GREMLIN Database
PURT - Phosphoribosylglycinamide formyltransferase 2
UniProt: Q981B9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (372)
Sequences: 22729 (12461)
Seq/√Len: 646.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_K170_I3.6991.00
130_K195_E3.2461.00
169_K172_N3.1871.00
141_K174_E3.0771.00
136_N139_E3.0691.00
253_G257_K3.0261.00
68_A72_R2.9491.00
13_K36_E2.8201.00
91_I108_K2.6611.00
62_N65_A2.6241.00
149_F170_I2.6161.00
132_A146_D2.5351.00
379_S382_E2.4821.00
309_R314_L2.4421.00
249_E253_G2.3541.00
275_S278_R2.3071.00
91_I95_S2.3061.00
29_E32_R2.2901.00
71_K96_N2.1961.00
168_N172_N2.1611.00
120_A258_V2.1451.00
250_T278_R2.1271.00
123_K261_E2.1101.00
377_G382_E2.0981.00
244_S247_V2.0171.00
256_Q260_E2.0101.00
86_N111_M1.9971.00
92_E96_N1.9451.00
170_I174_E1.9261.00
300_D322_V1.9011.00
245_Q249_E1.8831.00
43_Y57_V1.8781.00
166_L196_F1.8771.00
118_R123_K1.8571.00
115_E118_R1.8501.00
143_A146_D1.8471.00
16_L27_A1.8391.00
250_T254_I1.8271.00
300_D320_K1.8141.00
67_K96_N1.8061.00
305_Q309_R1.8041.00
378_N382_E1.8041.00
143_A147_I1.7981.00
67_K71_K1.7761.00
254_I279_I1.7681.00
56_Y69_V1.7411.00
31_Q53_H1.7291.00
63_P92_E1.7281.00
174_E178_R1.7021.00
32_R305_Q1.6961.00
108_K115_E1.6931.00
258_V262_L1.6901.00
258_V261_E1.6841.00
168_N198_K1.6821.00
306_I317_P1.6501.00
137_E141_K1.6361.00
65_A68_A1.6271.00
78_I98_F1.6141.00
254_I257_K1.6141.00
114_I118_R1.6111.00
257_K260_E1.6101.00
141_K170_I1.6091.00
109_A119_F1.6001.00
355_Q358_L1.5951.00
30_A37_V1.5941.00
247_V250_T1.5941.00
328_H387_V1.5791.00
208_Y306_I1.5721.00
137_E174_E1.5711.00
358_L361_K1.5531.00
114_I133_F1.5521.00
137_E178_R1.5491.00
29_E305_Q1.5311.00
361_K366_E1.5301.00
103_N106_A1.5291.00
151_C193_V1.5241.00
118_R122_E1.5201.00
175_E179_E1.5121.00
94_E104_A1.5081.00
259_A262_L1.5041.00
363_V366_E1.4891.00
135_E139_E1.4701.00
49_M55_K1.4701.00
181_I189_R1.4691.00
132_A143_A1.4671.00
142_R146_D1.4611.00
361_K364_T1.4551.00
361_K365_Y1.4431.00
355_Q359_F1.4411.00
208_Y267_I1.4391.00
119_F124_L1.4351.00
92_E95_S1.4341.00
250_T253_G1.4341.00
122_E130_K1.4291.00
359_F365_Y1.4241.00
144_C149_F1.4231.00
117_R194_E1.4211.00
13_K38_V1.4171.00
203_L274_V1.4121.00
109_A115_E1.4101.00
141_K145_K1.4041.00
297_A374_L1.4031.00
63_P67_K1.4021.00
359_F362_P1.3991.00
119_F123_K1.3981.00
14_I101_V1.3961.00
68_A71_K1.3891.00
248_K252_R1.3801.00
54_R73_E1.3641.00
137_E177_Y1.3581.00
64_N92_E1.3581.00
195_E280_L1.3321.00
356_V359_F1.3311.00
340_P343_L1.3301.00
297_A376_T1.3291.00
247_V274_V1.3281.00
156_E190_R1.3271.00
135_E190_R1.3251.00
14_I30_A1.3181.00
142_R145_K1.3141.00
116_L120_A1.3121.00
112_N156_E1.3071.00
39_A54_R1.3051.00
69_V73_E1.3031.00
249_E252_R1.3021.00
105_N109_A1.2921.00
339_G342_F1.2861.00
94_E103_N1.2831.00
354_V357_R1.2811.00
207_T259_A1.2801.00
341_K344_N1.2701.00
381_E385_E1.2681.00
208_Y310_S1.2661.00
144_C151_C1.2571.00
119_F261_E1.2511.00
15_L40_L1.2471.00
118_R131_Y1.2461.00
120_A281_F1.2451.00
36_E54_R1.2431.00
124_L261_E1.2421.00
28_I32_R1.2361.00
382_E386_K1.2321.00
149_F169_K1.2301.00
214_S260_E1.2301.00
33_M309_R1.2291.00
205_V251_A1.2251.00
127_P278_R1.2051.00
197_V282_S1.1991.00
56_Y73_E1.1951.00
99_R312_I1.1901.00
138_E142_R1.1881.00
139_E142_R1.1861.00
35_L312_I1.1851.00
331_L368_R1.1801.00
152_L166_L1.1711.00
110_C284_V1.1631.00
114_I156_E1.1401.00
377_G386_K1.1351.00
375_A387_V1.1311.00
178_R182_S1.1231.00
239_H298_S1.1231.00
67_K92_E1.1221.00
252_R256_Q1.1211.00
15_L70_V1.1171.00
246_G250_T1.1141.00
99_R102_P1.1131.00
207_T270_V1.1131.00
134_A143_A1.1131.00
26_M79_I1.1091.00
362_P365_Y1.1031.00
138_E141_K1.1001.00
133_F190_R1.0981.00
328_H372_V1.0951.00
103_N265_L1.0931.00
86_N89_A1.0911.00
91_I105_N1.0891.00
93_L100_V1.0851.00
117_R128_T1.0841.00
130_K147_I1.0831.00
357_R365_Y1.0801.00
356_V364_T1.0661.00
354_V358_L1.0641.00
198_K276_G1.0601.00
145_K174_E1.0581.00
339_G343_L1.0561.00
70_V98_F1.0551.00
13_K76_D1.0551.00
377_G383_A1.0511.00
384_L388_R1.0511.00
357_R361_K1.0481.00
356_V361_K1.0461.00
274_V279_I1.0441.00
93_L98_F1.0411.00
373_V390_A1.0401.00
171_E175_E1.0371.00
33_M302_N1.0341.00
105_N108_K1.0281.00
152_L196_F1.0281.00
354_V359_F1.0221.00
207_T268_Y1.0201.00
165_V180_S1.0191.00
324_P378_N1.0171.00
354_V361_K1.0121.00
165_V179_E1.0091.00
288_P303_E1.0061.00
91_I104_A1.0061.00
147_I151_C1.0021.00
78_I93_L0.9981.00
386_K389_K0.9951.00
322_V376_T0.9941.00
14_I35_L0.9841.00
140_V173_V0.9821.00
134_A140_V0.9821.00
245_Q248_K0.9801.00
175_E178_R0.9791.00
172_N175_E0.9781.00
122_E131_Y0.9771.00
296_L374_L0.9761.00
165_V176_A0.9751.00
210_Y214_S0.9741.00
41_D46_A0.9621.00
27_A52_A0.9601.00
89_A93_L0.9581.00
357_R360_G0.9561.00
270_V284_V0.9561.00
149_F173_V0.9561.00
177_Y181_I0.9541.00
209_R217_I0.9531.00
385_E389_K0.9521.00
127_P254_I0.9461.00
243_V247_V0.9411.00
359_F363_V0.9391.00
253_G256_Q0.9351.00
306_I309_R0.9341.00
130_K146_D0.9331.00
14_I308_V0.9291.00
244_S277_N0.9291.00
226_E229_R0.9281.00
255_A259_A0.9281.00
301_I306_I0.9251.00
257_K261_E0.9241.00
209_R260_E0.9241.00
356_V365_Y0.9241.00
360_G364_T0.9181.00
69_V75_P0.9171.00
126_L281_F0.9121.00
33_M305_Q0.9061.00
167_V176_A0.9051.00
27_A37_V0.9031.00
238_W298_S0.9021.00
41_D55_K0.9011.00
144_C173_V0.9001.00
342_F346_E0.8991.00
30_A308_V0.8951.00
359_F366_E0.8931.00
357_R364_T0.8901.00
122_E132_A0.8871.00
362_P366_E0.8861.00
207_T255_A0.8851.00
64_N68_A0.8811.00
359_F364_T0.8801.00
375_A390_A0.8741.00
151_C167_V0.8731.00
112_N157_M0.8671.00
177_Y191_V0.8531.00
140_V177_Y0.8501.00
259_A268_Y0.8501.00
139_E143_A0.8501.00
198_K275_S0.8491.00
251_A254_I0.8481.00
308_V312_I0.8471.00
355_Q361_K0.8441.00
347_K350_E0.8441.00
343_L346_E0.8421.00
70_V78_I0.8421.00
251_A279_I0.8411.00
212_S315_P0.8401.00
221_T224_P0.8401.00
91_I94_E0.8391.00
205_V255_A0.8361.00
63_P89_A0.8351.00
13_K54_R0.8321.00
197_V280_L0.8291.00
153_I167_V0.8271.00
67_K95_S0.8221.00
293_L296_L0.8201.00
153_I191_V0.8201.00
152_L164_H0.8181.00
94_E265_L0.8161.00
324_P376_T0.8121.00
358_L362_P0.8081.00
234_Y237_S0.8021.00
16_L30_A0.8021.00
255_A272_I0.7991.00
344_N347_K0.7971.00
114_I190_R0.7971.00
30_A79_I0.7961.00
357_R366_E0.7961.00
153_I176_A0.7941.00
79_I307_H0.7861.00
171_E174_E0.7821.00
348_A352_P0.7801.00
205_V252_R0.7801.00
43_Y46_A0.7791.00
358_L365_Y0.7791.00
358_L363_V0.7771.00
356_V363_V0.7771.00
157_M188_S0.7761.00
246_G249_E0.7711.00
382_E385_E0.7701.00
66_I93_L0.7691.00
255_A270_V0.7661.00
355_Q366_E0.7661.00
224_P227_H0.7651.00
86_N90_L0.7631.00
30_A35_L0.7631.00
219_T252_R0.7611.00
219_T222_I0.7591.00
356_V366_E0.7581.00
258_V263_G0.7561.00
88_D91_I0.7561.00
326_A383_A0.7531.00
213_N260_E0.7511.00
39_A52_A0.7491.00
342_F345_I0.7481.00
132_A139_E0.7471.00
255_A258_V0.7431.00
360_G365_Y0.7421.00
344_N348_A0.7391.00
144_C148_G0.7371.00
224_P240_P0.7361.00
106_A263_G0.7361.00
110_C262_L0.7341.00
203_L251_A0.7311.00
39_A50_H0.7311.00
265_L310_S0.7281.00
179_E183_H0.7281.00
36_E308_V0.7251.00
13_K39_A0.7231.00
371_G374_L0.7231.00
112_N190_R0.7221.00
42_R53_H0.7201.00
165_V183_H0.7181.00
250_T279_I0.7181.00
242_N274_V0.7161.00
119_F262_L0.7161.00
257_K262_L0.7161.00
58_V69_V0.7151.00
247_V254_I0.7141.00
273_I282_S0.7121.00
147_I195_E0.7081.00
15_L75_P0.7081.00
221_T321_L0.7061.00
140_V193_V0.7051.00
153_I177_Y0.7041.00
255_A262_L0.7021.00
209_R265_L0.7021.00
330_I333_Q0.7021.00
357_R362_P0.7001.00
259_A263_G0.7001.00
88_D92_E0.6991.00
36_E305_Q0.6961.00
13_K73_E0.6951.00
375_A383_A0.6941.00
141_K178_R0.6921.00
180_S191_V0.6921.00
205_V221_T0.6911.00
31_Q37_V0.6901.00
201_T274_V0.6891.00
381_E384_L0.6891.00
254_I258_V0.6881.00
360_G366_E0.6861.00
36_E53_H0.6861.00
307_H311_A0.6831.00
298_S325_A0.6831.00
223_E242_N0.6821.00
87_T108_K0.6811.00
52_A55_K0.6801.00
209_R259_A0.6761.00
179_E182_S0.6751.00
90_L94_E0.6751.00
153_I193_V0.6751.00
355_Q363_V0.6741.00
103_N263_G0.6731.00
93_L96_N0.6721.00
46_A49_M0.6721.00
358_L366_E0.6711.00
122_E128_T0.6681.00
38_V56_Y0.6681.00
277_N280_L0.6671.00
206_L267_I0.6641.00
354_V366_E0.6641.00
58_V65_A0.6631.00
137_E181_I0.6601.00
345_I348_A0.6601.00
355_Q360_G0.6591.00
355_Q362_P0.6591.00
114_I192_I0.6581.00
14_I37_V0.6581.00
264_G268_Y0.6581.00
338_W342_F0.6561.00
208_Y219_T0.6551.00
94_E105_N0.6551.00
41_D69_V0.6531.00
38_V54_R0.6531.00
167_V173_V0.6501.00
156_E192_I0.6491.00
220_K239_H0.6481.00
339_G346_E0.6471.00
356_V360_G0.6441.00
299_S321_L0.6441.00
118_R133_F0.6421.00
24_K50_H0.6391.00
342_F347_K0.6371.00
210_Y316_T0.6361.00
314_L317_P0.6361.00
119_F258_V0.6351.00
176_A180_S0.6331.00
346_E350_E0.6331.00
17_L89_A0.6331.00
127_P280_L0.6311.00
230_P234_Y0.6291.00
230_P233_Y0.6271.00
90_L93_L0.6271.00
70_V93_L0.6271.00
112_N115_E0.6261.00
195_E278_R0.6261.00
88_D108_K0.6261.00
243_V248_K0.6231.00
186_G189_R0.6221.00
13_K74_R0.6211.00
223_E226_E0.6211.00
99_R265_L0.6201.00
354_V360_G0.6191.00
283_E287_R0.6181.00
214_S315_P0.6181.00
219_T224_P0.6151.00
326_A384_L0.6151.00
29_E33_M0.6141.00
109_A123_K0.6131.00
247_V277_N0.6131.00
358_L364_T0.6121.00
309_R312_I0.6111.00
115_E119_F0.6101.00
206_L269_G0.6081.00
223_E241_S0.6071.00
201_T223_E0.6031.00
144_C177_Y0.6021.00
357_R363_V0.6021.00
329_V332_A0.6001.00
40_L58_V0.5971.00
219_T223_E0.5961.00
65_A69_V0.5961.00
309_R317_P0.5951.00
327_S384_L0.5951.00
254_I272_I0.5941.00
346_E349_M0.5941.00
338_W343_L0.5931.00
143_A193_V0.5901.00
137_E173_V0.5881.00
137_E140_V0.5881.00
88_D93_L0.5871.00
181_I191_V0.5861.00
104_A108_K0.5861.00
308_V311_A0.5851.00
353_G386_K0.5831.00
148_G170_I0.5811.00
136_N177_Y0.5771.00
220_K299_S0.5771.00
229_R234_Y0.5751.00
40_L66_I0.5721.00
197_V275_S0.5721.00
33_M308_V0.5701.00
240_P243_V0.5681.00
345_I349_M0.5671.00
90_L104_A0.5671.00
201_T242_N0.5671.00
71_K95_S0.5641.00
306_I319_V0.5631.00
383_A387_V0.5631.00
348_A351_I0.5621.00
212_S313_G0.5621.00
220_K321_L0.5611.00
220_K223_E0.5601.00
244_S274_V0.5601.00
355_Q364_T0.5581.00
205_V272_I0.5561.00
172_N176_A0.5561.00
222_I225_I0.5551.00
141_K144_C0.5551.00
338_W344_N0.5551.00
70_V75_P0.5541.00
327_S332_A0.5541.00
222_I248_K0.5531.00
149_F168_N0.5521.00
340_P344_N0.5511.00
221_T319_V0.5501.00
294_V326_A0.5501.00
344_N362_P0.5491.00
24_K49_M0.5481.00
162_H183_H0.5471.00
203_L272_I0.5471.00
220_K295_T0.5471.00
195_E275_S0.5471.00
106_A265_L0.5461.00
355_Q365_Y0.5451.00
200_D276_G0.5451.00
303_E307_H0.5441.00
235_V328_H0.5421.00
77_A311_A0.5421.00
176_A179_E0.5421.00
334_T337_V0.5411.00
37_V304_F0.5411.00
150_P196_F0.5401.00
117_R129_T0.5361.00
69_V72_R0.5361.00
64_N67_K0.5350.99
67_K98_F0.5340.99
296_L302_N0.5320.99
360_G363_V0.5310.99
227_H234_Y0.5310.99
293_L327_S0.5300.99
298_S321_L0.5290.99
349_M352_P0.5290.99
251_A272_I0.5280.99
89_A92_E0.5280.99
294_V297_A0.5280.99
127_P250_T0.5260.99
267_I288_P0.5240.99
275_S280_L0.5240.99
369_R374_L0.5240.99
339_G344_N0.5230.99
342_F348_A0.5220.99
206_L222_I0.5220.99
380_V384_L0.5220.99
230_P235_V0.5210.99
270_V281_F0.5190.99
113_R154_K0.5190.99
167_V172_N0.5190.99
29_E302_N0.5180.99
168_N196_F0.5170.99
63_P88_D0.5170.99
220_K298_S0.5170.99
231_S234_Y0.5170.99
134_A137_E0.5130.99
44_D57_V0.5120.99
220_K224_P0.5120.99
250_T257_K0.5110.99
223_E238_W0.5090.99
299_S319_V0.5060.99
144_C193_V0.5030.99
144_C147_I0.5030.99
210_Y313_G0.5020.99
101_V308_V0.5010.99
246_G277_N0.5010.99
105_N115_E0.5000.99
221_T298_S0.5000.99
344_N363_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kjqA 2 0.9748 100 0.271 Contact Map
2dwcA 4 0.9572 100 0.276 Contact Map
4dimA 1 0.9395 100 0.281 Contact Map
3ax6A 2 0.8942 100 0.306 Contact Map
3ouzA 2 0.9748 100 0.307 Contact Map
4mamA 2 0.9018 100 0.307 Contact Map
3aw8A 2 0.8967 100 0.308 Contact Map
4qshA 4 0.8312 100 0.31 Contact Map
4rcnA 6 0.8841 100 0.315 Contact Map
3va7A 1 0.7985 100 0.316 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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