GREMLIN Database
Q981A0 - Uncharacterized protein
UniProt: Q981A0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 131 (122)
Sequences: 1018 (675)
Seq/√Len: 61.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_E78_R4.3781.00
13_I27_I4.0891.00
60_R72_E3.6511.00
51_D55_S3.0971.00
19_K34_T3.0881.00
122_I126_L2.9111.00
20_G26_Q2.5811.00
62_S72_E2.3981.00
30_E33_K2.2251.00
61_I71_Y2.0331.00
13_I46_I1.9571.00
18_S85_S1.9141.00
13_I49_A1.8491.00
95_E124_D1.7971.00
80_A84_M1.7800.99
84_M87_E1.7450.99
7_R10_K1.6900.99
96_Q100_S1.6850.99
79_K83_A1.6830.99
123_L126_L1.6310.99
64_V67_W1.6020.99
22_M30_E1.5990.99
61_I69_K1.5060.98
95_E99_F1.4990.98
99_F124_D1.4930.98
62_S65_D1.4910.98
92_E96_Q1.4690.98
82_G85_S1.4600.98
10_K56_E1.4030.97
107_N111_L1.3990.97
50_L71_Y1.3930.97
10_K49_A1.3840.97
79_K82_G1.3610.97
35_S39_W1.3590.97
112_N115_D1.3550.97
45_S49_A1.3500.97
97_L101_A1.3370.96
80_A83_A1.3310.96
111_L115_D1.3040.96
17_L73_L1.2990.96
31_I34_T1.2920.96
49_A53_L1.2800.95
33_K53_L1.2690.95
56_E73_L1.2330.94
18_S78_R1.2200.94
76_E79_K1.2010.93
92_E95_E1.1880.93
100_S105_V1.1500.92
54_E64_V1.1290.91
29_D40_R1.1140.90
115_D118_K1.1110.90
40_R46_I1.1100.90
15_Y19_K1.0960.90
122_I125_E1.0910.90
96_Q124_D1.0600.88
35_S70_Y1.0510.88
120_K124_D1.0360.87
100_S126_L1.0290.87
58_L80_A1.0010.85
93_A97_L0.9920.85
118_K122_I0.9820.84
22_M26_Q0.9770.84
49_A52_A0.9610.83
52_A80_A0.9560.82
97_L100_S0.9470.82
26_Q68_K0.9420.81
92_E122_I0.9370.81
81_I84_M0.9360.81
89_K97_L0.9290.80
89_K93_A0.9210.80
13_I84_M0.8940.78
6_R45_S0.8910.78
7_R45_S0.8830.77
60_R75_E0.8800.77
117_R124_D0.8770.76
6_R67_W0.8680.76
99_F103_Y0.8620.75
16_V21_P0.8600.75
58_L74_T0.8600.75
68_K105_V0.8460.74
113_D116_K0.8340.73
110_K119_V0.8300.72
9_L12_L0.8230.72
52_A55_S0.8230.72
43_P71_Y0.8210.72
76_E83_A0.8070.70
54_E61_I0.8010.70
57_G76_E0.7910.69
5_R13_I0.7910.69
18_S31_I0.7890.69
10_K67_W0.7830.68
54_E104_I0.7780.67
22_M27_I0.7770.67
93_A98_E0.7740.67
11_W39_W0.7670.66
11_W81_I0.7620.66
110_K115_D0.7610.66
23_T68_K0.7400.64
113_D117_R0.7340.63
75_E82_G0.7330.63
116_K120_K0.7320.63
17_L59_I0.7260.62
6_R13_I0.7260.62
8_G30_E0.7220.62
94_I98_E0.7200.61
61_I68_K0.7190.61
5_R97_L0.7130.61
52_A67_W0.7070.60
96_Q99_F0.7050.60
6_R9_L0.7030.60
23_T39_W0.6990.59
14_L81_I0.6970.59
13_I17_L0.6900.58
38_M71_Y0.6900.58
108_L111_L0.6870.58
98_E101_A0.6860.58
30_E34_T0.6860.58
78_R82_G0.6820.57
25_A29_D0.6800.57
8_G20_G0.6790.57
97_L104_I0.6760.57
17_L22_M0.6690.56
75_E79_K0.6620.55
117_R121_N0.6590.55
67_W72_E0.6570.54
121_N125_E0.6550.54
111_L119_V0.6400.53
97_L105_V0.6400.53
23_T26_Q0.6390.52
30_E60_R0.6350.52
7_R35_S0.6260.51
92_E100_S0.6210.50
93_A116_K0.6130.49
67_W122_I0.6110.49
55_S61_I0.6110.49
18_S75_E0.6060.49
6_R52_A0.6050.49
19_K87_E0.6030.48
114_E117_R0.6000.48
46_I61_I0.5980.48
10_K35_S0.5980.48
31_I38_M0.5960.48
89_K105_V0.5940.47
46_I101_A0.5810.46
68_K71_Y0.5760.45
78_R113_D0.5730.45
115_D119_V0.5720.45
93_A104_I0.5700.45
23_T70_Y0.5690.45
47_Y50_L0.5650.44
65_D72_E0.5600.44
106_E109_E0.5590.43
33_K68_K0.5560.43
90_I93_A0.5550.43
40_R69_K0.5480.42
24_G47_Y0.5440.42
98_E105_V0.5400.41
97_L119_V0.5370.41
95_E104_I0.5350.41
28_M55_S0.5340.41
76_E82_G0.5340.41
103_Y106_E0.5320.40
25_A39_W0.5320.40
51_D69_K0.5310.40
15_Y29_D0.5290.40
32_E40_R0.5280.40
32_E37_G0.5260.40
15_Y34_T0.5260.40
15_Y28_M0.5190.39
39_W81_I0.5180.39
104_I116_K0.5150.39
29_D39_W0.5150.39
10_K52_A0.5150.39
15_Y18_S0.5150.39
6_R26_Q0.5150.39
26_Q45_S0.5150.39
7_R74_T0.5140.38
33_K46_I0.5130.38
17_L111_L0.5110.38
15_Y81_I0.5100.38
118_K126_L0.5010.37
5_R68_K0.5000.37
98_E102_R0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bm9A 2 0.8015 99.9 0.51 Contact Map
2rkhA 2 0.916 99.8 0.557 Contact Map
3l9fA 2 0.916 99.7 0.577 Contact Map
1yg2A 2 0.8855 99.7 0.591 Contact Map
2zfwA 2 0.7099 99.6 0.615 Contact Map
2e1nA 2 0.7099 99.6 0.622 Contact Map
1xmaA 2 0.7481 99.6 0.627 Contact Map
2eshA 2 0.8244 99.6 0.629 Contact Map
3f8bA 2 0.7481 99.5 0.64 Contact Map
2dqlA 2 0.7328 99.5 0.644 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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