GREMLIN Database
Q981D8 - Deacetylase, putative
UniProt: Q981D8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (279)
Sequences: 5204 (3372)
Seq/√Len: 201.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_V62_E3.2281.00
261_S265_T3.1631.00
160_F166_I3.1131.00
45_K48_D3.0531.00
141_K228_A2.9161.00
92_A270_V2.9101.00
136_K163_D2.7581.00
144_A222_L2.7021.00
157_Q187_M2.6761.00
95_A268_Y2.5121.00
92_A134_P2.4711.00
52_I159_I2.3571.00
131_V231_A2.3021.00
256_S259_V2.2631.00
42_K48_D2.2481.00
215_I260_L2.1961.00
113_V158_E2.1691.00
50_Q58_V2.1591.00
81_T127_I2.1571.00
140_L228_A2.1461.00
123_L154_N2.1291.00
208_D253_T2.1021.00
58_V128_F2.0681.00
5_V94_E2.0221.00
61_V128_F1.9871.00
169_I218_I1.9861.00
95_A100_G1.9351.00
55_E59_K1.8811.00
167_L198_I1.8731.00
46_V50_Q1.8701.00
150_V245_A1.8661.00
50_Q55_E1.8481.00
54_S113_V1.8421.00
96_F134_P1.8321.00
198_I221_I1.8261.00
46_V59_K1.8221.00
261_S264_F1.8191.00
52_I136_K1.7851.00
238_S249_A1.7851.00
112_G158_E1.7741.00
193_A196_T1.7711.00
9_I87_Y1.7631.00
260_L264_F1.7481.00
97_E138_Y1.7291.00
249_A253_T1.7261.00
262_N265_T1.7261.00
136_K165_D1.7031.00
61_V127_I1.6981.00
164_P192_D1.6841.00
269_A286_F1.6771.00
132_A159_I1.6611.00
89_M133_Y1.6581.00
42_K94_E1.5861.00
44_I90_G1.5761.00
30_L34_N1.5751.00
211_Y256_S1.5631.00
152_Y157_Q1.5451.00
85_A128_F1.5411.00
236_F286_F1.5341.00
131_V270_V1.5151.00
135_I231_A1.5111.00
113_V159_I1.5091.00
62_E82_Y1.5071.00
46_V86_L1.4941.00
24_S27_D1.4881.00
202_I213_E1.4611.00
123_L179_Y1.4601.00
188_I194_E1.4301.00
101_F271_L1.4221.00
43_P87_Y1.4161.00
54_S114_N1.4151.00
222_L230_I1.4131.00
171_V214_L1.4111.00
29_A283_L1.4081.00
168_H233_S1.3961.00
112_G121_P1.3851.00
128_F133_Y1.3821.00
131_V233_S1.3691.00
112_G154_N1.3501.00
223_D263_K1.3481.00
240_M248_N1.3371.00
250_T253_T1.3361.00
145_I156_T1.3341.00
49_P86_L1.3141.00
57_Y122_T1.3091.00
240_M250_T1.3021.00
239_Y251_E1.2921.00
132_A160_F1.2861.00
144_A167_L1.2671.00
185_P201_L1.2651.00
210_L257_F1.2631.00
150_V247_V1.2601.00
49_P133_Y1.2601.00
59_K63_K1.2541.00
48_D51_I1.2501.00
251_E281_K1.2401.00
82_Y128_F1.2371.00
135_I145_I1.2161.00
9_I83_E1.2141.00
238_S254_F1.2071.00
202_I247_V1.2031.00
255_Y289_G1.2031.00
212_E216_P1.1881.00
173_Q246_S1.1811.00
156_T233_S1.1801.00
32_A284_K1.1791.00
31_S34_N1.1771.00
9_I12_Y1.1661.00
42_K87_Y1.1651.00
215_I256_S1.1531.00
94_E97_E1.1441.00
145_I166_I1.1441.00
92_A104_V1.1431.00
135_I143_V1.1401.00
148_F257_F1.1361.00
7_D40_F1.1361.00
49_P58_V1.1241.00
11_K27_D1.1241.00
167_L225_F1.1161.00
208_D250_T1.1101.00
4_I30_L1.1081.00
48_D93_L1.1041.00
146_I261_S1.1021.00
44_I48_D1.0941.00
21_E107_P1.0891.00
59_K62_E1.0851.00
161_Y197_K1.0761.00
260_L263_K1.0731.00
112_G123_L1.0701.00
232_Y261_S1.0631.00
44_I93_L1.0631.00
206_G209_D1.0621.00
144_A230_I1.0611.00
173_Q178_I1.0611.00
64_H77_T1.0551.00
148_F234_A1.0491.00
258_G286_F1.0441.00
10_Y91_G1.0381.00
231_A268_Y1.0351.00
12_Y80_Y1.0351.00
173_Q204_P1.0321.00
96_F268_Y1.0261.00
86_L90_G1.0111.00
169_I200_L1.0111.00
239_Y282_G1.0111.00
259_V289_G1.0061.00
232_Y269_A1.0051.00
214_L218_I1.0041.00
210_L249_A1.0001.00
96_F229_V0.9971.00
144_A169_I0.9971.00
223_D264_F0.9931.00
89_M130_N0.9891.00
204_P246_S0.9881.00
95_A102_A0.9871.00
46_V58_V0.9861.00
5_V91_G0.9841.00
260_L265_T0.9821.00
146_I169_I0.9781.00
42_K97_E0.9731.00
174_D201_L0.9711.00
52_I133_Y0.9670.99
43_P86_L0.9660.99
168_H197_K0.9610.99
205_L208_D0.9560.99
233_S272_E0.9540.99
46_V55_E0.9520.99
101_F262_N0.9510.99
140_L143_V0.9490.99
5_V39_K0.9480.99
32_A36_L0.9450.99
157_Q161_Y0.9450.99
183_G199_N0.9280.99
153_G168_H0.9170.99
136_K160_F0.9160.99
142_R225_F0.9110.99
47_D50_Q0.9090.99
62_E86_L0.9080.99
51_I136_K0.9020.99
220_A224_D0.9000.99
262_N267_K0.8980.99
211_Y215_I0.8970.99
96_F231_A0.8950.99
61_V82_Y0.8900.99
221_I224_D0.8850.99
164_P196_T0.8840.99
134_P231_A0.8780.99
219_Q223_D0.8740.99
145_I160_F0.8670.99
162_D192_D0.8670.99
230_I267_K0.8660.99
72_D75_T0.8610.99
43_P83_E0.8540.99
148_F258_G0.8510.99
144_A221_I0.8480.99
54_S57_Y0.8460.99
157_Q199_N0.8440.99
92_A268_Y0.8420.99
205_L209_D0.8390.99
132_A156_T0.8370.99
255_Y259_V0.8320.98
161_Y193_A0.8290.98
33_I287_L0.8270.98
231_A270_V0.8270.98
283_L286_F0.8240.98
49_P128_F0.8230.98
45_K90_G0.8160.98
279_L282_G0.8150.98
167_L221_I0.8140.98
219_Q260_L0.8140.98
258_G289_G0.8020.98
173_Q245_A0.7990.98
107_P130_N0.7960.98
32_A35_Q0.7950.98
158_E161_Y0.7930.98
52_I160_F0.7910.98
66_K69_E0.7880.98
88_A106_P0.7840.98
241_G276_D0.7830.98
27_D31_S0.7820.98
122_T127_I0.7810.98
171_V210_L0.7760.98
232_Y267_K0.7750.98
171_V213_E0.7730.98
34_N38_V0.7720.97
32_A281_K0.7690.97
7_D10_Y0.7690.97
251_E282_G0.7680.97
171_V202_I0.7660.97
80_Y84_S0.7650.97
146_I214_L0.7640.97
15_P78_N0.7640.97
85_A88_A0.7620.97
278_G281_K0.7610.97
198_I217_I0.7590.97
236_F272_E0.7530.97
50_Q59_K0.7480.97
44_I49_P0.7450.97
280_I283_L0.7440.97
284_K288_E0.7440.97
49_P89_M0.7420.97
52_I132_A0.7400.97
36_L284_K0.7380.97
91_G104_V0.7370.97
138_Y228_A0.7370.97
178_I204_P0.7350.97
178_I246_S0.7340.97
152_Y182_N0.7330.97
238_S247_V0.7310.97
259_V263_K0.7310.97
168_H172_H0.7300.96
52_I113_V0.7290.96
48_D90_G0.7280.96
210_L214_L0.7230.96
10_Y26_I0.7230.96
269_A291_A0.7160.96
129_N159_I0.7150.96
51_I89_M0.7130.96
90_G94_E0.7100.96
252_Y255_Y0.7090.96
161_Y189_G0.7030.96
161_Y187_M0.7030.96
81_T85_A0.6990.96
189_G193_A0.6980.95
221_I225_F0.6970.95
193_A197_K0.6960.95
142_R228_A0.6960.95
71_L74_D0.6960.95
51_I133_Y0.6950.95
93_L96_F0.6950.95
42_K45_K0.6940.95
91_G94_E0.6900.95
163_D225_F0.6900.95
31_S35_Q0.6890.95
114_N158_E0.6880.95
46_V82_Y0.6880.95
21_E105_R0.6880.95
152_Y183_G0.6860.95
145_I233_S0.6790.95
222_L264_F0.6780.95
82_Y86_L0.6780.95
206_G210_L0.6780.95
255_Y288_E0.6780.95
156_T168_H0.6750.95
8_D11_K0.6740.95
135_I156_T0.6730.95
148_F171_V0.6720.94
11_K26_I0.6720.94
146_I222_L0.6680.94
91_G102_A0.6640.94
130_N272_E0.6630.94
203_P206_G0.6600.94
114_N121_P0.6570.94
80_Y83_E0.6570.94
21_E25_R0.6560.94
200_L213_E0.6540.94
216_P220_A0.6510.93
70_N73_E0.6490.93
167_L196_T0.6470.93
46_V49_P0.6460.93
43_P90_G0.6440.93
229_V268_Y0.6400.93
30_L38_V0.6390.93
85_A130_N0.6390.93
148_F232_Y0.6370.93
104_V107_P0.6360.93
160_F163_D0.6350.93
60_L64_H0.6350.93
282_G285_A0.6340.93
135_I166_I0.6330.93
51_I137_K0.6320.92
14_A23_P0.6310.92
200_L217_I0.6310.92
47_D51_I0.6290.92
159_I166_I0.6280.92
143_V229_V0.6250.92
97_E137_K0.6240.92
189_G194_E0.6240.92
20_V125_F0.6240.92
208_D256_S0.6240.92
214_L257_F0.6220.92
232_Y258_G0.6200.92
91_G106_P0.6190.92
171_V218_I0.6180.92
71_L75_T0.6180.92
189_G195_G0.6180.92
171_V217_I0.6170.92
148_F214_L0.6150.91
112_G159_I0.6140.91
206_G213_E0.6140.91
28_K31_S0.6080.91
200_L218_I0.6080.91
254_F257_F0.6070.91
171_V200_L0.6070.91
232_Y286_F0.6070.91
70_N76_Y0.6060.91
88_A104_V0.6060.91
157_Q183_G0.6060.91
73_E122_T0.6040.91
150_V173_Q0.6020.91
150_V238_S0.6010.90
15_P76_Y0.5980.90
140_L229_V0.5960.90
41_K91_G0.5940.90
207_S248_N0.5940.90
258_G269_A0.5940.90
56_D59_K0.5940.90
74_D125_F0.5930.90
87_Y91_G0.5910.90
44_I89_M0.5910.90
21_E106_P0.5910.90
241_G281_K0.5900.90
105_R272_E0.5900.90
230_I261_S0.5890.90
24_S28_K0.5880.90
169_I217_I0.5870.89
57_Y61_V0.5840.89
146_I230_I0.5810.89
106_P272_E0.5800.89
280_I284_K0.5800.89
83_E87_Y0.5760.89
142_R226_K0.5760.89
174_D184_F0.5760.89
34_N37_K0.5750.88
146_I218_I0.5750.88
107_P272_E0.5750.88
134_P268_Y0.5740.88
29_A33_I0.5740.88
261_S266_K0.5730.88
138_Y143_V0.5710.88
26_I103_L0.5710.88
182_N187_M0.5710.88
33_I36_L0.5650.88
172_H183_G0.5650.88
39_K94_E0.5640.88
104_V130_N0.5570.87
174_D178_I0.5570.87
6_Y30_L0.5510.86
150_V244_L0.5490.86
147_D151_H0.5480.86
219_Q264_F0.5450.86
29_A287_L0.5450.86
25_R28_K0.5450.86
281_K284_K0.5450.86
255_Y285_A0.5400.85
223_D226_K0.5390.85
56_D60_L0.5380.85
174_D203_P0.5370.85
256_S260_L0.5370.85
92_A96_F0.5360.85
20_V25_R0.5350.85
218_I222_L0.5330.84
152_Y199_N0.5310.84
10_Y87_Y0.5290.84
77_T81_T0.5280.84
89_M128_F0.5270.84
85_A127_I0.5270.84
14_A24_S0.5260.84
57_Y112_G0.5260.84
210_L213_E0.5230.83
92_A231_A0.5230.83
21_E26_I0.5210.83
160_F193_A0.5200.83
157_Q197_K0.5190.83
236_F271_L0.5170.83
140_L165_D0.5150.82
125_F244_L0.5090.82
133_Y136_K0.5080.82
271_L279_L0.5060.81
5_V95_A0.5060.81
74_D178_I0.5030.81
10_Y104_V0.5020.81
21_E272_E0.5020.81
101_F283_L0.5020.81
12_Y83_E0.5010.81
61_V77_T0.5000.81
283_L287_L0.5000.81
253_T256_S0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vqmA 1 0.9633 100 0.154 Contact Map
1zz1A 4 0.9602 100 0.175 Contact Map
4a69A 1 0.9817 100 0.179 Contact Map
4ly1A 2 0.9786 100 0.181 Contact Map
4zurA 2 0.8685 100 0.183 Contact Map
4bkxB 1 0.9786 100 0.186 Contact Map
3menA 3 0.8807 100 0.187 Contact Map
1c3pA 1 0.9786 100 0.188 Contact Map
4qa5A 1 0.9755 100 0.193 Contact Map
4bz7A 3 0.9541 100 0.202 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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