GREMLIN Database
Q981E2 - Ribokinase (RbsK-1)
UniProt: Q981E2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (274)
Sequences: 22529 (16818)
Seq/√Len: 1016.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_S247_V3.1291.00
130_L152_I2.9371.00
69_I84_V2.6311.00
254_D257_T2.5481.00
214_L259_V2.5141.00
54_K78_D2.4971.00
207_L213_L2.4131.00
248_Y253_Y2.3611.00
212_A241_F2.2961.00
46_A51_S2.2801.00
3_I126_G2.2781.00
66_T84_V2.2271.00
196_L215_A2.1071.00
48_R75_E2.0991.00
152_I246_S2.0631.00
58_A85_K2.0541.00
176_E207_L2.0121.00
144_A149_G2.0091.00
240_V265_V1.9621.00
248_Y261_Y1.9221.00
279_K282_E1.9201.00
170_D201_K1.9191.00
4_V43_A1.9121.00
189_E221_K1.8511.00
173_T242_N1.8301.00
253_Y257_T1.8231.00
44_V75_E1.8141.00
128_I150_I1.8081.00
150_I170_D1.7851.00
45_S243_A1.7561.00
207_L223_L1.7461.00
272_K282_E1.7401.00
70_E74_S1.7371.00
58_A119_D1.7371.00
237_A270_V1.7271.00
222_V256_E1.7111.00
212_A263_N1.7031.00
214_L222_V1.6991.00
266_A270_V1.6901.00
69_I73_K1.6861.00
73_K79_V1.6791.00
256_E260_E1.6721.00
251_K280_L1.6531.00
128_I152_I1.6531.00
245_L258_A1.6451.00
71_F74_S1.6371.00
192_L215_A1.6271.00
244_A265_V1.6131.00
171_I202_A1.5931.00
213_L223_L1.5911.00
46_A247_V1.5881.00
204_I245_L1.5861.00
227_P264_K1.5711.00
233_D274_G1.5631.00
194_L198_K1.5561.00
194_L197_K1.5551.00
61_D66_T1.5541.00
66_T70_E1.5531.00
154_N206_T1.5511.00
8_Y57_V1.5371.00
224_I259_V1.5251.00
128_I246_S1.5011.00
214_L255_L1.4941.00
35_H68_A1.4711.00
216_T220_K1.4691.00
202_A216_T1.4291.00
33_I67_D1.4271.00
193_N197_K1.4191.00
155_P174_P1.4111.00
169_V172_I1.4011.00
187_D190_Y1.3981.00
244_A261_Y1.3981.00
65_G90_T1.3911.00
163_T198_K1.3891.00
150_I171_I1.3811.00
207_L210_R1.3791.00
189_E193_N1.3731.00
88_I114_Y1.3631.00
40_S72_W1.3331.00
196_L217_R1.3281.00
145_K168_L1.3161.00
227_P260_E1.3071.00
69_I82_V1.3061.00
12_V31_L1.2971.00
10_V67_D1.2941.00
61_D84_V1.2941.00
145_K170_D1.2891.00
245_L249_L1.2871.00
229_V271_T1.2831.00
52_H78_D1.2751.00
212_A259_V1.2691.00
206_T241_F1.2611.00
224_I263_N1.2471.00
202_A249_L1.2411.00
150_I201_K1.2351.00
245_L262_A1.2341.00
202_A245_L1.2341.00
244_A262_A1.2311.00
227_P263_N1.2261.00
257_T260_E1.2261.00
131_M151_K1.2251.00
173_T206_T1.2231.00
231_V270_V1.2201.00
15_K30_E1.2151.00
207_L211_G1.2121.00
49_L244_A1.2111.00
47_S77_I1.2081.00
202_A255_L1.1961.00
229_V270_V1.1961.00
70_E73_K1.1921.00
248_Y258_A1.1881.00
193_N221_K1.1851.00
35_H71_F1.1831.00
85_K88_I1.1821.00
46_A53_V1.1601.00
193_N215_A1.1561.00
42_Q130_L1.1441.00
227_P267_A1.1441.00
215_A221_K1.1301.00
71_F75_E1.1281.00
66_T69_I1.1281.00
179_F205_V1.1271.00
67_D70_E1.1261.00
140_V143_A1.1241.00
116_S119_D1.1221.00
171_I245_L1.1111.00
43_A53_V1.1081.00
167_S198_K1.1051.00
247_V251_K1.1041.00
231_V234_E1.1041.00
226_A263_N1.1011.00
61_D87_G1.0931.00
63_K66_T1.0911.00
268_L272_K1.0891.00
129_L144_A1.0871.00
268_L271_T1.0861.00
12_V33_I1.0661.00
129_L149_G1.0571.00
104_I107_V1.0541.00
192_L205_V1.0521.00
263_N266_A1.0511.00
62_D90_T1.0501.00
44_V48_R1.0491.00
190_Y193_N1.0451.00
45_S240_V1.0381.00
183_V191_G1.0351.00
60_G90_T1.0351.00
176_E210_R1.0291.00
106_V110_G1.0241.00
173_T245_L1.0221.00
126_G149_G1.0171.00
179_F191_G1.0151.00
240_V269_S1.0131.00
59_V69_I1.0111.00
258_A262_A1.0051.00
201_K217_R1.0021.00
171_I249_L1.0011.00
220_K256_E1.0001.00
202_A214_L0.9961.00
130_L242_N0.9931.00
141_K164_E0.9921.00
245_L255_L0.9891.00
59_V82_V0.9861.00
175_N178_E0.9841.00
4_V39_G0.9821.00
247_V261_Y0.9791.00
47_S76_N0.9761.00
153_L169_V0.9751.00
59_V65_G0.9721.00
8_Y68_A0.9711.00
130_L246_S0.9711.00
247_V280_L0.9651.00
54_K81_K0.9641.00
85_K114_Y0.9621.00
35_H67_D0.9581.00
210_R223_L0.9571.00
46_A243_A0.9571.00
49_L265_V0.9561.00
217_R220_K0.9521.00
253_Y261_Y0.9481.00
83_K119_D0.9401.00
211_G226_A0.9371.00
79_V82_V0.9361.00
51_S251_K0.9341.00
54_K126_G0.9331.00
67_D71_F0.9261.00
47_S52_H0.9251.00
5_V129_L0.9241.00
231_V271_T0.9201.00
260_E264_K0.9171.00
136_R139_V0.9051.00
51_S250_E0.9031.00
176_E180_K0.8981.00
3_I56_I0.8961.00
12_V64_H0.8941.00
248_Y251_K0.8901.00
8_Y40_S0.8811.00
230_N271_T0.8801.00
40_S276_L0.8791.00
15_K32_Y0.8781.00
69_I79_V0.8751.00
28_A106_V0.8741.00
13_I34_T0.8691.00
144_A147_F0.8691.00
154_N173_T0.8671.00
240_V244_A0.8671.00
174_P179_F0.8611.00
254_D258_A0.8601.00
12_V92_T0.8601.00
121_N124_L0.8571.00
14_L94_Y0.8571.00
152_I173_T0.8561.00
69_I83_K0.8531.00
121_N142_K0.8521.00
249_L258_A0.8521.00
222_V259_V0.8381.00
106_V109_R0.8351.00
42_Q242_N0.8351.00
179_F195_L0.8341.00
59_V84_V0.8291.00
8_Y55_I0.8271.00
117_E142_K0.8251.00
154_N174_P0.8251.00
22_I102_R0.8241.00
185_T190_Y0.8231.00
68_A90_T0.8131.00
9_N91_G0.8121.00
224_I256_E0.8111.00
240_V266_A0.8111.00
266_A269_S0.8101.00
118_D121_N0.8091.00
192_L203_V0.8041.00
241_F263_N0.8041.00
58_A83_K0.8041.00
244_A248_Y0.8021.00
103_N107_V0.8001.00
107_V110_G0.7981.00
128_I250_E0.7951.00
10_V64_H0.7931.00
261_Y283_V0.7911.00
102_R105_I0.7861.00
159_N163_T0.7851.00
166_L169_V0.7821.00
62_D65_G0.7801.00
104_I108_N0.7771.00
164_E167_S0.7771.00
193_N196_L0.7711.00
224_I260_E0.7701.00
229_V267_A0.7681.00
232_I273_I0.7641.00
119_D122_N0.7591.00
43_A55_I0.7531.00
263_N267_A0.7521.00
133_L153_L0.7471.00
49_L247_V0.7441.00
95_I105_I0.7421.00
204_I214_L0.7411.00
112_N115_L0.7401.00
189_E223_L0.7341.00
261_Y280_L0.7341.00
213_L221_K0.7321.00
11_D36_G0.7311.00
36_G41_N0.7281.00
33_I64_H0.7281.00
189_E215_A0.7261.00
47_S53_V0.7251.00
38_K156_A0.7231.00
241_F259_V0.7151.00
264_K268_L0.7131.00
209_E228_K0.7131.00
241_F262_A0.7101.00
52_H127_D0.7091.00
190_Y194_L0.7071.00
192_L221_K0.7061.00
49_L261_Y0.7051.00
44_V276_L0.7011.00
7_S156_A0.7011.00
253_Y258_A0.6991.00
104_I110_G0.6991.00
105_I109_R0.6971.00
102_R108_N0.6961.00
216_T255_L0.6901.00
25_T38_K0.6881.00
21_E24_E0.6881.00
196_L216_T0.6861.00
64_H92_T0.6861.00
196_L218_D0.6851.00
152_I171_I0.6831.00
3_I54_K0.6821.00
196_L199_V0.6811.00
120_L123_S0.6811.00
15_K99_K0.6801.00
95_I235_T0.6751.00
216_T222_V0.6741.00
98_D102_R0.6731.00
163_T167_S0.6731.00
145_K148_N0.6731.00
46_A246_S0.6721.00
49_L283_V0.6721.00
54_K80_S0.6691.00
196_L200_K0.6671.00
192_L196_L0.6651.00
71_F276_L0.6641.00
144_A148_N0.6631.00
32_Y273_I0.6551.00
172_I203_V0.6531.00
188_F207_L0.6511.00
128_I171_I0.6461.00
38_K134_E0.6441.00
151_K169_V0.6401.00
185_T188_F0.6351.00
243_A247_V0.6331.00
179_F188_F0.6301.00
43_A77_I0.6291.00
160_L163_T0.6291.00
7_S134_E0.6291.00
241_F266_A0.6281.00
212_A224_I0.6271.00
54_K124_L0.6261.00
259_V263_N0.6231.00
96_F106_V0.6221.00
268_L282_E0.6181.00
120_L124_L0.6141.00
268_L283_V0.6141.00
211_G223_L0.6131.00
49_L243_A0.6131.00
185_T223_L0.6101.00
115_L119_D0.6071.00
152_I242_N0.6071.00
57_V82_V0.6061.00
75_E279_K0.6061.00
10_V33_I0.6021.00
235_T275_A0.6021.00
81_K84_V0.6011.00
189_E213_L0.5991.00
117_E121_N0.5991.00
15_K273_I0.5921.00
112_N116_S0.5921.00
93_A107_V0.5911.00
41_N275_A0.5911.00
66_T73_K0.5901.00
118_D122_N0.5891.00
204_I241_F0.5871.00
22_I98_D0.5871.00
127_D149_G0.5871.00
40_S55_I0.5831.00
128_I249_L0.5821.00
224_I227_P0.5821.00
63_K67_D0.5811.00
180_K186_D0.5791.00
191_G195_L0.5791.00
249_L252_G0.5781.00
96_F104_I0.5741.00
72_W77_I0.5731.00
91_G112_N0.5731.00
14_L28_A0.5721.00
216_T221_K0.5661.00
154_N239_D0.5661.00
255_L259_V0.5661.00
265_V283_V0.5601.00
252_G258_A0.5581.00
50_G53_V0.5571.00
85_K119_D0.5561.00
14_L31_L0.5521.00
42_Q243_A0.5521.00
208_G234_E0.5501.00
152_I249_L0.5491.00
179_F215_A0.5491.00
183_V194_L0.5471.00
209_E231_V0.5471.00
188_F191_G0.5471.00
257_T261_Y0.5461.00
63_K70_E0.5451.00
40_S44_V0.5381.00
47_S75_E0.5381.00
42_Q246_S0.5371.00
42_Q46_A0.5351.00
174_P206_T0.5341.00
93_A134_E0.5331.00
105_I110_G0.5331.00
196_L203_V0.5321.00
111_A114_Y0.5301.00
255_L258_A0.5301.00
185_T189_E0.5281.00
173_T204_I0.5281.00
53_V77_I0.5271.00
176_E208_G0.5261.00
178_E242_N0.5241.00
39_G43_A0.5231.00
119_D123_S0.5231.00
137_E141_K0.5221.00
35_H276_L0.5211.00
117_E138_S0.5211.00
206_T239_D0.5201.00
12_V94_Y0.5181.00
278_P283_V0.5181.00
127_D150_I0.5171.00
185_T194_L0.5171.00
42_Q132_Q0.5171.00
138_S141_K0.5151.00
160_L164_E0.5151.00
44_V77_I0.5111.00
189_E192_L0.5111.00
204_I259_V0.5101.00
38_K42_Q0.5101.00
199_V203_V0.5101.00
186_D190_Y0.5081.00
177_I181_E0.5081.00
105_I108_N0.5061.00
264_K283_V0.5041.00
188_F192_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rbcA 2 1 100 0.187 Contact Map
1vm7A 2 0.9761 100 0.193 Contact Map
4xdaA 2 0.9898 100 0.202 Contact Map
1rkdA 2 0.9898 100 0.205 Contact Map
3vasA 1 0.9625 100 0.208 Contact Map
2fv7A 2 0.9829 100 0.209 Contact Map
3ry7A 2 0.9727 100 0.209 Contact Map
3ljsA 2 0.9659 100 0.227 Contact Map
3ikhA 2 0.9317 100 0.228 Contact Map
2c4eA 2 0.9693 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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