GREMLIN Database
Q981E1 - Uncharacterized protein
UniProt: Q981E1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (221)
Sequences: 7676 (5682)
Seq/√Len: 382.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_L163_V4.5461.00
164_D194_K3.5281.00
135_I142_R3.3471.00
5_F8_T3.3041.00
195_R218_N3.0031.00
2_K225_S2.9941.00
157_L193_N2.9641.00
2_K26_N2.8501.00
121_Y137_S2.7551.00
191_F196_I2.5921.00
31_L136_I2.4201.00
88_S92_N2.3221.00
5_F220_A2.2601.00
119_E137_S2.2091.00
50_A80_V2.1631.00
165_L197_F2.1471.00
40_R43_D2.1381.00
137_S142_R2.1341.00
123_I159_N2.1271.00
144_L160_I2.0771.00
125_A133_S2.0491.00
168_H182_T2.0001.00
52_F120_I1.9011.00
24_L28_K1.8931.00
189_E193_N1.8731.00
22_S37_A1.8251.00
158_E161_K1.8231.00
125_A131_A1.8121.00
114_K119_E1.8071.00
143_V167_I1.7961.00
80_V108_S1.7951.00
195_R216_K1.7351.00
160_I163_V1.6941.00
142_R163_V1.6601.00
154_N193_N1.6411.00
44_L223_G1.6411.00
218_N224_L1.6231.00
4_T225_S1.6081.00
167_I199_T1.5981.00
33_L53_I1.5711.00
112_S121_Y1.5421.00
131_A147_G1.5361.00
146_T168_H1.5281.00
221_F224_L1.4861.00
197_F220_A1.4781.00
138_D141_T1.4701.00
197_F218_N1.4671.00
50_A82_Y1.4601.00
186_Q189_E1.4521.00
125_A146_T1.4341.00
4_T26_N1.4221.00
36_G39_L1.3901.00
52_F134_Y1.3881.00
154_N157_L1.3841.00
126_C150_K1.3771.00
170_T198_A1.3661.00
124_Q130_Y1.3501.00
209_I213_A1.3401.00
80_V106_Y1.3361.00
21_S145_Y1.3331.00
37_A41_L1.3231.00
5_F197_F1.3201.00
210_I214_N1.3181.00
29_V50_A1.3141.00
135_I144_L1.3001.00
29_V118_M1.2701.00
135_I163_V1.2601.00
8_T18_R1.2511.00
49_K77_P1.2421.00
5_F23_I1.2381.00
184_I188_F1.2351.00
31_L52_F1.2221.00
5_F167_I1.1831.00
3_I143_V1.1661.00
19_V39_L1.1621.00
83_S87_F1.1531.00
185_K189_E1.1531.00
114_K117_E1.1421.00
209_I212_L1.1381.00
112_S119_E1.1331.00
157_L161_K1.1301.00
150_K186_Q1.1271.00
83_S88_S1.1221.00
133_S146_T1.1211.00
157_L190_L1.1201.00
30_L37_A1.1131.00
146_T149_T1.1081.00
189_E192_S1.1001.00
155_A158_E1.0961.00
54_T134_Y1.0941.00
122_S134_Y1.0911.00
209_I214_N1.0871.00
141_T164_D1.0831.00
165_L195_R1.0771.00
60_H200_H1.0731.00
183_S186_Q1.0701.00
58_I62_S1.0701.00
112_S115_I1.0671.00
220_A224_L1.0641.00
53_I64_V1.0631.00
101_I104_K1.0561.00
78_E106_Y1.0551.00
123_I156_I1.0471.00
199_T220_A1.0381.00
51_L64_V1.0351.00
27_D117_E1.0341.00
23_I199_T1.0311.00
89_E95_T1.0261.00
188_F191_F1.0161.00
208_K212_L1.0051.00
25_I136_I1.0051.00
170_T187_I1.0011.00
8_T222_D0.9981.00
3_I25_I0.9831.00
3_I23_I0.9701.00
188_F192_S0.9671.00
106_Y110_L0.9661.00
27_D118_M0.9611.00
24_L46_I0.9581.00
84_P132_V0.9561.00
210_I213_A0.9541.00
168_H187_I0.9531.00
24_L30_L0.9481.00
94_Y97_I0.9471.00
3_I165_L0.9421.00
153_C156_I0.9401.00
89_E93_I0.9371.00
192_S214_N0.9351.00
111_P115_I0.9321.00
150_K182_T0.9291.00
30_L33_L0.9201.00
39_L43_D0.9171.00
105_I109_D0.9141.00
197_F224_L0.9141.00
29_V120_I0.9131.00
150_K180_G0.9131.00
185_K212_L0.9111.00
128_S180_G0.9001.00
28_K47_H0.8971.00
201_I219_I0.8961.00
89_E92_N0.8901.00
6_I22_S0.8891.00
170_T184_I0.8881.00
27_D138_D0.8791.00
54_T145_Y0.8741.00
149_T156_I0.8671.00
33_L37_A0.8661.00
211_S214_N0.8651.00
166_I191_F0.8611.00
56_L86_G0.8531.00
214_N217_I0.8531.00
120_I136_I0.8501.00
3_I167_I0.8491.00
9_G18_R0.8471.00
161_K193_N0.8451.00
29_V136_I0.8451.00
56_L87_F0.8441.00
28_K49_K0.8421.00
35_P38_E0.8391.00
40_R223_G0.8361.00
162_D194_K0.8311.00
52_F113_G0.8301.00
169_E182_T0.8271.00
101_I105_I0.8211.00
33_L51_L0.8201.00
103_A108_S0.8201.00
31_L134_Y0.8181.00
168_H190_L0.8171.00
51_L67_Y0.8151.00
183_S187_I0.8141.00
84_P87_F0.8141.00
100_N103_A0.8131.00
85_K89_E0.8041.00
191_F198_A0.8021.00
52_F82_Y0.8021.00
209_I215_N0.7991.00
38_E42_E0.7991.00
156_I159_N0.7921.00
25_I143_V0.7911.00
160_I166_I0.7861.00
100_N104_K0.7831.00
30_L48_P0.7831.00
112_S122_S0.7821.00
19_V43_D0.7791.00
105_I108_S0.7791.00
154_N158_E0.7771.00
111_P121_Y0.7751.00
171_T202_P0.7731.00
125_A147_G0.7731.00
18_R222_D0.7711.00
53_I87_F0.7701.00
187_I191_F0.7701.00
95_T98_G0.7691.00
51_L79_L0.7681.00
145_Y199_T0.7681.00
146_T156_I0.7671.00
121_Y159_N0.7621.00
173_V177_S0.7611.00
92_N95_T0.7551.00
23_I31_L0.7541.00
172_C179_W0.7501.00
94_Y98_G0.7341.00
29_V52_F0.7341.00
56_L61_F0.7331.00
31_L54_T0.7331.00
93_I96_R0.7331.00
175_D212_L0.7271.00
125_A149_T0.7261.00
78_E104_K0.7251.00
123_I135_I0.7251.00
122_S132_V0.7241.00
31_L145_Y0.7221.00
38_E66_D0.7211.00
50_A115_I0.7201.00
19_V40_R0.7191.00
184_I205_I0.7191.00
213_A217_I0.7061.00
145_Y167_I0.7021.00
210_I218_N0.6990.99
146_T166_I0.6960.99
101_I108_S0.6940.99
135_I159_N0.6890.99
102_S105_I0.6880.99
84_P124_Q0.6810.99
68_L79_L0.6740.99
198_A217_I0.6730.99
208_K211_S0.6730.99
123_I133_S0.6710.99
25_I31_L0.6670.99
153_C157_L0.6660.99
35_P66_D0.6660.99
126_C153_C0.6640.99
106_Y109_D0.6630.99
126_C180_G0.6620.99
104_K108_S0.6620.99
85_K109_D0.6600.99
146_T169_E0.6580.99
189_E212_L0.6580.99
29_V115_I0.6550.99
201_I205_I0.6550.99
120_I134_Y0.6540.99
40_R44_L0.6520.99
172_C176_C0.6480.99
10_A171_T0.6480.99
22_S25_I0.6480.99
21_S199_T0.6400.99
35_P63_G0.6350.99
86_G109_D0.6350.99
152_P157_L0.6310.99
144_L166_I0.6290.99
188_F196_I0.6270.99
168_H196_I0.6260.99
174_D178_I0.6250.99
150_K177_S0.6250.99
111_P114_K0.6240.99
22_S30_L0.6240.99
30_L51_L0.6210.99
209_I219_I0.6190.99
16_L20_K0.6150.99
104_K107_E0.6140.99
121_Y135_I0.6140.99
152_P189_E0.6120.99
44_L225_S0.5990.98
9_G17_K0.5970.98
56_L84_P0.5960.98
90_V93_I0.5960.98
64_V81_I0.5960.98
143_V165_L0.5950.98
149_T169_E0.5940.98
56_L83_S0.5920.98
142_R164_D0.5920.98
36_G40_R0.5910.98
182_T190_L0.5900.98
213_A216_K0.5870.98
22_S34_G0.5820.98
169_E181_H0.5800.98
82_Y113_G0.5800.98
71_R77_P0.5790.98
124_Q132_V0.5750.98
175_D179_W0.5750.98
9_G15_G0.5750.98
138_D164_D0.5740.98
107_E110_L0.5720.98
82_Y108_S0.5720.98
113_G118_M0.5660.98
4_T44_L0.5660.98
19_V22_S0.5660.98
188_F213_A0.5650.98
20_K23_I0.5640.98
111_P122_S0.5640.98
192_S212_L0.5640.98
157_L160_I0.5630.98
16_L206_E0.5600.98
88_S109_D0.5600.98
101_I107_E0.5560.97
65_F69_V0.5540.97
198_A201_I0.5540.97
212_L215_N0.5530.97
35_P40_R0.5530.97
23_I167_I0.5520.97
53_I91_L0.5510.97
20_K35_P0.5470.97
99_N102_S0.5440.97
177_S186_Q0.5430.97
202_P205_I0.5420.97
211_S217_I0.5400.97
170_T183_S0.5390.97
28_K48_P0.5390.97
187_I196_I0.5380.97
94_Y99_N0.5380.97
149_T168_H0.5370.97
56_L90_V0.5360.97
14_L35_P0.5350.97
103_A107_E0.5310.97
105_I110_L0.5290.97
188_F217_I0.5280.97
53_I61_F0.5280.97
23_I27_D0.5270.97
23_I145_Y0.5260.96
137_S140_N0.5220.96
41_L46_I0.5210.96
102_S106_Y0.5200.96
147_G200_H0.5190.96
133_S144_L0.5170.96
71_R79_L0.5150.96
210_I217_I0.5150.96
72_K102_S0.5130.96
133_S149_T0.5090.96
96_R99_N0.5090.96
163_V166_I0.5010.95
18_R21_S0.5000.95
159_N163_V0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zwfA 2 0.9474 100 0.268 Contact Map
1y44A 2 0.9912 100 0.307 Contact Map
2cbnA 2 0.9868 100 0.311 Contact Map
1zkpA 2 0.9825 100 0.394 Contact Map
3jxpA 2 0.9649 100 0.395 Contact Map
3g1pA 2 0.9737 100 0.406 Contact Map
3md7A 2 0.9693 100 0.406 Contact Map
4ojvA 2 0.9825 100 0.421 Contact Map
2e7yA 2 0.943 100 0.444 Contact Map
3bk2A 2 0.9693 100 0.535 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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