GREMLIN Database
Q981E0 - Uncharacterized protein
UniProt: Q981E0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (211)
Sequences: 1672 (1017)
Seq/√Len: 70.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_S114_Y8.9691.00
233_I236_S4.1431.00
84_V116_A3.7541.00
6_A186_I3.5011.00
6_A174_S3.1361.00
143_I160_T2.8321.00
78_G83_G2.8051.00
86_H102_H2.6091.00
130_N141_E2.6041.00
100_H132_P2.5681.00
205_Y209_Y2.5301.00
107_R112_D2.5111.00
121_V139_I2.4901.00
216_I238_I2.4861.00
132_P137_Y2.4311.00
84_V174_S2.3731.00
139_I164_L2.2981.00
115_F140_L2.2871.00
115_F173_S2.2671.00
146_L163_K2.2501.00
105_Y114_Y2.1321.00
139_I173_S2.0091.00
45_F176_I1.9701.00
90_A93_K1.9691.00
117_H136_S1.8831.00
202_N205_Y1.8311.00
188_I216_I1.8031.00
177_Y185_S1.7741.00
100_H134_T1.7711.00
86_H100_H1.7641.00
152_S155_D1.7441.00
134_T137_Y1.7261.00
157_Y160_T1.7241.00
222_K227_V1.7141.00
71_Y105_Y1.7131.00
84_V176_I1.6751.00
100_H137_Y1.6640.99
140_L144_K1.5940.99
3_R8_H1.5780.99
4_I174_S1.5360.99
45_F114_Y1.5100.99
202_N206_Y1.4810.99
204_E209_Y1.4810.99
154_F157_Y1.4740.99
151_M155_D1.4710.99
116_A174_S1.4600.99
113_L175_L1.4570.99
113_L153_P1.4330.98
204_E207_K1.3810.98
146_L149_S1.3750.98
209_Y212_N1.3750.98
193_N231_E1.3490.98
59_S66_D1.3480.98
159_I162_D1.3470.98
153_P167_C1.3400.98
163_K166_D1.3340.98
42_L83_G1.3280.97
46_L55_I1.3030.97
154_F158_A1.2770.97
113_L134_T1.2690.97
179_N185_S1.2480.96
158_A161_L1.2430.96
123_R126_F1.2420.96
143_I175_L1.2290.96
106_M144_K1.2110.96
13_I16_E1.2100.96
28_D63_I1.2020.95
36_H87_A1.2020.95
206_Y210_T1.1530.94
209_Y214_R1.1520.94
60_E101_A1.1510.94
206_Y209_Y1.1410.94
161_L167_C1.1380.94
211_D214_R1.1360.94
156_A160_T1.1230.93
162_D166_D1.1210.93
1_M5_L1.1100.93
86_H116_A1.1050.93
82_V186_I1.1010.93
206_Y211_D1.0870.92
205_Y211_D1.0780.92
146_L160_T1.0750.92
203_E206_Y1.0640.91
17_Y76_A1.0580.91
45_F178_Y1.0560.91
12_E18_V1.0540.91
4_I116_A1.0520.91
91_G136_S1.0450.91
82_V176_I1.0380.90
28_D40_W1.0310.90
172_N217_F1.0040.89
3_R24_A1.0040.89
33_Y63_I0.9990.89
204_E208_L0.9990.89
163_K167_C0.9930.88
40_W62_P0.9860.88
11_G79_E0.9850.88
5_L20_A0.9730.87
155_D230_E0.9630.87
164_L168_S0.9620.87
104_Y134_T0.9620.87
42_L69_I0.9440.86
8_H82_V0.9420.86
155_D159_I0.9320.85
63_I86_H0.9260.85
82_V188_I0.9250.85
204_E211_D0.9140.84
7_F12_E0.9110.84
58_R78_G0.9110.84
112_D179_N0.9100.84
71_Y75_I0.9070.83
152_S161_L0.9030.83
149_S166_D0.9030.83
101_A193_N0.8990.83
125_S179_N0.8990.83
145_T149_S0.8950.83
69_I221_I0.8930.82
195_N231_E0.8900.82
132_P140_L0.8830.82
67_P71_Y0.8780.81
20_A24_A0.8760.81
205_Y208_L0.8690.81
203_E207_K0.8680.81
100_H140_L0.8640.80
232_L238_I0.8630.80
17_Y83_G0.8610.80
157_Y164_L0.8600.80
112_D216_I0.8570.80
102_H134_T0.8570.80
204_E212_N0.8550.80
217_F229_A0.8510.79
24_A28_D0.8500.79
91_G120_S0.8440.79
16_E19_N0.8430.79
139_I160_T0.8430.79
92_R120_S0.8430.79
57_Y66_D0.8410.78
2_C5_L0.8380.78
25_S74_D0.8350.78
156_A161_L0.8350.78
143_I157_Y0.8350.78
157_Y187_L0.8340.78
205_Y214_R0.8310.78
22_I25_S0.8300.78
98_L187_L0.8260.77
61_D217_F0.8260.77
33_Y91_G0.8210.77
141_E172_N0.8130.76
3_R218_S0.8120.76
203_E211_D0.8120.76
97_G133_F0.8110.76
223_Y228_D0.8090.76
36_H64_Y0.8070.76
150_N154_F0.8070.76
150_N153_P0.8070.76
156_A159_I0.7990.75
28_D33_Y0.7860.74
156_A168_S0.7750.73
4_I172_N0.7740.72
26_R29_I0.7720.72
63_I101_A0.7680.72
55_I75_I0.7650.72
106_M112_D0.7620.71
28_D64_Y0.7580.71
208_L213_K0.7570.71
202_N207_K0.7530.70
37_P65_E0.7510.70
55_I68_N0.7510.70
120_S173_S0.7430.69
169_T172_N0.7420.69
154_F187_L0.7380.69
203_E209_Y0.7360.69
156_A164_L0.7290.68
124_T140_L0.7280.68
153_P156_A0.7270.68
91_G170_S0.7270.68
210_T214_R0.7270.68
87_A220_T0.7260.68
3_R9_T0.7250.67
233_I237_I0.7240.67
117_H135_D0.7230.67
55_I76_A0.7220.67
146_L167_C0.7210.67
173_S189_G0.7200.67
56_Y105_Y0.7190.67
208_L214_R0.7090.66
5_L85_I0.7090.66
68_N72_L0.7070.66
174_S188_I0.7070.66
106_M141_E0.7060.65
107_R148_E0.7040.65
45_F54_V0.7020.65
208_L211_D0.6970.64
3_R34_G0.6950.64
58_R145_T0.6910.64
160_T164_L0.6900.64
142_E167_C0.6850.63
203_E212_N0.6840.63
47_K77_K0.6830.63
195_N219_S0.6830.63
39_G118_N0.6790.62
93_K136_S0.6770.62
178_Y220_T0.6740.62
158_A162_D0.6740.62
206_Y212_N0.6660.61
152_S168_S0.6630.61
196_R231_E0.6620.60
161_L168_S0.6610.60
231_E238_I0.6610.60
160_T168_S0.6580.60
19_N22_I0.6560.60
53_K112_D0.6550.60
174_S186_I0.6530.59
4_I86_H0.6520.59
24_A45_F0.6490.59
16_E21_L0.6490.59
45_F177_Y0.6480.59
24_A35_S0.6480.59
105_Y236_S0.6450.58
69_I73_I0.6450.58
40_W190_Y0.6450.58
165_K168_S0.6420.58
170_S193_N0.6370.58
1_M4_I0.6370.58
205_Y212_N0.6360.57
155_D158_A0.6360.57
125_S158_A0.6350.57
38_D62_P0.6350.57
30_F231_E0.6330.57
155_D164_L0.6300.57
10_K47_K0.6290.57
151_M167_C0.6280.56
191_Y235_G0.6250.56
130_N138_L0.6240.56
56_Y96_T0.6230.56
10_K222_K0.6230.56
204_E213_K0.6210.56
147_I172_N0.6190.55
215_Y226_G0.6180.55
154_F164_L0.6160.55
18_V24_A0.6070.54
59_S98_L0.6070.54
58_R166_D0.6060.54
84_V114_Y0.6050.54
44_I57_Y0.6040.54
55_I78_G0.6040.54
37_P64_Y0.5980.53
58_R77_K0.5960.53
146_L159_I0.5930.52
116_A235_G0.5920.52
44_I76_A0.5900.52
84_V186_I0.5860.51
25_S54_V0.5830.51
36_H89_K0.5830.51
154_F237_I0.5820.51
36_H83_G0.5820.51
170_S195_N0.5810.51
17_Y44_I0.5790.51
128_D138_L0.5790.51
20_A101_A0.5780.50
152_S158_A0.5780.50
146_L152_S0.5750.50
113_L143_I0.5750.50
145_T210_T0.5730.50
57_Y68_N0.5730.50
138_L167_C0.5730.50
10_K78_G0.5710.50
126_F162_D0.5710.50
151_M230_E0.5690.49
43_S54_V0.5670.49
217_F221_I0.5650.49
151_M154_F0.5650.49
103_P119_G0.5640.49
2_C118_N0.5640.49
158_A163_K0.5580.48
188_I237_I0.5580.48
87_A178_Y0.5570.48
9_T24_A0.5560.48
56_Y91_G0.5550.48
46_L75_I0.5490.47
93_K134_T0.5470.47
227_V235_G0.5460.47
165_K191_Y0.5450.46
21_L24_A0.5450.46
45_F68_N0.5440.46
158_A233_I0.5430.46
166_D212_N0.5410.46
152_S215_Y0.5410.46
127_K193_N0.5370.45
29_I33_Y0.5360.45
150_N156_A0.5360.45
18_V157_Y0.5340.45
60_E216_I0.5320.45
127_K232_L0.5320.45
101_A192_Y0.5260.44
96_T121_V0.5180.43
25_S28_D0.5180.43
3_R7_F0.5160.43
155_D210_T0.5150.43
74_D77_K0.5150.43
22_I63_I0.5140.43
188_I232_L0.5130.43
122_S232_L0.5130.43
39_G88_R0.5120.42
59_S101_A0.5110.42
147_I169_T0.5110.42
116_A189_G0.5090.42
161_L171_L0.5080.42
100_H133_F0.5080.42
175_L192_Y0.5070.42
57_Y63_I0.5060.42
215_Y221_I0.5050.42
89_K102_H0.5040.42
158_A165_K0.5030.41
54_V112_D0.5020.41
53_K107_R0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mdnA 4 0.7833 100 0.405 Contact Map
4zflA 5 0.8583 100 0.457 Contact Map
1te5A 2 0.9167 100 0.461 Contact Map
4amvA 2 0.8458 100 0.576 Contact Map
1xffA 2 0.8333 100 0.598 Contact Map
1ao0A 3 0.8375 99.9 0.607 Contact Map
1ecfA 4 0.8667 99.9 0.609 Contact Map
1ea0A 1 0.8708 99.8 0.696 Contact Map
1ofdA 1 0.8542 99.8 0.713 Contact Map
1jgtA 2 0.6958 99.6 0.757 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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