GREMLIN Database
Q980Z9 - Enoyl CoA hydratase (PaaF-1)
UniProt: Q980Z9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (236)
Sequences: 30239 (19809)
Seq/√Len: 1289.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_M164_V3.2441.00
122_S176_V3.0791.00
100_S117_S2.8181.00
186_A189_D2.7551.00
13_L188_L2.7081.00
42_N95_N2.5811.00
39_S90_K2.5511.00
23_Y57_N2.5051.00
125_K180_D2.4931.00
163_D193_E2.4321.00
169_E172_S2.2751.00
166_D169_E2.2411.00
157_R163_D2.1881.00
154_N173_I2.1671.00
216_Y219_K2.1301.00
134_K197_L2.1111.00
124_K168_N2.0641.00
13_L53_R2.0371.00
182_D185_K1.9941.00
7_E12_I1.9771.00
107_Y129_A1.9651.00
101_Q187_T1.9631.00
235_E244_T1.9571.00
124_K180_D1.9541.00
10_K48_R1.9331.00
157_R177_H1.9121.00
29_E33_Q1.9071.00
35_I90_K1.8981.00
121_I179_I1.8821.00
7_E44_N1.8781.00
101_Q184_D1.8721.00
159_A205_I1.8671.00
15_K55_E1.8641.00
238_L242_N1.7971.00
15_K53_R1.7681.00
156_K210_L1.7671.00
12_I41_I1.7591.00
18_Q55_E1.7501.00
169_E173_I1.7131.00
50_L94_L1.7071.00
188_L192_E1.6821.00
32_T83_Y1.6581.00
121_I190_L1.6261.00
120_V149_I1.6151.00
152_Y156_K1.5921.00
41_I50_L1.5861.00
42_N90_K1.5861.00
168_N172_S1.5771.00
40_A44_N1.5721.00
122_S128_F1.5611.00
12_I47_K1.5511.00
53_R103_K1.5381.00
9_D192_E1.5331.00
179_I186_A1.5331.00
123_E180_D1.5301.00
182_D186_A1.5201.00
49_F191_I1.5171.00
118_D206_K1.5051.00
114_L120_V1.5031.00
14_L37_V1.4721.00
156_K209_M1.4611.00
8_Y188_L1.4591.00
156_K160_M1.4561.00
120_V153_N1.4551.00
57_N103_K1.4531.00
103_K125_K1.4141.00
8_Y192_E1.4071.00
91_M98_V1.3991.00
102_V106_A1.3841.00
102_V114_L1.3761.00
171_K178_I1.3731.00
103_K123_E1.3651.00
163_D169_E1.3571.00
38_L94_L1.3521.00
73_D76_F1.3481.00
19_A22_R1.3431.00
111_M130_T1.3311.00
89_H93_D1.3301.00
158_I165_I1.3171.00
28_V66_E1.3141.00
8_Y13_L1.3071.00
27_N30_F1.3071.00
183_L187_T1.2871.00
133_V162_G1.2831.00
154_N157_R1.2831.00
35_I39_S1.2771.00
207_R211_R1.2701.00
129_A164_V1.2661.00
89_H218_D1.2351.00
16_F30_F1.2271.00
53_R184_D1.2201.00
35_I86_E1.2181.00
154_N169_E1.2161.00
42_N94_L1.2151.00
153_N177_H1.2111.00
215_N219_K1.2051.00
105_I127_M1.2051.00
33_Q37_V1.2011.00
13_L184_D1.1921.00
233_A237_L1.1871.00
151_G154_N1.1801.00
123_E183_L1.1731.00
184_D188_L1.1671.00
167_T178_I1.1531.00
16_F59_G1.1331.00
197_L202_T1.1251.00
184_D187_T1.1241.00
59_G110_S1.1221.00
165_I173_I1.1131.00
22_R65_R1.1091.00
204_Y226_V1.0951.00
84_M141_V1.0771.00
112_E143_S1.0621.00
119_Y190_L1.0591.00
36_D40_A1.0591.00
50_L96_K1.0571.00
33_Q36_D1.0541.00
191_I195_S1.0531.00
200_S232_E1.0431.00
28_V32_T1.0411.00
7_E40_A1.0151.00
98_V117_S1.0151.00
171_K176_V1.0041.00
19_A63_D1.0041.00
56_D103_K1.0011.00
103_K183_L0.9861.00
45_K96_K0.9831.00
51_V187_T0.9801.00
6_Y15_K0.9791.00
216_Y220_A0.9791.00
13_L51_V0.9671.00
149_I153_N0.9581.00
7_E46_G0.9531.00
111_M128_F0.9471.00
6_Y13_L0.9451.00
47_K96_K0.9421.00
95_N203_L0.9391.00
23_Y60_A0.9281.00
127_M166_D0.9271.00
102_V128_F0.9251.00
199_P203_L0.9231.00
150_L154_N0.9181.00
50_L98_V0.9141.00
53_R101_Q0.9131.00
119_Y177_H0.9121.00
37_V40_A0.9071.00
219_K222_D0.9061.00
168_N171_K0.9061.00
185_K189_D0.8991.00
11_Y49_F0.8961.00
112_E132_G0.8941.00
124_K178_I0.8941.00
31_M87_V0.8871.00
234_R238_L0.8821.00
133_V205_I0.8771.00
146_G150_L0.8691.00
186_A190_L0.8691.00
215_N220_A0.8581.00
102_V120_V0.8531.00
138_F227_Q0.8461.00
188_L191_I0.8351.00
38_L91_M0.8341.00
151_G155_V0.8301.00
123_E181_D0.8291.00
93_D218_D0.8211.00
189_D193_E0.8191.00
65_R241_L0.8121.00
41_I47_K0.8101.00
108_G131_P0.8071.00
39_S86_E0.8061.00
158_I173_I0.8061.00
78_V82_T0.8051.00
150_L158_I0.8031.00
14_L50_L0.7991.00
23_Y105_I0.7901.00
28_V83_Y0.7891.00
194_L202_T0.7891.00
167_T176_V0.7881.00
187_T191_I0.7861.00
52_I117_S0.7851.00
101_Q183_L0.7821.00
39_S43_E0.7811.00
207_R223_D0.7781.00
42_N96_K0.7761.00
204_Y223_D0.7761.00
134_K164_V0.7761.00
32_T36_D0.7751.00
7_E47_K0.7731.00
132_G140_P0.7731.00
204_Y207_R0.7691.00
88_F116_F0.7671.00
35_I87_V0.7641.00
218_D222_D0.7641.00
35_I83_Y0.7621.00
107_Y164_V0.7611.00
170_A175_L0.7571.00
103_K180_D0.7561.00
102_V126_A0.7541.00
198_A232_E0.7511.00
132_G139_P0.7471.00
27_N66_E0.7441.00
26_F30_F0.7431.00
112_E140_P0.7381.00
75_E79_T0.7361.00
217_I221_F0.7361.00
189_D192_E0.7361.00
48_R199_P0.7341.00
95_N207_R0.7321.00
193_E197_L0.7311.00
223_D226_V0.7311.00
231_E234_R0.7261.00
237_L241_L0.7251.00
185_K188_L0.7241.00
19_A25_L0.7221.00
115_L175_L0.7211.00
94_L98_V0.7191.00
179_I183_L0.7181.00
19_A27_N0.7171.00
11_Y51_V0.7161.00
125_K167_T0.7141.00
51_V188_L0.7081.00
159_A209_M0.7051.00
157_R161_K0.7031.00
41_I96_K0.6991.00
112_E142_L0.6991.00
235_E242_N0.6991.00
99_I191_I0.6971.00
52_I98_V0.6931.00
152_Y213_F0.6921.00
94_L97_I0.6881.00
37_V41_I0.6861.00
44_N96_K0.6821.00
7_E10_K0.6801.00
145_V220_A0.6791.00
10_K46_G0.6771.00
122_S126_A0.6751.00
211_R215_N0.6751.00
44_N47_K0.6751.00
121_I183_L0.6731.00
149_I177_H0.6711.00
121_I187_T0.6691.00
30_F33_Q0.6691.00
139_P205_I0.6671.00
51_V101_Q0.6671.00
121_I186_A0.6651.00
138_F208_N0.6651.00
128_F176_V0.6621.00
192_E196_T0.6591.00
132_G224_L0.6591.00
82_T86_E0.6591.00
107_Y131_P0.6571.00
205_I208_N0.6561.00
208_N223_D0.6541.00
200_S230_S0.6471.00
34_M87_V0.6471.00
129_A162_G0.6471.00
29_E32_T0.6421.00
36_D39_S0.6421.00
161_K190_L0.6411.00
232_E236_G0.6401.00
236_G239_S0.6371.00
152_Y209_M0.6341.00
147_H150_L0.6311.00
150_L155_V0.6261.00
103_K126_A0.6181.00
11_Y188_L0.6171.00
235_E239_S0.6161.00
49_F99_I0.6101.00
130_T143_S0.6101.00
11_Y191_I0.6081.00
167_T171_K0.6071.00
204_Y227_Q0.6051.00
154_N171_K0.6031.00
62_A67_L0.6021.00
38_L90_K0.5991.00
100_S120_V0.5981.00
190_L193_E0.5971.00
137_V233_A0.5961.00
14_L52_I0.5941.00
168_N178_I0.5921.00
14_L38_L0.5911.00
235_E238_L0.5891.00
108_G130_T0.5871.00
152_Y210_L0.5871.00
39_S42_N0.5861.00
166_D172_S0.5861.00
112_E130_T0.5861.00
160_M202_T0.5861.00
47_K50_L0.5851.00
79_T83_Y0.5841.00
238_L241_L0.5831.00
233_A236_G0.5811.00
231_E235_E0.5811.00
165_I170_A0.5801.00
150_L173_I0.5791.00
49_F195_S0.5791.00
74_S226_V0.5771.00
51_V184_D0.5771.00
133_V197_L0.5761.00
22_R63_D0.5751.00
132_G142_L0.5741.00
145_V148_F0.5731.00
119_Y194_L0.5711.00
68_I238_L0.5691.00
130_T159_A0.5691.00
147_H151_G0.5671.00
64_I67_L0.5671.00
86_E89_H0.5621.00
105_I164_V0.5591.00
114_L117_S0.5551.00
157_R190_L0.5551.00
217_I220_A0.5541.00
111_M115_L0.5521.00
109_A112_E0.5501.00
123_E126_A0.5471.00
133_V202_T0.5461.00
78_V225_I0.5421.00
170_A176_V0.5411.00
147_H212_T0.5401.00
14_L41_I0.5401.00
156_K206_K0.5391.00
22_R25_L0.5391.00
111_M175_L0.5391.00
74_S78_V0.5371.00
25_L60_A0.5361.00
38_L98_V0.5361.00
29_E66_E0.5311.00
26_F31_M0.5311.00
157_R169_E0.5301.00
26_F109_A0.5291.00
109_A141_V0.5291.00
154_N172_S0.5281.00
182_D189_D0.5261.00
15_K18_Q0.5251.00
161_K194_L0.5221.00
158_I161_K0.5201.00
48_R195_S0.5191.00
106_A111_M0.5171.00
38_L50_L0.5171.00
27_N63_D0.5171.00
101_Q191_I0.5161.00
161_K193_E0.5151.00
165_I175_L0.5111.00
64_I135_I0.5101.00
130_T146_G0.5091.00
120_V176_V0.5081.00
206_K210_L0.5081.00
193_E196_T0.5071.00
148_F216_Y0.5061.00
138_F205_I0.5061.00
147_H209_M0.5021.00
200_S227_Q0.5011.00
227_Q230_S0.5001.00
31_M35_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4olqA 3 0.996 100 0.135 Contact Map
4mouA 3 0.996 100 0.136 Contact Map
4k2nA 3 0.992 100 0.137 Contact Map
4lk5A 3 0.9558 100 0.14 Contact Map
4k3wA 3 0.996 100 0.14 Contact Map
2vx2A 3 0.992 100 0.141 Contact Map
3hp0A 3 0.9839 100 0.141 Contact Map
4jfcA 3 0.996 100 0.143 Contact Map
3mybA 3 0.9839 100 0.145 Contact Map
1uiyA 6 0.9839 100 0.145 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.