Q981D8 - SULSO - GREMLIN Contacts

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Q981D8 - Deacetylase, putative

UniProt:	Q981D8	Sequences: MITIVYDDIYKYHAPKGYHVENPSRIDKALSAINQLKVKFKKPIKVDDPQIIHSEDYVKLVEKHSKLEENLDEDTYTNRYTYESALYAMGGALEAFETNGFALVRPPGHHAGVNGRAFGAPTLGFCIFNNVAYPIKKYKLKRVAIIDFDVHYGNGTQEIFYDDPDILHIDVHQDPRTIYPGNGFPDMIGEKDAEGTKINLLIPPLGSDDLYEELIPIIQAILDDFKPAVIAYSAGFDSYMGDGLASVNATEYTFYSFGVLSNKFTKKYAVLEGGYDKGLIKGLKAFLEGFANIKMEYKKYQSNDSVRSRFMNYLSEEKNILRNYWSI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	327 (279)
Sequences:	5204 (3372)
Seq/√Len:	201.9

BACSU - ACUC
HALSA - Q9HSP7
SULSO - Q981D8 Q981B8 Q97Z24

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_V	62_E	3.228	1.00
261_S	265_T	3.163	1.00
160_F	166_I	3.113	1.00
45_K	48_D	3.053	1.00
141_K	228_A	2.916	1.00
92_A	270_V	2.910	1.00
136_K	163_D	2.758	1.00
144_A	222_L	2.702	1.00
157_Q	187_M	2.676	1.00
95_A	268_Y	2.512	1.00
92_A	134_P	2.471	1.00
52_I	159_I	2.357	1.00
131_V	231_A	2.302	1.00
256_S	259_V	2.263	1.00
42_K	48_D	2.248	1.00
215_I	260_L	2.196	1.00
113_V	158_E	2.169	1.00
50_Q	58_V	2.159	1.00
81_T	127_I	2.157	1.00
140_L	228_A	2.146	1.00
123_L	154_N	2.129	1.00
208_D	253_T	2.102	1.00
58_V	128_F	2.068	1.00
5_V	94_E	2.022	1.00
61_V	128_F	1.987	1.00
169_I	218_I	1.986	1.00
95_A	100_G	1.935	1.00
55_E	59_K	1.881	1.00
167_L	198_I	1.873	1.00
46_V	50_Q	1.870	1.00
150_V	245_A	1.866	1.00
50_Q	55_E	1.848	1.00
54_S	113_V	1.842	1.00
96_F	134_P	1.832	1.00
198_I	221_I	1.826	1.00
46_V	59_K	1.822	1.00
261_S	264_F	1.819	1.00
52_I	136_K	1.785	1.00
238_S	249_A	1.785	1.00
112_G	158_E	1.774	1.00
193_A	196_T	1.771	1.00
9_I	87_Y	1.763	1.00
260_L	264_F	1.748	1.00
97_E	138_Y	1.729	1.00
249_A	253_T	1.726	1.00
262_N	265_T	1.726	1.00
136_K	165_D	1.703	1.00
61_V	127_I	1.698	1.00
164_P	192_D	1.684	1.00
269_A	286_F	1.677	1.00
132_A	159_I	1.661	1.00
89_M	133_Y	1.658	1.00
42_K	94_E	1.586	1.00
44_I	90_G	1.576	1.00
30_L	34_N	1.575	1.00
211_Y	256_S	1.563	1.00
152_Y	157_Q	1.545	1.00
85_A	128_F	1.541	1.00
236_F	286_F	1.534	1.00
131_V	270_V	1.515	1.00
135_I	231_A	1.511	1.00
113_V	159_I	1.509	1.00
62_E	82_Y	1.507	1.00
46_V	86_L	1.494	1.00
24_S	27_D	1.488	1.00
202_I	213_E	1.461	1.00
123_L	179_Y	1.460	1.00
188_I	194_E	1.430	1.00
101_F	271_L	1.422	1.00
43_P	87_Y	1.416	1.00
54_S	114_N	1.415	1.00
222_L	230_I	1.413	1.00
171_V	214_L	1.411	1.00
29_A	283_L	1.408	1.00
168_H	233_S	1.396	1.00
112_G	121_P	1.385	1.00
128_F	133_Y	1.382	1.00
131_V	233_S	1.369	1.00
112_G	154_N	1.350	1.00
223_D	263_K	1.348	1.00
240_M	248_N	1.337	1.00
250_T	253_T	1.336	1.00
145_I	156_T	1.334	1.00
49_P	86_L	1.314	1.00
57_Y	122_T	1.309	1.00
240_M	250_T	1.302	1.00
239_Y	251_E	1.292	1.00
132_A	160_F	1.286	1.00
144_A	167_L	1.267	1.00
185_P	201_L	1.265	1.00
210_L	257_F	1.263	1.00
150_V	247_V	1.260	1.00
49_P	133_Y	1.260	1.00
59_K	63_K	1.254	1.00
48_D	51_I	1.250	1.00
251_E	281_K	1.240	1.00
82_Y	128_F	1.237	1.00
135_I	145_I	1.216	1.00
9_I	83_E	1.214	1.00
238_S	254_F	1.207	1.00
202_I	247_V	1.203	1.00
255_Y	289_G	1.203	1.00
212_E	216_P	1.188	1.00
173_Q	246_S	1.181	1.00
156_T	233_S	1.180	1.00
32_A	284_K	1.179	1.00
31_S	34_N	1.177	1.00
9_I	12_Y	1.166	1.00
42_K	87_Y	1.165	1.00
215_I	256_S	1.153	1.00
94_E	97_E	1.144	1.00
145_I	166_I	1.144	1.00
92_A	104_V	1.143	1.00
135_I	143_V	1.140	1.00
148_F	257_F	1.136	1.00
7_D	40_F	1.136	1.00
49_P	58_V	1.124	1.00
11_K	27_D	1.124	1.00
167_L	225_F	1.116	1.00
208_D	250_T	1.110	1.00
4_I	30_L	1.108	1.00
48_D	93_L	1.104	1.00
146_I	261_S	1.102	1.00
44_I	48_D	1.094	1.00
21_E	107_P	1.089	1.00
59_K	62_E	1.085	1.00
161_Y	197_K	1.076	1.00
260_L	263_K	1.073	1.00
112_G	123_L	1.070	1.00
232_Y	261_S	1.063	1.00
44_I	93_L	1.063	1.00
206_G	209_D	1.062	1.00
144_A	230_I	1.061	1.00
173_Q	178_I	1.061	1.00
64_H	77_T	1.055	1.00
148_F	234_A	1.049	1.00
258_G	286_F	1.044	1.00
10_Y	91_G	1.038	1.00
231_A	268_Y	1.035	1.00
12_Y	80_Y	1.035	1.00
173_Q	204_P	1.032	1.00
96_F	268_Y	1.026	1.00
86_L	90_G	1.011	1.00
169_I	200_L	1.011	1.00
239_Y	282_G	1.011	1.00
259_V	289_G	1.006	1.00
232_Y	269_A	1.005	1.00
214_L	218_I	1.004	1.00
210_L	249_A	1.000	1.00
96_F	229_V	0.997	1.00
144_A	169_I	0.997	1.00
223_D	264_F	0.993	1.00
89_M	130_N	0.989	1.00
204_P	246_S	0.988	1.00
95_A	102_A	0.987	1.00
46_V	58_V	0.986	1.00
5_V	91_G	0.984	1.00
260_L	265_T	0.982	1.00
146_I	169_I	0.978	1.00
42_K	97_E	0.973	1.00
174_D	201_L	0.971	1.00
52_I	133_Y	0.967	0.99
43_P	86_L	0.966	0.99
168_H	197_K	0.961	0.99
205_L	208_D	0.956	0.99
233_S	272_E	0.954	0.99
46_V	55_E	0.952	0.99
101_F	262_N	0.951	0.99
140_L	143_V	0.949	0.99
5_V	39_K	0.948	0.99
32_A	36_L	0.945	0.99
157_Q	161_Y	0.945	0.99
183_G	199_N	0.928	0.99
153_G	168_H	0.917	0.99
136_K	160_F	0.916	0.99
142_R	225_F	0.911	0.99
47_D	50_Q	0.909	0.99
62_E	86_L	0.908	0.99
51_I	136_K	0.902	0.99
220_A	224_D	0.900	0.99
262_N	267_K	0.898	0.99
211_Y	215_I	0.897	0.99
96_F	231_A	0.895	0.99
61_V	82_Y	0.890	0.99
221_I	224_D	0.885	0.99
164_P	196_T	0.884	0.99
134_P	231_A	0.878	0.99
219_Q	223_D	0.874	0.99
145_I	160_F	0.867	0.99
162_D	192_D	0.867	0.99
230_I	267_K	0.866	0.99
72_D	75_T	0.861	0.99
43_P	83_E	0.854	0.99
148_F	258_G	0.851	0.99
144_A	221_I	0.848	0.99
54_S	57_Y	0.846	0.99
157_Q	199_N	0.844	0.99
92_A	268_Y	0.842	0.99
205_L	209_D	0.839	0.99
132_A	156_T	0.837	0.99
255_Y	259_V	0.832	0.98
161_Y	193_A	0.829	0.98
33_I	287_L	0.827	0.98
231_A	270_V	0.827	0.98
283_L	286_F	0.824	0.98
49_P	128_F	0.823	0.98
45_K	90_G	0.816	0.98
279_L	282_G	0.815	0.98
167_L	221_I	0.814	0.98
219_Q	260_L	0.814	0.98
258_G	289_G	0.802	0.98
173_Q	245_A	0.799	0.98
107_P	130_N	0.796	0.98
32_A	35_Q	0.795	0.98
158_E	161_Y	0.793	0.98
52_I	160_F	0.791	0.98
66_K	69_E	0.788	0.98
88_A	106_P	0.784	0.98
241_G	276_D	0.783	0.98
27_D	31_S	0.782	0.98
122_T	127_I	0.781	0.98
171_V	210_L	0.776	0.98
232_Y	267_K	0.775	0.98
171_V	213_E	0.773	0.98
34_N	38_V	0.772	0.97
32_A	281_K	0.769	0.97
7_D	10_Y	0.769	0.97
251_E	282_G	0.768	0.97
171_V	202_I	0.766	0.97
80_Y	84_S	0.765	0.97
146_I	214_L	0.764	0.97
15_P	78_N	0.764	0.97
85_A	88_A	0.762	0.97
278_G	281_K	0.761	0.97
198_I	217_I	0.759	0.97
236_F	272_E	0.753	0.97
50_Q	59_K	0.748	0.97
44_I	49_P	0.745	0.97
280_I	283_L	0.744	0.97
284_K	288_E	0.744	0.97
49_P	89_M	0.742	0.97
52_I	132_A	0.740	0.97
36_L	284_K	0.738	0.97
91_G	104_V	0.737	0.97
138_Y	228_A	0.737	0.97
178_I	204_P	0.735	0.97
178_I	246_S	0.734	0.97
152_Y	182_N	0.733	0.97
238_S	247_V	0.731	0.97
259_V	263_K	0.731	0.97
168_H	172_H	0.730	0.96
52_I	113_V	0.729	0.96
48_D	90_G	0.728	0.96
210_L	214_L	0.723	0.96
10_Y	26_I	0.723	0.96
269_A	291_A	0.716	0.96
129_N	159_I	0.715	0.96
51_I	89_M	0.713	0.96
90_G	94_E	0.710	0.96
252_Y	255_Y	0.709	0.96
161_Y	189_G	0.703	0.96
161_Y	187_M	0.703	0.96
81_T	85_A	0.699	0.96
189_G	193_A	0.698	0.95
221_I	225_F	0.697	0.95
193_A	197_K	0.696	0.95
142_R	228_A	0.696	0.95
71_L	74_D	0.696	0.95
51_I	133_Y	0.695	0.95
93_L	96_F	0.695	0.95
42_K	45_K	0.694	0.95
91_G	94_E	0.690	0.95
163_D	225_F	0.690	0.95
31_S	35_Q	0.689	0.95
114_N	158_E	0.688	0.95
46_V	82_Y	0.688	0.95
21_E	105_R	0.688	0.95
152_Y	183_G	0.686	0.95
145_I	233_S	0.679	0.95
222_L	264_F	0.678	0.95
82_Y	86_L	0.678	0.95
206_G	210_L	0.678	0.95
255_Y	288_E	0.678	0.95
156_T	168_H	0.675	0.95
8_D	11_K	0.674	0.95
135_I	156_T	0.673	0.95
148_F	171_V	0.672	0.94
11_K	26_I	0.672	0.94
146_I	222_L	0.668	0.94
91_G	102_A	0.664	0.94
130_N	272_E	0.663	0.94
203_P	206_G	0.660	0.94
114_N	121_P	0.657	0.94
80_Y	83_E	0.657	0.94
21_E	25_R	0.656	0.94
200_L	213_E	0.654	0.94
216_P	220_A	0.651	0.93
70_N	73_E	0.649	0.93
167_L	196_T	0.647	0.93
46_V	49_P	0.646	0.93
43_P	90_G	0.644	0.93
229_V	268_Y	0.640	0.93
30_L	38_V	0.639	0.93
85_A	130_N	0.639	0.93
148_F	232_Y	0.637	0.93
104_V	107_P	0.636	0.93
160_F	163_D	0.635	0.93
60_L	64_H	0.635	0.93
282_G	285_A	0.634	0.93
135_I	166_I	0.633	0.93
51_I	137_K	0.632	0.92
14_A	23_P	0.631	0.92
200_L	217_I	0.631	0.92
47_D	51_I	0.629	0.92
159_I	166_I	0.628	0.92
143_V	229_V	0.625	0.92
97_E	137_K	0.624	0.92
189_G	194_E	0.624	0.92
20_V	125_F	0.624	0.92
208_D	256_S	0.624	0.92
214_L	257_F	0.622	0.92
232_Y	258_G	0.620	0.92
91_G	106_P	0.619	0.92
171_V	218_I	0.618	0.92
71_L	75_T	0.618	0.92
189_G	195_G	0.618	0.92
171_V	217_I	0.617	0.92
148_F	214_L	0.615	0.91
112_G	159_I	0.614	0.91
206_G	213_E	0.614	0.91
28_K	31_S	0.608	0.91
200_L	218_I	0.608	0.91
254_F	257_F	0.607	0.91
171_V	200_L	0.607	0.91
232_Y	286_F	0.607	0.91
70_N	76_Y	0.606	0.91
88_A	104_V	0.606	0.91
157_Q	183_G	0.606	0.91
73_E	122_T	0.604	0.91
150_V	173_Q	0.602	0.91
150_V	238_S	0.601	0.90
15_P	76_Y	0.598	0.90
140_L	229_V	0.596	0.90
41_K	91_G	0.594	0.90
207_S	248_N	0.594	0.90
258_G	269_A	0.594	0.90
56_D	59_K	0.594	0.90
74_D	125_F	0.593	0.90
87_Y	91_G	0.591	0.90
44_I	89_M	0.591	0.90
21_E	106_P	0.591	0.90
241_G	281_K	0.590	0.90
105_R	272_E	0.590	0.90
230_I	261_S	0.589	0.90
24_S	28_K	0.588	0.90
169_I	217_I	0.587	0.89
57_Y	61_V	0.584	0.89
146_I	230_I	0.581	0.89
106_P	272_E	0.580	0.89
280_I	284_K	0.580	0.89
83_E	87_Y	0.576	0.89
142_R	226_K	0.576	0.89
174_D	184_F	0.576	0.89
34_N	37_K	0.575	0.88
146_I	218_I	0.575	0.88
107_P	272_E	0.575	0.88
134_P	268_Y	0.574	0.88
29_A	33_I	0.574	0.88
261_S	266_K	0.573	0.88
138_Y	143_V	0.571	0.88
26_I	103_L	0.571	0.88
182_N	187_M	0.571	0.88
33_I	36_L	0.565	0.88
172_H	183_G	0.565	0.88
39_K	94_E	0.564	0.88
104_V	130_N	0.557	0.87
174_D	178_I	0.557	0.87
6_Y	30_L	0.551	0.86
150_V	244_L	0.549	0.86
147_D	151_H	0.548	0.86
219_Q	264_F	0.545	0.86
29_A	287_L	0.545	0.86
25_R	28_K	0.545	0.86
281_K	284_K	0.545	0.86
255_Y	285_A	0.540	0.85
223_D	226_K	0.539	0.85
56_D	60_L	0.538	0.85
174_D	203_P	0.537	0.85
256_S	260_L	0.537	0.85
92_A	96_F	0.536	0.85
20_V	25_R	0.535	0.85
218_I	222_L	0.533	0.84
152_Y	199_N	0.531	0.84
10_Y	87_Y	0.529	0.84
77_T	81_T	0.528	0.84
89_M	128_F	0.527	0.84
85_A	127_I	0.527	0.84
14_A	24_S	0.526	0.84
57_Y	112_G	0.526	0.84
210_L	213_E	0.523	0.83
92_A	231_A	0.523	0.83
21_E	26_I	0.521	0.83
160_F	193_A	0.520	0.83
157_Q	197_K	0.519	0.83
236_F	271_L	0.517	0.83
140_L	165_D	0.515	0.82
125_F	244_L	0.509	0.82
133_Y	136_K	0.508	0.82
271_L	279_L	0.506	0.81
5_V	95_A	0.506	0.81
74_D	178_I	0.503	0.81
10_Y	104_V	0.502	0.81
21_E	272_E	0.502	0.81
101_F	283_L	0.502	0.81
12_Y	83_E	0.501	0.81
61_V	77_T	0.500	0.81
283_L	287_L	0.500	0.81
253_T	256_S	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vqmA	1	0.9633	100	0.154	Contact Map
1zz1A	4	0.9602	100	0.175	Contact Map
4a69A	1	0.9817	100	0.179	Contact Map
4ly1A	2	0.9786	100	0.181	Contact Map
4zurA	2	0.8685	100	0.183	Contact Map
4bkxB	1	0.9786	100	0.186	Contact Map
3menA	3	0.8807	100	0.187	Contact Map
1c3pA	1	0.9786	100	0.188	Contact Map
4qa5A	1	0.9755	100	0.193	Contact Map
4bz7A	3	0.9541	100	0.202	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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