Q981B8 - SULSO - GREMLIN Contacts

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Q981B8 - Acetylpolyamine aminohydrolase

UniProt:	Q981B8	Sequences: MHKTAFIWTDEYYNYSFPDYHPFKSLRESMTKRLLEERGAFHFITLVEPKSIPEEALQLVHSKEYIEFVKYKSKEGQGYLDDGDTPAFKGIYEAALIRVSGSVKALELIKSGEFNHTINIGGGFHHAKRNRAAGFCVFNDVALISKLGESFFSRIAIVDIDGHHADGTQELLIDDNNILKISLHMFHPNFFPGTGDVNEIGLGKGEGYTINIPLPPGTGDDGYLLAFDEIVVPAIERYKPELIILVAGGDSHFNDPLVELKLSTHGYLDVVTKIHRLVHEYSNGRLIMLGGGGYNYDATARIWTISIAEIAGIYDLEYETLHDSFSTKSSQFVMEKIRNTISLIKKIHSLN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	351 (299)
Sequences:	5163 (3425)
Seq/√Len:	198.1

BACSU - ACUC
HALSA - Q9HSP7
SULSO - Q981B8 Q97Z24 Q981D8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
149_E	177_N	3.418	1.00
54_E	70_K	3.039	1.00
109_I	287_I	3.038	1.00
172_L	178_I	2.961	1.00
53_P	56_A	2.861	1.00
153_S	241_E	2.858	1.00
228_D	273_K	2.856	1.00
102_S	289_L	2.708	1.00
105_A	117_T	2.635	1.00
156_A	235_I	2.602	1.00
148_G	242_L	2.600	1.00
169_Q	199_E	2.588	1.00
146_K	175_D	2.408	1.00
219_G	222_G	2.385	1.00
146_K	149_E	2.385	1.00
102_S	144_I	2.381	1.00
106_L	148_G	2.259	1.00
60_V	171_L	2.256	1.00
220_D	266_G	2.250	1.00
59_L	150_S	2.244	1.00
141_V	244_I	2.244	1.00
104_K	108_L	2.187	1.00
5_A	114_F	2.182	1.00
105_A	287_I	2.162	1.00
269_D	272_T	2.144	1.00
50_K	56_A	2.143	1.00
152_F	241_E	2.129	1.00
107_E	147_L	2.096	1.00
129_R	170_E	2.074	1.00
66_I	138_F	2.061	1.00
58_Q	66_I	1.984	1.00
91_I	137_V	1.977	1.00
133_A	166_D	1.971	1.00
181_I	231_V	1.899	1.00
11_E	97_I	1.884	1.00
63_K	67_E	1.868	1.00
69_V	138_F	1.861	1.00
179_L	210_I	1.843	1.00
58_Q	63_K	1.834	1.00
54_E	58_Q	1.829	1.00
158_V	274_I	1.810	1.00
106_L	144_I	1.799	1.00
162_G	258_V	1.775	1.00
210_I	234_A	1.770	1.00
251_S	262_L	1.769	1.00
7_I	104_K	1.741	1.00
60_V	146_K	1.714	1.00
128_K	170_E	1.711	1.00
54_E	67_E	1.668	1.00
288_M	306_S	1.661	1.00
62_S	129_R	1.661	1.00
176_N	204_K	1.648	1.00
108_L	113_E	1.623	1.00
220_D	263_S	1.622	1.00
205_G	208_Y	1.611	1.00
52_I	100_S	1.605	1.00
262_L	266_G	1.587	1.00
69_V	137_V	1.587	1.00
142_A	171_L	1.572	1.00
116_H	275_H	1.566	1.00
32_K	36_E	1.562	1.00
99_V	143_L	1.558	1.00
141_V	289_L	1.542	1.00
7_I	108_L	1.537	1.00
95_A	138_F	1.529	1.00
51_S	97_I	1.522	1.00
145_S	244_I	1.517	1.00
146_K	150_S	1.514	1.00
50_K	104_K	1.510	1.00
249_G	306_S	1.503	1.00
31_T	303_W	1.496	1.00
70_K	92_Y	1.453	1.00
224_L	269_D	1.446	1.00
218_T	222_G	1.441	1.00
133_A	191_F	1.434	1.00
164_H	169_Q	1.428	1.00
129_R	171_L	1.421	1.00
214_L	226_A	1.402	1.00
26_L	29_S	1.396	1.00
110_K	152_F	1.369	1.00
245_L	274_I	1.363	1.00
180_K	246_V	1.361	1.00
62_S	130_N	1.358	1.00
157_I	168_T	1.356	1.00
54_E	96_L	1.351	1.00
183_L	227_F	1.346	1.00
141_V	246_V	1.324	1.00
272_T	309_E	1.303	1.00
200_I	206_E	1.302	1.00
253_F	261_K	1.298	1.00
235_I	277_L	1.295	1.00
128_K	131_R	1.284	1.00
142_A	172_L	1.277	1.00
57_L	143_L	1.276	1.00
6_F	32_K	1.271	1.00
138_F	143_L	1.269	1.00
128_K	166_D	1.259	1.00
253_F	263_S	1.248	1.00
12_Y	101_G	1.246	1.00
252_H	264_T	1.246	1.00
57_L	96_L	1.245	1.00
214_L	260_L	1.245	1.00
235_I	243_I	1.239	1.00
9_T	48_E	1.235	1.00
118_I	290_G	1.232	1.00
156_A	179_L	1.226	1.00
65_Y	132_A	1.225	1.00
162_G	260_L	1.224	1.00
268_L	309_E	1.220	1.00
223_Y	270_V	1.217	1.00
251_S	267_Y	1.216	1.00
149_E	175_D	1.212	1.00
288_M	310_I	1.201	1.00
264_T	301_R	1.197	1.00
271_V	306_S	1.193	1.00
228_D	269_D	1.192	1.00
56_A	147_L	1.190	1.00
160_I	270_V	1.186	1.00
275_H	286_L	1.185	1.00
92_Y	138_F	1.184	1.00
197_V	213_P	1.182	1.00
273_K	276_R	1.181	1.00
185_M	259_E	1.179	1.00
5_A	108_L	1.174	1.00
168_T	246_V	1.174	1.00
47_V	108_L	1.172	1.00
146_K	177_N	1.169	1.00
263_S	266_G	1.167	1.00
67_E	71_Y	1.167	1.00
186_F	189_N	1.147	1.00
225_L	229_E	1.139	1.00
23_F	123_G	1.135	1.00
145_S	157_I	1.118	1.00
50_K	97_I	1.109	1.00
11_E	93_E	1.107	1.00
101_G	119_N	1.095	1.00
33_R	36_E	1.093	1.00
57_L	66_I	1.089	1.00
67_E	70_K	1.086	1.00
56_A	103_V	1.076	1.00
157_I	178_I	1.075	1.00
56_A	59_L	1.058	1.00
13_Y	29_S	1.058	1.00
59_L	147_L	1.057	1.00
34_L	304_T	1.057	1.00
52_I	103_V	1.052	1.00
145_S	155_I	1.046	1.00
103_V	147_L	1.046	1.00
181_I	212_I	1.045	1.00
179_L	238_Y	1.038	1.00
99_V	140_D	1.038	1.00
216_P	259_E	1.023	1.00
11_E	14_N	1.017	1.00
272_T	276_R	1.015	1.00
76_G	79_Y	1.012	1.00
108_L	114_F	1.011	1.00
104_K	107_E	1.008	1.00
185_M	216_P	1.003	1.00
160_I	247_A	1.000	1.00
54_E	63_K	0.998	1.00
185_M	190_F	0.994	1.00
50_K	107_E	0.993	1.00
156_A	243_I	0.989	1.00
51_S	96_L	0.983	1.00
158_V	181_I	0.973	0.99
173_I	209_T	0.970	0.99
156_A	181_I	0.965	0.99
232_V	273_K	0.965	0.99
245_L	288_M	0.964	0.99
14_N	90_G	0.960	0.99
128_K	133_A	0.957	0.99
96_L	100_S	0.949	0.99
7_I	47_V	0.948	0.99
180_K	209_T	0.939	0.99
7_I	101_G	0.936	0.99
72_K	87_A	0.936	0.99
244_I	287_I	0.929	0.99
107_E	111_S	0.923	0.99
121_G	124_F	0.922	0.99
275_H	309_E	0.918	0.99
154_R	238_Y	0.917	0.99
252_H	302_I	0.917	0.99
264_T	302_I	0.914	0.99
59_L	146_K	0.912	0.99
195_G	211_N	0.910	0.99
54_E	66_I	0.907	0.99
223_Y	262_L	0.904	0.99
152_F	155_I	0.895	0.99
227_F	231_V	0.892	0.99
169_Q	173_I	0.891	0.99
60_V	143_L	0.891	0.99
70_K	96_L	0.887	0.99
158_V	227_F	0.885	0.99
55_E	58_Q	0.883	0.99
51_S	93_E	0.879	0.99
144_I	244_I	0.877	0.99
233_P	237_R	0.873	0.99
176_N	208_Y	0.866	0.99
174_D	204_K	0.863	0.99
160_I	274_I	0.862	0.99
186_F	213_P	0.860	0.99
52_I	56_A	0.857	0.99
165_A	180_K	0.851	0.99
106_L	287_I	0.846	0.99
34_L	38_R	0.842	0.98
246_V	291_G	0.840	0.98
235_I	284_G	0.839	0.98
102_S	120_I	0.837	0.98
23_F	121_G	0.834	0.98
252_H	298_A	0.833	0.98
243_I	286_L	0.829	0.98
243_I	284_G	0.828	0.98
232_V	236_E	0.827	0.98
156_A	234_A	0.824	0.98
38_R	304_T	0.822	0.98
69_V	92_Y	0.820	0.98
222_G	225_L	0.816	0.98
183_L	226_A	0.813	0.98
62_S	65_Y	0.803	0.98
169_Q	211_N	0.798	0.98
170_E	173_I	0.797	0.98
210_I	230_I	0.797	0.98
173_I	199_E	0.795	0.98
60_V	142_A	0.795	0.98
157_I	172_L	0.794	0.98
106_L	244_I	0.794	0.98
268_L	305_I	0.793	0.98
185_M	258_V	0.792	0.98
186_F	190_F	0.792	0.98
146_K	172_L	0.791	0.98
244_I	289_L	0.788	0.98
60_V	129_R	0.788	0.98
243_I	274_I	0.787	0.98
268_L	272_T	0.786	0.98
122_G	140_D	0.785	0.98
142_A	168_T	0.785	0.98
218_T	223_Y	0.781	0.98
58_Q	67_E	0.779	0.97
232_V	277_L	0.778	0.97
160_I	271_V	0.776	0.97
52_I	57_L	0.773	0.97
298_A	302_I	0.772	0.97
77_Q	81_D	0.769	0.97
179_L	234_A	0.768	0.97
269_D	273_K	0.765	0.97
234_A	237_R	0.763	0.97
98_R	121_G	0.760	0.97
183_L	214_L	0.759	0.97
57_L	138_F	0.757	0.97
57_L	99_V	0.756	0.97
186_F	196_D	0.753	0.97
215_P	218_T	0.752	0.97
41_F	46_L	0.745	0.97
304_T	308_A	0.742	0.97
102_S	287_I	0.742	0.97
132_A	137_V	0.741	0.97
231_V	274_I	0.740	0.97
32_K	46_L	0.740	0.97
17_F	88_F	0.736	0.96
147_L	150_S	0.734	0.96
224_L	228_D	0.731	0.96
251_S	260_L	0.731	0.96
9_T	12_Y	0.727	0.96
106_L	147_L	0.727	0.96
249_G	291_G	0.727	0.96
183_L	223_Y	0.727	0.96
173_I	205_G	0.726	0.96
271_V	309_E	0.726	0.96
254_N	295_N	0.725	0.96
148_G	151_F	0.725	0.96
145_S	168_T	0.725	0.96
217_G	261_K	0.723	0.96
190_F	259_E	0.716	0.96
51_S	100_S	0.715	0.96
150_S	177_N	0.714	0.96
31_T	35_L	0.712	0.96
212_I	230_I	0.711	0.96
212_I	226_A	0.709	0.96
34_L	301_R	0.704	0.95
139_N	171_L	0.703	0.95
175_D	238_Y	0.695	0.95
100_S	104_K	0.695	0.95
35_L	307_I	0.694	0.95
55_E	59_L	0.693	0.95
268_L	308_A	0.692	0.95
183_L	230_I	0.691	0.95
158_V	231_V	0.688	0.95
78_G	82_D	0.688	0.95
265_H	268_L	0.687	0.95
34_L	37_E	0.683	0.95
190_F	216_P	0.682	0.95
234_A	238_Y	0.682	0.95
54_E	57_L	0.680	0.95
183_L	231_V	0.680	0.95
53_P	100_S	0.679	0.94
295_N	298_A	0.679	0.94
12_Y	28_E	0.678	0.94
77_Q	82_D	0.678	0.94
60_V	172_L	0.678	0.94
91_I	95_A	0.677	0.94
154_R	241_E	0.676	0.94
13_Y	28_E	0.675	0.94
22_P	135_F	0.674	0.94
29_S	33_R	0.670	0.94
122_G	291_G	0.669	0.94
158_V	235_I	0.668	0.94
92_Y	96_L	0.668	0.94
273_K	277_L	0.665	0.94
33_R	37_E	0.664	0.94
130_N	170_E	0.663	0.94
157_I	246_V	0.661	0.94
68_F	72_K	0.660	0.94
155_I	242_L	0.659	0.94
102_S	119_N	0.658	0.94
54_E	92_Y	0.658	0.94
145_S	178_I	0.658	0.94
95_A	98_R	0.656	0.93
36_E	46_L	0.656	0.93
59_L	99_V	0.653	0.93
123_G	140_D	0.653	0.93
180_K	184_H	0.653	0.93
168_T	180_K	0.651	0.93
303_W	306_S	0.649	0.93
5_A	47_V	0.646	0.93
245_L	286_L	0.645	0.93
23_F	124_F	0.645	0.93
164_H	195_G	0.644	0.93
179_L	208_Y	0.643	0.93
164_H	194_T	0.642	0.93
50_K	53_P	0.642	0.93
68_F	79_Y	0.637	0.92
59_L	143_L	0.633	0.92
12_Y	49_P	0.633	0.92
254_N	298_A	0.632	0.92
90_G	94_A	0.631	0.92
299_T	302_I	0.628	0.92
76_G	80_L	0.628	0.92
36_E	41_F	0.627	0.92
8_W	32_K	0.626	0.92
101_G	121_G	0.625	0.92
140_D	291_G	0.624	0.92
162_G	251_S	0.619	0.91
249_G	299_T	0.619	0.91
271_V	288_M	0.617	0.91
71_Y	74_K	0.616	0.91
95_A	140_D	0.613	0.91
247_A	306_S	0.610	0.91
65_Y	128_K	0.605	0.90
56_A	100_S	0.604	0.90
186_F	215_P	0.603	0.90
203_G	207_G	0.603	0.90
162_G	185_M	0.601	0.90
84_D	135_F	0.599	0.90
49_P	101_G	0.594	0.90
90_G	93_E	0.594	0.90
30_M	33_R	0.593	0.89
149_E	152_F	0.591	0.89
160_I	183_L	0.590	0.89
227_F	270_V	0.590	0.89
195_G	199_E	0.589	0.89
121_G	291_G	0.589	0.89
219_G	261_K	0.589	0.89
123_G	291_G	0.588	0.89
203_G	208_Y	0.586	0.89
218_T	226_A	0.585	0.89
229_E	233_P	0.584	0.89
111_S	276_R	0.583	0.89
286_L	310_I	0.581	0.88
83_G	132_A	0.581	0.88
16_S	25_S	0.581	0.88
109_I	117_T	0.578	0.88
17_F	86_P	0.577	0.88
274_I	286_L	0.574	0.88
220_D	224_L	0.573	0.88
74_K	77_Q	0.572	0.88
45_T	114_F	0.570	0.88
21_H	135_F	0.566	0.87
64_E	67_E	0.565	0.87
144_I	287_I	0.565	0.87
95_A	137_V	0.564	0.87
160_I	245_L	0.561	0.87
164_H	211_N	0.559	0.87
23_F	122_G	0.556	0.86
119_N	122_G	0.554	0.86
7_I	105_A	0.554	0.86
181_I	230_I	0.554	0.86
152_F	242_L	0.553	0.86
124_F	291_G	0.553	0.86
128_K	171_L	0.553	0.86
93_E	97_I	0.552	0.86
183_L	212_I	0.551	0.86
151_F	241_E	0.550	0.86
154_R	239_K	0.549	0.86
189_N	194_T	0.547	0.85
214_L	219_G	0.545	0.85
44_I	307_I	0.544	0.85
114_F	117_T	0.543	0.85
212_I	231_V	0.542	0.85
103_V	107_E	0.541	0.85
242_L	287_I	0.540	0.85
169_Q	195_G	0.540	0.85
10_D	13_Y	0.540	0.85
110_K	242_L	0.537	0.84
162_G	257_L	0.536	0.84
99_V	138_F	0.536	0.84
14_N	93_E	0.535	0.84
64_E	68_F	0.535	0.84
105_A	118_I	0.534	0.84
245_L	271_V	0.533	0.84
6_F	44_I	0.532	0.84
108_L	112_G	0.531	0.84
34_L	300_A	0.530	0.84
271_V	275_H	0.528	0.83
69_V	87_A	0.528	0.83
52_I	99_V	0.527	0.83
245_L	306_S	0.527	0.83
103_V	106_L	0.526	0.83
221_D	269_D	0.525	0.83
194_T	199_E	0.525	0.83
290_G	299_T	0.524	0.83
173_I	200_I	0.523	0.83
65_Y	69_V	0.522	0.83
5_A	45_T	0.522	0.83
181_I	234_A	0.521	0.82
98_R	120_I	0.520	0.82
66_I	92_Y	0.519	0.82
96_L	138_F	0.518	0.82
144_I	289_L	0.517	0.82
149_E	153_S	0.517	0.82
222_G	226_A	0.515	0.82
106_L	242_L	0.514	0.82
122_G	246_V	0.513	0.82
301_R	304_T	0.513	0.82
105_A	119_N	0.512	0.81
297_D	301_R	0.512	0.81
215_P	222_G	0.511	0.81
160_I	227_F	0.509	0.81
224_L	266_G	0.508	0.81
122_G	249_G	0.507	0.81
102_S	244_I	0.506	0.81
23_F	291_G	0.506	0.81
300_A	303_W	0.506	0.81
158_V	243_I	0.505	0.81
32_K	41_F	0.503	0.80
159_D	163_H	0.502	0.80
23_F	27_R	0.501	0.80
265_H	305_I	0.500	0.80
76_G	82_D	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zz1A	4	0.9858	100	0.127	Contact Map
4bkxB	1	0.9829	100	0.13	Contact Map
4a69A	1	0.9858	100	0.133	Contact Map
4ly1A	2	0.9829	100	0.138	Contact Map
4qa5A	1	0.9801	100	0.144	Contact Map
1c3pA	1	0.9573	100	0.15	Contact Map
4bz7A	3	0.9573	100	0.15	Contact Map
2vqmA	1	0.9601	100	0.174	Contact Map
3menA	3	0.8604	100	0.178	Contact Map
4zurA	2	0.8519	100	0.185	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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