GREMLIN Database
Q981B6 - Uncharacterized protein
UniProt: Q981B6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (218)
Sequences: 13688 (9415)
Seq/√Len: 637.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_T112_R3.1591.00
6_V9_L2.8161.00
14_A35_W2.5721.00
184_A212_V2.5531.00
159_R162_E2.5091.00
186_V190_R2.4001.00
203_L208_S2.3921.00
13_S207_E2.3831.00
114_G130_L2.3211.00
71_T85_K2.2971.00
64_E85_K2.2961.00
116_S127_V2.2831.00
15_I46_E2.1201.00
57_Y76_D2.0691.00
30_L139_L2.0661.00
26_A211_I2.0261.00
136_E220_M2.0231.00
15_I50_L2.0141.00
24_E211_I2.0061.00
29_V56_A2.0001.00
19_E54_Y1.9631.00
19_E53_R1.9571.00
67_V98_I1.9261.00
27_E109_R1.8901.00
15_I19_E1.8851.00
13_S16_L1.8521.00
69_V85_K1.8491.00
20_K24_E1.8191.00
154_E157_R1.8171.00
108_Y111_I1.8111.00
166_G187_P1.7781.00
76_D109_R1.7491.00
75_D79_N1.7281.00
112_R136_E1.7131.00
138_I165_I1.7101.00
71_T83_I1.6331.00
49_K53_R1.6281.00
113_F137_I1.6131.00
47_F60_P1.6071.00
18_A29_V1.5961.00
92_E95_V1.5861.00
30_L170_A1.5831.00
14_A31_L1.5691.00
75_D81_K1.5461.00
16_L20_K1.5451.00
57_Y108_Y1.5411.00
156_L169_N1.5361.00
59_L139_L1.5361.00
62_A73_I1.5351.00
50_L54_Y1.5301.00
168_V184_A1.5101.00
116_S140_V1.4921.00
18_A58_I1.4911.00
48_Q74_I1.4851.00
51_A58_I1.4791.00
218_K221_Y1.4721.00
17_L20_K1.4701.00
91_N94_R1.4621.00
28_L139_L1.4591.00
57_Y81_K1.4471.00
185_I194_I1.4331.00
153_N157_R1.4141.00
127_V138_I1.4111.00
59_L115_I1.3851.00
62_A83_I1.3781.00
12_K16_L1.3781.00
116_S126_V1.3731.00
21_A209_Y1.3721.00
125_E128_R1.3301.00
19_E50_L1.3261.00
9_L12_K1.3261.00
113_F139_L1.3061.00
8_P12_K1.2961.00
221_Y225_D1.2891.00
44_L72_P1.2861.00
36_T43_P1.2801.00
18_A50_L1.2701.00
15_I53_R1.2491.00
129_E133_K1.2401.00
26_A29_V1.2331.00
18_A56_A1.2211.00
127_V140_V1.2191.00
82_G104_V1.2161.00
154_E161_L1.2121.00
172_V176_P1.2091.00
11_V46_E1.2021.00
119_Y123_F1.1971.00
69_V98_I1.1921.00
45_L48_Q1.1921.00
137_I168_V1.1911.00
45_L49_K1.1841.00
27_E76_D1.1841.00
46_E49_K1.1821.00
166_G195_V1.1731.00
9_L13_S1.1691.00
41_D44_L1.1671.00
186_V218_K1.1651.00
135_A138_I1.1541.00
12_K46_E1.1501.00
84_A104_V1.1451.00
11_V15_I1.1431.00
13_S17_L1.1381.00
153_N202_E1.1351.00
153_N201_G1.1341.00
17_L209_Y1.1291.00
203_L206_E1.1051.00
160_V167_I1.0781.00
55_T76_D1.0681.00
15_I49_K1.0631.00
73_I115_I1.0621.00
22_L56_A1.0621.00
156_L185_I1.0501.00
51_A75_D1.0491.00
156_L167_I1.0471.00
153_N183_V1.0361.00
49_K52_K1.0261.00
59_L73_I1.0101.00
8_P42_V1.0101.00
46_E50_L1.0071.00
156_L183_V0.9941.00
131_F165_I0.9931.00
111_I136_E0.9871.00
220_M224_G0.9871.00
57_Y73_I0.9841.00
186_V195_V0.9751.00
181_R204_G0.9721.00
154_E158_I0.9711.00
114_G135_A0.9701.00
82_G106_F0.9681.00
149_L181_R0.9611.00
160_V185_I0.9601.00
150_D157_R0.9581.00
111_I137_I0.9481.00
84_A120_D0.9451.00
62_A72_P0.9331.00
217_L220_M0.9311.00
128_R163_N0.9231.00
64_E71_T0.9141.00
217_L221_Y0.9111.00
20_K23_K0.9101.00
47_F58_I0.9061.00
105_L135_A0.9051.00
44_L48_Q0.9051.00
34_K97_L0.9051.00
19_E23_K0.9051.00
50_L53_R0.9041.00
173_Y206_E0.9001.00
57_Y109_R0.8821.00
22_L54_Y0.8811.00
202_E210_M0.8751.00
166_G219_Y0.8731.00
34_K39_I0.8731.00
215_D218_K0.8711.00
44_L80_L0.8711.00
73_I106_F0.8701.00
64_E69_V0.8701.00
150_D153_N0.8691.00
136_E216_P0.8681.00
152_W169_N0.8661.00
166_G214_I0.8651.00
87_I126_V0.8641.00
105_L112_R0.8571.00
128_R132_S0.8511.00
14_A60_P0.8491.00
44_L74_I0.8461.00
108_Y113_F0.8441.00
41_D45_L0.8421.00
74_I80_L0.8411.00
8_P46_E0.8271.00
21_A26_A0.8231.00
48_Q51_A0.8191.00
14_A47_F0.8191.00
143_K172_V0.8101.00
202_E208_S0.8031.00
88_H120_D0.8011.00
16_L19_E0.7951.00
30_L59_L0.7901.00
107_T110_G0.7891.00
7_Q11_V0.7881.00
145_R148_G0.7881.00
31_L35_W0.7791.00
18_A31_L0.7781.00
24_E209_Y0.7741.00
166_G218_K0.7731.00
121_I156_L0.7721.00
218_K222_L0.7701.00
173_Y207_E0.7641.00
140_V167_I0.7531.00
28_L59_L0.7521.00
201_G210_M0.7501.00
86_K118_C0.7491.00
28_L110_G0.7451.00
188_E222_L0.7441.00
130_L135_A0.7431.00
18_A54_Y0.7421.00
43_P46_E0.7391.00
116_S130_L0.7311.00
12_K15_I0.7271.00
138_I167_I0.7261.00
111_I216_P0.7251.00
216_P220_M0.7191.00
48_Q79_N0.7181.00
121_I140_V0.7161.00
143_K178_F0.7151.00
28_L57_Y0.7101.00
181_R202_E0.7081.00
14_A18_A0.7041.00
88_H123_F0.7021.00
131_F163_N0.7011.00
64_E83_I0.6971.00
195_V212_V0.6891.00
23_K54_Y0.6871.00
87_I103_A0.6851.00
11_V47_F0.6841.00
183_V194_I0.6841.00
7_Q43_P0.6821.00
51_A54_Y0.6801.00
90_F119_Y0.6781.00
34_K63_F0.6731.00
200_V210_M0.6711.00
172_V178_F0.6681.00
103_A126_V0.6671.00
219_Y223_R0.6631.00
57_Y110_G0.6631.00
102_E105_L0.6601.00
44_L50_L0.6591.00
35_W60_P0.6581.00
80_L83_I0.6581.00
27_E110_G0.6571.00
190_R218_K0.6551.00
21_A29_V0.6551.00
30_L168_V0.6541.00
144_I148_G0.6521.00
57_Y75_D0.6511.00
70_I86_K0.6501.00
204_G208_S0.6491.00
106_F113_F0.6491.00
171_N182_S0.6471.00
129_E132_S0.6361.00
65_D68_S0.6361.00
26_A56_A0.6331.00
21_A56_A0.6321.00
159_R163_N0.6271.00
62_A71_T0.6261.00
42_V45_L0.6251.00
150_D154_E0.6061.00
195_V200_V0.6061.00
122_D155_F0.6041.00
203_L210_M0.6021.00
103_A130_L0.6011.00
19_E22_L0.6011.00
170_A184_A0.6001.00
112_R133_K0.6001.00
63_F97_L0.5991.00
39_I97_L0.5961.00
21_A25_G0.5951.00
73_I83_I0.5931.00
119_Y122_D0.5921.00
48_Q52_K0.5921.00
186_V189_Q0.5911.00
57_Y74_I0.5891.00
36_T47_F0.5881.00
126_V130_L0.5841.00
29_V209_Y0.5831.00
155_F158_I0.5811.00
189_Q195_V0.5811.00
22_L55_T0.5781.00
90_F122_D0.5761.00
90_F144_I0.5751.00
20_K209_Y0.5751.00
48_Q80_L0.5681.00
36_T60_P0.5661.00
171_N179_P0.5641.00
122_D144_I0.5571.00
20_K208_S0.5551.00
70_I117_I0.5531.00
42_V46_E0.5491.00
105_L133_K0.5491.00
72_P75_D0.5481.00
61_G70_I0.5471.00
22_L26_A0.5451.00
59_L74_I0.5451.00
75_D80_L0.5451.00
70_I118_C0.5451.00
149_L179_P0.5441.00
114_G138_I0.5441.00
6_V10_E0.5431.00
57_Y113_F0.5421.00
11_V43_P0.5411.00
55_T77_S0.5401.00
121_I155_F0.5360.99
87_I129_E0.5330.99
148_G151_I0.5320.99
60_P74_I0.5300.99
11_V50_L0.5300.99
39_I118_C0.5290.99
27_E55_T0.5290.99
144_I179_P0.5290.99
131_F229_E0.5240.99
33_E118_C0.5230.99
164_R222_L0.5230.99
15_I54_Y0.5210.99
44_L60_P0.5210.99
11_V36_T0.5210.99
153_N185_I0.5200.99
93_E97_L0.5180.99
219_Y222_L0.5170.99
144_I169_N0.5160.99
139_L168_V0.5150.99
151_I188_E0.5140.99
213_D216_P0.5140.99
128_R229_E0.5140.99
34_K70_I0.5130.99
130_L138_I0.5130.99
34_K37_R0.5130.99
82_G115_I0.5120.99
153_N181_R0.5090.99
157_R185_I0.5090.99
137_I166_G0.5060.99
31_L60_P0.5030.99
117_I120_D0.5030.99
144_I152_W0.5020.99
17_L31_L0.5020.99
160_V189_Q0.5010.99
8_P11_V0.5010.99
131_F135_A0.5000.99
158_I161_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vhhA 5 0.9706 100 0.19 Contact Map
4izuA 2 0.9244 100 0.198 Contact Map
3ivzA 2 0.9538 100 0.199 Contact Map
3p8kA 2 0.9622 100 0.201 Contact Map
2w1vA 2 0.9664 100 0.205 Contact Map
1emsA 3 0.9664 100 0.215 Contact Map
1uf5A 4 0.9706 100 0.217 Contact Map
2e11A 2 0.9538 100 0.22 Contact Map
4hg5A 2 0.9664 100 0.221 Contact Map
3wuyA 2 0.9244 100 0.226 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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