GREMLIN Database
Q981B8 - Acetylpolyamine aminohydrolase
UniProt: Q981B8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 351 (299)
Sequences: 5163 (3425)
Seq/√Len: 198.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_E177_N3.4181.00
54_E70_K3.0391.00
109_I287_I3.0381.00
172_L178_I2.9611.00
53_P56_A2.8611.00
153_S241_E2.8581.00
228_D273_K2.8561.00
102_S289_L2.7081.00
105_A117_T2.6351.00
156_A235_I2.6021.00
148_G242_L2.6001.00
169_Q199_E2.5881.00
146_K175_D2.4081.00
219_G222_G2.3851.00
146_K149_E2.3851.00
102_S144_I2.3811.00
106_L148_G2.2591.00
60_V171_L2.2561.00
220_D266_G2.2501.00
59_L150_S2.2441.00
141_V244_I2.2441.00
104_K108_L2.1871.00
5_A114_F2.1821.00
105_A287_I2.1621.00
269_D272_T2.1441.00
50_K56_A2.1431.00
152_F241_E2.1291.00
107_E147_L2.0961.00
129_R170_E2.0741.00
66_I138_F2.0611.00
58_Q66_I1.9841.00
91_I137_V1.9771.00
133_A166_D1.9711.00
181_I231_V1.8991.00
11_E97_I1.8841.00
63_K67_E1.8681.00
69_V138_F1.8611.00
179_L210_I1.8431.00
58_Q63_K1.8341.00
54_E58_Q1.8291.00
158_V274_I1.8101.00
106_L144_I1.7991.00
162_G258_V1.7751.00
210_I234_A1.7701.00
251_S262_L1.7691.00
7_I104_K1.7411.00
60_V146_K1.7141.00
128_K170_E1.7111.00
54_E67_E1.6681.00
288_M306_S1.6611.00
62_S129_R1.6611.00
176_N204_K1.6481.00
108_L113_E1.6231.00
220_D263_S1.6221.00
205_G208_Y1.6111.00
52_I100_S1.6051.00
262_L266_G1.5871.00
69_V137_V1.5871.00
142_A171_L1.5721.00
116_H275_H1.5661.00
32_K36_E1.5621.00
99_V143_L1.5581.00
141_V289_L1.5421.00
7_I108_L1.5371.00
95_A138_F1.5291.00
51_S97_I1.5221.00
145_S244_I1.5171.00
146_K150_S1.5141.00
50_K104_K1.5101.00
249_G306_S1.5031.00
31_T303_W1.4961.00
70_K92_Y1.4531.00
224_L269_D1.4461.00
218_T222_G1.4411.00
133_A191_F1.4341.00
164_H169_Q1.4281.00
129_R171_L1.4211.00
214_L226_A1.4021.00
26_L29_S1.3961.00
110_K152_F1.3691.00
245_L274_I1.3631.00
180_K246_V1.3611.00
62_S130_N1.3581.00
157_I168_T1.3561.00
54_E96_L1.3511.00
183_L227_F1.3461.00
141_V246_V1.3241.00
272_T309_E1.3031.00
200_I206_E1.3021.00
253_F261_K1.2981.00
235_I277_L1.2951.00
128_K131_R1.2841.00
142_A172_L1.2771.00
57_L143_L1.2761.00
6_F32_K1.2711.00
138_F143_L1.2691.00
128_K166_D1.2591.00
253_F263_S1.2481.00
12_Y101_G1.2461.00
252_H264_T1.2461.00
57_L96_L1.2451.00
214_L260_L1.2451.00
235_I243_I1.2391.00
9_T48_E1.2351.00
118_I290_G1.2321.00
156_A179_L1.2261.00
65_Y132_A1.2251.00
162_G260_L1.2241.00
268_L309_E1.2201.00
223_Y270_V1.2171.00
251_S267_Y1.2161.00
149_E175_D1.2121.00
288_M310_I1.2011.00
264_T301_R1.1971.00
271_V306_S1.1931.00
228_D269_D1.1921.00
56_A147_L1.1901.00
160_I270_V1.1861.00
275_H286_L1.1851.00
92_Y138_F1.1841.00
197_V213_P1.1821.00
273_K276_R1.1811.00
185_M259_E1.1791.00
5_A108_L1.1741.00
168_T246_V1.1741.00
47_V108_L1.1721.00
146_K177_N1.1691.00
263_S266_G1.1671.00
67_E71_Y1.1671.00
186_F189_N1.1471.00
225_L229_E1.1391.00
23_F123_G1.1351.00
145_S157_I1.1181.00
50_K97_I1.1091.00
11_E93_E1.1071.00
101_G119_N1.0951.00
33_R36_E1.0931.00
57_L66_I1.0891.00
67_E70_K1.0861.00
56_A103_V1.0761.00
157_I178_I1.0751.00
56_A59_L1.0581.00
13_Y29_S1.0581.00
59_L147_L1.0571.00
34_L304_T1.0571.00
52_I103_V1.0521.00
145_S155_I1.0461.00
103_V147_L1.0461.00
181_I212_I1.0451.00
179_L238_Y1.0381.00
99_V140_D1.0381.00
216_P259_E1.0231.00
11_E14_N1.0171.00
272_T276_R1.0151.00
76_G79_Y1.0121.00
108_L114_F1.0111.00
104_K107_E1.0081.00
185_M216_P1.0031.00
160_I247_A1.0001.00
54_E63_K0.9981.00
185_M190_F0.9941.00
50_K107_E0.9931.00
156_A243_I0.9891.00
51_S96_L0.9831.00
158_V181_I0.9730.99
173_I209_T0.9700.99
156_A181_I0.9650.99
232_V273_K0.9650.99
245_L288_M0.9640.99
14_N90_G0.9600.99
128_K133_A0.9570.99
96_L100_S0.9490.99
7_I47_V0.9480.99
180_K209_T0.9390.99
7_I101_G0.9360.99
72_K87_A0.9360.99
244_I287_I0.9290.99
107_E111_S0.9230.99
121_G124_F0.9220.99
275_H309_E0.9180.99
154_R238_Y0.9170.99
252_H302_I0.9170.99
264_T302_I0.9140.99
59_L146_K0.9120.99
195_G211_N0.9100.99
54_E66_I0.9070.99
223_Y262_L0.9040.99
152_F155_I0.8950.99
227_F231_V0.8920.99
169_Q173_I0.8910.99
60_V143_L0.8910.99
70_K96_L0.8870.99
158_V227_F0.8850.99
55_E58_Q0.8830.99
51_S93_E0.8790.99
144_I244_I0.8770.99
233_P237_R0.8730.99
176_N208_Y0.8660.99
174_D204_K0.8630.99
160_I274_I0.8620.99
186_F213_P0.8600.99
52_I56_A0.8570.99
165_A180_K0.8510.99
106_L287_I0.8460.99
34_L38_R0.8420.98
246_V291_G0.8400.98
235_I284_G0.8390.98
102_S120_I0.8370.98
23_F121_G0.8340.98
252_H298_A0.8330.98
243_I286_L0.8290.98
243_I284_G0.8280.98
232_V236_E0.8270.98
156_A234_A0.8240.98
38_R304_T0.8220.98
69_V92_Y0.8200.98
222_G225_L0.8160.98
183_L226_A0.8130.98
62_S65_Y0.8030.98
169_Q211_N0.7980.98
170_E173_I0.7970.98
210_I230_I0.7970.98
173_I199_E0.7950.98
60_V142_A0.7950.98
157_I172_L0.7940.98
106_L244_I0.7940.98
268_L305_I0.7930.98
185_M258_V0.7920.98
186_F190_F0.7920.98
146_K172_L0.7910.98
244_I289_L0.7880.98
60_V129_R0.7880.98
243_I274_I0.7870.98
268_L272_T0.7860.98
122_G140_D0.7850.98
142_A168_T0.7850.98
218_T223_Y0.7810.98
58_Q67_E0.7790.97
232_V277_L0.7780.97
160_I271_V0.7760.97
52_I57_L0.7730.97
298_A302_I0.7720.97
77_Q81_D0.7690.97
179_L234_A0.7680.97
269_D273_K0.7650.97
234_A237_R0.7630.97
98_R121_G0.7600.97
183_L214_L0.7590.97
57_L138_F0.7570.97
57_L99_V0.7560.97
186_F196_D0.7530.97
215_P218_T0.7520.97
41_F46_L0.7450.97
304_T308_A0.7420.97
102_S287_I0.7420.97
132_A137_V0.7410.97
231_V274_I0.7400.97
32_K46_L0.7400.97
17_F88_F0.7360.96
147_L150_S0.7340.96
224_L228_D0.7310.96
251_S260_L0.7310.96
9_T12_Y0.7270.96
106_L147_L0.7270.96
249_G291_G0.7270.96
183_L223_Y0.7270.96
173_I205_G0.7260.96
271_V309_E0.7260.96
254_N295_N0.7250.96
148_G151_F0.7250.96
145_S168_T0.7250.96
217_G261_K0.7230.96
190_F259_E0.7160.96
51_S100_S0.7150.96
150_S177_N0.7140.96
31_T35_L0.7120.96
212_I230_I0.7110.96
212_I226_A0.7090.96
34_L301_R0.7040.95
139_N171_L0.7030.95
175_D238_Y0.6950.95
100_S104_K0.6950.95
35_L307_I0.6940.95
55_E59_L0.6930.95
268_L308_A0.6920.95
183_L230_I0.6910.95
158_V231_V0.6880.95
78_G82_D0.6880.95
265_H268_L0.6870.95
34_L37_E0.6830.95
190_F216_P0.6820.95
234_A238_Y0.6820.95
54_E57_L0.6800.95
183_L231_V0.6800.95
53_P100_S0.6790.94
295_N298_A0.6790.94
12_Y28_E0.6780.94
77_Q82_D0.6780.94
60_V172_L0.6780.94
91_I95_A0.6770.94
154_R241_E0.6760.94
13_Y28_E0.6750.94
22_P135_F0.6740.94
29_S33_R0.6700.94
122_G291_G0.6690.94
158_V235_I0.6680.94
92_Y96_L0.6680.94
273_K277_L0.6650.94
33_R37_E0.6640.94
130_N170_E0.6630.94
157_I246_V0.6610.94
68_F72_K0.6600.94
155_I242_L0.6590.94
102_S119_N0.6580.94
54_E92_Y0.6580.94
145_S178_I0.6580.94
95_A98_R0.6560.93
36_E46_L0.6560.93
59_L99_V0.6530.93
123_G140_D0.6530.93
180_K184_H0.6530.93
168_T180_K0.6510.93
303_W306_S0.6490.93
5_A47_V0.6460.93
245_L286_L0.6450.93
23_F124_F0.6450.93
164_H195_G0.6440.93
179_L208_Y0.6430.93
164_H194_T0.6420.93
50_K53_P0.6420.93
68_F79_Y0.6370.92
59_L143_L0.6330.92
12_Y49_P0.6330.92
254_N298_A0.6320.92
90_G94_A0.6310.92
299_T302_I0.6280.92
76_G80_L0.6280.92
36_E41_F0.6270.92
8_W32_K0.6260.92
101_G121_G0.6250.92
140_D291_G0.6240.92
162_G251_S0.6190.91
249_G299_T0.6190.91
271_V288_M0.6170.91
71_Y74_K0.6160.91
95_A140_D0.6130.91
247_A306_S0.6100.91
65_Y128_K0.6050.90
56_A100_S0.6040.90
186_F215_P0.6030.90
203_G207_G0.6030.90
162_G185_M0.6010.90
84_D135_F0.5990.90
49_P101_G0.5940.90
90_G93_E0.5940.90
30_M33_R0.5930.89
149_E152_F0.5910.89
160_I183_L0.5900.89
227_F270_V0.5900.89
195_G199_E0.5890.89
121_G291_G0.5890.89
219_G261_K0.5890.89
123_G291_G0.5880.89
203_G208_Y0.5860.89
218_T226_A0.5850.89
229_E233_P0.5840.89
111_S276_R0.5830.89
286_L310_I0.5810.88
83_G132_A0.5810.88
16_S25_S0.5810.88
109_I117_T0.5780.88
17_F86_P0.5770.88
274_I286_L0.5740.88
220_D224_L0.5730.88
74_K77_Q0.5720.88
45_T114_F0.5700.88
21_H135_F0.5660.87
64_E67_E0.5650.87
144_I287_I0.5650.87
95_A137_V0.5640.87
160_I245_L0.5610.87
164_H211_N0.5590.87
23_F122_G0.5560.86
119_N122_G0.5540.86
7_I105_A0.5540.86
181_I230_I0.5540.86
152_F242_L0.5530.86
124_F291_G0.5530.86
128_K171_L0.5530.86
93_E97_I0.5520.86
183_L212_I0.5510.86
151_F241_E0.5500.86
154_R239_K0.5490.86
189_N194_T0.5470.85
214_L219_G0.5450.85
44_I307_I0.5440.85
114_F117_T0.5430.85
212_I231_V0.5420.85
103_V107_E0.5410.85
242_L287_I0.5400.85
169_Q195_G0.5400.85
10_D13_Y0.5400.85
110_K242_L0.5370.84
162_G257_L0.5360.84
99_V138_F0.5360.84
14_N93_E0.5350.84
64_E68_F0.5350.84
105_A118_I0.5340.84
245_L271_V0.5330.84
6_F44_I0.5320.84
108_L112_G0.5310.84
34_L300_A0.5300.84
271_V275_H0.5280.83
69_V87_A0.5280.83
52_I99_V0.5270.83
245_L306_S0.5270.83
103_V106_L0.5260.83
221_D269_D0.5250.83
194_T199_E0.5250.83
290_G299_T0.5240.83
173_I200_I0.5230.83
65_Y69_V0.5220.83
5_A45_T0.5220.83
181_I234_A0.5210.82
98_R120_I0.5200.82
66_I92_Y0.5190.82
96_L138_F0.5180.82
144_I289_L0.5170.82
149_E153_S0.5170.82
222_G226_A0.5150.82
106_L242_L0.5140.82
122_G246_V0.5130.82
301_R304_T0.5130.82
105_A119_N0.5120.81
297_D301_R0.5120.81
215_P222_G0.5110.81
160_I227_F0.5090.81
224_L266_G0.5080.81
122_G249_G0.5070.81
102_S244_I0.5060.81
23_F291_G0.5060.81
300_A303_W0.5060.81
158_V243_I0.5050.81
32_K41_F0.5030.80
159_D163_H0.5020.80
23_F27_R0.5010.80
265_H305_I0.5000.80
76_G82_D0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zz1A 4 0.9858 100 0.127 Contact Map
4bkxB 1 0.9829 100 0.13 Contact Map
4a69A 1 0.9858 100 0.133 Contact Map
4ly1A 2 0.9829 100 0.138 Contact Map
4qa5A 1 0.9801 100 0.144 Contact Map
1c3pA 1 0.9573 100 0.15 Contact Map
4bz7A 3 0.9573 100 0.15 Contact Map
2vqmA 1 0.9601 100 0.174 Contact Map
3menA 3 0.8604 100 0.178 Contact Map
4zurA 2 0.8519 100 0.185 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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