GREMLIN Database
Q981B7 - Uncharacterized protein
UniProt: Q981B7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (313)
Sequences: 131 (99)
Seq/√Len: 5.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_E194_K6.3561.00
191_S194_K5.6160.99
215_A238_V3.2970.82
190_E193_M3.2520.81
172_I207_I3.0870.77
147_R151_L3.0490.76
136_A173_S3.0190.76
187_R191_S2.8340.71
213_I233_I2.7230.67
186_G191_S2.5920.63
83_I96_V2.4690.59
53_L143_D2.3240.54
116_L128_A2.3180.54
171_I233_I2.2940.53
111_S248_I2.2650.52
163_T186_G2.2270.51
93_V195_D2.1340.48
54_S104_I2.1170.47
341_T344_E2.1110.47
145_I223_D2.1110.47
171_I195_D2.0910.47
86_F94_I2.0550.45
188_K191_S1.9940.43
186_G190_E1.9830.43
74_Q219_D1.9490.42
248_I272_P1.9270.41
148_A283_A1.9260.41
128_A224_V1.9170.41
126_R215_A1.9010.40
82_L293_L1.8660.39
360_I371_N1.8360.38
207_I248_I1.8230.38
77_E245_S1.7910.37
187_R190_E1.7810.36
150_W154_R1.7530.35
78_D334_G1.7220.34
99_E107_V1.7110.34
63_A242_D1.6880.33
209_K231_F1.6770.33
90_K194_K1.6700.33
111_S244_L1.6690.33
95_P331_T1.6420.32
145_I303_I1.6330.32
143_D171_I1.6180.31
340_D358_E1.6150.31
289_L325_A1.6080.31
187_R194_K1.6070.31
73_V139_I1.5960.31
62_K348_A1.5960.31
356_I360_I1.5900.30
341_T358_E1.5770.30
90_K276_K1.5500.29
186_G194_K1.5310.29
91_A303_I1.5300.29
142_N164_K1.5260.29
178_V181_L1.5180.28
178_V220_S1.5030.28
171_I273_Q1.4960.28
54_S57_V1.4850.27
159_R173_S1.4840.27
139_I160_L1.4830.27
168_L212_V1.4830.27
133_T316_S1.4750.27
139_I243_R1.4680.27
77_E127_T1.4670.27
63_A219_D1.4610.27
165_E169_T1.4480.26
171_I234_S1.4430.26
143_D262_Q1.4410.26
53_L147_R1.4350.26
53_L56_R1.4270.26
81_R219_D1.4230.26
92_R323_Y1.4140.26
207_I288_I1.4050.25
96_V161_P1.3940.25
66_I160_L1.3930.25
126_R220_S1.3830.25
170_G176_D1.3830.25
176_D208_M1.3760.25
90_K188_K1.3740.25
224_V327_V1.3560.24
244_L248_I1.3550.24
232_R295_K1.3540.24
79_I115_Y1.3520.24
54_S213_I1.3490.24
234_S284_N1.3480.24
207_I290_E1.3320.23
172_I216_N1.3310.23
340_D344_E1.3300.23
118_K226_E1.3250.23
114_S239_M1.3140.23
74_Q107_V1.3120.23
160_L204_V1.3020.23
139_I151_L1.2920.23
163_T366_K1.2920.23
132_M142_N1.2870.22
81_R106_L1.2670.22
207_I222_T1.2640.22
97_I137_T1.2640.22
228_L364_L1.2560.22
165_E336_Y1.2530.22
223_D291_R1.2350.21
148_A233_I1.2300.21
69_P100_K1.2250.21
179_D298_R1.2140.21
94_I326_M1.2110.21
95_P133_T1.2060.21
189_R209_K1.1910.20
83_I254_I1.1820.20
164_K291_R1.1810.20
334_G348_A1.1780.20
343_W365_R1.1750.20
161_P328_R1.1750.20
73_V112_L1.1730.20
200_M239_M1.1730.20
53_L187_R1.1590.19
85_K94_I1.1510.19
99_E254_I1.1510.19
111_S247_V1.1470.19
131_Y139_I1.1450.19
227_K245_S1.1420.19
81_R172_I1.1370.19
128_A253_I1.1180.19
128_A236_M1.1140.19
187_R284_N1.1110.18
131_Y244_L1.1050.18
219_D227_K1.1000.18
82_L350_K1.0980.18
226_E248_I1.0980.18
144_S242_D1.0980.18
289_L295_K1.0940.18
145_I245_S1.0940.18
285_I297_E1.0890.18
162_A172_I1.0790.18
148_A339_R1.0780.18
56_R104_I1.0640.18
224_V328_R1.0620.17
230_K345_P1.0590.17
143_D147_R1.0580.17
133_T232_R1.0420.17
224_V236_M1.0350.17
95_P225_V1.0320.17
207_I273_Q1.0310.17
63_A67_M1.0310.17
151_L310_K1.0220.17
122_I258_A1.0190.17
57_V132_M1.0170.17
173_S221_L1.0150.17
195_D247_V1.0110.17
112_L274_E1.0100.16
305_F331_T1.0090.16
142_N167_R1.0020.16
229_L264_S1.0020.16
179_D239_M0.9950.16
169_T281_F0.9930.16
172_I332_K0.9920.16
164_K169_T0.9900.16
106_L276_K0.9900.16
221_L371_N0.9890.16
123_P267_I0.9860.16
76_D207_I0.9790.16
290_E333_I0.9780.16
143_D209_K0.9750.16
187_R192_I0.9740.16
112_L177_I0.9740.16
143_D240_E0.9690.16
172_I233_I0.9660.16
95_P112_L0.9660.16
109_R363_K0.9630.16
185_S301_E0.9610.16
173_S235_G0.9610.16
221_L338_A0.9560.15
107_V138_S0.9540.15
53_L58_S0.9530.15
100_K230_K0.9530.15
171_I209_K0.9520.15
166_Y276_K0.9440.15
127_T130_E0.9430.15
68_S114_S0.9430.15
145_I199_V0.9420.15
165_E248_I0.9420.15
306_K360_I0.9400.15
76_D165_E0.9400.15
114_S178_V0.9370.15
147_R310_K0.9360.15
73_V132_M0.9350.15
116_L238_V0.9310.15
166_Y215_A0.9290.15
313_M361_L0.9210.15
82_L213_I0.9180.15
204_V318_G0.9140.15
63_A345_P0.9130.15
101_R238_V0.9130.15
56_R185_S0.9030.15
96_V254_I0.9000.15
349_L360_I0.8980.14
67_M73_V0.8950.14
100_K171_I0.8940.14
90_K172_I0.8920.14
168_L318_G0.8910.14
123_P183_S0.8900.14
163_T171_I0.8890.14
139_I253_I0.8880.14
203_P255_K0.8880.14
96_V162_A0.8880.14
147_R207_I0.8840.14
157_I295_K0.8830.14
54_S60_E0.8760.14
188_K192_I0.8760.14
185_S199_V0.8720.14
263_L351_N0.8710.14
233_I350_K0.8700.14
215_A219_D0.8700.14
291_R298_R0.8700.14
65_N210_Y0.8660.14
165_E297_E0.8650.14
140_D171_I0.8650.14
240_E291_R0.8630.14
148_A172_I0.8620.14
137_T164_K0.8620.14
156_N346_V0.8580.14
54_S61_T0.8570.14
63_A102_E0.8550.14
224_V238_V0.8520.14
157_I173_S0.8510.14
99_E169_T0.8510.14
69_P136_A0.8500.14
164_K209_K0.8480.14
170_G208_M0.8460.14
82_L323_Y0.8450.14
137_T272_P0.8440.14
102_E262_Q0.8430.14
105_G170_G0.8410.14
172_I177_I0.8360.13
148_A290_E0.8340.13
133_T249_S0.8300.13
123_P157_I0.8280.13
131_Y276_K0.8280.13
113_L334_G0.8280.13
56_R333_I0.8270.13
145_I373_K0.8240.13
66_I126_R0.8230.13
225_V328_R0.8230.13
102_E107_V0.8220.13
55_R58_S0.8220.13
217_G247_V0.8220.13
111_S218_K0.8200.13
64_I247_V0.8180.13
52_L172_I0.8180.13
167_R188_K0.8140.13
188_K194_K0.8120.13
200_M340_D0.8100.13
70_S172_I0.8090.13
180_A350_K0.8090.13
124_E135_P0.8070.13
67_M106_L0.8030.13
144_S327_V0.8000.13
338_A371_N0.8000.13
190_E325_A0.7990.13
228_L247_V0.7990.13
322_L341_T0.7980.13
208_M348_A0.7900.13
329_V364_L0.7890.13
153_I228_L0.7880.13
52_L202_M0.7870.13
164_K336_Y0.7870.13
53_L190_E0.7860.13
321_K341_T0.7850.13
159_R235_G0.7840.13
186_G192_I0.7840.13
258_A311_E0.7790.13
138_S346_V0.7780.13
152_M292_Y0.7760.13
73_V277_S0.7740.12
220_S323_Y0.7730.12
187_R290_E0.7720.12
292_Y326_M0.7710.12
76_D178_V0.7690.12
164_K215_A0.7650.12
302_V327_V0.7620.12
245_S291_R0.7610.12
141_E205_K0.7610.12
255_K337_V0.7600.12
90_K204_V0.7590.12
73_V79_I0.7570.12
161_P168_L0.7570.12
68_S248_I0.7540.12
197_E262_Q0.7540.12
90_K101_R0.7530.12
141_E261_M0.7520.12
351_N361_L0.7500.12
56_R66_I0.7490.12
111_S138_S0.7470.12
53_L57_V0.7440.12
216_N238_V0.7440.12
116_L225_V0.7430.12
200_M312_E0.7420.12
194_K223_D0.7410.12
61_T106_L0.7330.12
139_I184_V0.7280.12
77_E82_L0.7270.12
253_I329_V0.7260.12
53_L220_S0.7260.12
327_V352_A0.7220.12
63_A164_K0.7210.12
112_L295_K0.7200.12
96_V236_M0.7180.12
177_I264_S0.7160.12
135_P310_K0.7160.12
237_P344_E0.7160.12
272_P307_V0.7140.12
234_S309_F0.7130.12
58_S234_S0.7110.12
322_L352_A0.7090.12
208_M334_G0.7080.12
143_D163_T0.7080.12
78_D112_L0.7080.12
173_S365_R0.7060.12
325_A370_S0.7060.12
157_I249_S0.7060.12
67_M167_R0.7050.11
61_T168_L0.7050.11
84_A313_M0.7020.11
56_R142_N0.6980.11
223_D283_A0.6980.11
53_L366_K0.6970.11
163_T357_E0.6970.11
322_L340_D0.6970.11
72_T172_I0.6960.11
160_L349_L0.6950.11
201_A343_W0.6940.11
82_L332_K0.6940.11
294_S301_E0.6920.11
196_E207_I0.6910.11
75_I277_S0.6900.11
60_E77_E0.6880.11
74_Q298_R0.6880.11
77_E309_F0.6870.11
186_G189_R0.6850.11
54_S164_K0.6810.11
109_R234_S0.6800.11
105_G148_A0.6780.11
56_R60_E0.6750.11
178_V233_I0.6740.11
156_N159_R0.6740.11
302_V352_A0.6720.11
207_I346_V0.6720.11
257_V307_V0.6700.11
139_I226_E0.6700.11
83_I166_Y0.6690.11
66_I215_A0.6690.11
280_E309_F0.6670.11
59_L365_R0.6650.11
101_R368_E0.6630.11
108_T289_L0.6610.11
302_V306_K0.6580.11
138_S160_L0.6580.11
296_I324_T0.6550.11
125_N343_W0.6530.11
206_E305_F0.6530.11
274_E343_W0.6530.11
281_F372_K0.6510.11
177_I253_I0.6500.11
236_M325_A0.6490.11
142_N363_K0.6460.11
54_S132_M0.6450.11
101_R138_S0.6430.11
79_I99_E0.6400.11
74_Q102_E0.6370.11
160_L249_S0.6330.11
94_I205_K0.6320.11
214_T364_L0.6300.10
168_L254_I0.6290.10
81_R311_E0.6290.10
54_S100_K0.6270.10
187_R264_S0.6260.10
111_S132_M0.6250.10
164_K216_N0.6240.10
248_I256_A0.6230.10
95_P246_G0.6170.10
174_A247_V0.6160.10
322_L344_E0.6150.10
149_R344_E0.6130.10
109_R219_D0.6120.10
158_S168_L0.6100.10
54_S233_I0.6080.10
101_R223_D0.6080.10
53_L172_I0.6050.10
70_S282_K0.6010.10
322_L361_L0.6010.10
156_N298_R0.5980.10
250_G321_K0.5970.10
268_E329_V0.5970.10
79_I163_T0.5960.10
186_G280_E0.5950.10
146_A251_L0.5940.10
101_R337_V0.5920.10
136_A141_E0.5900.10
61_T369_E0.5890.10
242_D245_S0.5870.10
129_R134_S0.5860.10
147_R291_R0.5860.10
130_E139_I0.5860.10
214_T228_L0.5840.10
335_D364_L0.5830.10
203_P211_P0.5790.10
158_S307_V0.5790.10
249_S342_D0.5770.10
83_I172_I0.5740.10
166_Y281_F0.5730.10
52_L55_R0.5720.10
123_P321_K0.5670.10
52_L178_V0.5660.10
128_A238_V0.5650.10
54_S209_K0.5640.10
183_S260_K0.5630.10
68_S75_I0.5610.10
165_E265_I0.5600.10
178_V273_Q0.5580.10
103_F269_A0.5560.10
152_M370_S0.5560.10
63_A118_K0.5540.10
75_I99_E0.5530.10
97_I104_I0.5530.10
171_I213_I0.5520.10
242_D285_I0.5510.10
143_D189_R0.5450.09
134_S219_D0.5450.09
213_I276_K0.5440.09
95_P305_F0.5440.09
135_P160_L0.5420.09
123_P364_L0.5410.09
99_E214_T0.5410.09
129_R310_K0.5400.09
177_I363_K0.5390.09
314_R322_L0.5380.09
218_K253_I0.5380.09
140_D215_A0.5340.09
177_I307_V0.5330.09
206_E331_T0.5320.09
84_A364_L0.5320.09
183_S225_V0.5300.09
212_V340_D0.5290.09
178_V184_V0.5280.09
189_R339_R0.5270.09
114_S243_R0.5270.09
169_T336_Y0.5270.09
140_D231_F0.5250.09
253_I349_L0.5250.09
172_I241_G0.5210.09
155_D269_A0.5210.09
287_D291_R0.5200.09
281_F284_N0.5170.09
177_I247_V0.5140.09
115_Y182_Y0.5140.09
103_F371_N0.5140.09
207_I298_R0.5130.09
312_E340_D0.5100.09
170_G252_D0.5100.09
221_L235_G0.5090.09
189_R233_I0.5080.09
255_K338_A0.5080.09
161_P238_V0.5070.09
158_S173_S0.5060.09
147_R187_R0.5060.09
138_S204_V0.5030.09
89_T248_I0.5020.09
344_E348_A0.5010.09
312_E323_Y0.5010.09
280_E310_K0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yzqA 2 0.5763 100 0.675 Contact Map
3kh5A 1 0.6658 100 0.687 Contact Map
3ddjA 1 0.6816 100 0.69 Contact Map
3t4nC 1 0.6526 100 0.707 Contact Map
2qrdG 1 0.6789 100 0.709 Contact Map
2v8qE 1 0.6526 100 0.713 Contact Map
3l2bA 2 0.3395 99.9 0.795 Contact Map
2j9lA 3 0.3974 99.9 0.81 Contact Map
3pc3A 2 0.5579 99.9 0.812 Contact Map
4esyA 2 0.4 99.9 0.812 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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