GREMLIN Database
Q981D7 - X-pro aminopeptidase
UniProt: Q981D7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 351 (334)
Sequences: 11038 (8117)
Seq/√Len: 444.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_E339_K5.1471.00
307_Q335_K4.3051.00
253_V333_V3.1391.00
131_L332_V2.9821.00
240_E244_T2.5651.00
143_Q172_E2.4991.00
147_E168_F2.4461.00
136_K139_K2.4371.00
25_S290_D2.4161.00
46_I49_D2.3831.00
248_E269_V2.3501.00
164_K167_S2.3471.00
167_S171_E2.3001.00
102_E105_N2.2951.00
186_P198_K2.2891.00
260_K302_D2.2501.00
263_D267_R2.2461.00
258_R261_E2.2411.00
157_T199_K2.2351.00
125_V306_E2.2331.00
247_E251_K2.2201.00
134_M310_V2.1961.00
16_A90_L2.1831.00
252_H265_F2.1341.00
249_A266_A2.1061.00
287_I330_E2.1021.00
233_P237_E2.0871.00
233_P322_K2.0791.00
268_E272_N2.0321.00
135_E139_K1.9831.00
88_N111_R1.9471.00
133_K215_D1.9311.00
202_R228_G1.9291.00
231_N235_I1.9011.00
200_V227_L1.8901.00
201_K204_E1.8851.00
43_L46_I1.8641.00
238_I323_F1.8391.00
248_E251_K1.8371.00
151_N164_K1.8351.00
10_E13_R1.7861.00
166_K170_I1.7611.00
232_D237_E1.7491.00
159_C197_D1.7331.00
198_K204_E1.7181.00
334_K339_K1.7151.00
241_I273_K1.6971.00
264_Y268_E1.6911.00
236_L240_E1.6851.00
168_F171_E1.6841.00
244_T248_E1.6801.00
238_I325_I1.6741.00
60_E64_K1.6661.00
149_V225_F1.6641.00
205_A235_I1.6551.00
242_V325_I1.6111.00
313_I331_V1.5931.00
168_F172_E1.5911.00
258_R304_V1.5751.00
250_E331_V1.5401.00
254_R257_M1.5191.00
243_K247_E1.5181.00
142_E344_L1.5101.00
157_T160_Q1.5021.00
69_I74_G1.4941.00
182_V206_I1.4941.00
209_D220_D1.4831.00
306_E309_M1.4781.00
71_Y74_G1.4771.00
312_T330_E1.4641.00
88_N113_G1.4591.00
270_I317_I1.4511.00
76_D79_S1.4421.00
220_D328_E1.4411.00
154_E202_R1.4401.00
163_R167_S1.4401.00
249_A262_I1.4381.00
177_S218_S1.4361.00
184_S198_K1.4341.00
269_V273_K1.4151.00
7_V30_L1.4131.00
124_Q309_M1.4081.00
226_S230_P1.3981.00
69_I73_D1.3951.00
31_I44_L1.3921.00
245_A269_V1.3921.00
213_K218_S1.3751.00
332_V341_L1.3731.00
147_E172_E1.3701.00
12_E48_R1.3671.00
146_L150_S1.3651.00
56_P59_Y1.3531.00
205_A226_S1.3531.00
246_N250_E1.3441.00
10_E14_A1.3381.00
28_Y216_G1.3271.00
54_L80_K1.3261.00
16_A113_G1.3201.00
161_I200_V1.3191.00
238_I319_L1.3181.00
17_D87_S1.3151.00
128_D132_E1.3081.00
244_T272_N1.3011.00
132_E136_K1.3011.00
164_K168_F1.3001.00
160_Q171_E1.2951.00
266_A283_T1.2811.00
209_D328_E1.2731.00
147_E150_S1.2731.00
9_K13_R1.2651.00
257_M261_E1.2601.00
305_I311_F1.2551.00
237_E273_K1.2521.00
140_K174_G1.2511.00
68_L73_D1.2441.00
184_S200_V1.2431.00
68_L71_Y1.2401.00
60_E63_L1.2301.00
101_I105_N1.2131.00
261_E264_Y1.1961.00
162_E166_K1.1931.00
61_E65_Q1.1921.00
8_Q46_I1.1861.00
260_K264_Y1.1771.00
246_N329_D1.1771.00
255_E307_Q1.1721.00
145_I221_T1.1701.00
271_T276_G1.1681.00
305_I333_V1.1681.00
30_L122_L1.1541.00
121_K306_E1.1541.00
244_T269_V1.1501.00
42_L46_I1.1491.00
141_A221_T1.1391.00
125_V309_M1.1381.00
139_K143_Q1.1361.00
140_K216_G1.1341.00
42_L45_F1.1331.00
161_I206_I1.1321.00
239_V327_I1.1281.00
250_E340_T1.1281.00
76_D80_K1.1211.00
41_P46_I1.1211.00
248_E265_F1.1171.00
129_E133_K1.1161.00
164_K171_E1.1101.00
134_M138_V1.1091.00
5_Q9_K1.1081.00
153_K156_M1.1011.00
136_K214_H1.1001.00
253_V262_I1.0881.00
74_G78_Y1.0811.00
62_Q65_Q1.0801.00
156_M164_K1.0741.00
17_D88_N1.0711.00
232_D236_L1.0691.00
70_V73_D1.0641.00
257_M265_F1.0561.00
66_F71_Y1.0551.00
73_D77_P1.0551.00
244_T273_K1.0501.00
147_E164_K1.0481.00
185_G204_E1.0481.00
237_E240_E1.0451.00
308_N332_V1.0441.00
132_E135_E1.0431.00
166_K176_I1.0421.00
310_V332_V1.0411.00
183_T193_L1.0331.00
74_G77_P1.0321.00
334_K337_Y1.0281.00
237_E241_I1.0281.00
263_D283_T1.0271.00
75_E80_K1.0241.00
205_A224_V1.0231.00
249_A265_F1.0201.00
70_V74_G1.0181.00
138_V142_E1.0131.00
198_K201_K1.0091.00
147_E171_E1.0031.00
252_H257_M1.0001.00
7_V19_L1.0001.00
187_N193_L0.9991.00
77_P80_K0.9991.00
331_V340_T0.9981.00
250_E313_I0.9971.00
68_L74_G0.9961.00
129_E132_E0.9881.00
26_N120_G0.9861.00
174_G212_I0.9781.00
135_E332_V0.9691.00
268_E271_T0.9671.00
11_L16_A0.9631.00
176_I180_P0.9621.00
319_L322_K0.9601.00
260_K300_D0.9601.00
166_K180_P0.9491.00
241_I270_I0.9491.00
61_E64_K0.9481.00
241_I269_V0.9471.00
30_L119_L0.9461.00
98_L102_E0.9441.00
262_I265_F0.9431.00
265_F268_E0.9421.00
241_I244_T0.9401.00
152_I225_F0.9391.00
115_A118_I0.9391.00
142_E343_M0.9331.00
21_T30_L0.9321.00
98_L101_I0.9311.00
311_F333_V0.9311.00
245_A270_I0.9281.00
6_R9_K0.9271.00
184_S204_E0.9261.00
73_D76_D0.9221.00
159_C163_R0.9191.00
248_E252_H0.9141.00
298_S301_N0.9141.00
208_I225_F0.9121.00
253_V331_V0.9051.00
90_L115_A0.9041.00
145_I225_F0.9031.00
10_E121_K0.9011.00
331_V338_G0.9011.00
121_K303_D0.8981.00
253_V313_I0.8961.00
138_V330_E0.8931.00
66_F69_I0.8921.00
128_D334_K0.8911.00
26_N92_D0.8911.00
262_I305_I0.8861.00
187_N198_K0.8851.00
188_S207_V0.8841.00
152_I161_I0.8841.00
144_L168_F0.8831.00
179_D194_R0.8801.00
67_P71_Y0.8761.00
9_K12_E0.8761.00
253_V338_G0.8761.00
136_K140_K0.8731.00
136_K215_D0.8711.00
206_I227_L0.8701.00
161_I182_V0.8641.00
60_E65_Q0.8641.00
8_Q11_L0.8641.00
252_H262_I0.8621.00
6_R122_L0.8611.00
11_L18_Y0.8611.00
102_E106_R0.8601.00
269_V272_N0.8521.00
240_E243_K0.8471.00
78_Y81_L0.8461.00
183_T188_S0.8421.00
265_F269_V0.8391.00
50_D67_P0.8361.00
250_E338_G0.8361.00
266_A279_F0.8351.00
169_L212_I0.8331.00
156_M160_Q0.8311.00
187_N190_M0.8281.00
146_L344_L0.8281.00
257_M262_I0.8261.00
259_A305_I0.8251.00
8_Q51_Y0.8251.00
303_D306_E0.8221.00
287_I310_V0.8171.00
133_K136_K0.8141.00
8_Q47_T0.8121.00
226_S235_I0.8111.00
178_F211_G0.8101.00
286_G295_P0.8081.00
154_E227_L0.8061.00
141_A219_T0.8051.00
239_V243_K0.8021.00
21_T119_L0.8001.00
255_E335_K0.7991.00
147_E151_N0.7981.00
243_K327_I0.7981.00
333_V338_G0.7961.00
142_E146_L0.7891.00
130_E217_Y0.7821.00
233_P319_L0.7811.00
285_H328_E0.7781.00
151_N168_F0.7761.00
223_R329_D0.7741.00
19_L115_A0.7741.00
143_Q146_L0.7731.00
158_E187_N0.7681.00
255_E334_K0.7651.00
53_L63_L0.7651.00
18_Y89_V0.7641.00
118_I121_K0.7621.00
73_D78_Y0.7611.00
332_V339_K0.7611.00
131_L135_E0.7601.00
26_N29_Y0.7601.00
249_A313_I0.7561.00
91_I98_L0.7561.00
245_A249_A0.7541.00
5_Q8_Q0.7531.00
86_N89_V0.7531.00
138_V342_N0.7521.00
28_Y289_I0.7521.00
124_Q306_E0.7511.00
139_K142_E0.7511.00
29_Y122_L0.7491.00
270_I275_Y0.7471.00
138_V219_T0.7431.00
140_K214_H0.7421.00
286_G293_E0.7411.00
220_D285_H0.7401.00
202_R229_K0.7381.00
144_L169_L0.7351.00
209_D314_E0.7321.00
248_E266_A0.7301.00
314_E328_E0.7281.00
97_S100_T0.7241.00
184_S227_L0.7171.00
165_L169_L0.7141.00
99_F103_I0.7131.00
31_I51_Y0.7091.00
165_L208_I0.7081.00
252_H255_E0.7061.00
334_K338_G0.7041.00
318_Y326_R0.7031.00
203_G227_L0.7011.00
190_M193_L0.7001.00
133_K214_H0.6981.00
25_S289_I0.6981.00
66_F70_V0.6981.00
258_R302_D0.6961.00
148_F208_I0.6961.00
238_I275_Y0.6951.00
245_A265_F0.6951.00
75_E79_S0.6941.00
140_K172_E0.6931.00
182_V208_I0.6901.00
297_I311_F0.6891.00
191_P281_H0.6881.00
254_R338_G0.6851.00
188_S205_A0.6851.00
71_Y77_P0.6841.00
267_R279_F0.6801.00
46_I51_Y0.6801.00
188_S324_G0.6761.00
246_N313_I0.6751.00
41_P45_F0.6751.00
11_L19_L0.6741.00
186_P321_G0.6741.00
255_E306_E0.6711.00
67_P70_V0.6681.00
7_V122_L0.6681.00
15_N88_N0.6671.00
218_S291_V0.6661.00
278_Y320_P0.6651.00
52_F72_R0.6621.00
226_S231_N0.6601.00
167_S170_I0.6571.00
316_G326_R0.6561.00
212_I219_T0.6541.00
84_K87_S0.6531.00
249_A252_H0.6521.00
27_M42_L0.6491.00
287_I312_T0.6480.99
192_H292_H0.6470.99
238_I241_I0.6460.99
138_V341_L0.6450.99
24_T27_M0.6440.99
165_L210_Y0.6410.99
103_I106_R0.6400.99
255_E333_V0.6400.99
301_N304_V0.6400.99
261_E265_F0.6310.99
97_S103_I0.6300.99
229_K236_L0.6290.99
26_N119_L0.6280.99
203_G229_K0.6280.99
188_S323_F0.6260.99
72_R80_K0.6250.99
69_I72_R0.6240.99
220_D314_E0.6220.99
233_P238_I0.6210.99
22_G25_S0.6210.99
6_R10_E0.6190.99
144_L165_L0.6180.99
16_A19_L0.6160.99
66_F74_G0.6160.99
160_Q163_R0.6160.99
93_D102_E0.6140.99
124_Q303_D0.6140.99
307_Q334_K0.6130.99
303_D309_M0.6130.99
8_Q12_E0.6100.99
319_L323_F0.6090.99
18_Y21_T0.6080.99
70_V78_Y0.6070.99
140_K212_I0.6060.99
304_V307_Q0.6050.99
148_F161_I0.6010.99
148_F151_N0.6010.99
222_T328_E0.6010.99
157_T197_D0.6000.99
145_I148_F0.5990.99
17_D21_T0.5970.99
145_I210_Y0.5970.99
18_Y47_T0.5970.99
141_A144_L0.5970.99
138_V221_T0.5960.99
150_S154_E0.5960.99
28_Y34_S0.5950.99
43_L49_D0.5920.99
248_E268_E0.5900.99
152_I227_L0.5900.99
68_L77_P0.5900.99
100_T104_L0.5880.99
148_F164_K0.5860.99
186_P189_S0.5850.99
163_R170_I0.5850.99
93_D114_R0.5840.99
235_I322_K0.5840.99
204_E235_I0.5840.99
128_D308_N0.5830.99
101_I104_L0.5830.99
247_E250_E0.5810.99
230_P236_L0.5810.99
255_E338_G0.5800.99
176_I179_D0.5800.99
241_I317_I0.5740.99
270_I276_G0.5740.99
209_D285_H0.5740.99
249_A283_T0.5720.99
43_L47_T0.5710.99
57_K280_I0.5710.99
260_K301_N0.5710.99
96_F101_I0.5690.99
8_Q48_R0.5690.99
131_L310_V0.5690.99
229_K232_D0.5690.99
75_E78_Y0.5630.99
245_A266_A0.5600.99
141_A210_Y0.5590.99
310_V330_E0.5590.99
47_T52_F0.5580.98
318_Y324_G0.5550.98
68_L72_R0.5520.98
132_E139_K0.5520.98
97_S101_I0.5510.98
296_Y311_F0.5510.98
10_E122_L0.5490.98
17_D47_T0.5490.98
281_H292_H0.5480.98
264_Y299_P0.5450.98
72_R76_D0.5420.98
108_K112_I0.5410.98
235_I323_F0.5400.98
120_G294_D0.5390.98
162_E195_C0.5390.98
188_S191_P0.5390.98
241_I275_Y0.5380.98
339_K343_M0.5370.98
255_E337_Y0.5370.98
126_K130_E0.5370.98
161_I208_I0.5360.98
152_I206_I0.5330.98
285_H314_E0.5330.98
74_G80_K0.5310.98
254_R336_G0.5300.98
33_F36_E0.5280.98
340_T343_M0.5280.98
16_A21_T0.5250.98
27_M31_I0.5250.98
71_Y78_Y0.5240.98
96_F100_T0.5230.98
143_Q168_F0.5220.98
253_V305_I0.5220.98
262_I283_T0.5210.98
12_E47_T0.5210.98
241_I245_A0.5210.98
149_V344_L0.5210.98
221_T330_E0.5200.98
273_K276_G0.5190.98
232_D235_I0.5180.98
259_A297_I0.5150.97
266_A269_V0.5130.97
244_T247_E0.5120.97
245_A248_E0.5100.97
226_S229_K0.5090.97
169_L174_G0.5090.97
145_I149_V0.5090.97
121_K124_Q0.5080.97
267_R271_T0.5070.97
264_Y271_T0.5070.97
148_F165_L0.5070.97
10_E118_I0.5050.97
166_K175_N0.5050.97
259_A284_G0.5040.97
256_G304_V0.5030.97
163_R171_E0.5020.97
137_G141_A0.5010.97
20_I89_V0.5010.97
259_A301_N0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wn1A 2 0.9886 100 0.134 Contact Map
4fkcA 2 0.9915 100 0.142 Contact Map
2zsgA 2 0.9858 100 0.146 Contact Map
3q6dA 1 0.9829 100 0.155 Contact Map
1wy2A 2 0.9744 100 0.159 Contact Map
4r60A 2 0.9943 100 0.166 Contact Map
4egeA 2 0.9886 100 0.172 Contact Map
1kp0A 2 0.8889 100 0.193 Contact Map
1chmA 2 0.9943 100 0.196 Contact Map
2v3zA 3 0.9829 100 0.206 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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