Q980Z2 - SULSO - GREMLIN Contacts

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Q980Z2 - 4-hydroxybenzoate octaprenyltransferase (UbiA-1)

UniProt:	Q980Z2	Sequences: MSWDPGGLNKNTRNKLYIILRFLRIEQTFFSLPMAYLGAFVAIKGIPPIPTLILIFLALFFLRTAGMTNDNLADIEIDAKNPRTKNRPLVTGAIKIREARTMIVASLILFFITSYFVNIWAFILAPIVALIIMSYPYMKRYTAFANYHLASIQGLAVFSGAVAVLGLYYNSLDQILLRVPWFFVIGTILWAVGFDLYNHIPDAEFDKKMGLHSFAVVLGRWALTFAGLNQLFSVVLDLLGDFYYGLGPIAIFATVLHGLIMAYAYYLASQKNDFGRAFYYNIYSSIVLGLGVDIDVILGIPF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	302 (275)
Sequences:	6425 (4302)
Seq/√Len:	259.4

ECOLI - UBIA CYOE MENA
BACSU - COXX1 COXX2 MENA
HALSA - COXX DGGGP LYEL Q9HQN6
SULSO - Q980Z2 COXX DGGGP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
75_I	96_I	4.528	1.00
72_L	96_I	4.291	1.00
18_I	93_A	3.502	1.00
72_L	100_R	3.427	1.00
15_K	98_E	3.074	1.00
82_P	85_K	3.051	1.00
21_R	93_A	3.039	1.00
65_A	107_L	2.961	1.00
95_K	98_E	2.723	1.00
118_N	121_A	2.667	1.00
77_I	211_L	2.607	1.00
220_R	224_T	2.410	1.00
68_T	106_S	2.349	1.00
263_Y	267_L	2.340	1.00
119_I	123_I	2.329	1.00
19_I	98_E	2.303	1.00
121_A	162_V	2.303	1.00
204_E	207_K	2.290	1.00
79_A	90_V	2.261	1.00
167_L	177_L	2.234	1.00
234_V	258_G	2.228	1.00
54_L	116_F	2.180	1.00
97_R	101_T	2.097	1.00
62_L	110_F	2.090	1.00
253_A	291_G	2.072	1.00
241_D	250_A	2.065	1.00
189_L	232_F	2.051	1.00
20_L	25_I	2.049	1.00
54_L	113_T	2.048	1.00
36_Y	56_F	1.987	1.00
241_D	251_I	1.978	1.00
203_A	207_K	1.885	1.00
72_L	99_A	1.804	1.00
247_G	295_D	1.799	1.00
73_A	137_Y	1.783	1.00
270_Q	273_D	1.704	1.00
207_K	216_V	1.671	1.00
130_L	133_M	1.664	1.00
193_G	230_Q	1.663	1.00
68_T	102_M	1.628	1.00
151_S	184_V	1.622	1.00
23_L	106_S	1.620	1.00
120_W	162_V	1.614	1.00
221_W	224_T	1.610	1.00
80_K	209_M	1.604	1.00
94_I	99_A	1.598	1.00
281_N	285_S	1.589	1.00
186_G	237_D	1.584	1.00
107_L	129_A	1.582	1.00
61_F	109_L	1.575	1.00
138_M	141_Y	1.575	1.00
134_S	148_H	1.545	1.00
115_Y	122_F	1.534	1.00
182_F	243_Y	1.517	1.00
17_Y	21_R	1.516	1.00
23_L	102_M	1.502	1.00
259_L	263_Y	1.496	1.00
101_T	105_A	1.481	1.00
123_I	127_I	1.477	1.00
177_L	180_P	1.469	1.00
138_M	148_H	1.468	1.00
68_T	103_I	1.444	1.00
75_I	79_A	1.444	1.00
145_A	213_S	1.428	1.00
48_P	51_T	1.424	1.00
273_D	277_A	1.418	1.00
64_T	106_S	1.416	1.00
200_I	222_A	1.413	1.00
89_L	99_A	1.411	1.00
131_I	152_I	1.407	1.00
62_L	125_A	1.396	1.00
94_I	102_M	1.395	1.00
203_A	216_V	1.393	1.00
74_D	140_R	1.384	1.00
189_L	229_N	1.380	1.00
22_F	94_I	1.370	1.00
276_R	279_Y	1.365	1.00
23_L	64_T	1.343	1.00
282_I	286_I	1.340	1.00
39_A	52_L	1.320	1.00
68_T	94_I	1.315	1.00
181_W	185_I	1.302	1.00
256_L	260_I	1.290	1.00
283_Y	287_V	1.289	1.00
32_L	36_Y	1.277	1.00
257_H	288_L	1.253	1.00
89_L	94_I	1.250	1.00
104_V	108_I	1.248	1.00
262_A	266_Y	1.233	1.00
61_F	110_F	1.232	1.00
260_I	263_Y	1.231	1.00
54_L	117_V	1.224	1.00
168_Y	177_L	1.220	1.00
77_I	140_R	1.210	1.00
74_D	77_I	1.205	1.00
233_S	237_D	1.177	1.00
53_I	57_L	1.171	1.00
193_G	233_S	1.168	1.00
222_A	226_A	1.166	1.00
25_I	60_F	1.162	1.00
20_L	23_L	1.161	1.00
225_F	229_N	1.157	1.00
264_A	280_Y	1.141	1.00
100_R	104_V	1.120	1.00
158_F	184_V	1.120	1.00
260_I	280_Y	1.116	1.00
168_Y	180_P	1.115	1.00
32_L	56_F	1.115	1.00
72_L	89_L	1.113	1.00
221_W	225_F	1.112	1.00
96_I	100_R	1.110	1.00
271_K	274_F	1.108	1.00
238_L	254_T	1.107	1.00
275_G	279_Y	1.104	1.00
154_G	191_A	1.101	1.00
35_A	55_I	1.095	1.00
58_A	114_S	1.090	1.00
257_H	284_S	1.079	1.00
231_L	235_V	1.078	1.00
61_F	106_S	1.069	1.00
260_I	264_A	1.062	1.00
154_G	187_T	1.061	1.00
112_I	116_F	1.057	1.00
228_L	232_F	1.054	1.00
154_G	188_I	1.050	1.00
186_G	236_L	1.048	1.00
42_A	164_V	1.037	1.00
75_I	89_L	1.035	1.00
50_P	54_L	1.033	1.00
168_Y	181_W	1.033	1.00
246_L	292_V	1.031	1.00
250_A	254_T	1.031	1.00
121_A	159_S	1.027	1.00
72_L	103_I	1.023	1.00
35_A	59_L	1.021	1.00
48_P	164_V	1.021	1.00
73_A	136_P	1.018	1.00
19_I	102_M	1.016	1.00
248_P	252_F	1.013	1.00
111_F	126_P	1.009	1.00
199_H	215_A	1.005	1.00
14_N	17_Y	1.002	1.00
187_T	191_A	1.000	1.00
224_T	228_L	0.999	1.00
281_N	286_I	0.995	1.00
204_E	208_K	0.991	1.00
114_S	125_A	0.988	1.00
112_I	115_Y	0.984	1.00
291_G	295_D	0.981	1.00
115_Y	119_I	0.980	1.00
94_I	98_E	0.971	1.00
178_R	182_F	0.970	1.00
128_V	155_L	0.964	1.00
39_A	55_I	0.962	1.00
158_F	180_P	0.961	1.00
246_L	295_D	0.957	1.00
247_G	250_A	0.955	1.00
81_N	205_F	0.953	1.00
68_T	99_A	0.946	1.00
201_P	275_G	0.943	1.00
272_N	276_R	0.942	1.00
130_L	134_S	0.941	1.00
261_M	268_A	0.937	1.00
76_E	80_K	0.936	1.00
153_Q	191_A	0.933	1.00
138_M	142_T	0.929	1.00
74_D	136_P	0.928	1.00
254_T	258_G	0.924	1.00
50_P	53_I	0.920	1.00
82_P	204_E	0.919	1.00
264_A	267_L	0.918	1.00
23_L	68_T	0.912	1.00
214_F	218_L	0.910	1.00
185_I	236_L	0.904	1.00
69_N	103_I	0.904	1.00
42_A	161_A	0.901	1.00
226_A	230_Q	0.900	1.00
128_V	159_S	0.898	1.00
143_A	212_H	0.897	1.00
189_L	236_L	0.895	1.00
212_H	217_V	0.889	1.00
223_L	226_A	0.884	1.00
125_A	159_S	0.880	1.00
126_P	130_L	0.879	1.00
161_A	180_P	0.875	1.00
239_L	243_Y	0.867	1.00
41_V	161_A	0.862	1.00
102_M	106_S	0.859	1.00
185_I	189_L	0.854	1.00
265_Y	269_S	0.854	1.00
202_D	206_D	0.854	1.00
283_Y	286_I	0.852	0.99
227_G	231_L	0.852	0.99
120_W	123_I	0.850	0.99
279_Y	282_I	0.847	0.99
281_N	288_L	0.844	0.99
76_E	79_A	0.841	0.99
127_I	130_L	0.840	0.99
224_T	227_G	0.837	0.99
197_Y	268_A	0.832	0.99
111_F	122_F	0.832	0.99
28_T	60_F	0.830	0.99
19_I	94_I	0.827	0.99
131_I	151_S	0.826	0.99
230_Q	265_Y	0.817	0.99
40_F	289_G	0.812	0.99
179_V	243_Y	0.810	0.99
267_L	277_A	0.808	0.99
120_W	166_G	0.807	0.99
77_I	209_M	0.807	0.99
39_A	164_V	0.806	0.99
225_F	228_L	0.805	0.99
279_Y	283_Y	0.803	0.99
74_D	211_L	0.801	0.99
146_N	196_L	0.798	0.99
111_F	115_Y	0.796	0.99
274_F	277_A	0.792	0.99
90_V	99_A	0.792	0.99
182_F	239_L	0.791	0.99
142_T	214_F	0.790	0.99
206_D	213_S	0.787	0.99
227_G	269_S	0.786	0.99
37_L	293_D	0.786	0.99
72_L	75_I	0.782	0.99
251_I	255_V	0.780	0.99
150_A	192_V	0.779	0.99
238_L	242_F	0.779	0.99
118_N	124_L	0.777	0.99
238_L	251_I	0.772	0.99
265_Y	268_A	0.758	0.99
105_A	112_I	0.758	0.99
149_L	194_F	0.756	0.99
71_N	74_D	0.755	0.99
197_Y	226_A	0.750	0.99
117_V	121_A	0.747	0.99
38_G	160_G	0.746	0.99
195_D	198_N	0.746	0.99
113_T	116_F	0.746	0.99
223_L	269_S	0.740	0.99
147_Y	192_V	0.738	0.99
235_V	239_L	0.737	0.99
223_L	265_Y	0.735	0.99
186_G	233_S	0.733	0.98
116_F	119_I	0.733	0.98
57_L	113_T	0.731	0.98
261_M	264_A	0.730	0.98
69_N	73_A	0.730	0.98
260_I	267_L	0.730	0.98
69_N	104_V	0.729	0.98
249_I	253_A	0.727	0.98
98_E	101_T	0.727	0.98
61_F	113_T	0.725	0.98
114_S	122_F	0.724	0.98
271_K	275_G	0.724	0.98
39_A	43_I	0.724	0.98
266_Y	269_S	0.721	0.98
157_V	187_T	0.721	0.98
134_S	138_M	0.718	0.98
119_I	122_F	0.717	0.98
88_P	92_G	0.715	0.98
43_I	164_V	0.715	0.98
16_L	20_L	0.713	0.98
120_W	124_L	0.712	0.98
242_F	251_I	0.711	0.98
15_K	18_I	0.703	0.98
108_I	112_I	0.701	0.98
288_L	291_G	0.698	0.98
182_F	236_L	0.696	0.98
157_V	163_A	0.696	0.98
35_A	156_A	0.696	0.98
177_L	181_W	0.694	0.98
186_G	240_G	0.694	0.98
155_L	159_S	0.690	0.98
161_A	165_L	0.689	0.98
263_Y	266_Y	0.686	0.98
280_Y	284_S	0.684	0.98
272_N	279_Y	0.684	0.98
282_I	285_S	0.682	0.98
40_F	293_D	0.681	0.98
146_N	195_D	0.672	0.97
237_D	258_G	0.671	0.97
142_T	148_H	0.667	0.97
146_N	191_A	0.666	0.97
154_G	160_G	0.666	0.97
178_R	181_W	0.664	0.97
205_F	208_K	0.664	0.97
227_G	265_Y	0.663	0.97
103_I	107_L	0.662	0.97
124_L	162_V	0.659	0.97
267_L	276_R	0.657	0.97
196_L	214_F	0.655	0.97
200_I	203_A	0.655	0.97
237_D	241_D	0.650	0.97
50_P	57_L	0.650	0.97
254_T	291_G	0.644	0.97
67_M	71_N	0.642	0.97
282_I	289_G	0.641	0.96
114_S	117_V	0.640	0.96
21_R	88_P	0.639	0.96
234_V	237_D	0.637	0.96
284_S	288_L	0.636	0.96
77_I	80_K	0.635	0.96
64_T	102_M	0.632	0.96
218_L	225_F	0.631	0.96
161_A	177_L	0.630	0.96
43_I	47_P	0.625	0.96
14_N	93_A	0.625	0.96
285_S	288_L	0.619	0.96
236_L	239_L	0.619	0.96
30_F	34_M	0.616	0.96
227_G	266_Y	0.616	0.96
256_L	259_L	0.614	0.96
285_S	291_G	0.613	0.95
31_S	34_M	0.612	0.95
255_V	258_G	0.610	0.95
232_F	236_L	0.609	0.95
81_N	206_D	0.607	0.95
63_R	67_M	0.606	0.95
241_D	244_Y	0.606	0.95
44_K	47_P	0.606	0.95
264_A	277_A	0.597	0.95
253_A	256_L	0.597	0.95
194_F	198_N	0.596	0.95
98_E	102_M	0.595	0.95
42_A	160_G	0.591	0.94
22_F	99_A	0.590	0.94
30_F	285_S	0.588	0.94
253_A	295_D	0.587	0.94
290_L	294_I	0.586	0.94
239_L	242_F	0.581	0.94
31_S	37_L	0.579	0.94
268_A	273_D	0.578	0.94
38_G	42_A	0.576	0.94
23_L	60_F	0.574	0.94
253_A	257_H	0.572	0.93
182_F	240_G	0.571	0.93
273_D	276_R	0.570	0.93
179_V	182_F	0.570	0.93
143_A	217_V	0.570	0.93
41_V	246_L	0.570	0.93
114_S	159_S	0.570	0.93
63_R	198_N	0.567	0.93
268_A	274_F	0.566	0.93
249_I	294_I	0.565	0.93
255_V	259_L	0.564	0.93
47_P	52_L	0.563	0.93
241_D	246_L	0.562	0.93
153_Q	194_F	0.559	0.93
76_E	96_I	0.558	0.93
32_L	35_A	0.557	0.93
30_F	33_P	0.556	0.93
263_Y	280_Y	0.556	0.93
263_Y	283_Y	0.554	0.92
56_F	60_F	0.554	0.92
258_G	262_A	0.553	0.92
147_Y	151_S	0.553	0.92
88_P	93_A	0.552	0.92
131_I	148_H	0.552	0.92
149_L	191_A	0.549	0.92
231_L	266_Y	0.548	0.92
167_L	180_P	0.547	0.92
223_L	227_G	0.545	0.92
27_Q	195_D	0.545	0.92
149_L	198_N	0.545	0.92
69_N	133_M	0.543	0.92
218_L	221_W	0.542	0.92
18_I	98_E	0.542	0.92
51_T	117_V	0.540	0.91
38_G	240_G	0.539	0.91
234_V	238_L	0.538	0.91
149_L	195_D	0.538	0.91
167_L	179_V	0.536	0.91
117_V	122_F	0.535	0.91
62_L	129_A	0.535	0.91
195_D	199_H	0.534	0.91
58_A	113_T	0.533	0.91
100_R	103_I	0.533	0.91
198_N	201_P	0.531	0.91
82_P	205_F	0.529	0.91
285_S	290_L	0.528	0.90
54_L	57_L	0.527	0.90
82_P	86_N	0.526	0.90
246_L	250_A	0.525	0.90
89_L	92_G	0.523	0.90
64_T	68_T	0.522	0.90
177_L	182_F	0.521	0.90
158_F	168_Y	0.520	0.90
154_G	157_V	0.519	0.90
157_V	161_A	0.519	0.90
287_V	291_G	0.518	0.90
40_F	296_V	0.517	0.90
230_Q	233_S	0.517	0.90
238_L	255_V	0.517	0.90
28_T	67_M	0.517	0.90
146_N	192_V	0.514	0.89
55_I	117_V	0.513	0.89
214_F	221_W	0.513	0.89
36_Y	40_F	0.511	0.89
43_I	52_L	0.510	0.89
118_N	163_A	0.509	0.89
190_W	194_F	0.509	0.89
278_F	282_I	0.509	0.89
31_S	35_A	0.508	0.89
285_S	289_G	0.507	0.89
282_I	288_L	0.506	0.89
200_I	274_F	0.506	0.89
179_V	240_G	0.505	0.88
31_S	128_V	0.503	0.88
136_P	195_D	0.502	0.88
79_A	92_G	0.502	0.88
71_N	88_P	0.501	0.88
286_I	290_L	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4od4A	1	0.904	100	0.229	Contact Map
4tq3A	1	0.894	100	0.323	Contact Map
3ze3A	4	0.3642	17.7	0.953	Contact Map
4xnjA	1	0.5596	6.8	0.961	Contact Map
2xq2A	2	0.7881	4.5	0.964	Contact Map
2wdqC	1	0.3907	3.8	0.966	Contact Map
3rlfF	1	0.2715	3.3	0.967	Contact Map
4uisB	1	0.1258	3	0.967	Contact Map
1fftA	1	0.0298	3	0.967	Contact Map
3o7qA	1	0.8245	2.8	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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