Q981D0 - SULSO - GREMLIN Contacts

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Q981D0 - Uncharacterized protein

UniProt:	Q981D0	Sequences: MLTPIEFFVTVVLISALSGILGALTGLGGATFLVPIYTLYLNVPIAYASGASLISTIATSSGAASAYVKDRITNVKIGMGLEIATTTGSIAGALTVAYIYAHHLEFIVYIVFGIVLLSQVYVQLAKSKFELPKPIKPDWTTRVFELYGKYYDTVLKQEVEYHGVRWWLGEIIMFFAGFISGLLGIGSGALKVLGMDWAMNLPMKVSTTTSNFMIGVTAATGSSIYWIFGYIQPFLAAGTALGVLIGAFVGTKILVRVTNKTIRYIFTAILIFLGIQMILRGFGYGL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	286 (244)
Sequences:	7778 (5365)
Seq/√Len:	343.5

ECOLI - YFCA
BACSU - YUNE YRKJ YJNA YDHB YTNM
HALSA - O54662
SULSO - Q981D0 Q97WF4 Q97UT0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
88_G	174_F	3.616	1.00
20_I	253_I	3.363	1.00
95_T	178_F	3.331	1.00
276_Q	280_R	3.189	1.00
62_G	244_L	2.993	1.00
12_V	242_G	2.795	1.00
58_A	240_A	2.760	1.00
74_N	205_V	2.631	1.00
68_V	75_V	2.629	1.00
82_E	216_V	2.437	1.00
14_I	36_I	2.414	1.00
62_G	248_F	2.405	1.00
121_Y	125_A	2.398	1.00
78_G	212_F	2.274	1.00
84_A	170_E	2.230	1.00
260_K	264_Y	2.205	1.00
53_L	221_G	2.198	1.00
172_I	194_G	2.172	1.00
16_A	245_I	2.064	1.00
77_I	201_L	2.047	1.00
275_I	279_L	2.010	1.00
271_I	275_I	1.973	1.00
202_P	205_V	1.945	1.00
47_Y	50_G	1.845	1.00
261_T	264_Y	1.833	1.00
67_Y	72_I	1.832	1.00
258_T	261_T	1.827	1.00
120_V	274_G	1.812	1.00
174_F	178_F	1.782	1.00
90_I	224_I	1.780	1.00
15_S	239_T	1.778	1.00
226_W	233_P	1.777	1.00
252_K	256_R	1.777	1.00
51_A	236_A	1.750	1.00
66_A	251_T	1.717	1.00
237_A	241_L	1.705	1.00
120_V	271_I	1.698	1.00
76_K	79_M	1.691	1.00
12_V	238_G	1.691	1.00
54_I	236_A	1.664	1.00
44_P	47_Y	1.626	1.00
20_I	249_V	1.621	1.00
37_Y	239_T	1.618	1.00
61_S	215_G	1.615	1.00
67_Y	254_L	1.594	1.00
8_F	238_G	1.593	1.00
18_S	32_F	1.583	1.00
79_M	83_I	1.581	1.00
74_N	77_I	1.580	1.00
264_Y	268_A	1.571	1.00
85_T	217_T	1.571	1.00
241_L	245_I	1.565	1.00
113_G	274_G	1.564	1.00
78_G	209_T	1.558	1.00
192_V	206_S	1.551	1.00
232_Q	235_L	1.547	1.00
91_A	174_F	1.545	1.00
114_I	118_S	1.545	1.00
43_V	235_L	1.513	1.00
76_K	80_G	1.513	1.00
16_A	246_G	1.488	1.00
120_V	267_T	1.466	1.00
128_K	131_L	1.446	1.00
70_D	255_V	1.442	1.00
13_L	17_L	1.441	1.00
64_A	212_F	1.441	1.00
169_G	199_M	1.437	1.00
125_A	128_K	1.436	1.00
234_F	238_G	1.427	1.00
9_V	13_L	1.411	1.00
115_V	183_L	1.394	1.00
113_G	278_I	1.377	1.00
248_F	252_K	1.373	1.00
124_L	267_T	1.365	1.00
79_M	82_E	1.361	1.00
47_Y	232_Q	1.350	1.00
117_L	274_G	1.345	1.00
89_S	221_G	1.343	1.00
167_W	171_I	1.334	1.00
42_N	48_A	1.330	1.00
176_A	190_L	1.322	1.00
63_A	247_A	1.307	1.00
49_S	225_Y	1.281	1.00
50_G	231_I	1.266	1.00
99_I	182_L	1.260	1.00
94_L	98_Y	1.257	1.00
223_S	227_I	1.245	1.00
75_V	79_M	1.217	1.00
15_S	242_G	1.203	1.00
192_V	210_S	1.201	1.00
93_A	221_G	1.194	1.00
230_Y	234_F	1.175	1.00
81_L	195_M	1.174	1.00
12_V	241_L	1.162	1.00
93_A	224_I	1.162	1.00
72_I	208_T	1.149	1.00
83_I	87_T	1.145	1.00
68_V	73_T	1.140	1.00
34_V	52_S	1.135	1.00
88_G	178_F	1.129	1.00
10_T	13_L	1.125	1.00
246_G	250_G	1.124	1.00
63_A	211_N	1.108	1.00
90_I	94_L	1.100	1.00
16_A	242_G	1.097	1.00
187_S	191_K	1.097	1.00
128_K	132_P	1.096	1.00
75_V	78_G	1.085	1.00
268_A	272_F	1.084	1.00
86_T	220_T	1.079	1.00
196_D	206_S	1.077	1.00
224_I	228_F	1.077	1.00
123_Q	266_F	1.064	1.00
84_A	88_G	1.057	1.00
118_S	122_V	1.057	1.00
73_T	78_G	1.043	1.00
167_W	170_E	1.039	1.00
16_A	249_V	1.032	1.00
130_E	134_P	1.031	1.00
67_Y	251_T	1.030	1.00
171_I	175_F	1.028	1.00
94_L	97_A	1.027	1.00
191_K	213_M	1.006	1.00
64_A	75_V	1.006	1.00
65_S	69_K	1.005	1.00
73_T	209_T	0.998	1.00
214_I	217_T	0.995	1.00
67_Y	208_T	0.986	1.00
187_S	193_L	0.984	1.00
110_I	114_I	0.983	1.00
30_A	181_G	0.983	1.00
192_V	207_T	0.981	1.00
64_A	68_V	0.979	1.00
132_P	136_K	0.976	1.00
91_A	94_L	0.973	1.00
165_R	168_L	0.972	1.00
88_G	92_G	0.970	1.00
57_I	219_A	0.967	1.00
66_A	70_D	0.966	1.00
18_S	33_L	0.963	1.00
75_V	212_F	0.962	1.00
84_A	173_M	0.961	1.00
24_L	262_I	0.955	1.00
43_V	232_Q	0.950	1.00
196_D	203_M	0.949	1.00
50_G	222_S	0.947	1.00
85_T	213_M	0.945	1.00
107_I	111_V	0.935	1.00
272_F	275_I	0.930	1.00
204_K	254_L	0.928	1.00
252_K	255_V	0.924	1.00
64_A	215_G	0.913	1.00
43_V	47_Y	0.911	1.00
66_A	248_F	0.902	1.00
91_A	178_F	0.897	1.00
203_M	207_T	0.896	1.00
126_K	263_R	0.889	1.00
132_P	135_I	0.887	1.00
126_K	129_F	0.880	1.00
23_A	251_T	0.869	1.00
51_A	231_I	0.866	1.00
62_G	247_A	0.864	1.00
84_A	87_T	0.862	1.00
23_A	63_A	0.859	1.00
222_S	236_A	0.855	1.00
234_F	237_A	0.853	1.00
254_L	262_I	0.851	1.00
91_A	95_T	0.841	1.00
180_S	217_T	0.837	1.00
68_V	71_R	0.833	1.00
47_Y	51_A	0.831	1.00
62_G	66_A	0.830	1.00
57_I	222_S	0.830	1.00
12_V	16_A	0.827	1.00
101_A	109_Y	0.827	1.00
54_I	222_S	0.827	1.00
85_T	191_K	0.825	1.00
65_S	68_V	0.824	1.00
33_L	239_T	0.821	1.00
173_M	191_K	0.819	1.00
66_A	252_K	0.818	1.00
261_T	265_I	0.813	1.00
93_A	220_T	0.811	1.00
176_A	187_S	0.806	1.00
52_S	56_T	0.806	1.00
54_I	240_A	0.805	1.00
78_G	213_M	0.802	1.00
81_L	213_M	0.799	1.00
11_V	239_T	0.797	1.00
237_A	240_A	0.790	1.00
10_T	14_I	0.788	1.00
59_T	243_V	0.780	1.00
66_A	69_K	0.778	1.00
190_L	193_L	0.778	1.00
56_T	180_S	0.777	1.00
60_S	214_I	0.772	1.00
55_S	243_V	0.770	1.00
92_G	178_F	0.769	1.00
266_F	270_L	0.766	1.00
38_T	45_I	0.765	1.00
45_I	108_V	0.758	1.00
96_V	225_Y	0.756	1.00
61_S	65_S	0.755	1.00
242_G	246_G	0.752	1.00
87_T	91_A	0.749	1.00
120_V	124_L	0.749	1.00
102_H	110_I	0.749	1.00
187_S	214_I	0.747	1.00
80_G	166_W	0.745	1.00
111_V	183_L	0.738	0.99
43_V	48_A	0.738	0.99
60_S	184_G	0.735	0.99
24_L	253_I	0.735	0.99
19_G	29_G	0.729	0.99
22_G	30_A	0.729	0.99
56_T	60_S	0.727	0.99
22_G	180_S	0.724	0.99
113_G	117_L	0.722	0.99
180_S	187_S	0.721	0.99
210_S	214_I	0.720	0.99
162_H	165_R	0.717	0.99
267_T	271_I	0.717	0.99
16_A	19_G	0.716	0.99
15_S	19_G	0.709	0.99
163_G	167_W	0.703	0.99
247_A	251_T	0.703	0.99
244_L	248_F	0.702	0.99
272_F	276_Q	0.700	0.99
56_T	218_A	0.693	0.99
90_I	227_I	0.692	0.99
53_L	56_T	0.692	0.99
87_T	174_F	0.691	0.99
107_I	110_I	0.690	0.99
102_H	107_I	0.688	0.99
24_L	250_G	0.687	0.99
19_G	243_V	0.686	0.99
117_L	121_Y	0.685	0.99
257_V	261_T	0.685	0.99
129_F	132_P	0.680	0.99
80_G	83_I	0.678	0.99
89_S	93_A	0.677	0.99
76_K	166_W	0.677	0.99
53_L	184_G	0.672	0.99
94_L	224_I	0.672	0.99
95_T	98_Y	0.671	0.99
203_M	266_F	0.657	0.99
97_A	228_F	0.657	0.99
131_L	135_I	0.656	0.99
51_A	232_Q	0.653	0.99
226_W	231_I	0.653	0.99
49_S	96_V	0.652	0.99
57_I	60_S	0.651	0.99
110_I	113_G	0.649	0.99
11_V	235_L	0.649	0.99
28_G	57_I	0.648	0.99
38_T	48_A	0.645	0.99
195_M	213_M	0.644	0.99
133_K	136_K	0.643	0.99
168_L	171_I	0.639	0.99
191_K	195_M	0.636	0.98
222_S	226_W	0.636	0.98
18_S	36_I	0.634	0.98
12_V	15_S	0.634	0.98
130_E	133_K	0.633	0.98
171_I	174_F	0.632	0.98
15_S	33_L	0.632	0.98
161_Y	165_R	0.631	0.98
274_G	278_I	0.631	0.98
30_A	56_T	0.631	0.98
60_S	247_A	0.631	0.98
77_I	81_L	0.627	0.98
117_L	271_I	0.627	0.98
184_G	187_S	0.626	0.98
11_V	41_L	0.624	0.98
276_Q	279_L	0.624	0.98
217_T	243_V	0.621	0.98
258_T	262_I	0.619	0.98
163_G	166_W	0.618	0.98
22_G	59_T	0.616	0.98
33_L	56_T	0.616	0.98
211_N	214_I	0.614	0.98
24_L	257_V	0.614	0.98
238_G	242_G	0.614	0.98
131_L	134_P	0.612	0.98
43_V	51_A	0.611	0.98
128_K	264_Y	0.607	0.98
56_T	187_S	0.606	0.98
93_A	181_G	0.606	0.98
49_S	108_V	0.606	0.98
22_G	214_I	0.605	0.98
11_V	238_G	0.603	0.98
10_T	41_L	0.602	0.98
119_Q	122_V	0.602	0.98
46_A	50_G	0.600	0.98
127_S	131_L	0.596	0.98
12_V	245_I	0.593	0.98
22_G	32_F	0.593	0.98
204_K	259_N	0.592	0.98
215_G	219_A	0.590	0.98
58_A	244_L	0.588	0.97
46_A	49_S	0.586	0.97
70_D	252_K	0.583	0.97
168_L	194_G	0.582	0.97
49_S	53_L	0.581	0.97
30_A	33_L	0.581	0.97
187_S	190_L	0.580	0.97
93_A	96_V	0.580	0.97
100_Y	107_I	0.579	0.97
77_I	205_V	0.575	0.97
16_A	20_I	0.575	0.97
212_F	216_V	0.574	0.97
15_S	235_L	0.574	0.97
221_G	224_I	0.572	0.97
187_S	210_S	0.570	0.97
113_G	116_L	0.568	0.97
93_A	225_Y	0.566	0.97
25_T	247_A	0.566	0.97
53_L	180_S	0.566	0.97
243_V	247_A	0.558	0.97
23_A	243_V	0.557	0.97
184_G	210_S	0.555	0.96
72_I	205_V	0.553	0.96
38_T	52_S	0.553	0.96
249_V	252_K	0.553	0.96
28_G	35_P	0.552	0.96
22_G	27_L	0.552	0.96
172_I	175_F	0.550	0.96
136_K	175_F	0.550	0.96
164_V	168_L	0.550	0.96
71_R	74_N	0.550	0.96
74_N	201_L	0.545	0.96
127_S	130_E	0.544	0.96
61_S	64_A	0.544	0.96
26_G	186_G	0.543	0.96
45_I	48_A	0.542	0.96
89_S	220_T	0.541	0.96
194_G	198_A	0.539	0.96
30_A	185_I	0.537	0.96
176_A	191_K	0.530	0.95
25_T	173_M	0.529	0.95
133_K	202_P	0.529	0.95
201_L	206_S	0.527	0.95
225_Y	230_Y	0.527	0.95
72_I	204_K	0.525	0.95
195_M	209_T	0.520	0.95
185_I	189_A	0.520	0.95
46_A	108_V	0.519	0.95
169_G	195_M	0.519	0.95
23_A	207_T	0.518	0.95
88_G	91_A	0.517	0.95
218_A	221_G	0.516	0.95
205_V	208_T	0.516	0.95
190_L	194_G	0.515	0.95
23_A	33_L	0.514	0.95
120_V	123_Q	0.514	0.95
31_T	116_L	0.509	0.94
87_T	225_Y	0.508	0.94
267_T	274_G	0.507	0.94
253_I	257_V	0.507	0.94
249_V	253_I	0.507	0.94
22_G	60_S	0.506	0.94
184_G	217_T	0.506	0.94
201_L	205_V	0.504	0.94
191_K	214_I	0.504	0.94
25_T	269_I	0.502	0.94
22_G	56_T	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1pw4A	1	0.8217	88.9	0.907	Contact Map
3o7qA	1	0.8497	68.4	0.925	Contact Map
4j05A	3	0.7203	66.7	0.925	Contact Map
4pypA	1	0.8112	66.7	0.925	Contact Map
2cfqA	1	0.8357	66.1	0.926	Contact Map
4xnjA	1	0.8566	51.9	0.932	Contact Map
2gfpA	2	0.8007	49.2	0.933	Contact Map
2b2hA	3	0.4895	42.9	0.935	Contact Map
4m64A	1	0.8392	37.8	0.937	Contact Map
4ldsA	2	0.8112	33.8	0.939	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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