Q981E2 - SULSO - GREMLIN Contacts

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Q981E2 - Ribokinase (RbsK-1)

UniProt:	Q981E2	Sequences: MIIVVGSYNVDVILKVNKIPEIGETVIADELYITHGGKGSNQAVSASRLGSHVKIIVAVGDDKHGTDAIEFWKSENIDVSKVKVKSGINTGTAYIFVDKKGRNIIVVNRGANYYLSEDDLNNSLEGDILLMQLEIRESVVKKAAKEFNGIKILNPAPANLKDTEILSLVDIITPNEIEFKELVNTDDFEYGLNLLLKKVKKAVIVTLGERGALLATRDGKKVLIPAPKVNVIDETGAGDVFNAALSVYLEKGYDLETAVEYANKVAALSVTKIGALGPKLDEVVRFLEEIDKA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	293 (274)
Sequences:	22529 (16818)
Seq/√Len:	1016.0

ECOLI - RBSK SQUV PSUK YDJH YEII YEGV PFKB K1PF KDGK FRLD INGK HLDE
BACSU - IOLC RBSK YDJE KDGK FRLD K1PF
HALSA - Q9HP13 Q9HMJ3 Q9HSM7
SULSO - Q981E2 KDGK Q97W01 Q980X6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_S	247_V	3.129	1.00
130_L	152_I	2.937	1.00
69_I	84_V	2.631	1.00
254_D	257_T	2.548	1.00
214_L	259_V	2.514	1.00
54_K	78_D	2.497	1.00
207_L	213_L	2.413	1.00
248_Y	253_Y	2.361	1.00
212_A	241_F	2.296	1.00
46_A	51_S	2.280	1.00
3_I	126_G	2.278	1.00
66_T	84_V	2.227	1.00
196_L	215_A	2.107	1.00
48_R	75_E	2.099	1.00
152_I	246_S	2.063	1.00
58_A	85_K	2.054	1.00
176_E	207_L	2.012	1.00
144_A	149_G	2.009	1.00
240_V	265_V	1.962	1.00
248_Y	261_Y	1.922	1.00
279_K	282_E	1.920	1.00
170_D	201_K	1.919	1.00
4_V	43_A	1.912	1.00
189_E	221_K	1.851	1.00
173_T	242_N	1.830	1.00
253_Y	257_T	1.823	1.00
44_V	75_E	1.814	1.00
128_I	150_I	1.808	1.00
150_I	170_D	1.785	1.00
45_S	243_A	1.756	1.00
207_L	223_L	1.746	1.00
272_K	282_E	1.740	1.00
70_E	74_S	1.737	1.00
58_A	119_D	1.737	1.00
237_A	270_V	1.727	1.00
222_V	256_E	1.711	1.00
212_A	263_N	1.703	1.00
214_L	222_V	1.699	1.00
266_A	270_V	1.690	1.00
69_I	73_K	1.686	1.00
73_K	79_V	1.679	1.00
256_E	260_E	1.672	1.00
251_K	280_L	1.653	1.00
128_I	152_I	1.653	1.00
245_L	258_A	1.645	1.00
71_F	74_S	1.637	1.00
192_L	215_A	1.627	1.00
244_A	265_V	1.613	1.00
171_I	202_A	1.593	1.00
213_L	223_L	1.591	1.00
46_A	247_V	1.588	1.00
204_I	245_L	1.586	1.00
227_P	264_K	1.571	1.00
233_D	274_G	1.563	1.00
194_L	198_K	1.556	1.00
194_L	197_K	1.555	1.00
61_D	66_T	1.554	1.00
66_T	70_E	1.553	1.00
154_N	206_T	1.551	1.00
8_Y	57_V	1.537	1.00
224_I	259_V	1.525	1.00
128_I	246_S	1.501	1.00
214_L	255_L	1.494	1.00
35_H	68_A	1.471	1.00
216_T	220_K	1.469	1.00
202_A	216_T	1.429	1.00
33_I	67_D	1.427	1.00
193_N	197_K	1.419	1.00
155_P	174_P	1.411	1.00
169_V	172_I	1.401	1.00
187_D	190_Y	1.398	1.00
244_A	261_Y	1.398	1.00
65_G	90_T	1.391	1.00
163_T	198_K	1.389	1.00
150_I	171_I	1.381	1.00
207_L	210_R	1.379	1.00
189_E	193_N	1.373	1.00
88_I	114_Y	1.363	1.00
40_S	72_W	1.333	1.00
196_L	217_R	1.328	1.00
145_K	168_L	1.316	1.00
227_P	260_E	1.307	1.00
69_I	82_V	1.306	1.00
12_V	31_L	1.297	1.00
10_V	67_D	1.294	1.00
61_D	84_V	1.294	1.00
145_K	170_D	1.289	1.00
245_L	249_L	1.287	1.00
229_V	271_T	1.283	1.00
52_H	78_D	1.275	1.00
212_A	259_V	1.269	1.00
206_T	241_F	1.261	1.00
224_I	263_N	1.247	1.00
202_A	249_L	1.241	1.00
150_I	201_K	1.235	1.00
245_L	262_A	1.234	1.00
202_A	245_L	1.234	1.00
244_A	262_A	1.231	1.00
227_P	263_N	1.226	1.00
257_T	260_E	1.226	1.00
131_M	151_K	1.225	1.00
173_T	206_T	1.223	1.00
231_V	270_V	1.220	1.00
15_K	30_E	1.215	1.00
207_L	211_G	1.212	1.00
49_L	244_A	1.211	1.00
47_S	77_I	1.208	1.00
202_A	255_L	1.196	1.00
229_V	270_V	1.196	1.00
70_E	73_K	1.192	1.00
248_Y	258_A	1.188	1.00
193_N	221_K	1.185	1.00
35_H	71_F	1.183	1.00
85_K	88_I	1.182	1.00
46_A	53_V	1.160	1.00
193_N	215_A	1.156	1.00
42_Q	130_L	1.144	1.00
227_P	267_A	1.144	1.00
215_A	221_K	1.130	1.00
71_F	75_E	1.128	1.00
66_T	69_I	1.128	1.00
179_F	205_V	1.127	1.00
67_D	70_E	1.126	1.00
140_V	143_A	1.124	1.00
116_S	119_D	1.122	1.00
171_I	245_L	1.111	1.00
43_A	53_V	1.108	1.00
167_S	198_K	1.105	1.00
247_V	251_K	1.104	1.00
231_V	234_E	1.104	1.00
226_A	263_N	1.101	1.00
61_D	87_G	1.093	1.00
63_K	66_T	1.091	1.00
268_L	272_K	1.089	1.00
129_L	144_A	1.087	1.00
268_L	271_T	1.086	1.00
12_V	33_I	1.066	1.00
129_L	149_G	1.057	1.00
104_I	107_V	1.054	1.00
192_L	205_V	1.052	1.00
263_N	266_A	1.051	1.00
62_D	90_T	1.050	1.00
44_V	48_R	1.049	1.00
190_Y	193_N	1.045	1.00
45_S	240_V	1.038	1.00
183_V	191_G	1.035	1.00
60_G	90_T	1.035	1.00
176_E	210_R	1.029	1.00
106_V	110_G	1.024	1.00
173_T	245_L	1.022	1.00
126_G	149_G	1.017	1.00
179_F	191_G	1.015	1.00
240_V	269_S	1.013	1.00
59_V	69_I	1.011	1.00
258_A	262_A	1.005	1.00
201_K	217_R	1.002	1.00
171_I	249_L	1.001	1.00
220_K	256_E	1.000	1.00
202_A	214_L	0.996	1.00
130_L	242_N	0.993	1.00
141_K	164_E	0.992	1.00
245_L	255_L	0.989	1.00
59_V	82_V	0.986	1.00
175_N	178_E	0.984	1.00
4_V	39_G	0.982	1.00
247_V	261_Y	0.979	1.00
47_S	76_N	0.976	1.00
153_L	169_V	0.975	1.00
59_V	65_G	0.972	1.00
8_Y	68_A	0.971	1.00
130_L	246_S	0.971	1.00
247_V	280_L	0.965	1.00
54_K	81_K	0.964	1.00
85_K	114_Y	0.962	1.00
35_H	67_D	0.958	1.00
210_R	223_L	0.957	1.00
46_A	243_A	0.957	1.00
49_L	265_V	0.956	1.00
217_R	220_K	0.952	1.00
253_Y	261_Y	0.948	1.00
83_K	119_D	0.940	1.00
211_G	226_A	0.937	1.00
79_V	82_V	0.936	1.00
51_S	251_K	0.934	1.00
54_K	126_G	0.933	1.00
67_D	71_F	0.926	1.00
47_S	52_H	0.925	1.00
5_V	129_L	0.924	1.00
231_V	271_T	0.920	1.00
260_E	264_K	0.917	1.00
136_R	139_V	0.905	1.00
51_S	250_E	0.903	1.00
176_E	180_K	0.898	1.00
3_I	56_I	0.896	1.00
12_V	64_H	0.894	1.00
248_Y	251_K	0.890	1.00
8_Y	40_S	0.881	1.00
230_N	271_T	0.880	1.00
40_S	276_L	0.879	1.00
15_K	32_Y	0.878	1.00
69_I	79_V	0.875	1.00
28_A	106_V	0.874	1.00
13_I	34_T	0.869	1.00
144_A	147_F	0.869	1.00
154_N	173_T	0.867	1.00
240_V	244_A	0.867	1.00
174_P	179_F	0.861	1.00
254_D	258_A	0.860	1.00
12_V	92_T	0.860	1.00
121_N	124_L	0.857	1.00
14_L	94_Y	0.857	1.00
152_I	173_T	0.856	1.00
69_I	83_K	0.853	1.00
121_N	142_K	0.852	1.00
249_L	258_A	0.852	1.00
222_V	259_V	0.838	1.00
106_V	109_R	0.835	1.00
42_Q	242_N	0.835	1.00
179_F	195_L	0.834	1.00
59_V	84_V	0.829	1.00
8_Y	55_I	0.827	1.00
117_E	142_K	0.825	1.00
154_N	174_P	0.825	1.00
22_I	102_R	0.824	1.00
185_T	190_Y	0.823	1.00
68_A	90_T	0.813	1.00
9_N	91_G	0.812	1.00
224_I	256_E	0.811	1.00
240_V	266_A	0.811	1.00
266_A	269_S	0.810	1.00
118_D	121_N	0.809	1.00
192_L	203_V	0.804	1.00
241_F	263_N	0.804	1.00
58_A	83_K	0.804	1.00
244_A	248_Y	0.802	1.00
103_N	107_V	0.800	1.00
107_V	110_G	0.798	1.00
128_I	250_E	0.795	1.00
10_V	64_H	0.793	1.00
261_Y	283_V	0.791	1.00
102_R	105_I	0.786	1.00
159_N	163_T	0.785	1.00
166_L	169_V	0.782	1.00
62_D	65_G	0.780	1.00
104_I	108_N	0.777	1.00
164_E	167_S	0.777	1.00
193_N	196_L	0.771	1.00
224_I	260_E	0.770	1.00
229_V	267_A	0.768	1.00
232_I	273_I	0.764	1.00
119_D	122_N	0.759	1.00
43_A	55_I	0.753	1.00
263_N	267_A	0.752	1.00
133_L	153_L	0.747	1.00
49_L	247_V	0.744	1.00
95_I	105_I	0.742	1.00
204_I	214_L	0.741	1.00
112_N	115_L	0.740	1.00
189_E	223_L	0.734	1.00
261_Y	280_L	0.734	1.00
213_L	221_K	0.732	1.00
11_D	36_G	0.731	1.00
36_G	41_N	0.728	1.00
33_I	64_H	0.728	1.00
189_E	215_A	0.726	1.00
47_S	53_V	0.725	1.00
38_K	156_A	0.723	1.00
241_F	259_V	0.715	1.00
264_K	268_L	0.713	1.00
209_E	228_K	0.713	1.00
241_F	262_A	0.710	1.00
52_H	127_D	0.709	1.00
190_Y	194_L	0.707	1.00
192_L	221_K	0.706	1.00
49_L	261_Y	0.705	1.00
44_V	276_L	0.701	1.00
7_S	156_A	0.701	1.00
253_Y	258_A	0.699	1.00
104_I	110_G	0.699	1.00
105_I	109_R	0.697	1.00
102_R	108_N	0.696	1.00
216_T	255_L	0.690	1.00
25_T	38_K	0.688	1.00
21_E	24_E	0.688	1.00
196_L	216_T	0.686	1.00
64_H	92_T	0.686	1.00
196_L	218_D	0.685	1.00
152_I	171_I	0.683	1.00
3_I	54_K	0.682	1.00
196_L	199_V	0.681	1.00
120_L	123_S	0.681	1.00
15_K	99_K	0.680	1.00
95_I	235_T	0.675	1.00
216_T	222_V	0.674	1.00
98_D	102_R	0.673	1.00
163_T	167_S	0.673	1.00
145_K	148_N	0.673	1.00
46_A	246_S	0.672	1.00
49_L	283_V	0.672	1.00
54_K	80_S	0.669	1.00
196_L	200_K	0.667	1.00
192_L	196_L	0.665	1.00
71_F	276_L	0.664	1.00
144_A	148_N	0.663	1.00
32_Y	273_I	0.655	1.00
172_I	203_V	0.653	1.00
188_F	207_L	0.651	1.00
128_I	171_I	0.646	1.00
38_K	134_E	0.644	1.00
151_K	169_V	0.640	1.00
185_T	188_F	0.635	1.00
243_A	247_V	0.633	1.00
179_F	188_F	0.630	1.00
43_A	77_I	0.629	1.00
160_L	163_T	0.629	1.00
7_S	134_E	0.629	1.00
241_F	266_A	0.628	1.00
212_A	224_I	0.627	1.00
54_K	124_L	0.626	1.00
259_V	263_N	0.623	1.00
96_F	106_V	0.622	1.00
268_L	282_E	0.618	1.00
120_L	124_L	0.614	1.00
268_L	283_V	0.614	1.00
211_G	223_L	0.613	1.00
49_L	243_A	0.613	1.00
185_T	223_L	0.610	1.00
115_L	119_D	0.607	1.00
152_I	242_N	0.607	1.00
57_V	82_V	0.606	1.00
75_E	279_K	0.606	1.00
10_V	33_I	0.602	1.00
235_T	275_A	0.602	1.00
81_K	84_V	0.601	1.00
189_E	213_L	0.599	1.00
117_E	121_N	0.599	1.00
15_K	273_I	0.592	1.00
112_N	116_S	0.592	1.00
93_A	107_V	0.591	1.00
41_N	275_A	0.591	1.00
66_T	73_K	0.590	1.00
118_D	122_N	0.589	1.00
204_I	241_F	0.587	1.00
22_I	98_D	0.587	1.00
127_D	149_G	0.587	1.00
40_S	55_I	0.583	1.00
128_I	249_L	0.582	1.00
224_I	227_P	0.582	1.00
63_K	67_D	0.581	1.00
180_K	186_D	0.579	1.00
191_G	195_L	0.579	1.00
249_L	252_G	0.578	1.00
96_F	104_I	0.574	1.00
72_W	77_I	0.573	1.00
91_G	112_N	0.573	1.00
14_L	28_A	0.572	1.00
216_T	221_K	0.566	1.00
154_N	239_D	0.566	1.00
255_L	259_V	0.566	1.00
265_V	283_V	0.560	1.00
252_G	258_A	0.558	1.00
50_G	53_V	0.557	1.00
85_K	119_D	0.556	1.00
14_L	31_L	0.552	1.00
42_Q	243_A	0.552	1.00
208_G	234_E	0.550	1.00
152_I	249_L	0.549	1.00
179_F	215_A	0.549	1.00
183_V	194_L	0.547	1.00
209_E	231_V	0.547	1.00
188_F	191_G	0.547	1.00
257_T	261_Y	0.546	1.00
63_K	70_E	0.545	1.00
40_S	44_V	0.538	1.00
47_S	75_E	0.538	1.00
42_Q	246_S	0.537	1.00
42_Q	46_A	0.535	1.00
174_P	206_T	0.534	1.00
93_A	134_E	0.533	1.00
105_I	110_G	0.533	1.00
196_L	203_V	0.532	1.00
111_A	114_Y	0.530	1.00
255_L	258_A	0.530	1.00
185_T	189_E	0.528	1.00
173_T	204_I	0.528	1.00
53_V	77_I	0.527	1.00
176_E	208_G	0.526	1.00
178_E	242_N	0.524	1.00
39_G	43_A	0.523	1.00
119_D	123_S	0.523	1.00
137_E	141_K	0.522	1.00
35_H	276_L	0.521	1.00
117_E	138_S	0.521	1.00
206_T	239_D	0.520	1.00
12_V	94_Y	0.518	1.00
278_P	283_V	0.518	1.00
127_D	150_I	0.517	1.00
185_T	194_L	0.517	1.00
42_Q	132_Q	0.517	1.00
138_S	141_K	0.515	1.00
160_L	164_E	0.515	1.00
44_V	77_I	0.511	1.00
189_E	192_L	0.511	1.00
204_I	259_V	0.510	1.00
38_K	42_Q	0.510	1.00
199_V	203_V	0.510	1.00
186_D	190_Y	0.508	1.00
177_I	181_E	0.508	1.00
105_I	108_N	0.506	1.00
264_K	283_V	0.504	1.00
188_F	192_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2rbcA	2	1	100	0.187	Contact Map
1vm7A	2	0.9761	100	0.193	Contact Map
4xdaA	2	0.9898	100	0.202	Contact Map
1rkdA	2	0.9898	100	0.205	Contact Map
3vasA	1	0.9625	100	0.208	Contact Map
2fv7A	2	0.9829	100	0.209	Contact Map
3ry7A	2	0.9727	100	0.209	Contact Map
3ljsA	2	0.9659	100	0.227	Contact Map
3ikhA	2	0.9317	100	0.228	Contact Map
2c4eA	2	0.9693	100	0.232	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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