640.20
113_G116_L0.5620.20
110_A304_L0.5620.20
19_A106_P0.5580.19
24_D45_Q0.5580.19
27_T210_S0.5570.19
287_N297_M0.5570.19
174_G179_D0.5560.19
19_A141_E0.5560.19
129_M135_S0.5560.19
143_E149_K0.5560.19
233_T236_V0.5550.19
156_V206_V0.5550.19
303_V315_D0.5530.19
7_V222_K0.5520.19
315_D324_L0.5490.19
136_T211_I0.5490.19
138_N173_K0.5480.19
85_G215_L0.5480.19
51_T223_D0.5470.19
271_L283_L0.5460.19
12_G40_T0.5460.19
112_S203_S0.5460.19
13_S21_L0.5450.19
283_L291_K0.5450.19
156_V180_Y0.5430.19
7_V75_T0.5420.19
115_L242_L0.5420.19
125_I248_P0.5420.19
249_V312_K0.5410.19
76_H134_I0.5390.19
76_H185_G0.5370.19
165_S244_G0.5360.18
70_L122_S0.5360.18
5_P229_K0.5340.18
64_Q243_G0.5330.18
96_R184_D0.5300.18
302_D339_P0.5280.18
89_E124_Q0.5280.18
111_K251_P0.5280.18
282_I289_T0.5270.18
151_N186_E0.5260.18
11_A203_S0.5250.18
208_S321_G0.5250.18
303_V362_I0.5240.18
149_K152_S0.5230.18
160_A331_I0.5230.18
173_K203_S0.5210.18
311_I330_E0.5200.18
149_K223_D0.5190.18
183_I188_I0.5190.18
42_L68_V0.5190.18
200_T248_P0.5180.18
74_P154_D0.5180.18
300_Y304_L0.5170.18
354_L361_K0.5160.18
17_G82_L0.5160.18
47_T296_Y0.5150.18
54_L60_F0.5140.18
121_I125_I0.5140.18
11_A35_G0.5120.18
25_L134_I0.5120.18
116_L121_I0.5110.18
77_A134_I0.5110.18
27_T174_G0.5100.17
77_A212_T0.5090.17
40_T280_N0.5090.17
173_K207_F0.5090.17
109_V315_D0.5080.17
107_V138_N0.5070.17
37_T167_Y0.5070.17
51_T63_A0.5070.17
295_A303_V0.5070.17
158_K222_K0.5070.17
215_L224_A0.5060.17
26_K35_G0.5060.17
11_A247_G0.5050.17
215_L236_V0.5030.17
171_V317_L0.5030.17
199_N241_D0.5020.17
108_M125_I0.5010.17
22_Q128_A0.5000.17
72_L125_I0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rm5A 2 0.9775 100 0.497 Contact Map
2i5bA 2 0.6475 100 0.586 Contact Map
1ub0A 2 0.6025 100 0.623 Contact Map
3h74A 2 0.665 100 0.635 Contact Map
4yl5A 2 0.5425 100 0.635 Contact Map
4c5kA 2 0.6625 100 0.637 Contact Map
1jxhA 2 0.6025 100 0.638 Contact Map
3mbhA 5 0.6725 100 0.648 Contact Map
2ddmA 2 0.6225 100 0.659 Contact Map
4jjpA 2 0.56 100 0.666 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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