GREMLIN Database
Q981C6 - Molybdenum cofactor biosynthesis protein B (MoaB)
UniProt: Q981C6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 182 (145)
Sequences: 7921 (5249)
Seq/√Len: 435.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_Y85_T3.6661.00
73_L108_R3.4591.00
52_I57_Y3.2291.00
124_V127_N2.4781.00
51_L165_K2.2031.00
69_K108_R2.1951.00
107_R113_E2.1451.00
119_D122_R2.0391.00
69_K73_L2.0211.00
60_I85_T2.0051.00
47_I161_R1.8801.00
66_P71_K1.8611.00
21_F52_I1.8151.00
73_L77_A1.8141.00
49_K53_I1.7941.00
20_N58_N1.7821.00
151_F168_I1.7661.00
68_E71_K1.7511.00
28_T99_S1.7381.00
63_E75_A1.7321.00
69_K105_T1.7261.00
23_V49_K1.7241.00
106_I152_L1.7011.00
31_Y39_P1.6881.00
75_A78_N1.6641.00
24_I79_A1.6561.00
55_S164_M1.6321.00
22_Y79_A1.6261.00
77_A109_I1.6221.00
69_K104_E1.6221.00
55_S169_L1.5431.00
73_L109_I1.5231.00
169_L173_G1.5211.00
96_Y114_I1.5091.00
164_M168_I1.4961.00
20_N60_I1.4351.00
122_R167_L1.3941.00
48_I164_M1.3821.00
65_V75_A1.3791.00
18_N58_N1.3721.00
106_I150_I1.3701.00
44_S91_T1.3491.00
80_L148_K1.3451.00
49_K62_Y1.3391.00
87_V172_I1.3161.00
25_T91_T1.2771.00
32_E39_P1.2681.00
88_I148_K1.2491.00
43_E157_P1.2361.00
151_F171_E1.2161.00
75_A79_A1.1971.00
111_D146_N1.1911.00
113_E136_Y1.1891.00
120_V167_L1.1751.00
24_I75_A1.1561.00
71_K75_A1.1301.00
120_V123_L1.1291.00
30_R40_L1.1281.00
26_I72_I1.1281.00
70_V74_K1.1271.00
26_I65_V1.1211.00
52_I59_I1.1121.00
74_K78_N1.1091.00
51_L164_M1.0891.00
158_D162_L1.0831.00
70_V73_L1.0801.00
22_Y62_Y1.0711.00
52_I164_M1.0701.00
133_S152_L1.0621.00
78_N84_Q1.0531.00
29_S40_L1.0521.00
47_I157_P1.0501.00
90_S150_I1.0451.00
71_K74_K1.0431.00
28_T66_P1.0421.00
24_I65_V1.0341.00
93_G102_T1.0271.00
47_I51_L1.0241.00
63_E78_N1.0241.00
50_Q54_Q1.0211.00
104_E107_R1.0191.00
153_L163_A1.0121.00
51_L55_S0.9851.00
89_I153_L0.9841.00
73_L105_T0.9821.00
165_K169_L0.9781.00
69_K101_V0.9751.00
42_D45_G0.9751.00
46_D50_Q0.9711.00
32_E46_D0.9671.00
25_T45_G0.9571.00
123_L127_N0.9271.00
81_D84_Q0.9231.00
117_F134_A0.9201.00
23_V59_I0.9171.00
103_V118_S0.9151.00
81_D146_N0.9061.00
47_I160_V0.9051.00
47_I50_Q0.9041.00
62_Y85_T0.8991.00
45_G61_G0.8941.00
121_F163_A0.8831.00
87_V151_F0.8821.00
62_Y79_A0.8781.00
115_E136_Y0.8711.00
122_R163_A0.8661.00
132_K167_L0.8591.00
103_V107_R0.8551.00
89_I168_I0.8521.00
173_G178_I0.8501.00
24_I63_E0.8491.00
25_T64_L0.8471.00
69_K72_I0.8461.00
42_D46_D0.8441.00
48_I91_T0.8221.00
68_E72_I0.8211.00
26_I102_T0.8161.00
21_F57_Y0.8101.00
19_I57_Y0.8101.00
79_A85_T0.8051.00
31_Y41_I0.8041.00
77_A146_N0.7951.00
161_R165_K0.7941.00
32_E42_D0.7941.00
134_A149_V0.7881.00
49_K59_I0.7861.00
72_I105_T0.7831.00
20_N86_D0.7711.00
17_T86_D0.7691.00
23_V52_I0.7661.00
25_T42_D0.7591.00
16_P176_L0.7491.00
76_F106_I0.7461.00
46_D62_Y0.7441.00
56_N59_I0.7441.00
164_M169_L0.7391.00
112_R135_S0.7361.00
118_S133_S0.7281.00
126_Y159_A0.7111.00
62_Y84_Q0.7051.00
134_A151_F0.7041.00
125_S163_A0.7011.00
118_S122_R0.6951.00
20_N85_T0.6941.00
163_A167_L0.6941.00
51_L161_R0.6921.00
149_V175_L0.6791.00
72_I101_V0.6771.00
90_S102_T0.6741.00
49_K61_G0.6701.00
42_D64_L0.6701.00
21_F87_V0.6691.00
115_E118_S0.6671.00
25_T63_E0.6671.00
132_K163_A0.6621.00
173_G176_L0.6601.00
105_T109_I0.6601.00
80_L88_I0.6571.00
120_V126_Y0.6430.99
23_V45_G0.6400.99
90_S152_L0.6380.99
153_L160_V0.6330.99
78_N81_D0.6320.99
154_P159_A0.6320.99
52_I89_I0.6310.99
22_Y61_G0.6310.99
29_S39_P0.6300.99
137_L146_N0.6180.99
76_F90_S0.6170.99
175_L178_I0.6120.99
60_I84_Q0.6100.99
94_T152_L0.6080.99
48_I153_L0.6070.99
79_A88_I0.6050.99
48_I160_V0.6040.99
87_V149_V0.6020.99
23_V48_I0.6000.99
65_V71_K0.5980.99
94_T102_T0.5980.99
57_Y172_I0.5980.99
124_V167_L0.5960.99
77_A81_D0.5960.99
120_V132_K0.5870.99
123_L126_Y0.5870.99
171_E175_L0.5860.99
80_L146_N0.5820.99
120_V124_V0.5810.99
53_I58_N0.5770.99
101_V104_E0.5740.99
96_Y119_D0.5720.99
76_F88_I0.5680.99
114_I118_S0.5640.99
90_S106_I0.5630.98
87_V175_L0.5560.98
67_D155_G0.5560.98
103_V133_S0.5560.98
154_P163_A0.5520.98
94_T103_V0.5490.98
50_Q53_I0.5490.98
26_I90_S0.5480.98
72_I76_F0.5460.98
90_S94_T0.5370.98
68_E101_V0.5320.98
106_I112_R0.5290.98
104_E108_R0.5270.98
25_T44_S0.5260.98
102_T150_I0.5240.98
81_D85_T0.5190.97
55_S173_G0.5140.97
45_G62_Y0.5140.97
32_E62_Y0.5130.97
105_T108_R0.5120.97
112_R137_L0.5070.97
85_T88_I0.5050.97
95_G127_N0.5040.97
136_Y149_V0.5030.97
113_E118_S0.5010.97
149_V171_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pd0A 2 0.9396 100 0.219 Contact Map
1g8lA 2 0.9066 100 0.23 Contact Map
1uz5A 1 0.8791 100 0.233 Contact Map
1wu2A 2 0.8242 100 0.272 Contact Map
1jljA 3 0.8297 100 0.305 Contact Map
4lhbA 4 0.8297 100 0.307 Contact Map
3rfqA 5 0.8407 100 0.31 Contact Map
3iwtA 4 0.8736 100 0.319 Contact Map
1y5eA 4 0.8516 100 0.328 Contact Map
1di6A 3 0.8077 100 0.343 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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