GREMLIN Database
Q981A9 - Uncharacterized protein
UniProt: Q981A9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (138)
Sequences: 1005 (662)
Seq/√Len: 56.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_N143_Q6.7111.00
80_E83_K4.2821.00
133_I144_L4.0741.00
19_V33_I3.5681.00
66_E77_I3.2741.00
136_Y140_C3.2111.00
57_K61_E2.9491.00
109_Q138_R2.4341.00
25_E40_K2.4261.00
26_R32_E2.3601.00
36_T39_K2.1041.00
93_S97_L1.9821.00
126_D129_N1.9641.00
90_K94_L1.9601.00
94_L98_G1.9451.00
24_N90_K1.8190.99
67_V76_Y1.7910.99
84_N88_E1.7790.99
69_V72_N1.7530.99
135_E142_N1.6460.99
85_E89_I1.6430.99
89_I92_K1.5680.98
81_K84_N1.5550.98
129_N132_K1.5480.98
19_V52_V1.5440.98
118_L144_L1.5340.98
87_Q90_K1.5330.98
28_M36_T1.5290.98
13_G16_K1.4530.97
62_K78_I1.3900.96
39_K59_L1.3840.96
137_L140_C1.3780.96
67_V74_K1.3770.96
140_C144_L1.3650.96
136_Y143_Q1.3480.96
113_Q138_R1.3450.95
109_Q113_Q1.3420.95
56_L76_Y1.3350.95
110_E138_R1.3300.95
23_L78_I1.3190.95
24_N83_K1.3140.95
41_F45_Y1.2960.94
132_K135_E1.2910.94
73_K94_L1.2640.94
84_N87_Q1.2500.93
85_E88_E1.2490.93
68_K77_I1.1910.92
10_L45_Y1.1670.91
64_L85_E1.1310.89
131_Q138_R1.1280.89
40_K101_T1.1180.89
125_I129_N1.1180.89
114_I144_L1.0850.87
55_V59_L1.0730.87
22_S27_P1.0500.85
12_K15_L1.0350.85
114_I140_C1.0230.84
106_Q136_Y1.0200.84
83_K87_Q1.0190.84
125_I133_I1.0090.83
10_L99_D1.0010.83
111_L115_A1.0000.82
21_E97_L0.9960.82
55_V58_S0.9880.82
21_E25_E0.9780.81
23_L28_M0.9720.81
139_N142_N0.9620.80
19_V55_V0.9470.79
51_S55_V0.9470.79
15_L145_K0.9310.78
24_N68_K0.9180.77
41_F100_N0.9170.77
16_K55_V0.8960.75
41_F75_I0.8960.75
16_K107_I0.8950.75
73_K119_Y0.8860.74
25_E128_N0.8790.74
28_M33_I0.8790.74
121_N125_I0.8770.73
67_V73_K0.8760.73
35_K46_R0.8740.73
60_V67_V0.8730.73
66_E80_E0.8660.72
24_N37_I0.8660.72
36_T40_K0.8600.72
49_T76_Y0.8590.72
24_N80_E0.8580.72
11_K19_V0.8550.71
9_R12_K0.8470.71
19_V89_I0.8470.71
132_K143_Q0.8380.70
138_R142_N0.8350.70
16_K62_K0.8330.69
86_L89_I0.8240.69
63_N81_K0.8060.67
60_V69_V0.8030.67
38_E43_G0.8000.66
17_Y78_I0.8000.66
28_M32_E0.7980.66
134_I138_R0.7950.66
39_K73_K0.7940.66
46_R52_V0.7870.65
13_G51_S0.7820.65
37_I40_K0.7770.64
10_L19_V0.7710.63
93_S96_L0.7700.63
98_G114_I0.7680.63
120_D145_K0.7540.62
133_I141_R0.7540.62
108_L116_F0.7470.61
80_E87_Q0.7400.60
141_R145_K0.7370.60
25_E107_I0.7270.59
50_G54_P0.7190.58
44_S76_Y0.7160.58
13_G79_T0.7140.58
58_S72_N0.7120.57
29_R32_E0.7100.57
127_E130_I0.7060.57
10_L15_L0.7050.57
110_E134_I0.7030.56
64_L79_T0.7000.56
21_E24_N0.6960.56
37_I44_S0.6960.56
60_V118_L0.6850.54
37_I104_S0.6840.54
34_I61_E0.6830.54
9_R46_R0.6820.54
91_N101_T0.6810.54
22_S33_I0.6800.54
71_N75_I0.6760.53
64_L104_S0.6670.52
58_S61_E0.6670.52
118_L130_I0.6530.51
113_Q123_S0.6490.51
16_K85_E0.6480.50
37_I134_I0.6460.50
124_K128_N0.6450.50
58_S62_K0.6440.50
53_Y56_L0.6380.49
23_L65_V0.6380.49
72_N77_I0.6350.49
58_S85_E0.6320.49
113_Q117_Y0.6240.48
29_R108_L0.6230.48
86_L93_S0.6230.48
32_E61_E0.6220.48
110_E137_L0.6220.48
29_R45_Y0.6200.47
41_F117_Y0.6180.47
43_G76_Y0.6180.47
22_S52_V0.6180.47
36_T66_E0.6170.47
66_E110_E0.6170.47
89_I122_R0.6080.46
11_K73_K0.6070.46
61_E64_L0.6050.46
29_R75_I0.6030.46
48_S54_P0.5950.45
106_Q116_F0.5900.44
32_E73_K0.5820.43
17_Y37_I0.5800.43
15_L18_L0.5790.43
30_T56_L0.5780.43
25_E28_M0.5770.43
81_K87_Q0.5750.43
107_I111_L0.5740.42
117_Y120_D0.5730.42
18_L22_S0.5710.42
84_N118_L0.5670.42
131_Q135_E0.5650.41
21_E40_K0.5630.41
105_R136_Y0.5620.41
100_N103_F0.5590.41
33_I40_K0.5540.40
16_K41_F0.5510.40
114_I119_Y0.5510.40
18_L41_F0.5490.40
124_K132_K0.5490.40
37_I55_V0.5480.40
62_K85_E0.5470.40
31_Y45_Y0.5420.39
17_Y93_S0.5400.39
22_S30_T0.5360.38
12_K32_E0.5360.38
106_Q109_Q0.5350.38
77_I83_K0.5350.38
98_G135_E0.5300.38
55_V141_R0.5290.38
17_Y86_L0.5280.38
124_K142_N0.5220.37
21_E90_K0.5190.37
57_K74_K0.5160.36
107_I140_C0.5150.36
57_K70_E0.5120.36
90_K98_G0.5090.36
39_K52_V0.5080.36
107_I125_I0.5080.36
75_I134_I0.5070.35
73_K106_Q0.5060.35
128_N131_Q0.5030.35
115_A134_I0.5020.35
32_E99_D0.5020.35
69_V85_E0.5020.35
28_M35_K0.5010.35
14_A26_R0.5000.35
136_Y139_N0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bm9A 2 0.723 99.9 0.524 Contact Map
2rkhA 2 0.8311 99.8 0.584 Contact Map
3l9fA 2 0.8176 99.8 0.592 Contact Map
2zfwA 2 0.6622 99.7 0.599 Contact Map
2e1nA 2 0.6622 99.7 0.611 Contact Map
1xmaA 2 0.6689 99.7 0.614 Contact Map
2eshA 2 0.7365 99.7 0.616 Contact Map
1yg2A 2 0.8243 99.7 0.617 Contact Map
2dqlA 2 0.6824 99.7 0.623 Contact Map
3f8bA 2 0.6757 99.6 0.651 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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