GREMLIN Database
Q981D4 - Uncharacterized protein
UniProt: Q981D4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (193)
Sequences: 2513 (1719)
Seq/√Len: 123.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_A157_A3.8531.00
27_K143_E3.5951.00
55_I111_L3.4191.00
37_L141_V3.2871.00
14_I73_I3.2081.00
163_I182_G3.1171.00
38_G74_S3.1121.00
189_L193_Y2.9711.00
160_S183_S2.8381.00
40_I140_L2.7371.00
102_S184_F2.5871.00
99_V184_F2.5501.00
47_I60_I2.5241.00
184_F188_I2.3671.00
109_A161_G2.3221.00
113_Y122_V2.3181.00
101_L130_G2.2531.00
29_L141_V2.1381.00
55_I115_Y2.0581.00
94_A191_I2.0541.00
127_A158_L2.0421.00
189_L195_F1.9891.00
95_I188_I1.9741.00
23_K141_V1.9281.00
177_F181_L1.8971.00
152_I156_A1.8971.00
101_L157_A1.8331.00
6_E10_I1.7731.00
166_F170_Y1.6851.00
42_S70_S1.6701.00
53_L117_L1.6461.00
143_E149_T1.5831.00
54_G57_P1.5681.00
117_L121_S1.5271.00
109_A122_V1.5261.00
16_F100_G1.5031.00
43_Y70_S1.4881.00
159_L186_L1.4771.00
123_G165_Y1.4731.00
18_I77_V1.4651.00
156_A186_L1.4611.00
35_V71_V1.4581.00
64_L68_L1.4451.00
112_A125_I1.4361.00
52_L61_L1.4221.00
109_A165_Y1.4101.00
122_V165_Y1.3991.00
140_L148_L1.3871.00
9_N66_Y1.3751.00
39_V70_S1.3731.00
31_I78_F1.3721.00
190_S195_F1.3641.00
167_T172_H1.3441.00
12_G16_F1.3411.00
167_T175_S1.3391.00
181_L185_L1.3331.00
28_G199_K1.3101.00
48_I128_I1.3071.00
32_F154_A1.2981.00
84_L88_P1.2801.00
123_G162_F1.2761.00
176_L180_F1.2691.00
44_A136_I1.2641.00
125_I129_V1.2631.00
68_L72_G1.2611.00
131_T147_V1.2561.00
175_S179_A1.2380.99
135_V147_V1.2300.99
48_I132_G1.2230.99
71_V75_I1.1980.99
6_E65_N1.1840.99
6_E63_E1.1840.99
102_S106_T1.1750.99
102_S180_F1.1750.99
35_V74_S1.1660.99
38_G70_S1.1640.99
166_F169_P1.1460.99
111_L115_Y1.1390.99
40_I136_I1.1290.99
119_P165_Y1.1260.99
106_T183_S1.1220.99
105_A109_A1.1170.99
98_A184_F1.1080.99
119_P123_G1.0940.99
98_A188_I1.0920.99
73_I77_V1.0890.99
102_S160_S1.0790.99
162_F166_F1.0690.98
13_I16_F1.0590.98
53_L115_Y1.0430.98
105_A161_G1.0390.98
47_I132_G1.0350.98
105_A183_S1.0310.98
34_V78_F1.0250.98
14_I69_L1.0050.98
48_I136_I1.0000.98
36_T148_L0.9980.98
109_A164_Y0.9930.98
155_T197_L0.9920.97
109_A126_A0.9820.97
36_T154_A0.9780.97
94_A98_A0.9760.97
21_S34_V0.9750.97
8_L103_T0.9700.97
156_A160_S0.9620.97
25_T34_V0.9610.97
150_K196_N0.9590.97
186_L195_F0.9570.97
19_S96_S0.9550.97
130_G183_S0.9480.97
159_L182_G0.9470.97
13_I43_Y0.9410.97
190_S194_N0.9300.96
160_S179_A0.9190.96
110_S114_S0.9190.96
145_P148_L0.9160.96
18_I96_S0.9120.96
196_N199_K0.9060.96
188_I192_K0.9060.96
127_A131_T0.9020.96
39_V67_L0.8970.95
100_G104_F0.8950.95
70_S78_F0.8890.95
16_F19_S0.8800.95
14_I18_I0.8720.95
24_G34_V0.8700.95
103_T180_F0.8680.95
60_I121_S0.8670.95
182_G186_L0.8640.94
106_T167_T0.8610.94
60_I132_G0.8600.94
103_T107_L0.8570.94
13_I17_T0.8560.94
163_I167_T0.8450.94
106_T179_A0.8430.94
12_G104_F0.8300.93
15_A100_G0.8250.93
152_I197_L0.8200.93
164_Y179_A0.8140.92
32_F131_T0.8100.92
123_G158_L0.8090.92
29_L144_I0.8090.92
18_I73_I0.8010.92
47_I59_Q0.7850.91
47_I52_L0.7770.91
152_I186_L0.7710.90
127_A154_A0.7700.90
102_S183_S0.7610.90
76_F166_F0.7530.89
53_L112_A0.7510.89
70_S74_S0.7510.89
93_I96_S0.7440.89
9_N23_K0.7410.89
126_A179_A0.7410.89
8_L180_F0.7390.88
99_V103_T0.7350.88
78_F200_R0.7350.88
32_F36_T0.7290.88
10_I69_L0.7270.88
58_P61_L0.7260.87
79_Y83_W0.7160.87
11_I195_F0.7040.86
135_V148_L0.7040.86
30_D145_P0.7000.86
118_N125_I0.6990.85
110_S164_Y0.6980.85
144_I147_V0.6980.85
163_I179_A0.6970.85
135_V146_M0.6960.85
106_T164_Y0.6890.85
59_Q66_Y0.6880.85
27_K109_A0.6870.84
72_G173_H0.6840.84
121_S125_I0.6840.84
167_T171_L0.6830.84
122_V126_A0.6820.84
71_V74_S0.6810.84
135_V140_L0.6810.84
7_L173_H0.6780.84
102_S126_A0.6770.84
25_T200_R0.6730.83
5_L103_T0.6670.83
101_L183_S0.6550.82
144_I149_T0.6550.82
67_L120_I0.6540.81
9_N18_I0.6520.81
16_F20_G0.6520.81
25_T81_Y0.6520.81
188_I191_I0.6490.81
171_L178_V0.6450.81
9_N16_F0.6440.80
158_L161_G0.6430.80
89_I92_I0.6400.80
164_Y168_T0.6380.80
64_L118_N0.6340.79
37_L142_N0.6340.79
70_S73_I0.6340.79
19_S100_G0.6320.79
11_I15_A0.6300.79
77_V81_Y0.6300.79
163_I178_V0.6290.79
39_V43_Y0.6270.79
156_A190_S0.6260.79
32_F158_L0.6260.79
61_L117_L0.6250.78
37_L136_I0.6250.78
43_Y67_L0.6230.78
61_L121_S0.6220.78
117_L122_V0.6170.78
67_L124_L0.6150.77
18_I84_L0.6150.77
10_I14_I0.6150.77
168_T175_S0.6130.77
34_V74_S0.6130.77
109_A183_S0.6030.76
74_S78_F0.6010.76
165_Y168_T0.6000.76
106_T176_L0.5980.75
107_L129_V0.5970.75
104_F130_G0.5960.75
113_Y168_T0.5960.75
59_Q129_V0.5920.75
40_I44_A0.5900.74
178_V182_G0.5900.74
43_Y156_A0.5900.74
105_A160_S0.5900.74
20_G147_V0.5890.74
159_L188_I0.5850.74
41_T44_A0.5840.74
26_N29_L0.5820.73
68_L120_I0.5810.73
104_F187_R0.5790.73
95_I99_V0.5780.73
29_L148_L0.5760.73
150_K183_S0.5760.73
23_K27_K0.5750.73
60_I164_Y0.5730.72
39_V42_S0.5720.72
9_N13_I0.5720.72
21_S74_S0.5710.72
131_T154_A0.5700.72
30_D153_Y0.5680.72
39_V74_S0.5650.71
169_P181_L0.5640.71
48_I52_L0.5640.71
66_Y69_L0.5620.71
170_Y173_H0.5610.71
21_S77_V0.5590.70
33_G37_L0.5570.70
52_L128_I0.5560.70
21_S38_G0.5540.70
142_N189_L0.5490.69
12_G96_S0.5470.69
167_T179_A0.5470.69
31_I192_K0.5460.69
32_F150_K0.5420.68
107_L179_A0.5410.68
72_G76_F0.5350.67
37_L129_V0.5340.67
116_G119_P0.5320.67
21_S25_T0.5310.67
25_T77_V0.5280.66
29_L33_G0.5270.66
53_L111_L0.5250.66
9_N93_I0.5230.65
47_I51_I0.5230.65
72_G178_V0.5220.65
7_L11_I0.5200.65
50_D111_L0.5190.65
51_I85_Q0.5190.65
15_A96_S0.5170.64
65_N69_L0.5160.64
59_Q125_I0.5160.64
5_L107_L0.5160.64
20_G158_L0.5130.64
107_L111_L0.5130.64
126_A156_A0.5130.64
139_V182_G0.5120.64
48_I147_V0.5110.64
9_N124_L0.5100.63
157_A164_Y0.5100.63
15_A69_L0.5090.63
53_L136_I0.5080.63
172_H178_V0.5070.63
118_N121_S0.5040.63
95_I191_I0.5040.63
71_V82_K0.5020.62
36_T124_L0.5010.62
24_G37_L0.5010.62
22_L85_Q0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f2bA 4 0.4195 3.7 0.966 Contact Map
1vryA 1 0.1659 2.2 0.97 Contact Map
2cfqA 1 0.8683 1.9 0.971 Contact Map
3llqA 3 0.4146 1.6 0.972 Contact Map
2gfpA 2 0.8341 1.4 0.973 Contact Map
3cn5A 3 0.4293 1.4 0.973 Contact Map
3wu2J 1 0.1902 1.3 0.974 Contact Map
4qncA 2 0.361 1.3 0.974 Contact Map
1s4zC 1 0.1415 1.2 0.974 Contact Map
2jlnA 1 0.4488 1.2 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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