GREMLIN Database
QUEC - 7-cyano-7-deazaguanine synthase
UniProt: Q981C9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 464 (376)
Sequences: 248 (208)
Seq/√Len: 10.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_K156_Q3.4530.97
287_V291_A3.2580.96
287_V295_Q3.2420.96
1_M4_V3.2310.96
228_K231_T3.0110.94
275_Y291_A2.7770.91
22_L77_A2.6850.90
291_A295_Q2.5540.87
318_G321_I2.5240.86
283_E287_V2.4420.84
139_L153_I2.3930.83
272_H295_Q2.3820.83
276_H291_A2.3810.83
122_Y126_R2.3740.83
276_H280_E2.3560.82
270_L273_F2.3130.81
27_K61_E2.2980.80
276_H287_V2.2970.80
273_F276_H2.2820.80
273_F295_Q2.2790.80
283_E291_A2.2580.79
291_A294_L2.2560.79
281_E291_A2.2280.78
320_E323_K2.2250.78
273_F280_E2.2210.78
231_T234_P2.2150.78
275_Y287_V2.2070.78
318_G324_D2.2000.77
280_E295_Q2.1870.77
280_E291_A2.1860.77
312_A315_I2.1800.77
275_Y294_L2.1620.76
273_F287_V2.1610.76
273_F278_K2.1200.75
58_S62_E2.1060.74
185_M213_I2.0940.74
284_R291_A2.0900.74
148_E151_K2.0560.72
275_Y295_Q2.0550.72
272_H278_K2.0470.72
150_L163_L2.0030.70
281_E295_Q1.9990.70
276_H295_Q1.9910.70
318_G322_V1.9870.70
275_Y278_K1.9600.68
119_E126_R1.9600.68
272_H287_V1.8850.65
137_L140_D1.8640.64
276_H281_E1.8180.62
139_L165_I1.8150.62
281_E287_V1.8100.62
280_E287_V1.8070.62
278_K281_E1.7900.61
277_H280_E1.7710.60
330_G335_H1.7520.59
277_H287_V1.7480.59
124_L137_L1.7360.59
275_Y284_R1.7330.59
273_F291_A1.7300.58
227_N231_T1.7240.58
317_G321_I1.7120.58
275_Y283_E1.7080.57
330_G333_F1.7050.57
278_K287_V1.7020.57
228_K232_T1.6890.56
2_C6_G1.6820.56
272_H285_E1.6740.56
41_V74_V1.6640.55
278_K284_R1.6500.55
269_T273_F1.6310.54
278_K291_A1.6130.53
281_E284_R1.6080.53
275_Y281_E1.6060.53
271_I280_E1.5900.52
333_F336_E1.5890.52
272_H280_E1.5840.52
277_H281_E1.5780.51
284_R287_V1.5660.51
280_E284_R1.5660.51
330_G334_A1.5590.50
304_D309_I1.5530.50
283_E295_Q1.5520.50
275_Y280_E1.5290.49
272_H275_Y1.5200.48
287_V294_L1.5130.48
229_L232_T1.4850.47
32_R35_D1.4830.47
285_E295_Q1.4760.46
273_F294_L1.4630.46
298_L302_N1.4610.46
62_E65_Y1.4480.45
278_K285_E1.4270.44
341_R347_S1.4160.44
271_I278_K1.4160.44
286_A295_Q1.4150.44
285_E291_A1.4030.43
280_E294_L1.3970.43
278_K295_Q1.3660.41
139_L150_L1.3650.41
272_H276_H1.3630.41
276_H284_R1.3530.41
6_G38_G1.3420.40
272_H291_A1.3340.40
332_E342_N1.3320.40
200_D204_D1.3260.39
271_I295_Q1.3240.39
281_E288_R1.3200.39
126_R134_I1.3170.39
233_L236_M1.3120.39
306_F309_I1.3090.39
286_A291_A1.3080.39
285_E292_E1.3070.39
285_E289_K1.3000.38
209_D237_E1.2980.38
282_K286_A1.2960.38
273_F290_I1.2950.38
318_G323_K1.2910.38
119_E336_E1.2880.38
106_V209_D1.2870.38
268_V273_F1.2850.38
284_R295_Q1.2770.37
330_G339_P1.2750.37
1_M6_G1.2740.37
299_L306_F1.2620.37
319_G322_V1.2620.37
269_T294_L1.2600.36
249_S258_A1.2590.36
286_A294_L1.2590.36
273_F286_A1.2590.36
272_H290_I1.2580.36
278_K294_L1.2530.36
335_H341_R1.2440.36
188_D193_S1.2400.36
161_F197_T1.2280.35
139_L369_E1.2170.35
299_L302_N1.2140.34
300_E303_T1.2130.34
272_H277_H1.2120.34
139_L163_L1.2120.34
275_Y285_E1.2060.34
179_N351_A1.1940.34
280_E289_K1.1910.33
252_L263_R1.1900.33
330_G338_V1.1900.33
361_I364_G1.1870.33
275_Y286_A1.1780.33
334_A338_V1.1760.33
298_L303_T1.1640.32
53_S63_L1.1610.32
342_N363_S1.1600.32
160_S180_F1.1550.32
296_I301_I1.1550.32
249_S255_T1.1540.32
270_L292_E1.1520.32
288_R291_A1.1470.32
273_F292_E1.1460.32
31_D34_R1.1450.32
146_N170_N1.1450.32
334_A339_P1.1450.32
276_H294_L1.1380.31
268_V295_Q1.1340.31
143_W167_D1.1220.31
277_H284_R1.1210.31
249_S256_V1.1120.30
164_V203_F1.1110.30
270_L275_Y1.1100.30
331_A334_A1.0990.30
357_G360_A1.0930.29
333_F338_V1.0930.29
76_I172_D1.0900.29
272_H294_L1.0880.29
374_P381_I1.0880.29
333_F341_R1.0800.29
335_H339_P1.0770.29
282_K291_A1.0670.28
381_I388_S1.0650.28
277_H291_A1.0640.28
59_E215_K1.0630.28
287_V292_E1.0590.28
271_I284_R1.0590.28
154_L157_I1.0560.28
39_I189_H1.0550.28
226_S231_T1.0530.28
332_E335_H1.0530.28
195_F206_K1.0420.28
299_L303_T1.0410.27
292_E295_Q1.0390.27
126_R133_A1.0380.27
316_K321_I1.0360.27
319_G324_D1.0340.27
362_A371_G1.0240.27
284_R288_R1.0220.27
174_I215_K1.0150.26
330_G336_E1.0100.26
271_I291_A1.0090.26
278_K292_E1.0040.26
51_R238_K1.0040.26
13_K209_D0.9990.26
270_L294_L0.9860.25
276_H288_R0.9840.25
321_I324_D0.9830.25
333_F347_S0.9830.25
280_E286_A0.9820.25
319_G323_K0.9760.25
302_N306_F0.9760.25
282_K295_Q0.9740.25
255_T266_H0.9720.25
273_F281_E0.9710.25
281_E294_L0.9700.25
285_E288_R0.9690.25
276_H285_E0.9680.25
271_I276_H0.9650.25
333_F339_P0.9600.25
281_E285_E0.9600.25
269_T291_A0.9590.24
170_N365_I0.9570.24
82_E110_G0.9550.24
249_S264_E0.9540.24
100_I117_E0.9530.24
120_K372_A0.9480.24
42_I361_I0.9470.24
320_E324_D0.9410.24
270_L276_H0.9370.24
302_N307_K0.9360.24
270_L278_K0.9340.24
227_N234_P0.9290.23
128_T132_S0.9230.23
104_Y167_D0.9220.23
2_C33_G0.9220.23
143_W146_N0.9210.23
11_N103_R0.9190.23
269_T275_Y0.9150.23
339_P347_S0.9150.23
354_E357_G0.9100.23
38_G159_G0.9080.23
155_E232_T0.9050.23
7_V264_E0.9030.23
276_H282_K0.9030.23
332_E341_R0.9010.22
167_D362_A0.9000.22
331_A347_S0.8990.22
254_S257_A0.8980.22
271_I292_E0.8970.22
379_E382_R0.8960.22
275_Y290_I0.8930.22
351_A360_A0.8870.22
290_I295_Q0.8860.22
251_G254_S0.8860.22
226_S234_P0.8850.22
278_K289_K0.8820.22
87_Y133_A0.8820.22
272_H286_A0.8760.22
290_I294_L0.8750.22
54_I217_E0.8730.22
256_V259_T0.8700.21
208_F213_I0.8700.21
335_H347_S0.8690.21
256_V262_L0.8670.21
228_K234_P0.8590.21
351_A380_F0.8580.21
177_A192_E0.8510.21
126_R164_V0.8490.21
296_I311_H0.8470.21
227_N232_T0.8440.21
277_H295_Q0.8430.21
273_F285_E0.8430.21
281_E286_A0.8420.21
309_I313_T0.8390.21
276_H286_A0.8360.20
180_F351_A0.8360.20
57_P215_K0.8330.20
275_Y292_E0.8330.20
271_I281_E0.8320.20
256_V264_E0.8280.20
281_E290_I0.8230.20
197_T346_F0.8220.20
364_G370_A0.8220.20
269_T295_Q0.8190.20
330_G341_R0.8180.20
271_I277_H0.8180.20
301_I304_D0.8160.20
243_R260_K0.8160.20
289_K295_Q0.8150.20
158_K237_E0.8150.20
332_E363_S0.8130.20
269_T287_V0.8120.20
168_K361_I0.8110.20
24_S62_E0.8090.20
2_C32_R0.8090.20
61_E117_E0.8090.20
148_E231_T0.8070.20
306_F311_H0.8040.19
249_S260_K0.8020.19
334_A347_S0.8010.19
158_K236_M0.7990.19
270_L291_A0.7940.19
150_L165_I0.7930.19
158_K180_F0.7920.19
268_V276_H0.7890.19
48_V141_K0.7860.19
98_P131_D0.7860.19
109_N131_D0.7860.19
98_P198_S0.7860.19
98_P109_N0.7860.19
109_N198_S0.7860.19
131_D198_S0.7860.19
280_E285_E0.7850.19
242_Y249_S0.7810.19
14_N20_L0.7800.19
124_L140_D0.7730.19
330_G342_N0.7700.18
123_E128_T0.7690.18
272_H284_R0.7640.18
188_D192_E0.7590.18
298_L306_F0.7590.18
155_E185_M0.7580.18
383_M390_Y0.7580.18
249_S259_T0.7580.18
130_I339_P0.7580.18
278_K282_K0.7560.18
233_L253_D0.7550.18
25_I184_Y0.7540.18
124_L134_I0.7540.18
35_D182_P0.7530.18
179_N216_L0.7520.18
102_D117_E0.7500.18
219_Y222_V0.7480.18
364_G369_E0.7480.18
271_I294_L0.7480.18
203_F212_N0.7470.18
58_S67_I0.7460.18
268_V291_A0.7460.18
67_I170_N0.7430.18
271_I286_A0.7380.18
59_E241_K0.7370.18
298_L301_I0.7360.17
276_H289_K0.7360.17
101_G364_G0.7350.17
300_E306_F0.7320.17
283_E290_I0.7310.17
329_E339_P0.7310.17
273_F282_K0.7280.17
221_V228_K0.7230.17
254_S351_A0.7220.17
128_T133_A0.7190.17
180_F237_E0.7190.17
282_K294_L0.7140.17
56_K115_D0.7140.17
20_L72_S0.7140.17
219_Y233_L0.7090.17
316_K322_V0.7060.17
329_E334_A0.7060.17
41_V186_A0.7040.17
129_K146_N0.7020.17
138_L186_A0.7000.17
101_G124_L0.6970.16
1_M33_G0.6970.16
255_T258_A0.6940.16
289_K319_G0.6940.16
385_N389_P0.6930.16
287_V304_D0.6920.16
268_V275_Y0.6920.16
274_N287_V0.6920.16
160_S349_S0.6910.16
268_V272_H0.6910.16
278_K288_R0.6910.16
46_G253_D0.6900.16
251_G260_K0.6890.16
269_T272_H0.6890.16
167_D253_D0.6880.16
316_K319_G0.6870.16
272_H281_E0.6860.16
130_I335_H0.6840.16
306_F310_G0.6840.16
176_L179_N0.6830.16
204_D263_R0.6810.16
377_E381_I0.6810.16
297_P307_K0.6800.16
271_I285_E0.6780.16
114_N159_G0.6780.16
242_Y258_A0.6730.16
258_A264_E0.6710.16
272_H292_E0.6690.16
2_C5_S0.6680.16
96_I119_E0.6680.16
140_D170_N0.6670.16
85_T111_I0.6660.16
323_K330_G0.6650.16
43_Q51_R0.6650.16
296_I299_L0.6640.16
263_R305_L0.6620.16
271_I287_V0.6610.16
47_T120_K0.6590.15
209_D239_R0.6580.15
333_F356_Y0.6550.15
18_V22_L0.6520.15
113_A199_L0.6510.15
112_I295_Q0.6500.15
309_I312_A0.6500.15
232_T236_M0.6470.15
284_R294_L0.6450.15
360_A365_I0.6450.15
20_L74_V0.6410.15
333_F342_N0.6410.15
145_G253_D0.6400.15
39_I49_K0.6370.15
309_I315_I0.6370.15
296_I302_N0.6340.15
123_E132_S0.6310.15
135_L153_I0.6300.15
295_Q311_H0.6300.15
146_N253_D0.6300.15
276_H283_E0.6300.15
88_V106_V0.6290.15
179_N254_S0.6290.15
336_E341_R0.6270.15
289_K294_L0.6270.15
281_E289_K0.6250.15
138_L157_I0.6250.15
49_K144_D0.6250.15
226_S230_I0.6240.15
285_E294_L0.6220.15
160_S179_N0.6210.15
26_L30_E0.6210.15
255_T260_K0.6200.15
48_V67_I0.6180.14
269_T285_E0.6170.14
22_L143_W0.6160.14
274_N283_E0.6140.14
25_I29_A0.6130.14
66_G172_D0.6130.14
273_F277_H0.6120.14
49_K226_S0.6110.14
297_P301_I0.6110.14
1_M5_S0.6100.14
270_L287_V0.6100.14
83_P199_L0.6090.14
157_I233_L0.6090.14
277_H283_E0.6090.14
36_S123_E0.6080.14
256_V260_K0.6080.14
135_L170_N0.6060.14
300_E304_D0.6060.14
164_V212_N0.6030.14
329_E335_H0.6030.14
232_T235_I0.6020.14
278_K290_I0.6000.14
304_D308_I0.6000.14
47_T94_D0.6000.14
144_D148_E0.6000.14
335_H342_N0.5990.14
197_T348_V0.5950.14
311_H315_I0.5940.14
335_H338_V0.5940.14
274_N277_H0.5940.14
6_G159_G0.5930.14
36_S128_T0.5920.14
83_P113_A0.5920.14
269_T278_K0.5920.14
268_V294_L0.5910.14
280_E290_I0.5910.14
140_D252_L0.5910.14
268_V284_R0.5900.14
49_K189_H0.5890.14
331_A335_H0.5890.14
249_S252_L0.5890.14
289_K293_Y0.5890.14
48_V150_L0.5870.14
192_E195_F0.5860.14
119_E137_L0.5850.14
384_L389_P0.5840.14
62_E233_L0.5820.14
47_T146_N0.5810.14
243_R249_S0.5790.14
335_H340_A0.5780.14
331_A341_R0.5750.14
86_E169_K0.5740.13
1_M32_R0.5740.13
73_R231_T0.5720.13
289_K309_I0.5720.13
34_R83_P0.5720.13
339_P342_N0.5700.13
351_A370_A0.5680.13
115_D157_I0.5670.13
359_D364_G0.5660.13
144_D170_N0.5640.13
324_D329_E0.5640.13
135_L192_E0.5630.13
124_L141_K0.5620.13
269_T284_R0.5620.13
106_V137_L0.5620.13
209_D235_I0.5590.13
169_K173_R0.5590.13
337_W341_R0.5560.13
104_Y120_K0.5550.13
185_M238_K0.5550.13
186_A207_P0.5530.13
291_A304_D0.5520.13
255_T264_E0.5520.13
372_A375_D0.5520.13
309_I314_L0.5510.13
242_Y256_V0.5510.13
156_Q223_M0.5490.13
299_L304_D0.5470.13
142_T153_I0.5470.13
332_E347_S0.5460.13
331_A339_P0.5460.13
303_T306_F0.5440.13
355_A361_I0.5430.13
186_A192_E0.5420.13
46_G360_A0.5410.13
204_D361_I0.5400.13
341_R356_Y0.5390.13
284_R289_K0.5390.13
120_K230_I0.5360.13
291_A298_L0.5360.13
302_N305_L0.5350.13
153_I165_I0.5330.13
33_G98_P0.5330.13
33_G131_D0.5330.13
33_G198_S0.5330.13
33_G109_N0.5330.13
287_V290_I0.5320.13
302_N310_G0.5320.13
84_T122_Y0.5320.13
380_F385_N0.5300.13
156_Q235_I0.5300.13
127_K230_I0.5290.13
89_R186_A0.5290.13
39_I174_I0.5270.12
12_P225_T0.5260.12
170_N252_L0.5260.12
59_E239_R0.5260.12
73_R232_T0.5230.12
249_S263_R0.5220.12
270_L280_E0.5220.12
152_G157_I0.5220.12
2_C35_D0.5220.12
170_N245_L0.5210.12
203_F211_V0.5210.12
41_V141_K0.5210.12
253_D257_A0.5210.12
111_I199_L0.5190.12
255_T259_T0.5180.12
102_D137_L0.5150.12
230_I245_L0.5140.12
248_A255_T0.5110.12
386_K390_Y0.5100.12
242_Y259_T0.5090.12
271_I275_Y0.5090.12
150_L351_A0.5080.12
298_L305_L0.5080.12
62_E71_D0.5070.12
125_K231_T0.5070.12
142_T152_G0.5070.12
161_F179_N0.5060.12
104_Y155_E0.5060.12
27_K224_V0.5040.12
49_K145_G0.5020.12
112_I253_D0.5020.12
140_D161_F0.5020.12
175_F178_Q0.5010.12
117_E315_I0.5000.12
2_C109_N0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ct9A 2 0.8578 100 0.569 Contact Map
1jgtA 2 0.8319 100 0.61 Contact Map
4amvA 2 0.9246 100 0.625 Contact Map
1q15A 3 0.8082 100 0.64 Contact Map
1xffA 2 0.4957 100 0.687 Contact Map
1ao0A 3 0.8578 100 0.725 Contact Map
1ecfA 4 0.8836 100 0.731 Contact Map
1te5A 2 0.444 100 0.741 Contact Map
3mdnA 4 0.4224 100 0.746 Contact Map
4zflA 5 0.4612 100 0.748 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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