GREMLIN Database
Q981A8 - Uncharacterized protein
UniProt: Q981A8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (172)
Sequences: 344 (277)
Seq/√Len: 21.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_G53_A4.9071.00
55_P71_P4.1801.00
168_D174_V4.1561.00
40_Y171_P3.9851.00
45_A87_M3.7361.00
52_A73_F2.9080.99
41_A45_A2.7620.99
82_V167_L2.4640.98
39_G83_I2.2800.96
10_V73_F2.2190.95
117_F137_M2.1670.95
86_V167_L2.0980.94
119_R122_E2.0640.93
119_R160_K2.0330.93
42_V73_F2.0320.93
101_Y155_L1.9960.92
11_L73_F1.9620.91
55_P69_M1.9480.91
10_V52_A1.9050.90
123_P136_F1.8870.89
154_D165_F1.8730.89
18_V54_I1.8480.88
41_A87_M1.8340.88
35_R59_T1.8270.88
14_L171_P1.7200.85
122_E160_K1.7010.84
38_I97_I1.6930.84
53_A75_A1.6810.83
90_D148_V1.6540.82
17_A175_V1.6460.82
171_P175_V1.6390.81
119_R136_F1.6240.81
30_L105_V1.5770.79
150_N177_K1.5720.79
95_S174_V1.5580.78
117_F154_D1.5390.77
22_V67_Y1.5130.76
34_V37_N1.4870.75
114_L150_N1.4680.74
11_L52_A1.3940.70
14_L52_A1.3850.69
159_G162_P1.3750.69
109_L151_Y1.3650.68
170_D173_T1.3560.67
119_R123_P1.3530.67
36_T65_V1.3380.66
53_A76_S1.3220.65
37_N78_H1.3220.65
77_D81_R1.3200.65
13_R170_D1.3000.64
136_F160_K1.2980.64
101_Y106_I1.2620.62
143_R182_L1.2540.61
134_M154_D1.2430.60
76_S162_P1.2390.60
10_V42_V1.2260.59
42_V52_A1.2260.59
123_P137_M1.2180.59
31_I65_V1.1920.57
14_L40_Y1.1900.57
98_N163_S1.1740.56
34_V156_G1.1700.56
71_P165_F1.1680.56
96_A167_L1.1520.55
42_V93_I1.1170.52
83_I87_M1.1140.52
35_R60_T1.1110.52
160_K163_S1.1100.52
82_V154_D1.1070.52
57_R78_H1.1040.51
82_V117_F1.0860.50
92_N169_R1.0800.50
149_P152_I1.0740.49
108_K151_Y1.0670.49
34_V57_R1.0590.48
47_D111_S1.0580.48
156_G161_E1.0510.48
21_F178_S1.0490.48
13_R172_V1.0070.45
95_S171_P1.0000.44
41_A51_V0.9920.44
59_T69_M0.9910.44
39_G79_V0.9760.43
86_V141_C0.9730.43
44_N54_I0.9660.42
36_T58_L0.9630.42
52_A171_P0.9590.42
41_A54_I0.9540.41
106_I148_V0.9530.41
156_G159_G0.9500.41
79_V96_A0.9420.41
100_K142_I0.9280.40
65_V181_L0.9250.40
90_D149_P0.9250.40
166_I178_S0.9230.39
34_V78_H0.9220.39
50_D74_G0.9210.39
21_F179_L0.9170.39
34_V161_E0.9150.39
14_L38_I0.9140.39
47_D182_L0.9120.39
37_N156_G0.9120.39
13_R40_Y0.9100.39
168_D171_P0.9020.38
122_E136_F0.9020.38
71_P163_S0.8960.38
120_S157_D0.8930.38
97_I178_S0.8910.37
107_E111_S0.8870.37
118_D157_D0.8740.36
81_R134_M0.8630.36
7_R125_E0.8620.36
91_R94_R0.8580.35
40_Y95_S0.8510.35
24_N179_L0.8360.34
123_P160_K0.8360.34
45_A132_S0.8290.34
21_F65_V0.8170.33
166_I177_K0.8160.33
30_L109_L0.8130.33
51_V63_K0.8110.33
152_I163_S0.8070.32
110_P124_K0.8060.32
85_T88_K0.8000.32
118_D136_F0.7980.32
115_C150_N0.7900.31
57_R98_N0.7810.31
8_E109_L0.7790.31
119_R163_S0.7760.31
106_I164_L0.7720.30
85_T135_N0.7680.30
42_V154_D0.7610.30
17_A179_L0.7580.30
30_L102_Y0.7580.30
13_R171_P0.7580.30
40_Y172_V0.7490.29
40_Y94_R0.7470.29
105_V108_K0.7470.29
54_I154_D0.7470.29
20_I175_V0.7470.29
35_R54_I0.7420.29
136_F163_S0.7380.28
119_R165_F0.7360.28
31_I36_T0.7340.28
119_R154_D0.7320.28
51_V84_L0.7290.28
78_H161_E0.7260.28
168_D175_V0.7250.28
34_V163_S0.7230.28
14_L174_V0.7170.27
167_L170_D0.7160.27
60_T65_V0.7080.27
114_L180_E0.7050.27
36_T99_L0.7030.27
136_F165_F0.6970.26
106_I153_V0.6970.26
156_G162_P0.6970.26
90_D167_L0.6960.26
63_K103_R0.6930.26
117_F121_S0.6890.26
169_R173_T0.6860.26
30_L124_K0.6850.26
126_V132_S0.6820.26
31_I169_R0.6780.25
166_I176_N0.6780.25
103_R143_R0.6770.25
7_R88_K0.6760.25
83_I109_L0.6760.25
172_V176_N0.6700.25
21_F27_A0.6700.25
115_C181_L0.6670.25
37_N161_E0.6670.25
137_M142_I0.6640.25
120_S132_S0.6590.24
142_I152_I0.6580.24
31_I166_I0.6580.24
117_F132_S0.6570.24
137_M160_K0.6560.24
34_V98_N0.6530.24
74_G83_I0.6470.24
175_V179_L0.6470.24
53_A82_V0.6460.24
117_F165_F0.6450.24
27_A65_V0.6430.24
14_L95_S0.6430.24
173_T177_K0.6400.23
27_A36_T0.6380.23
119_R156_G0.6380.23
39_G96_A0.6370.23
152_I177_K0.6360.23
97_I174_V0.6340.23
53_A140_S0.6330.23
157_D162_P0.6280.23
91_R138_V0.6270.23
153_V165_F0.6230.23
17_A39_G0.6190.22
55_P67_Y0.6170.22
34_V165_F0.6100.22
50_D100_K0.6040.22
114_L181_L0.6020.22
151_Y170_D0.6020.22
119_R133_T0.6000.22
85_T164_L0.6000.22
62_F67_Y0.6000.22
143_R147_K0.5960.21
78_H119_R0.5940.21
61_A80_A0.5880.21
37_N154_D0.5850.21
39_G42_V0.5810.21
139_D176_N0.5810.21
126_V137_M0.5800.21
59_T108_K0.5770.21
92_N103_R0.5750.20
78_H149_P0.5740.20
21_F62_F0.5700.20
145_L181_L0.5680.20
112_Q169_R0.5670.20
97_I182_L0.5650.20
152_I180_E0.5630.20
126_V136_F0.5630.20
100_K139_D0.5620.20
32_P57_R0.5600.20
147_K181_L0.5590.20
57_R160_K0.5590.20
123_P126_V0.5580.20
41_A59_T0.5520.20
82_V157_D0.5520.20
61_A109_L0.5480.19
23_S183_K0.5460.19
19_D72_A0.5460.19
54_I71_P0.5440.19
17_A95_S0.5430.19
62_F72_A0.5410.19
139_D143_R0.5390.19
35_R79_V0.5390.19
37_N162_P0.5390.19
23_S143_R0.5380.19
33_E119_R0.5380.19
78_H163_S0.5350.19
15_K175_V0.5340.19
33_E98_N0.5310.19
20_I40_Y0.5300.19
31_I146_S0.5270.18
109_L170_D0.5240.18
104_E107_E0.5240.18
88_K155_L0.5230.18
119_R134_M0.5210.18
113_D168_D0.5150.18
55_P72_A0.5130.18
17_A171_P0.5120.18
122_E163_S0.5090.18
175_V182_L0.5070.18
115_C147_K0.5050.18
85_T139_D0.5050.18
51_V94_R0.5040.18
97_I166_I0.5020.17
39_G70_L0.5000.17
37_N76_S0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pb9A 3 0.9263 100 0.152 Contact Map
2phpA 3 0.9579 100 0.172 Contact Map
1egzA 1 0.7579 41.9 0.946 Contact Map
4aweA 1 0.6947 26 0.952 Contact Map
3ondA 4 0.7842 23.8 0.953 Contact Map
1tvnA 2 0.7579 23.6 0.953 Contact Map
7a3hA 1 0.7263 22.9 0.953 Contact Map
2cksA 1 0.7158 19.9 0.954 Contact Map
3qoqA 3 0.2632 19 0.955 Contact Map
2c0hA 1 0.7053 16.8 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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