GREMLIN Database
Q981D0 - Uncharacterized protein
UniProt: Q981D0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (244)
Sequences: 7778 (5365)
Seq/√Len: 343.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_G174_F3.6161.00
20_I253_I3.3631.00
95_T178_F3.3311.00
276_Q280_R3.1891.00
62_G244_L2.9931.00
12_V242_G2.7951.00
58_A240_A2.7601.00
74_N205_V2.6311.00
68_V75_V2.6291.00
82_E216_V2.4371.00
14_I36_I2.4141.00
62_G248_F2.4051.00
121_Y125_A2.3981.00
78_G212_F2.2741.00
84_A170_E2.2301.00
260_K264_Y2.2051.00
53_L221_G2.1981.00
172_I194_G2.1721.00
16_A245_I2.0641.00
77_I201_L2.0471.00
275_I279_L2.0101.00
271_I275_I1.9731.00
202_P205_V1.9451.00
47_Y50_G1.8451.00
261_T264_Y1.8331.00
67_Y72_I1.8321.00
258_T261_T1.8271.00
120_V274_G1.8121.00
174_F178_F1.7821.00
90_I224_I1.7801.00
15_S239_T1.7781.00
226_W233_P1.7771.00
252_K256_R1.7771.00
51_A236_A1.7501.00
66_A251_T1.7171.00
237_A241_L1.7051.00
120_V271_I1.6981.00
76_K79_M1.6911.00
12_V238_G1.6911.00
54_I236_A1.6641.00
44_P47_Y1.6261.00
20_I249_V1.6211.00
37_Y239_T1.6181.00
61_S215_G1.6151.00
67_Y254_L1.5941.00
8_F238_G1.5931.00
18_S32_F1.5831.00
79_M83_I1.5811.00
74_N77_I1.5801.00
264_Y268_A1.5711.00
85_T217_T1.5711.00
241_L245_I1.5651.00
113_G274_G1.5641.00
78_G209_T1.5581.00
192_V206_S1.5511.00
232_Q235_L1.5471.00
91_A174_F1.5451.00
114_I118_S1.5451.00
43_V235_L1.5131.00
76_K80_G1.5131.00
16_A246_G1.4881.00
120_V267_T1.4661.00
128_K131_L1.4461.00
70_D255_V1.4421.00
13_L17_L1.4411.00
64_A212_F1.4411.00
169_G199_M1.4371.00
125_A128_K1.4361.00
234_F238_G1.4271.00
9_V13_L1.4111.00
115_V183_L1.3941.00
113_G278_I1.3771.00
248_F252_K1.3731.00
124_L267_T1.3651.00
79_M82_E1.3611.00
47_Y232_Q1.3501.00
117_L274_G1.3451.00
89_S221_G1.3431.00
167_W171_I1.3341.00
42_N48_A1.3301.00
176_A190_L1.3221.00
63_A247_A1.3071.00
49_S225_Y1.2811.00
50_G231_I1.2661.00
99_I182_L1.2601.00
94_L98_Y1.2571.00
223_S227_I1.2451.00
75_V79_M1.2171.00
15_S242_G1.2031.00
192_V210_S1.2011.00
93_A221_G1.1941.00
230_Y234_F1.1751.00
81_L195_M1.1741.00
12_V241_L1.1621.00
93_A224_I1.1621.00
72_I208_T1.1491.00
83_I87_T1.1451.00
68_V73_T1.1401.00
34_V52_S1.1351.00
88_G178_F1.1291.00
10_T13_L1.1251.00
246_G250_G1.1241.00
63_A211_N1.1081.00
90_I94_L1.1001.00
16_A242_G1.0971.00
187_S191_K1.0971.00
128_K132_P1.0961.00
75_V78_G1.0851.00
268_A272_F1.0841.00
86_T220_T1.0791.00
196_D206_S1.0771.00
224_I228_F1.0771.00
123_Q266_F1.0641.00
84_A88_G1.0571.00
118_S122_V1.0571.00
73_T78_G1.0431.00
167_W170_E1.0391.00
16_A249_V1.0321.00
130_E134_P1.0311.00
67_Y251_T1.0301.00
171_I175_F1.0281.00
94_L97_A1.0271.00
191_K213_M1.0061.00
64_A75_V1.0061.00
65_S69_K1.0051.00
73_T209_T0.9981.00
214_I217_T0.9951.00
67_Y208_T0.9861.00
187_S193_L0.9841.00
110_I114_I0.9831.00
30_A181_G0.9831.00
192_V207_T0.9811.00
64_A68_V0.9791.00
132_P136_K0.9761.00
91_A94_L0.9731.00
165_R168_L0.9721.00
88_G92_G0.9701.00
57_I219_A0.9671.00
66_A70_D0.9661.00
18_S33_L0.9631.00
75_V212_F0.9621.00
84_A173_M0.9611.00
24_L262_I0.9551.00
43_V232_Q0.9501.00
196_D203_M0.9491.00
50_G222_S0.9471.00
85_T213_M0.9451.00
107_I111_V0.9351.00
272_F275_I0.9301.00
204_K254_L0.9281.00
252_K255_V0.9241.00
64_A215_G0.9131.00
43_V47_Y0.9111.00
66_A248_F0.9021.00
91_A178_F0.8971.00
203_M207_T0.8961.00
126_K263_R0.8891.00
132_P135_I0.8871.00
126_K129_F0.8801.00
23_A251_T0.8691.00
51_A231_I0.8661.00
62_G247_A0.8641.00
84_A87_T0.8621.00
23_A63_A0.8591.00
222_S236_A0.8551.00
234_F237_A0.8531.00
254_L262_I0.8511.00
91_A95_T0.8411.00
180_S217_T0.8371.00
68_V71_R0.8331.00
47_Y51_A0.8311.00
62_G66_A0.8301.00
57_I222_S0.8301.00
12_V16_A0.8271.00
101_A109_Y0.8271.00
54_I222_S0.8271.00
85_T191_K0.8251.00
65_S68_V0.8241.00
33_L239_T0.8211.00
173_M191_K0.8191.00
66_A252_K0.8181.00
261_T265_I0.8131.00
93_A220_T0.8111.00
176_A187_S0.8061.00
52_S56_T0.8061.00
54_I240_A0.8051.00
78_G213_M0.8021.00
81_L213_M0.7991.00
11_V239_T0.7971.00
237_A240_A0.7901.00
10_T14_I0.7881.00
59_T243_V0.7801.00
66_A69_K0.7781.00
190_L193_L0.7781.00
56_T180_S0.7771.00
60_S214_I0.7721.00
55_S243_V0.7701.00
92_G178_F0.7691.00
266_F270_L0.7661.00
38_T45_I0.7651.00
45_I108_V0.7581.00
96_V225_Y0.7561.00
61_S65_S0.7551.00
242_G246_G0.7521.00
87_T91_A0.7491.00
120_V124_L0.7491.00
102_H110_I0.7491.00
187_S214_I0.7471.00
80_G166_W0.7451.00
111_V183_L0.7380.99
43_V48_A0.7380.99
60_S184_G0.7350.99
24_L253_I0.7350.99
19_G29_G0.7290.99
22_G30_A0.7290.99
56_T60_S0.7270.99
22_G180_S0.7240.99
113_G117_L0.7220.99
180_S187_S0.7210.99
210_S214_I0.7200.99
162_H165_R0.7170.99
267_T271_I0.7170.99
16_A19_G0.7160.99
15_S19_G0.7090.99
163_G167_W0.7030.99
247_A251_T0.7030.99
244_L248_F0.7020.99
272_F276_Q0.7000.99
56_T218_A0.6930.99
90_I227_I0.6920.99
53_L56_T0.6920.99
87_T174_F0.6910.99
107_I110_I0.6900.99
102_H107_I0.6880.99
24_L250_G0.6870.99
19_G243_V0.6860.99
117_L121_Y0.6850.99
257_V261_T0.6850.99
129_F132_P0.6800.99
80_G83_I0.6780.99
89_S93_A0.6770.99
76_K166_W0.6770.99
53_L184_G0.6720.99
94_L224_I0.6720.99
95_T98_Y0.6710.99
203_M266_F0.6570.99
97_A228_F0.6570.99
131_L135_I0.6560.99
51_A232_Q0.6530.99
226_W231_I0.6530.99
49_S96_V0.6520.99
57_I60_S0.6510.99
110_I113_G0.6490.99
11_V235_L0.6490.99
28_G57_I0.6480.99
38_T48_A0.6450.99
195_M213_M0.6440.99
133_K136_K0.6430.99
168_L171_I0.6390.99
191_K195_M0.6360.98
222_S226_W0.6360.98
18_S36_I0.6340.98
12_V15_S0.6340.98
130_E133_K0.6330.98
171_I174_F0.6320.98
15_S33_L0.6320.98
161_Y165_R0.6310.98
274_G278_I0.6310.98
30_A56_T0.6310.98
60_S247_A0.6310.98
77_I81_L0.6270.98
117_L271_I0.6270.98
184_G187_S0.6260.98
11_V41_L0.6240.98
276_Q279_L0.6240.98
217_T243_V0.6210.98
258_T262_I0.6190.98
163_G166_W0.6180.98
22_G59_T0.6160.98
33_L56_T0.6160.98
211_N214_I0.6140.98
24_L257_V0.6140.98
238_G242_G0.6140.98
131_L134_P0.6120.98
43_V51_A0.6110.98
128_K264_Y0.6070.98
56_T187_S0.6060.98
93_A181_G0.6060.98
49_S108_V0.6060.98
22_G214_I0.6050.98
11_V238_G0.6030.98
10_T41_L0.6020.98
119_Q122_V0.6020.98
46_A50_G0.6000.98
127_S131_L0.5960.98
12_V245_I0.5930.98
22_G32_F0.5930.98
204_K259_N0.5920.98
215_G219_A0.5900.98
58_A244_L0.5880.97
46_A49_S0.5860.97
70_D252_K0.5830.97
168_L194_G0.5820.97
49_S53_L0.5810.97
30_A33_L0.5810.97
187_S190_L0.5800.97
93_A96_V0.5800.97
100_Y107_I0.5790.97
77_I205_V0.5750.97
16_A20_I0.5750.97
212_F216_V0.5740.97
15_S235_L0.5740.97
221_G224_I0.5720.97
187_S210_S0.5700.97
113_G116_L0.5680.97
93_A225_Y0.5660.97
25_T247_A0.5660.97
53_L180_S0.5660.97
243_V247_A0.5580.97
23_A243_V0.5570.97
184_G210_S0.5550.96
72_I205_V0.5530.96
38_T52_S0.5530.96
249_V252_K0.5530.96
28_G35_P0.5520.96
22_G27_L0.5520.96
172_I175_F0.5500.96
136_K175_F0.5500.96
164_V168_L0.5500.96
71_R74_N0.5500.96
74_N201_L0.5450.96
127_S130_E0.5440.96
61_S64_A0.5440.96
26_G186_G0.5430.96
45_I48_A0.5420.96
89_S220_T0.5410.96
194_G198_A0.5390.96
30_A185_I0.5370.96
176_A191_K0.5300.95
25_T173_M0.5290.95
133_K202_P0.5290.95
201_L206_S0.5270.95
225_Y230_Y0.5270.95
72_I204_K0.5250.95
195_M209_T0.5200.95
185_I189_A0.5200.95
46_A108_V0.5190.95
169_G195_M0.5190.95
23_A207_T0.5180.95
88_G91_A0.5170.95
218_A221_G0.5160.95
205_V208_T0.5160.95
190_L194_G0.5150.95
23_A33_L0.5140.95
120_V123_Q0.5140.95
31_T116_L0.5090.94
87_T225_Y0.5080.94
267_T274_G0.5070.94
253_I257_V0.5070.94
249_V253_I0.5070.94
22_G60_S0.5060.94
184_G217_T0.5060.94
201_L205_V0.5040.94
191_K214_I0.5040.94
25_T269_I0.5020.94
22_G56_T0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.8217 88.9 0.907 Contact Map
3o7qA 1 0.8497 68.4 0.925 Contact Map
4j05A 3 0.7203 66.7 0.925 Contact Map
4pypA 1 0.8112 66.7 0.925 Contact Map
2cfqA 1 0.8357 66.1 0.926 Contact Map
4xnjA 1 0.8566 51.9 0.932 Contact Map
2gfpA 2 0.8007 49.2 0.933 Contact Map
2b2hA 3 0.4895 42.9 0.935 Contact Map
4m64A 1 0.8392 37.8 0.937 Contact Map
4ldsA 2 0.8112 33.8 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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