Q981C5 - SULSO - GREMLIN Contacts

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Q981C5 - Uncharacterized protein

UniProt:	Q981C5	Sequences: MIVEGYFLKYRDVIWSIKGCYHPDGYAVAIPRLFNGVKIKRLNDALEVVRTKFSNLLKYVDEIGFNVPLVPLNESEILDPFNAKIFNNRVREFLRFFNGDVGITGSYLYLGKGNDMDFLSFKPEHYYVLEELRKKGITKPLSTVEESEIETLDYSSFKILKSKRILEGIFEGRGYTFKIVQCEKFGPVREVKEFEGYVRILKSIKPFTIPVKYLVTDNHGNEYILTSFRTRFTELLPNMEIFIKGKILVRDEFNDMDLDIAEIVKLKSF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (251)
Sequences:	139 (126)
Seq/√Len:	8.0

SULSO - Q981C5 Q980R7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
200_I	241_I	4.388	0.99
171_E	200_I	3.085	0.89
35_N	243_I	2.893	0.85
155_S	162_S	2.794	0.83
101_V	233_T	2.625	0.79
8_L	70_V	2.591	0.78
200_I	225_L	2.526	0.76
229_R	234_E	2.463	0.74
12_D	93_F	2.459	0.74
198_V	217_D	2.458	0.74
32_R	176_T	2.423	0.73
194_F	247_I	2.405	0.72
76_E	101_V	2.374	0.71
20_C	157_F	2.328	0.70
22_H	183_E	2.281	0.68
236_L	241_I	2.248	0.67
189_R	249_V	2.165	0.64
75_S	199_R	2.139	0.63
53_F	198_V	2.132	0.63
127_Y	138_T	2.061	0.60
164_R	175_Y	2.028	0.59
104_T	108_L	2.018	0.58
16_S	30_I	2.017	0.58
167_E	178_K	1.994	0.57
148_E	175_Y	1.899	0.53
22_H	79_D	1.871	0.52
161_K	164_R	1.858	0.52
32_R	38_K	1.844	0.51
157_F	230_T	1.833	0.51
8_L	84_K	1.791	0.49
24_D	184_K	1.789	0.49
27_A	75_S	1.787	0.49
148_E	164_R	1.786	0.49
129_L	177_F	1.766	0.48
176_T	229_R	1.754	0.47
27_A	93_F	1.745	0.47
79_D	183_E	1.716	0.46
194_F	256_M	1.713	0.46
66_N	142_S	1.706	0.45
38_K	41_R	1.693	0.45
38_K	45_A	1.685	0.45
104_T	242_F	1.672	0.44
161_K	229_R	1.661	0.44
114_N	164_R	1.643	0.43
176_T	230_T	1.639	0.43
97_F	135_K	1.632	0.42
60_V	63_I	1.628	0.42
93_F	191_V	1.627	0.42
32_R	207_F	1.626	0.42
173_R	243_I	1.609	0.42
194_F	243_I	1.607	0.41
231_R	234_E	1.603	0.41
117_D	210_P	1.587	0.41
115_D	210_P	1.587	0.41
9_K	76_E	1.580	0.40
31_P	234_E	1.572	0.40
82_N	124_E	1.560	0.40
176_T	231_R	1.549	0.39
160_L	235_L	1.546	0.39
131_E	199_R	1.529	0.38
214_L	254_N	1.508	0.38
78_L	227_S	1.470	0.36
98_N	221_N	1.460	0.36
175_Y	235_L	1.459	0.36
126_Y	176_T	1.452	0.35
148_E	161_K	1.437	0.35
92_E	247_I	1.436	0.35
114_N	161_K	1.425	0.34
31_P	229_R	1.408	0.34
70_V	153_D	1.402	0.34
161_K	234_E	1.396	0.33
148_E	258_L	1.389	0.33
80_P	102_G	1.388	0.33
176_T	234_E	1.377	0.33
145_E	163_K	1.357	0.32
207_F	228_F	1.355	0.32
63_I	253_F	1.347	0.32
19_G	180_V	1.346	0.32
176_T	208_T	1.344	0.32
198_V	215_V	1.328	0.31
16_S	32_R	1.315	0.31
114_N	121_F	1.276	0.29
78_L	108_L	1.268	0.29
161_K	176_T	1.263	0.29
12_D	109_Y	1.237	0.28
239_M	248_L	1.235	0.28
166_L	232_F	1.229	0.28
81_F	183_E	1.217	0.27
32_R	229_R	1.210	0.27
131_E	189_R	1.193	0.26
19_G	67_V	1.190	0.26
49_V	56_L	1.174	0.26
188_V	250_R	1.171	0.26
110_L	119_L	1.170	0.26
16_S	116_M	1.157	0.25
91_R	130_E	1.154	0.25
119_L	136_G	1.148	0.25
201_L	240_E	1.143	0.25
236_L	239_M	1.140	0.25
178_K	229_R	1.133	0.25
103_I	121_F	1.124	0.24
129_L	242_F	1.120	0.24
35_N	71_P	1.115	0.24
101_V	116_M	1.102	0.24
168_G	175_Y	1.090	0.23
68_P	174_G	1.088	0.23
139_K	199_R	1.087	0.23
8_L	237_P	1.084	0.23
101_V	118_F	1.084	0.23
77_I	227_S	1.081	0.23
34_F	103_I	1.078	0.23
80_P	168_G	1.070	0.23
60_V	253_F	1.068	0.23
39_I	54_S	1.065	0.23
92_E	171_E	1.064	0.23
32_R	248_L	1.060	0.22
22_H	149_I	1.041	0.22
178_K	230_T	1.036	0.22
97_F	257_D	1.034	0.22
166_L	234_E	1.024	0.21
50_R	84_K	1.021	0.21
90_V	97_F	1.020	0.21
76_E	88_N	1.018	0.21
146_E	225_L	1.015	0.21
134_K	250_R	1.011	0.21
162_S	177_F	1.010	0.21
27_A	104_T	1.007	0.21
199_R	215_V	1.005	0.21
188_V	226_T	1.004	0.21
71_P	238_N	0.999	0.21
124_E	131_E	0.998	0.21
105_G	117_D	0.987	0.20
105_G	115_D	0.987	0.20
105_G	210_P	0.987	0.20
23_P	179_I	0.983	0.20
140_P	184_K	0.978	0.20
68_P	160_L	0.974	0.20
195_E	244_K	0.973	0.20
11_R	103_I	0.968	0.20
152_L	227_S	0.963	0.20
13_V	70_V	0.962	0.20
96_F	116_M	0.959	0.20
67_V	119_L	0.955	0.20
38_K	54_S	0.952	0.20
35_N	173_R	0.949	0.19
8_L	113_G	0.947	0.19
15_W	126_Y	0.942	0.19
161_K	239_M	0.940	0.19
121_F	125_H	0.939	0.19
114_N	259_D	0.932	0.19
147_S	244_K	0.931	0.19
140_P	153_D	0.929	0.19
176_T	236_L	0.929	0.19
64_G	126_Y	0.921	0.19
12_D	136_G	0.920	0.19
75_S	114_N	0.915	0.19
61_D	107_Y	0.914	0.19
85_I	89_R	0.909	0.18
16_S	80_P	0.901	0.18
65_F	212_K	0.900	0.18
16_S	176_T	0.894	0.18
164_R	239_M	0.894	0.18
44_D	191_V	0.892	0.18
64_G	247_I	0.884	0.18
51_T	93_F	0.882	0.18
24_D	73_N	0.878	0.18
75_S	124_E	0.877	0.18
173_R	230_T	0.868	0.17
20_C	208_T	0.868	0.17
49_V	159_I	0.866	0.17
37_V	252_E	0.858	0.17
160_L	176_T	0.857	0.17
157_F	176_T	0.857	0.17
113_G	155_S	0.856	0.17
44_D	47_E	0.852	0.17
78_L	109_Y	0.842	0.17
145_E	232_F	0.842	0.17
89_R	173_R	0.842	0.17
178_K	259_D	0.842	0.17
147_S	167_E	0.841	0.17
160_L	175_Y	0.840	0.17
26_Y	173_R	0.837	0.17
106_S	210_P	0.836	0.17
106_S	115_D	0.836	0.17
106_S	117_D	0.836	0.17
126_Y	233_T	0.836	0.17
29_A	65_F	0.830	0.17
61_D	146_E	0.829	0.17
68_P	166_L	0.810	0.16
121_F	259_D	0.809	0.16
14_I	103_I	0.806	0.16
96_F	101_V	0.804	0.16
217_D	242_F	0.803	0.16
203_S	237_P	0.801	0.16
50_R	72_L	0.800	0.16
177_F	248_L	0.795	0.16
84_K	91_R	0.793	0.16
95_R	206_P	0.790	0.16
119_L	241_I	0.787	0.16
13_V	226_T	0.780	0.15
46_L	61_D	0.780	0.15
84_K	139_K	0.779	0.15
78_L	168_G	0.778	0.15
69_L	93_F	0.776	0.15
200_I	205_K	0.775	0.15
167_E	259_D	0.772	0.15
114_N	148_E	0.769	0.15
14_I	40_K	0.769	0.15
67_V	222_E	0.769	0.15
37_V	189_R	0.769	0.15
27_A	196_G	0.766	0.15
19_G	140_P	0.765	0.15
59_Y	243_I	0.761	0.15
68_P	177_F	0.759	0.15
101_V	182_C	0.758	0.15
178_K	234_E	0.756	0.15
79_D	133_R	0.752	0.15
139_K	155_S	0.749	0.15
157_F	161_K	0.748	0.15
182_C	200_I	0.747	0.15
164_R	177_F	0.746	0.15
131_E	136_G	0.743	0.15
9_K	56_L	0.741	0.15
126_Y	231_R	0.739	0.15
16_S	175_Y	0.736	0.15
199_R	240_E	0.736	0.15
155_S	221_N	0.733	0.14
15_W	119_L	0.732	0.14
75_S	196_G	0.731	0.14
15_W	233_T	0.730	0.14
21_Y	224_I	0.729	0.14
13_V	67_V	0.729	0.14
23_P	64_G	0.727	0.14
38_K	57_L	0.724	0.14
145_E	234_E	0.723	0.14
38_K	63_I	0.722	0.14
90_V	212_K	0.721	0.14
231_R	259_D	0.715	0.14
53_F	78_L	0.715	0.14
153_D	240_E	0.713	0.14
232_F	245_G	0.710	0.14
45_A	54_S	0.709	0.14
82_N	94_L	0.707	0.14
102_G	114_N	0.707	0.14
16_S	229_R	0.702	0.14
130_E	134_K	0.694	0.14
161_K	208_T	0.690	0.14
166_L	229_R	0.689	0.14
89_R	120_S	0.686	0.14
14_I	146_E	0.686	0.14
94_L	151_T	0.684	0.14
76_E	112_K	0.681	0.13
31_P	231_R	0.680	0.13
20_C	230_T	0.679	0.13
31_P	259_D	0.678	0.13
157_F	167_E	0.678	0.13
129_L	254_N	0.672	0.13
49_V	232_F	0.666	0.13
188_V	243_I	0.666	0.13
20_C	167_E	0.666	0.13
92_E	195_E	0.662	0.13
64_G	190_E	0.661	0.13
86_F	89_R	0.658	0.13
55_N	202_K	0.657	0.13
161_K	235_L	0.650	0.13
24_D	88_N	0.648	0.13
209_I	259_D	0.648	0.13
86_F	247_I	0.646	0.13
49_V	57_L	0.645	0.13
134_K	158_K	0.645	0.13
49_V	104_T	0.645	0.13
39_I	146_E	0.642	0.13
97_F	170_F	0.639	0.13
224_I	255_D	0.638	0.13
229_R	235_L	0.637	0.13
121_F	258_L	0.636	0.13
84_K	194_F	0.633	0.13
132_L	226_T	0.632	0.13
20_C	32_R	0.628	0.12
25_G	199_R	0.627	0.12
200_I	213_Y	0.626	0.12
36_G	145_E	0.626	0.12
178_K	181_Q	0.623	0.12
28_V	253_F	0.622	0.12
8_L	27_A	0.620	0.12
78_L	200_I	0.619	0.12
90_V	116_M	0.617	0.12
34_F	162_S	0.617	0.12
195_E	242_F	0.616	0.12
243_I	256_M	0.616	0.12
46_L	49_V	0.612	0.12
213_Y	250_R	0.611	0.12
78_L	189_R	0.610	0.12
59_Y	189_R	0.608	0.12
32_R	236_L	0.607	0.12
65_F	119_L	0.606	0.12
161_K	231_R	0.606	0.12
155_S	180_V	0.605	0.12
109_Y	206_P	0.604	0.12
62_E	184_K	0.602	0.12
92_E	154_Y	0.600	0.12
32_R	161_K	0.600	0.12
79_D	214_L	0.600	0.12
196_G	217_D	0.598	0.12
23_P	246_K	0.597	0.12
209_I	243_I	0.597	0.12
92_E	257_D	0.596	0.12
166_L	231_R	0.596	0.12
64_G	128_V	0.596	0.12
80_P	105_G	0.594	0.12
20_C	164_R	0.594	0.12
79_D	165_I	0.593	0.12
19_G	22_H	0.590	0.12
12_D	241_I	0.586	0.12
30_I	176_T	0.582	0.12
209_I	247_I	0.580	0.12
152_L	157_F	0.580	0.12
100_D	103_I	0.579	0.12
163_K	234_E	0.576	0.12
32_R	230_T	0.576	0.12
31_P	175_Y	0.576	0.12
157_F	181_Q	0.575	0.12
12_D	85_I	0.572	0.12
116_M	216_T	0.571	0.11
155_S	184_K	0.569	0.11
63_I	132_L	0.566	0.11
58_K	75_S	0.564	0.11
58_K	73_N	0.563	0.11
114_N	225_L	0.562	0.11
14_I	70_V	0.561	0.11
103_I	189_R	0.561	0.11
212_K	216_T	0.561	0.11
62_E	215_V	0.558	0.11
168_G	172_G	0.557	0.11
114_N	232_F	0.556	0.11
99_G	140_P	0.555	0.11
19_G	28_V	0.553	0.11
37_V	215_V	0.553	0.11
32_R	157_F	0.553	0.11
169_I	251_D	0.552	0.11
94_L	256_M	0.552	0.11
240_E	249_V	0.548	0.11
31_P	166_L	0.548	0.11
93_F	211_V	0.548	0.11
27_A	197_Y	0.541	0.11
148_E	239_M	0.541	0.11
231_R	248_L	0.540	0.11
51_T	215_V	0.539	0.11
16_S	168_G	0.538	0.11
80_P	239_M	0.537	0.11
25_G	61_D	0.535	0.11
54_S	85_I	0.533	0.11
78_L	205_K	0.531	0.11
50_R	214_L	0.530	0.11
147_S	208_T	0.530	0.11
88_N	130_E	0.529	0.11
234_E	259_D	0.524	0.11
200_I	254_N	0.523	0.11
39_I	73_N	0.522	0.11
69_L	144_V	0.520	0.11
46_L	147_S	0.519	0.11
66_N	200_I	0.519	0.11
39_I	90_V	0.516	0.11
7_F	69_L	0.516	0.11
149_I	250_R	0.515	0.11
27_A	76_E	0.514	0.11
82_N	136_G	0.514	0.11
53_F	149_I	0.512	0.11
153_D	246_K	0.510	0.11
54_S	57_L	0.509	0.11
9_K	158_K	0.508	0.10
176_T	239_M	0.508	0.10
185_F	201_L	0.507	0.10
142_S	207_F	0.506	0.10
93_F	116_M	0.506	0.10
176_T	207_F	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ylqA	2	0.316	66.2	0.955	Contact Map
1wotA	1	0.3532	63.8	0.955	Contact Map
4cs6A	1	0.6989	55.4	0.958	Contact Map
4mkmA	1	0.2751	54.6	0.958	Contact Map
1no5A	4	0.3643	50	0.959	Contact Map
3nybA	1	0.5985	44.6	0.96	Contact Map
2pbeA	1	0.6245	44	0.96	Contact Map
1jajA	1	0.5836	37.8	0.962	Contact Map
4s3nA	1	0.6691	35.5	0.962	Contact Map
3jz0A	2	0.6431	35.1	0.962	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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