GREMLIN Database
Q981C5 - Uncharacterized protein
UniProt: Q981C5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (251)
Sequences: 139 (126)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
200_I241_I4.3880.99
171_E200_I3.0850.89
35_N243_I2.8930.85
155_S162_S2.7940.83
101_V233_T2.6250.79
8_L70_V2.5910.78
200_I225_L2.5260.76
229_R234_E2.4630.74
12_D93_F2.4590.74
198_V217_D2.4580.74
32_R176_T2.4230.73
194_F247_I2.4050.72
76_E101_V2.3740.71
20_C157_F2.3280.70
22_H183_E2.2810.68
236_L241_I2.2480.67
189_R249_V2.1650.64
75_S199_R2.1390.63
53_F198_V2.1320.63
127_Y138_T2.0610.60
164_R175_Y2.0280.59
104_T108_L2.0180.58
16_S30_I2.0170.58
167_E178_K1.9940.57
148_E175_Y1.8990.53
22_H79_D1.8710.52
161_K164_R1.8580.52
32_R38_K1.8440.51
157_F230_T1.8330.51
8_L84_K1.7910.49
24_D184_K1.7890.49
27_A75_S1.7870.49
148_E164_R1.7860.49
129_L177_F1.7660.48
176_T229_R1.7540.47
27_A93_F1.7450.47
79_D183_E1.7160.46
194_F256_M1.7130.46
66_N142_S1.7060.45
38_K41_R1.6930.45
38_K45_A1.6850.45
104_T242_F1.6720.44
161_K229_R1.6610.44
114_N164_R1.6430.43
176_T230_T1.6390.43
97_F135_K1.6320.42
60_V63_I1.6280.42
93_F191_V1.6270.42
32_R207_F1.6260.42
173_R243_I1.6090.42
194_F243_I1.6070.41
231_R234_E1.6030.41
117_D210_P1.5870.41
115_D210_P1.5870.41
9_K76_E1.5800.40
31_P234_E1.5720.40
82_N124_E1.5600.40
176_T231_R1.5490.39
160_L235_L1.5460.39
131_E199_R1.5290.38
214_L254_N1.5080.38
78_L227_S1.4700.36
98_N221_N1.4600.36
175_Y235_L1.4590.36
126_Y176_T1.4520.35
148_E161_K1.4370.35
92_E247_I1.4360.35
114_N161_K1.4250.34
31_P229_R1.4080.34
70_V153_D1.4020.34
161_K234_E1.3960.33
148_E258_L1.3890.33
80_P102_G1.3880.33
176_T234_E1.3770.33
145_E163_K1.3570.32
207_F228_F1.3550.32
63_I253_F1.3470.32
19_G180_V1.3460.32
176_T208_T1.3440.32
198_V215_V1.3280.31
16_S32_R1.3150.31
114_N121_F1.2760.29
78_L108_L1.2680.29
161_K176_T1.2630.29
12_D109_Y1.2370.28
239_M248_L1.2350.28
166_L232_F1.2290.28
81_F183_E1.2170.27
32_R229_R1.2100.27
131_E189_R1.1930.26
19_G67_V1.1900.26
49_V56_L1.1740.26
188_V250_R1.1710.26
110_L119_L1.1700.26
16_S116_M1.1570.25
91_R130_E1.1540.25
119_L136_G1.1480.25
201_L240_E1.1430.25
236_L239_M1.1400.25
178_K229_R1.1330.25
103_I121_F1.1240.24
129_L242_F1.1200.24
35_N71_P1.1150.24
101_V116_M1.1020.24
168_G175_Y1.0900.23
68_P174_G1.0880.23
139_K199_R1.0870.23
8_L237_P1.0840.23
101_V118_F1.0840.23
77_I227_S1.0810.23
34_F103_I1.0780.23
80_P168_G1.0700.23
60_V253_F1.0680.23
39_I54_S1.0650.23
92_E171_E1.0640.23
32_R248_L1.0600.22
22_H149_I1.0410.22
178_K230_T1.0360.22
97_F257_D1.0340.22
166_L234_E1.0240.21
50_R84_K1.0210.21
90_V97_F1.0200.21
76_E88_N1.0180.21
146_E225_L1.0150.21
134_K250_R1.0110.21
162_S177_F1.0100.21
27_A104_T1.0070.21
199_R215_V1.0050.21
188_V226_T1.0040.21
71_P238_N0.9990.21
124_E131_E0.9980.21
105_G117_D0.9870.20
105_G115_D0.9870.20
105_G210_P0.9870.20
23_P179_I0.9830.20
140_P184_K0.9780.20
68_P160_L0.9740.20
195_E244_K0.9730.20
11_R103_I0.9680.20
152_L227_S0.9630.20
13_V70_V0.9620.20
96_F116_M0.9590.20
67_V119_L0.9550.20
38_K54_S0.9520.20
35_N173_R0.9490.19
8_L113_G0.9470.19
15_W126_Y0.9420.19
161_K239_M0.9400.19
121_F125_H0.9390.19
114_N259_D0.9320.19
147_S244_K0.9310.19
140_P153_D0.9290.19
176_T236_L0.9290.19
64_G126_Y0.9210.19
12_D136_G0.9200.19
75_S114_N0.9150.19
61_D107_Y0.9140.19
85_I89_R0.9090.18
16_S80_P0.9010.18
65_F212_K0.9000.18
16_S176_T0.8940.18
164_R239_M0.8940.18
44_D191_V0.8920.18
64_G247_I0.8840.18
51_T93_F0.8820.18
24_D73_N0.8780.18
75_S124_E0.8770.18
173_R230_T0.8680.17
20_C208_T0.8680.17
49_V159_I0.8660.17
37_V252_E0.8580.17
160_L176_T0.8570.17
157_F176_T0.8570.17
113_G155_S0.8560.17
44_D47_E0.8520.17
78_L109_Y0.8420.17
145_E232_F0.8420.17
89_R173_R0.8420.17
178_K259_D0.8420.17
147_S167_E0.8410.17
160_L175_Y0.8400.17
26_Y173_R0.8370.17
106_S210_P0.8360.17
106_S115_D0.8360.17
106_S117_D0.8360.17
126_Y233_T0.8360.17
29_A65_F0.8300.17
61_D146_E0.8290.17
68_P166_L0.8100.16
121_F259_D0.8090.16
14_I103_I0.8060.16
96_F101_V0.8040.16
217_D242_F0.8030.16
203_S237_P0.8010.16
50_R72_L0.8000.16
177_F248_L0.7950.16
84_K91_R0.7930.16
95_R206_P0.7900.16
119_L241_I0.7870.16
13_V226_T0.7800.15
46_L61_D0.7800.15
84_K139_K0.7790.15
78_L168_G0.7780.15
69_L93_F0.7760.15
200_I205_K0.7750.15
167_E259_D0.7720.15
114_N148_E0.7690.15
14_I40_K0.7690.15
67_V222_E0.7690.15
37_V189_R0.7690.15
27_A196_G0.7660.15
19_G140_P0.7650.15
59_Y243_I0.7610.15
68_P177_F0.7590.15
101_V182_C0.7580.15
178_K234_E0.7560.15
79_D133_R0.7520.15
139_K155_S0.7490.15
157_F161_K0.7480.15
182_C200_I0.7470.15
164_R177_F0.7460.15
131_E136_G0.7430.15
9_K56_L0.7410.15
126_Y231_R0.7390.15
16_S175_Y0.7360.15
199_R240_E0.7360.15
155_S221_N0.7330.14
15_W119_L0.7320.14
75_S196_G0.7310.14
15_W233_T0.7300.14
21_Y224_I0.7290.14
13_V67_V0.7290.14
23_P64_G0.7270.14
38_K57_L0.7240.14
145_E234_E0.7230.14
38_K63_I0.7220.14
90_V212_K0.7210.14
231_R259_D0.7150.14
53_F78_L0.7150.14
153_D240_E0.7130.14
232_F245_G0.7100.14
45_A54_S0.7090.14
82_N94_L0.7070.14
102_G114_N0.7070.14
16_S229_R0.7020.14
130_E134_K0.6940.14
161_K208_T0.6900.14
166_L229_R0.6890.14
89_R120_S0.6860.14
14_I146_E0.6860.14
94_L151_T0.6840.14
76_E112_K0.6810.13
31_P231_R0.6800.13
20_C230_T0.6790.13
31_P259_D0.6780.13
157_F167_E0.6780.13
129_L254_N0.6720.13
49_V232_F0.6660.13
188_V243_I0.6660.13
20_C167_E0.6660.13
92_E195_E0.6620.13
64_G190_E0.6610.13
86_F89_R0.6580.13
55_N202_K0.6570.13
161_K235_L0.6500.13
24_D88_N0.6480.13
209_I259_D0.6480.13
86_F247_I0.6460.13
49_V57_L0.6450.13
134_K158_K0.6450.13
49_V104_T0.6450.13
39_I146_E0.6420.13
97_F170_F0.6390.13
224_I255_D0.6380.13
229_R235_L0.6370.13
121_F258_L0.6360.13
84_K194_F0.6330.13
132_L226_T0.6320.13
20_C32_R0.6280.12
25_G199_R0.6270.12
200_I213_Y0.6260.12
36_G145_E0.6260.12
178_K181_Q0.6230.12
28_V253_F0.6220.12
8_L27_A0.6200.12
78_L200_I0.6190.12
90_V116_M0.6170.12
34_F162_S0.6170.12
195_E242_F0.6160.12
243_I256_M0.6160.12
46_L49_V0.6120.12
213_Y250_R0.6110.12
78_L189_R0.6100.12
59_Y189_R0.6080.12
32_R236_L0.6070.12
65_F119_L0.6060.12
161_K231_R0.6060.12
155_S180_V0.6050.12
109_Y206_P0.6040.12
62_E184_K0.6020.12
92_E154_Y0.6000.12
32_R161_K0.6000.12
79_D214_L0.6000.12
196_G217_D0.5980.12
23_P246_K0.5970.12
209_I243_I0.5970.12
92_E257_D0.5960.12
166_L231_R0.5960.12
64_G128_V0.5960.12
80_P105_G0.5940.12
20_C164_R0.5940.12
79_D165_I0.5930.12
19_G22_H0.5900.12
12_D241_I0.5860.12
30_I176_T0.5820.12
209_I247_I0.5800.12
152_L157_F0.5800.12
100_D103_I0.5790.12
163_K234_E0.5760.12
32_R230_T0.5760.12
31_P175_Y0.5760.12
157_F181_Q0.5750.12
12_D85_I0.5720.12
116_M216_T0.5710.11
155_S184_K0.5690.11
63_I132_L0.5660.11
58_K75_S0.5640.11
58_K73_N0.5630.11
114_N225_L0.5620.11
14_I70_V0.5610.11
103_I189_R0.5610.11
212_K216_T0.5610.11
62_E215_V0.5580.11
168_G172_G0.5570.11
114_N232_F0.5560.11
99_G140_P0.5550.11
19_G28_V0.5530.11
37_V215_V0.5530.11
32_R157_F0.5530.11
169_I251_D0.5520.11
94_L256_M0.5520.11
240_E249_V0.5480.11
31_P166_L0.5480.11
93_F211_V0.5480.11
27_A197_Y0.5410.11
148_E239_M0.5410.11
231_R248_L0.5400.11
51_T215_V0.5390.11
16_S168_G0.5380.11
80_P239_M0.5370.11
25_G61_D0.5350.11
54_S85_I0.5330.11
78_L205_K0.5310.11
50_R214_L0.5300.11
147_S208_T0.5300.11
88_N130_E0.5290.11
234_E259_D0.5240.11
200_I254_N0.5230.11
39_I73_N0.5220.11
69_L144_V0.5200.11
46_L147_S0.5190.11
66_N200_I0.5190.11
39_I90_V0.5160.11
7_F69_L0.5160.11
149_I250_R0.5150.11
27_A76_E0.5140.11
82_N136_G0.5140.11
53_F149_I0.5120.11
153_D246_K0.5100.11
54_S57_L0.5090.11
9_K158_K0.5080.10
176_T239_M0.5080.10
185_F201_L0.5070.10
142_S207_F0.5060.10
93_F116_M0.5060.10
176_T207_F0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ylqA 2 0.316 66.2 0.955 Contact Map
1wotA 1 0.3532 63.8 0.955 Contact Map
4cs6A 1 0.6989 55.4 0.958 Contact Map
4mkmA 1 0.2751 54.6 0.958 Contact Map
1no5A 4 0.3643 50 0.959 Contact Map
3nybA 1 0.5985 44.6 0.96 Contact Map
2pbeA 1 0.6245 44 0.96 Contact Map
1jajA 1 0.5836 37.8 0.962 Contact Map
4s3nA 1 0.6691 35.5 0.962 Contact Map
3jz0A 2 0.6431 35.1 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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