GREMLIN Database
Q980Z2 - 4-hydroxybenzoate octaprenyltransferase (UbiA-1)
UniProt: Q980Z2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 302 (275)
Sequences: 6425 (4302)
Seq/√Len: 259.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_I96_I4.5281.00
72_L96_I4.2911.00
18_I93_A3.5021.00
72_L100_R3.4271.00
15_K98_E3.0741.00
82_P85_K3.0511.00
21_R93_A3.0391.00
65_A107_L2.9611.00
95_K98_E2.7231.00
118_N121_A2.6671.00
77_I211_L2.6071.00
220_R224_T2.4101.00
68_T106_S2.3491.00
263_Y267_L2.3401.00
119_I123_I2.3291.00
19_I98_E2.3031.00
121_A162_V2.3031.00
204_E207_K2.2901.00
79_A90_V2.2611.00
167_L177_L2.2341.00
234_V258_G2.2281.00
54_L116_F2.1801.00
97_R101_T2.0971.00
62_L110_F2.0901.00
253_A291_G2.0721.00
241_D250_A2.0651.00
189_L232_F2.0511.00
20_L25_I2.0491.00
54_L113_T2.0481.00
36_Y56_F1.9871.00
241_D251_I1.9781.00
203_A207_K1.8851.00
72_L99_A1.8041.00
247_G295_D1.7991.00
73_A137_Y1.7831.00
270_Q273_D1.7041.00
207_K216_V1.6711.00
130_L133_M1.6641.00
193_G230_Q1.6631.00
68_T102_M1.6281.00
151_S184_V1.6221.00
23_L106_S1.6201.00
120_W162_V1.6141.00
221_W224_T1.6101.00
80_K209_M1.6041.00
94_I99_A1.5981.00
281_N285_S1.5891.00
186_G237_D1.5841.00
107_L129_A1.5821.00
61_F109_L1.5751.00
138_M141_Y1.5751.00
134_S148_H1.5451.00
115_Y122_F1.5341.00
182_F243_Y1.5171.00
17_Y21_R1.5161.00
23_L102_M1.5021.00
259_L263_Y1.4961.00
101_T105_A1.4811.00
123_I127_I1.4771.00
177_L180_P1.4691.00
138_M148_H1.4681.00
68_T103_I1.4441.00
75_I79_A1.4441.00
145_A213_S1.4281.00
48_P51_T1.4241.00
273_D277_A1.4181.00
64_T106_S1.4161.00
200_I222_A1.4131.00
89_L99_A1.4111.00
131_I152_I1.4071.00
62_L125_A1.3961.00
94_I102_M1.3951.00
203_A216_V1.3931.00
74_D140_R1.3841.00
189_L229_N1.3801.00
22_F94_I1.3701.00
276_R279_Y1.3651.00
23_L64_T1.3431.00
282_I286_I1.3401.00
39_A52_L1.3201.00
68_T94_I1.3151.00
181_W185_I1.3021.00
256_L260_I1.2901.00
283_Y287_V1.2891.00
32_L36_Y1.2771.00
257_H288_L1.2531.00
89_L94_I1.2501.00
104_V108_I1.2481.00
262_A266_Y1.2331.00
61_F110_F1.2321.00
260_I263_Y1.2311.00
54_L117_V1.2241.00
168_Y177_L1.2201.00
77_I140_R1.2101.00
74_D77_I1.2051.00
233_S237_D1.1771.00
53_I57_L1.1711.00
193_G233_S1.1681.00
222_A226_A1.1661.00
25_I60_F1.1621.00
20_L23_L1.1611.00
225_F229_N1.1571.00
264_A280_Y1.1411.00
100_R104_V1.1201.00
158_F184_V1.1201.00
260_I280_Y1.1161.00
168_Y180_P1.1151.00
32_L56_F1.1151.00
72_L89_L1.1131.00
221_W225_F1.1121.00
96_I100_R1.1101.00
271_K274_F1.1081.00
238_L254_T1.1071.00
275_G279_Y1.1041.00
154_G191_A1.1011.00
35_A55_I1.0951.00
58_A114_S1.0901.00
257_H284_S1.0791.00
231_L235_V1.0781.00
61_F106_S1.0691.00
260_I264_A1.0621.00
154_G187_T1.0611.00
112_I116_F1.0571.00
228_L232_F1.0541.00
154_G188_I1.0501.00
186_G236_L1.0481.00
42_A164_V1.0371.00
75_I89_L1.0351.00
50_P54_L1.0331.00
168_Y181_W1.0331.00
246_L292_V1.0311.00
250_A254_T1.0311.00
121_A159_S1.0271.00
72_L103_I1.0231.00
35_A59_L1.0211.00
48_P164_V1.0211.00
73_A136_P1.0181.00
19_I102_M1.0161.00
248_P252_F1.0131.00
111_F126_P1.0091.00
199_H215_A1.0051.00
14_N17_Y1.0021.00
187_T191_A1.0001.00
224_T228_L0.9991.00
281_N286_I0.9951.00
204_E208_K0.9911.00
114_S125_A0.9881.00
112_I115_Y0.9841.00
291_G295_D0.9811.00
115_Y119_I0.9801.00
94_I98_E0.9711.00
178_R182_F0.9701.00
128_V155_L0.9641.00
39_A55_I0.9621.00
158_F180_P0.9611.00
246_L295_D0.9571.00
247_G250_A0.9551.00
81_N205_F0.9531.00
68_T99_A0.9461.00
201_P275_G0.9431.00
272_N276_R0.9421.00
130_L134_S0.9411.00
261_M268_A0.9371.00
76_E80_K0.9361.00
153_Q191_A0.9331.00
138_M142_T0.9291.00
74_D136_P0.9281.00
254_T258_G0.9241.00
50_P53_I0.9201.00
82_P204_E0.9191.00
264_A267_L0.9181.00
23_L68_T0.9121.00
214_F218_L0.9101.00
185_I236_L0.9041.00
69_N103_I0.9041.00
42_A161_A0.9011.00
226_A230_Q0.9001.00
128_V159_S0.8981.00
143_A212_H0.8971.00
189_L236_L0.8951.00
212_H217_V0.8891.00
223_L226_A0.8841.00
125_A159_S0.8801.00
126_P130_L0.8791.00
161_A180_P0.8751.00
239_L243_Y0.8671.00
41_V161_A0.8621.00
102_M106_S0.8591.00
185_I189_L0.8541.00
265_Y269_S0.8541.00
202_D206_D0.8541.00
283_Y286_I0.8520.99
227_G231_L0.8520.99
120_W123_I0.8500.99
279_Y282_I0.8470.99
281_N288_L0.8440.99
76_E79_A0.8410.99
127_I130_L0.8400.99
224_T227_G0.8370.99
197_Y268_A0.8320.99
111_F122_F0.8320.99
28_T60_F0.8300.99
19_I94_I0.8270.99
131_I151_S0.8260.99
230_Q265_Y0.8170.99
40_F289_G0.8120.99
179_V243_Y0.8100.99
267_L277_A0.8080.99
120_W166_G0.8070.99
77_I209_M0.8070.99
39_A164_V0.8060.99
225_F228_L0.8050.99
279_Y283_Y0.8030.99
74_D211_L0.8010.99
146_N196_L0.7980.99
111_F115_Y0.7960.99
274_F277_A0.7920.99
90_V99_A0.7920.99
182_F239_L0.7910.99
142_T214_F0.7900.99
206_D213_S0.7870.99
227_G269_S0.7860.99
37_L293_D0.7860.99
72_L75_I0.7820.99
251_I255_V0.7800.99
150_A192_V0.7790.99
238_L242_F0.7790.99
118_N124_L0.7770.99
238_L251_I0.7720.99
265_Y268_A0.7580.99
105_A112_I0.7580.99
149_L194_F0.7560.99
71_N74_D0.7550.99
197_Y226_A0.7500.99
117_V121_A0.7470.99
38_G160_G0.7460.99
195_D198_N0.7460.99
113_T116_F0.7460.99
223_L269_S0.7400.99
147_Y192_V0.7380.99
235_V239_L0.7370.99
223_L265_Y0.7350.99
186_G233_S0.7330.98
116_F119_I0.7330.98
57_L113_T0.7310.98
261_M264_A0.7300.98
69_N73_A0.7300.98
260_I267_L0.7300.98
69_N104_V0.7290.98
249_I253_A0.7270.98
98_E101_T0.7270.98
61_F113_T0.7250.98
114_S122_F0.7240.98
271_K275_G0.7240.98
39_A43_I0.7240.98
266_Y269_S0.7210.98
157_V187_T0.7210.98
134_S138_M0.7180.98
119_I122_F0.7170.98
88_P92_G0.7150.98
43_I164_V0.7150.98
16_L20_L0.7130.98
120_W124_L0.7120.98
242_F251_I0.7110.98
15_K18_I0.7030.98
108_I112_I0.7010.98
288_L291_G0.6980.98
182_F236_L0.6960.98
157_V163_A0.6960.98
35_A156_A0.6960.98
177_L181_W0.6940.98
186_G240_G0.6940.98
155_L159_S0.6900.98
161_A165_L0.6890.98
263_Y266_Y0.6860.98
280_Y284_S0.6840.98
272_N279_Y0.6840.98
282_I285_S0.6820.98
40_F293_D0.6810.98
146_N195_D0.6720.97
237_D258_G0.6710.97
142_T148_H0.6670.97
146_N191_A0.6660.97
154_G160_G0.6660.97
178_R181_W0.6640.97
205_F208_K0.6640.97
227_G265_Y0.6630.97
103_I107_L0.6620.97
124_L162_V0.6590.97
267_L276_R0.6570.97
196_L214_F0.6550.97
200_I203_A0.6550.97
237_D241_D0.6500.97
50_P57_L0.6500.97
254_T291_G0.6440.97
67_M71_N0.6420.97
282_I289_G0.6410.96
114_S117_V0.6400.96
21_R88_P0.6390.96
234_V237_D0.6370.96
284_S288_L0.6360.96
77_I80_K0.6350.96
64_T102_M0.6320.96
218_L225_F0.6310.96
161_A177_L0.6300.96
43_I47_P0.6250.96
14_N93_A0.6250.96
285_S288_L0.6190.96
236_L239_L0.6190.96
30_F34_M0.6160.96
227_G266_Y0.6160.96
256_L259_L0.6140.96
285_S291_G0.6130.95
31_S34_M0.6120.95
255_V258_G0.6100.95
232_F236_L0.6090.95
81_N206_D0.6070.95
63_R67_M0.6060.95
241_D244_Y0.6060.95
44_K47_P0.6060.95
264_A277_A0.5970.95
253_A256_L0.5970.95
194_F198_N0.5960.95
98_E102_M0.5950.95
42_A160_G0.5910.94
22_F99_A0.5900.94
30_F285_S0.5880.94
253_A295_D0.5870.94
290_L294_I0.5860.94
239_L242_F0.5810.94
31_S37_L0.5790.94
268_A273_D0.5780.94
38_G42_A0.5760.94
23_L60_F0.5740.94
253_A257_H0.5720.93
182_F240_G0.5710.93
273_D276_R0.5700.93
179_V182_F0.5700.93
143_A217_V0.5700.93
41_V246_L0.5700.93
114_S159_S0.5700.93
63_R198_N0.5670.93
268_A274_F0.5660.93
249_I294_I0.5650.93
255_V259_L0.5640.93
47_P52_L0.5630.93
241_D246_L0.5620.93
153_Q194_F0.5590.93
76_E96_I0.5580.93
32_L35_A0.5570.93
30_F33_P0.5560.93
263_Y280_Y0.5560.93
263_Y283_Y0.5540.92
56_F60_F0.5540.92
258_G262_A0.5530.92
147_Y151_S0.5530.92
88_P93_A0.5520.92
131_I148_H0.5520.92
149_L191_A0.5490.92
231_L266_Y0.5480.92
167_L180_P0.5470.92
223_L227_G0.5450.92
27_Q195_D0.5450.92
149_L198_N0.5450.92
69_N133_M0.5430.92
218_L221_W0.5420.92
18_I98_E0.5420.92
51_T117_V0.5400.91
38_G240_G0.5390.91
234_V238_L0.5380.91
149_L195_D0.5380.91
167_L179_V0.5360.91
117_V122_F0.5350.91
62_L129_A0.5350.91
195_D199_H0.5340.91
58_A113_T0.5330.91
100_R103_I0.5330.91
198_N201_P0.5310.91
82_P205_F0.5290.91
285_S290_L0.5280.90
54_L57_L0.5270.90
82_P86_N0.5260.90
246_L250_A0.5250.90
89_L92_G0.5230.90
64_T68_T0.5220.90
177_L182_F0.5210.90
158_F168_Y0.5200.90
154_G157_V0.5190.90
157_V161_A0.5190.90
287_V291_G0.5180.90
40_F296_V0.5170.90
230_Q233_S0.5170.90
238_L255_V0.5170.90
28_T67_M0.5170.90
146_N192_V0.5140.89
55_I117_V0.5130.89
214_F221_W0.5130.89
36_Y40_F0.5110.89
43_I52_L0.5100.89
118_N163_A0.5090.89
190_W194_F0.5090.89
278_F282_I0.5090.89
31_S35_A0.5080.89
285_S289_G0.5070.89
282_I288_L0.5060.89
200_I274_F0.5060.89
179_V240_G0.5050.88
31_S128_V0.5030.88
136_P195_D0.5020.88
79_A92_G0.5020.88
71_N88_P0.5010.88
286_I290_L0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.904 100 0.229 Contact Map
4tq3A 1 0.894 100 0.323 Contact Map
3ze3A 4 0.3642 17.7 0.953 Contact Map
4xnjA 1 0.5596 6.8 0.961 Contact Map
2xq2A 2 0.7881 4.5 0.964 Contact Map
2wdqC 1 0.3907 3.8 0.966 Contact Map
3rlfF 1 0.2715 3.3 0.967 Contact Map
4uisB 1 0.1258 3 0.967 Contact Map
1fftA 1 0.0298 3 0.967 Contact Map
3o7qA 1 0.8245 2.8 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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