GREMLIN Database
Q981A2 - Uncharacterized protein
UniProt: Q981A2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (238)
Sequences: 7167 (5029)
Seq/√Len: 326.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_L115_K3.2741.00
107_E137_S3.0081.00
151_V182_E2.7961.00
216_Q219_L2.7211.00
90_Y130_D2.4561.00
110_L120_V2.2901.00
24_E206_K2.2671.00
142_F162_G2.2481.00
234_K238_S2.1841.00
215_K225_E2.1691.00
136_N156_K2.1071.00
47_K79_Y2.0941.00
177_Q216_Q2.0731.00
124_I131_F1.9801.00
103_I130_D1.9471.00
111_Q138_Y1.9121.00
185_L221_K1.8651.00
46_A54_P1.8531.00
77_T83_I1.8471.00
185_L231_K1.8311.00
223_I228_I1.8081.00
17_D204_R1.8041.00
7_A29_I1.7991.00
15_D18_R1.7771.00
107_E138_Y1.7741.00
90_Y99_R1.7621.00
230_E234_K1.7591.00
26_Q51_N1.7401.00
104_E108_K1.7211.00
185_L223_I1.7111.00
180_A217_I1.7051.00
136_N160_Y1.7041.00
129_K133_E1.7041.00
151_V155_N1.6861.00
28_L53_I1.6541.00
156_K159_E1.6411.00
214_V225_E1.6381.00
28_L237_V1.6311.00
55_A121_I1.6301.00
40_L72_K1.6281.00
146_S167_P1.6221.00
144_I157_V1.6191.00
190_T214_V1.6011.00
86_V109_F1.5971.00
5_S236_F1.5551.00
143_V239_L1.5241.00
108_K111_Q1.5171.00
74_L116_E1.5161.00
86_V120_V1.4911.00
155_N182_E1.4791.00
155_N159_E1.4791.00
19_E48_K1.4621.00
170_I217_I1.4591.00
44_E48_K1.4511.00
166_I180_A1.4501.00
124_I128_M1.4481.00
215_K219_L1.4381.00
163_L238_S1.4151.00
103_I133_E1.4111.00
154_A164_I1.3981.00
211_K215_K1.3971.00
178_K181_K1.3961.00
77_T116_E1.3901.00
117_N141_R1.3821.00
163_L187_F1.3821.00
132_L156_K1.3811.00
150_S153_I1.3741.00
106_L122_I1.3731.00
133_E137_S1.3511.00
35_D38_S1.3481.00
3_V28_L1.3461.00
3_V30_V1.3171.00
177_Q220_L1.3171.00
107_E134_I1.3161.00
233_Y237_V1.3031.00
72_K75_E1.2991.00
103_I107_E1.2831.00
42_T54_P1.2811.00
44_E47_K1.2791.00
10_D38_S1.2771.00
114_E138_Y1.2771.00
212_I215_K1.2681.00
106_L131_F1.2651.00
2_L229_E1.2441.00
164_I183_I1.2341.00
227_E230_E1.2301.00
3_V233_Y1.2221.00
93_I97_D1.2191.00
233_Y236_F1.2121.00
61_E92_W1.2121.00
184_P187_F1.2121.00
7_A194_S1.2061.00
90_Y103_I1.2051.00
223_I227_E1.2021.00
33_G39_N1.2001.00
98_L101_K1.1961.00
103_I134_I1.1881.00
224_E227_E1.1871.00
217_I228_I1.1821.00
158_I187_F1.1711.00
25_C29_I1.1631.00
2_L214_V1.1631.00
36_F39_N1.1611.00
99_R103_I1.1581.00
214_V232_I1.1491.00
75_E78_R1.1491.00
166_I188_I1.1451.00
152_K155_N1.1361.00
31_N42_T1.1351.00
43_L54_P1.1341.00
189_L239_L1.1271.00
93_I99_R1.1241.00
20_F24_E1.1191.00
29_I52_I1.0971.00
178_K182_E1.0961.00
216_Q220_L1.0941.00
114_E139_R1.0941.00
232_I236_F1.0841.00
70_I108_K1.0801.00
3_V236_F1.0711.00
163_L239_L1.0691.00
190_T210_V1.0681.00
17_D20_F1.0651.00
2_L210_V1.0631.00
43_L79_Y1.0581.00
63_V105_V1.0511.00
111_Q115_K1.0421.00
128_M153_I1.0391.00
32_A121_I1.0351.00
151_V179_V1.0341.00
19_E23_N1.0341.00
205_N209_N1.0321.00
100_K104_E1.0311.00
173_D200_E1.0301.00
180_A221_K1.0291.00
129_K156_K1.0281.00
36_F69_E1.0211.00
36_F72_K1.0211.00
43_L56_I1.0131.00
101_K104_E1.0131.00
129_K153_I1.0091.00
20_F23_N1.0051.00
190_T217_I1.0021.00
61_E97_D0.9981.00
231_K234_K0.9981.00
100_K103_I0.9921.00
172_R198_G0.9921.00
31_N52_I0.9871.00
40_L44_E0.9831.00
24_E208_C0.9811.00
14_F204_R0.9801.00
149_G153_I0.9741.00
62_F65_D0.9721.00
170_I180_A0.9621.00
41_H44_E0.9491.00
46_A52_I0.9481.00
71_D74_L0.9451.00
206_K209_N0.9441.00
91_F126_G0.9441.00
166_I183_I0.9351.00
214_V229_E0.9291.00
74_L112_I0.9251.00
142_F239_L0.9251.00
229_E233_Y0.9241.00
143_V240_F0.9141.00
132_L157_V0.9051.00
19_E49_Y0.9031.00
151_V178_K0.9031.00
14_F17_D0.9031.00
30_V236_F0.8991.00
75_E79_Y0.8981.00
32_A55_A0.8951.00
165_S189_L0.8921.00
211_K225_E0.8911.00
40_L76_L0.8901.00
221_K228_I0.8861.00
9_I207_P0.8811.00
190_T232_I0.8801.00
227_E231_K0.8791.00
99_R130_D0.8751.00
22_I49_Y0.8701.00
228_I232_I0.8691.00
214_V228_I0.8641.00
63_V101_K0.8561.00
5_S189_L0.8521.00
42_T46_A0.8511.00
185_L228_I0.8501.00
225_E229_E0.8491.00
30_V55_A0.8471.00
122_I144_I0.8421.00
158_I184_P0.8401.00
180_A220_L0.8371.00
43_L47_K0.8351.00
23_N26_Q0.8341.00
66_K105_V0.8331.00
34_V38_S0.8291.00
69_E72_K0.8271.00
17_D21_V0.8221.00
110_L114_E0.8171.00
122_I131_F0.8161.00
27_I233_Y0.8101.00
141_R241_T0.8011.00
93_I96_E0.7951.00
72_K76_L0.7951.00
5_S143_V0.7901.00
210_V213_V0.7891.00
130_D133_E0.7811.00
74_L78_R0.7811.00
54_P82_I0.7731.00
2_L233_Y0.7661.00
2_L211_K0.7651.00
181_K220_L0.7641.00
226_I230_E0.7590.99
10_D41_H0.7590.99
61_E96_E0.7580.99
128_M149_G0.7560.99
188_I221_K0.7550.99
132_L153_I0.7510.99
58_F66_K0.7500.99
83_I86_V0.7470.99
124_I149_G0.7470.99
107_E111_Q0.7460.99
112_I116_E0.7450.99
78_R116_E0.7430.99
71_D75_E0.7420.99
217_I221_K0.7420.99
158_I164_I0.7410.99
134_I137_S0.7410.99
184_P221_K0.7400.99
22_I29_I0.7380.99
128_M157_V0.7350.99
214_V218_S0.7320.99
234_K237_V0.7280.99
47_K81_K0.7190.99
163_L189_L0.7180.99
56_I76_L0.7130.99
92_W96_E0.7110.99
143_V165_S0.7080.99
169_I172_R0.7070.99
136_N159_E0.7060.99
67_V108_K0.7050.99
93_I98_L0.7050.99
188_I228_I0.7010.99
96_E99_R0.6950.99
101_K105_V0.6920.99
38_S42_T0.6910.99
181_K222_R0.6870.99
39_N76_L0.6790.99
198_G209_N0.6730.99
70_I74_L0.6730.99
11_V14_F0.6710.99
223_I231_K0.6670.99
154_A158_I0.6620.99
134_I138_Y0.6580.99
86_V105_V0.6550.99
2_L190_T0.6540.99
39_N42_T0.6510.98
33_G42_T0.6510.98
15_D41_H0.6510.98
12_K15_D0.6510.98
39_N56_I0.6500.98
22_I26_Q0.6480.98
169_I197_M0.6470.98
2_L225_E0.6430.98
63_V97_D0.6400.98
158_I182_E0.6380.98
110_L134_I0.6360.98
110_L138_Y0.6340.98
231_K238_S0.6310.98
39_N73_C0.6300.98
183_I188_I0.6280.98
64_K98_L0.6270.98
35_D65_D0.6260.98
158_I183_I0.6250.98
157_V164_I0.6240.98
117_N241_T0.6240.98
132_L136_N0.6220.98
154_A183_I0.6200.98
66_K69_E0.6190.98
66_K70_I0.6140.98
14_F18_R0.6140.98
5_S121_I0.6130.98
88_L127_G0.6110.98
169_I175_V0.6110.98
186_D238_S0.6090.98
124_I157_V0.6080.98
25_C206_K0.6070.98
121_I240_F0.6070.98
147_F153_I0.6060.98
105_V109_F0.6040.97
154_A179_V0.6020.97
188_I232_I0.6020.97
144_I165_S0.5980.97
186_D231_K0.5980.97
64_K97_D0.5970.97
171_V200_E0.5960.97
64_K101_K0.5950.97
25_C208_C0.5950.97
37_Q41_H0.5930.97
166_I169_I0.5900.97
11_V34_V0.5900.97
3_V237_V0.5890.97
128_M132_L0.5870.97
189_L236_F0.5850.97
170_I228_I0.5770.97
156_K160_Y0.5760.97
67_V104_E0.5750.97
18_R204_R0.5740.97
221_K231_K0.5740.97
132_L160_Y0.5740.97
21_V24_E0.5740.97
34_V62_F0.5740.97
18_R21_V0.5730.97
21_V25_C0.5710.97
218_S225_E0.5700.96
17_D24_E0.5700.96
30_V240_F0.5680.96
114_E140_I0.5660.96
143_V189_L0.5650.96
91_F125_R0.5610.96
21_V204_R0.5590.96
11_V196_F0.5580.96
231_K235_N0.5570.96
128_M131_F0.5560.96
10_D31_N0.5550.96
226_I229_E0.5550.96
170_I177_Q0.5540.96
122_I142_F0.5480.96
39_N54_P0.5470.96
167_P197_M0.5470.96
163_L235_N0.5450.95
111_Q114_E0.5410.95
10_D34_V0.5380.95
209_N212_I0.5380.95
43_L46_A0.5330.95
45_L52_I0.5310.95
177_Q181_K0.5310.95
61_E93_I0.5310.95
57_G109_F0.5240.94
108_K112_I0.5120.94
165_S197_M0.5120.94
168_P171_V0.5100.94
67_V70_I0.5100.94
9_I18_R0.5100.94
219_L222_R0.5100.94
43_L76_L0.5070.93
109_F113_A0.5070.93
69_E105_V0.5060.93
22_I52_I0.5060.93
235_N238_S0.5050.93
70_I112_I0.5030.93
90_Y127_G0.5030.93
147_F157_V0.5030.93
49_Y52_I0.5010.93
113_A120_V0.5010.93
112_I115_K0.5010.93
153_I157_V0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e2vA 1 0.9676 100 0.216 Contact Map
3ipwA 1 0.9798 100 0.275 Contact Map
2xioA 1 0.9798 100 0.336 Contact Map
3gg7A 1 0.9717 100 0.345 Contact Map
1j6oA 1 0.9838 100 0.37 Contact Map
3rcmA 1 0.9879 100 0.41 Contact Map
2y1hA 2 0.9919 100 0.42 Contact Map
1xwyA 1 0.9717 100 0.421 Contact Map
2gzxA 1 0.9636 100 0.422 Contact Map
1zzmA 1 0.9757 100 0.442 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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