Q980Z1 - SULSO - GREMLIN Contacts

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Q980Z1 - 2-isopropylmalate synthase, putative (LeuA-1)

UniProt:	Q980Z1	Sequences: MALKMKYDFLLLSLKLLNLPIIFHLCSVSKKSVEVLDTTLRDGSQGANISFTLNDKIKIALLLDELGVDYIEGGWPGSNPKDEEFFREIKKYRLSKAKIAAFGSTKRKDVSVKEDISLNSIVKADVDVAVIFGKSWSLHATEVLKVTKQDNLDIVYDSINYLKSHGLKVIFDAEHFYQGFKEDPEYALEVVKTAESAGADVIALADTNGGTPPFEVYEITKKVREVLQVKLGIHAHNDIGCAVANSLMAIKAGARHVQGTINGIGERTGNADLIQIIPTLILKMGLNALNGQESLRKLREVSRIVYEILGLPPNPYQPYVGDNAFAHKAGVHVDAVMKVPRAYEHVDPSLVGNDRKFVISELSGTANLVSYLQGLGIAVDKKDERLKKALNKIKELEARGYSFDVGPASAILITLKELNIYKNYINLEYWKVINENNGLSIGIVKVNSQLEVAEGVGPVNAIDRALRMALQRVYPEIGEVKLIDYRVILPSEIKNTESVVRVTIEFTDNKMNWRTEGVSKSVVEASVMALVDGLDYYLQLKKTLKTAVDNYIV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	553 (486)
Sequences:	4132 (2069)
Seq/√Len:	93.9

ECOLI - LEU1
BACSU - LEU1
SULSO - Q980Z1 HOSA LEU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
76_P	101_A	3.878	1.00
233_I	249_A	3.751	1.00
153_D	157_D	3.712	1.00
147_T	150_D	3.547	1.00
217_Y	252_A	3.524	1.00
334_D	338_K	3.448	1.00
191_V	202_I	3.253	1.00
155_V	190_V	3.152	1.00
485_Y	526_S	3.048	1.00
137_S	183_D	2.928	1.00
137_S	148_K	2.825	1.00
519_S	528_M	2.813	1.00
149_Q	189_E	2.804	1.00
31_K	255_R	2.767	1.00
214_F	251_K	2.750	1.00
80_P	84_E	2.704	1.00
111_S	161_Y	2.703	1.00
220_T	231_L	2.680	1.00
156_Y	197_A	2.679	1.00
240_G	275_Q	2.645	1.00
347_D	350_L	2.624	1.00
163_K	200_D	2.613	1.00
88_E	92_Y	2.609	1.00
235_A	246_S	2.607	1.00
500_V	525_A	2.578	1.00
66_L	301_V	2.542	1.00
155_V	194_A	2.519	1.00
140_A	148_K	2.510	1.00
156_Y	160_N	2.497	1.00
271_A	276_I	2.497	1.00
373_Q	378_A	2.453	1.00
146_V	154_I	2.406	1.00
152_L	190_V	2.368	1.00
184_P	222_K	2.334	1.00
107_R	157_D	2.314	1.00
519_S	524_E	2.306	1.00
148_K	189_E	2.298	1.00
297_K	300_E	2.281	1.00
221_K	225_E	2.266	1.00
451_E	468_M	2.232	1.00
462_I	527_V	2.177	1.00
135_S	182_E	2.165	1.00
62_L	65_E	2.140	1.00
32_S	292_Q	2.137	1.00
204_L	219_I	2.132	1.00
87_R	91_K	2.082	1.00
192_K	224_R	2.070	1.00
58_K	307_E	2.015	1.00
152_L	189_E	1.998	1.00
171_F	190_V	1.992	1.00
156_Y	193_T	1.986	1.00
146_V	150_D	1.945	1.00
204_L	223_V	1.939	1.00
224_R	231_L	1.901	1.00
64_D	96_K	1.899	1.00
64_D	97_A	1.891	1.00
336_V	356_K	1.877	1.00
302_S	313_P	1.872	1.00
277_I	293_E	1.867	1.00
35_V	68_V	1.855	1.00
61_L	94_L	1.855	1.00
149_Q	152_L	1.854	1.00
140_A	183_D	1.803	1.00
206_D	245_N	1.803	1.00
142_E	339_V	1.801	1.00
91_K	123_K	1.800	1.00
140_A	186_Y	1.783	1.00
148_K	186_Y	1.779	1.00
217_Y	251_K	1.771	1.00
143_V	174_E	1.771	1.00
156_Y	194_A	1.770	1.00
231_L	254_A	1.762	1.00
57_I	94_L	1.761	1.00
34_E	230_K	1.740	1.00
140_A	182_E	1.740	1.00
217_Y	221_K	1.734	1.00
372_L	414_T	1.732	1.00
126_V	170_I	1.730	1.00
156_Y	196_S	1.701	1.00
84_E	88_E	1.692	1.00
186_Y	190_V	1.682	1.00
181_K	215_E	1.668	1.00
294_S	297_K	1.654	1.00
149_Q	153_D	1.650	1.00
68_V	293_E	1.647	1.00
88_E	91_K	1.629	1.00
73_G	86_F	1.628	1.00
121_I	127_D	1.626	1.00
118_L	158_S	1.614	1.00
456_V	460_N	1.610	1.00
65_E	297_K	1.601	1.00
152_L	186_Y	1.585	1.00
60_A	85_F	1.582	1.00
368_L	389_A	1.577	1.00
118_L	166_G	1.575	1.00
62_L	301_V	1.568	1.00
185_E	188_L	1.567	1.00
299_R	353_N	1.560	1.00
161_Y	165_H	1.559	1.00
230_K	255_R	1.553	1.00
148_K	183_D	1.550	1.00
370_S	373_Q	1.550	1.00
150_D	153_D	1.548	1.00
76_P	86_F	1.535	1.00
221_K	252_A	1.533	1.00
188_L	222_K	1.526	1.00
250_I	257_V	1.518	1.00
86_F	101_A	1.511	1.00
325_F	351_V	1.509	1.00
456_V	520_K	1.505	1.00
87_R	123_K	1.496	1.00
441_I	452_V	1.490	1.00
134_K	179_G	1.484	1.00
53_L	88_E	1.481	1.00
423_N	426_N	1.476	1.00
445_K	450_L	1.476	1.00
246_S	250_I	1.476	1.00
391_N	395_E	1.464	1.00
137_S	141_T	1.463	1.00
191_V	204_L	1.461	1.00
195_E	202_I	1.460	1.00
62_L	304_I	1.457	1.00
218_E	222_K	1.448	1.00
59_I	305_V	1.443	1.00
134_K	139_H	1.436	1.00
220_T	223_V	1.428	0.99
246_S	257_V	1.426	0.99
428_E	445_K	1.425	0.99
146_V	151_N	1.417	0.99
132_F	331_V	1.415	0.99
424_Y	447_N	1.413	0.99
262_N	302_S	1.410	0.99
237_N	240_G	1.385	0.99
247_L	279_T	1.384	0.99
89_I	99_I	1.380	0.99
165_H	168_K	1.375	0.99
139_H	179_G	1.372	0.99
140_A	151_N	1.372	0.99
51_F	59_I	1.367	0.99
61_L	92_Y	1.363	0.99
193_T	196_S	1.361	0.99
159_I	197_A	1.360	0.99
188_L	192_K	1.344	0.99
192_K	195_E	1.342	0.99
396_L	403_F	1.341	0.99
395_E	399_R	1.337	0.99
388_K	417_E	1.333	0.99
495_N	500_V	1.331	0.99
65_E	300_E	1.316	0.99
380_D	385_R	1.316	0.99
457_G	498_S	1.312	0.99
180_F	211_T	1.305	0.99
184_P	219_I	1.304	0.99
195_E	229_V	1.298	0.99
392_K	395_E	1.294	0.99
246_S	276_I	1.281	0.99
70_Y	168_K	1.278	0.99
138_L	142_E	1.271	0.99
192_K	196_S	1.269	0.99
462_I	523_V	1.259	0.99
243_V	276_I	1.257	0.99
259_G	277_I	1.251	0.99
34_E	70_Y	1.249	0.99
453_A	464_R	1.245	0.99
173_A	191_V	1.243	0.99
155_V	193_T	1.241	0.99
328_K	362_L	1.236	0.98
145_K	338_K	1.227	0.98
34_E	201_V	1.227	0.98
522_V	526_S	1.227	0.98
135_S	190_V	1.227	0.98
101_A	104_S	1.226	0.98
220_T	233_I	1.224	0.98
51_F	308_I	1.218	0.98
143_V	334_D	1.214	0.98
168_K	200_D	1.212	0.98
78_S	362_L	1.209	0.98
54_N	88_E	1.205	0.98
159_I	173_A	1.198	0.98
160_N	197_A	1.179	0.98
137_S	140_A	1.178	0.98
385_R	388_K	1.178	0.98
240_G	318_P	1.177	0.98
459_V	482_L	1.176	0.98
397_E	413_I	1.169	0.98
369_V	373_Q	1.163	0.98
81_K	361_E	1.163	0.98
246_S	271_A	1.161	0.98
188_L	223_V	1.157	0.98
458_P	521_S	1.157	0.98
496_T	499_V	1.156	0.98
119_N	122_V	1.154	0.98
431_K	435_E	1.150	0.98
185_E	189_E	1.148	0.98
497_E	500_V	1.140	0.97
304_I	308_I	1.133	0.97
105_T	131_I	1.124	0.97
202_I	231_L	1.118	0.97
97_A	125_D	1.118	0.97
47_A	323_N	1.109	0.97
144_L	343_Y	1.109	0.97
495_N	499_V	1.108	0.97
57_I	92_Y	1.107	0.97
240_G	272_D	1.106	0.97
452_V	468_M	1.097	0.97
184_P	218_E	1.097	0.97
107_R	111_S	1.097	0.97
84_E	87_R	1.087	0.97
103_G	117_S	1.085	0.97
51_F	309_L	1.084	0.97
189_E	193_T	1.081	0.96
161_Y	164_S	1.077	0.96
35_V	277_I	1.072	0.96
46_G	49_I	1.072	0.96
131_I	198_G	1.071	0.96
192_K	226_V	1.070	0.96
328_K	360_S	1.067	0.96
506_F	537_Y	1.063	0.96
333_V	367_N	1.062	0.96
101_A	117_S	1.062	0.96
32_S	69_D	1.060	0.96
488_I	501_R	1.060	0.96
384_E	388_K	1.049	0.96
451_E	469_A	1.047	0.96
62_L	300_E	1.045	0.96
181_K	210_G	1.042	0.96
495_N	501_R	1.042	0.96
62_L	297_K	1.034	0.95
157_D	161_Y	1.033	0.95
237_N	242_A	1.031	0.95
107_R	161_Y	1.031	0.95
77_G	108_K	1.029	0.95
496_T	500_V	1.027	0.95
243_V	271_A	1.025	0.95
104_S	109_D	1.025	0.95
248_M	252_A	1.024	0.95
368_L	410_A	1.021	0.95
371_Y	374_G	1.020	0.95
246_S	259_G	1.019	0.95
217_Y	248_M	1.018	0.95
121_I	129_A	1.014	0.95
411_I	415_L	1.010	0.95
498_S	501_R	1.009	0.95
277_I	295_L	1.007	0.95
278_P	346_V	1.001	0.95
126_V	167_L	0.992	0.94
36_L	130_V	0.991	0.94
493_I	497_E	0.990	0.94
243_V	246_S	0.989	0.94
95_S	125_D	0.989	0.94
495_N	498_S	0.979	0.94
44_S	51_F	0.975	0.94
57_I	88_E	0.973	0.94
248_M	251_K	0.972	0.94
107_R	131_I	0.968	0.94
496_T	501_R	0.967	0.94
281_I	293_E	0.964	0.93
264_I	311_L	0.961	0.93
95_S	101_A	0.956	0.93
159_I	169_V	0.954	0.93
191_V	223_V	0.953	0.93
426_N	445_K	0.949	0.93
219_I	223_V	0.948	0.93
38_T	139_H	0.946	0.93
370_S	374_G	0.945	0.93
380_D	384_E	0.943	0.93
137_S	182_E	0.940	0.93
105_T	158_S	0.935	0.92
445_K	454_E	0.930	0.92
190_V	194_A	0.928	0.92
133_G	175_H	0.928	0.92
131_I	159_I	0.927	0.92
49_I	310_G	0.927	0.92
314_N	317_Q	0.920	0.92
233_I	250_I	0.918	0.92
131_I	158_S	0.917	0.92
339_V	342_A	0.912	0.91
173_A	187_A	0.911	0.91
153_D	156_Y	0.909	0.91
460_N	464_R	0.907	0.91
98_K	168_K	0.902	0.91
261_I	305_V	0.900	0.91
197_A	200_D	0.897	0.91
57_I	61_L	0.894	0.91
375_L	407_P	0.892	0.90
396_L	400_G	0.891	0.90
216_V	233_I	0.890	0.90
392_K	417_E	0.883	0.90
89_I	92_Y	0.881	0.90
104_S	110_V	0.881	0.90
377_I	501_R	0.880	0.90
511_M	540_L	0.875	0.90
55_D	310_G	0.874	0.90
98_K	126_V	0.871	0.89
49_I	59_I	0.869	0.89
212_P	251_K	0.868	0.89
218_E	221_K	0.868	0.89
440_S	446_V	0.867	0.89
442_G	445_K	0.867	0.89
181_K	206_D	0.864	0.89
51_F	305_V	0.862	0.89
493_I	496_T	0.861	0.89
250_I	280_L	0.859	0.89
313_P	320_V	0.858	0.89
68_V	277_I	0.857	0.89
485_Y	498_S	0.856	0.89
106_K	154_I	0.856	0.89
100_A	130_V	0.856	0.89
136_W	139_H	0.855	0.89
118_L	127_D	0.855	0.89
69_D	292_Q	0.854	0.88
134_K	143_V	0.854	0.88
214_F	218_E	0.853	0.88
272_D	275_Q	0.852	0.88
134_K	144_L	0.851	0.88
46_G	311_L	0.851	0.88
489_L	493_I	0.850	0.88
164_S	168_K	0.850	0.88
152_L	193_T	0.848	0.88
483_I	505_E	0.847	0.88
444_V	451_E	0.847	0.88
201_V	256_H	0.845	0.88
69_D	96_K	0.840	0.88
32_S	287_N	0.837	0.87
46_G	316_Y	0.837	0.87
211_T	215_E	0.836	0.87
173_A	204_L	0.834	0.87
188_L	219_I	0.834	0.87
159_I	194_A	0.833	0.87
483_I	512_N	0.829	0.87
109_D	161_Y	0.829	0.87
434_N	521_S	0.828	0.87
35_V	246_S	0.826	0.87
81_K	398_A	0.823	0.87
60_A	64_D	0.822	0.86
141_T	147_T	0.821	0.86
195_E	225_E	0.820	0.86
435_E	441_I	0.818	0.86
36_L	102_F	0.817	0.86
466_L	527_V	0.816	0.86
148_K	182_E	0.815	0.86
281_I	350_L	0.815	0.86
46_G	264_I	0.814	0.86
133_G	171_F	0.812	0.86
427_L	531_V	0.809	0.86
366_A	370_S	0.808	0.86
457_G	485_Y	0.808	0.86
442_G	446_V	0.805	0.85
513_W	537_Y	0.802	0.85
61_L	65_E	0.801	0.85
44_S	362_L	0.800	0.85
387_K	391_N	0.800	0.85
100_A	128_V	0.800	0.85
365_T	387_K	0.797	0.85
500_V	506_F	0.797	0.85
462_I	530_L	0.794	0.85
389_A	536_Y	0.792	0.84
480_V	534_L	0.791	0.84
223_V	231_L	0.791	0.84
154_I	158_S	0.790	0.84
412_L	416_K	0.789	0.84
259_G	273_L	0.785	0.84
439_L	442_G	0.783	0.84
126_V	172_D	0.780	0.83
505_E	512_N	0.778	0.83
390_L	394_K	0.778	0.83
148_K	185_E	0.778	0.83
214_F	217_Y	0.777	0.83
235_A	271_A	0.776	0.83
144_L	174_E	0.775	0.83
220_T	252_A	0.774	0.83
410_A	414_T	0.771	0.83
463_D	467_R	0.771	0.83
119_N	161_Y	0.770	0.83
497_E	501_R	0.769	0.83
442_G	461_A	0.767	0.82
157_D	160_N	0.767	0.82
489_L	500_V	0.767	0.82
450_L	454_E	0.765	0.82
134_K	174_E	0.763	0.82
214_F	248_M	0.763	0.82
60_A	89_I	0.763	0.82
457_G	522_V	0.761	0.82
243_V	275_Q	0.761	0.82
163_K	199_A	0.760	0.82
247_L	284_M	0.759	0.82
143_V	342_A	0.759	0.82
66_L	277_I	0.759	0.82
77_G	112_V	0.757	0.82
41_R	45_Q	0.755	0.81
278_P	295_L	0.754	0.81
98_K	127_D	0.751	0.81
182_E	191_V	0.750	0.81
103_G	106_K	0.748	0.81
484_D	488_I	0.748	0.81
152_L	156_Y	0.747	0.81
80_P	112_V	0.747	0.81
170_I	232_G	0.746	0.81
314_N	318_P	0.745	0.81
168_K	201_V	0.744	0.80
185_E	391_N	0.743	0.80
164_S	167_L	0.742	0.80
78_S	361_E	0.741	0.80
49_I	264_I	0.741	0.80
490_P	496_T	0.741	0.80
58_K	300_E	0.741	0.80
67_G	96_K	0.740	0.80
431_K	441_I	0.740	0.80
349_S	355_R	0.738	0.80
74_G	86_F	0.736	0.80
275_Q	318_P	0.736	0.80
281_I	287_N	0.735	0.80
333_V	363_S	0.735	0.80
69_D	98_K	0.732	0.79
195_E	228_Q	0.731	0.79
506_F	513_W	0.730	0.79
495_N	506_F	0.730	0.79
458_P	522_V	0.730	0.79
136_W	179_G	0.730	0.79
202_I	229_V	0.729	0.79
415_L	420_I	0.728	0.79
368_L	390_L	0.727	0.79
241_C	279_T	0.727	0.79
130_V	203_A	0.726	0.79
104_S	112_V	0.725	0.79
153_D	160_N	0.724	0.79
135_S	187_A	0.724	0.79
425_I	531_V	0.723	0.79
261_I	274_I	0.723	0.79
465_A	469_A	0.722	0.78
64_D	99_I	0.721	0.78
121_I	126_V	0.720	0.78
392_K	396_L	0.720	0.78
394_K	413_I	0.720	0.78
384_E	387_K	0.719	0.78
278_P	319_Y	0.718	0.78
225_E	228_Q	0.716	0.78
75_W	331_V	0.714	0.78
463_D	530_L	0.713	0.78
134_K	151_N	0.712	0.78
397_E	401_Y	0.712	0.78
33_V	255_R	0.710	0.77
133_G	173_A	0.710	0.77
358_V	362_L	0.707	0.77
501_R	506_F	0.705	0.77
131_I	162_L	0.704	0.77
201_V	255_R	0.704	0.77
361_E	394_K	0.702	0.77
163_K	167_L	0.701	0.76
264_I	309_L	0.701	0.76
57_I	89_I	0.701	0.76
338_K	369_V	0.700	0.76
237_N	314_N	0.700	0.76
371_Y	410_A	0.698	0.76
49_I	311_L	0.697	0.76
397_E	400_G	0.696	0.76
52_T	402_S	0.696	0.76
430_W	527_V	0.696	0.76
122_V	125_D	0.694	0.76
59_I	374_G	0.694	0.76
33_V	286_L	0.693	0.76
67_G	294_S	0.693	0.76
479_E	508_D	0.692	0.75
493_I	500_V	0.690	0.75
439_L	443_I	0.689	0.75
118_L	161_Y	0.688	0.75
80_P	395_E	0.687	0.75
242_A	280_L	0.685	0.75
160_N	164_S	0.685	0.75
274_I	278_P	0.684	0.75
137_S	186_Y	0.682	0.74
215_E	218_E	0.681	0.74
224_R	255_R	0.680	0.74
523_V	526_S	0.679	0.74
174_E	343_Y	0.677	0.74
427_L	521_S	0.677	0.74
497_E	506_F	0.677	0.74
192_K	229_V	0.676	0.74
140_A	146_V	0.675	0.74
459_V	526_S	0.672	0.73
372_L	379_V	0.672	0.73
155_V	160_N	0.669	0.73
311_L	314_N	0.668	0.73
481_K	505_E	0.668	0.73
443_I	452_V	0.668	0.73
235_A	276_I	0.668	0.73
388_K	391_N	0.668	0.73
143_V	343_Y	0.666	0.73
141_T	148_K	0.665	0.73
71_I	97_A	0.665	0.73
215_E	219_I	0.664	0.72
140_A	147_T	0.663	0.72
151_N	179_G	0.663	0.72
283_K	346_V	0.662	0.72
96_K	125_D	0.661	0.72
193_T	197_A	0.661	0.72
128_V	168_K	0.660	0.72
123_K	127_D	0.659	0.72
80_P	391_N	0.659	0.72
279_T	319_Y	0.658	0.72
90_K	124_A	0.658	0.72
427_L	430_W	0.658	0.72
274_I	317_Q	0.657	0.72
487_V	496_T	0.657	0.72
219_I	231_L	0.656	0.72
98_K	102_F	0.655	0.71
134_K	186_Y	0.655	0.71
83_E	112_V	0.650	0.71
487_V	498_S	0.650	0.71
506_F	533_G	0.649	0.71
480_V	506_F	0.648	0.71
302_S	322_D	0.648	0.71
281_I	291_G	0.647	0.71
102_F	128_V	0.645	0.70
118_L	129_A	0.645	0.70
348_P	356_K	0.644	0.70
457_G	526_S	0.642	0.70
155_V	158_S	0.641	0.70
480_V	533_G	0.640	0.70
392_K	416_K	0.640	0.70
287_N	292_Q	0.640	0.70
508_D	537_Y	0.640	0.70
46_G	51_F	0.639	0.70
100_A	170_I	0.637	0.69
63_L	71_I	0.637	0.69
122_V	165_H	0.636	0.69
152_L	155_V	0.634	0.69
81_K	399_R	0.633	0.69
181_K	245_N	0.633	0.69
278_P	298_L	0.631	0.69
372_L	410_A	0.630	0.68
211_T	216_V	0.628	0.68
68_V	259_G	0.626	0.68
163_K	325_F	0.624	0.68
104_S	107_R	0.624	0.68
275_Q	317_Q	0.623	0.68
212_P	287_N	0.622	0.68
301_V	304_I	0.621	0.67
424_Y	535_D	0.619	0.67
429_Y	434_N	0.619	0.67
459_V	530_L	0.618	0.67
154_I	157_D	0.616	0.67
156_Y	190_V	0.616	0.67
66_L	298_L	0.615	0.67
494_K	500_V	0.614	0.67
499_V	518_V	0.614	0.67
33_V	280_L	0.614	0.67
191_V	226_V	0.613	0.66
88_E	94_L	0.613	0.66
298_L	356_K	0.612	0.66
141_T	145_K	0.612	0.66
180_F	219_I	0.612	0.66
315_P	322_D	0.611	0.66
302_S	320_V	0.610	0.66
397_E	403_F	0.610	0.66
303_R	307_E	0.610	0.66
393_I	417_E	0.610	0.66
328_K	361_E	0.610	0.66
206_D	210_G	0.608	0.66
111_S	165_H	0.606	0.66
262_N	305_V	0.605	0.65
486_R	505_E	0.605	0.65
375_L	411_I	0.605	0.65
460_N	522_V	0.602	0.65
467_R	479_E	0.599	0.65
38_T	159_I	0.599	0.65
490_P	518_V	0.599	0.65
480_V	484_D	0.599	0.65
126_V	129_A	0.598	0.64
174_E	198_G	0.598	0.64
170_I	256_H	0.598	0.64
185_E	218_E	0.597	0.64
222_K	225_E	0.596	0.64
490_P	497_E	0.596	0.64
337_M	373_Q	0.595	0.64
251_K	286_L	0.595	0.64
118_L	122_V	0.594	0.64
462_I	466_L	0.594	0.64
262_N	313_P	0.593	0.64
54_N	58_K	0.593	0.64
50_S	361_E	0.592	0.64
153_D	189_E	0.592	0.64
328_K	394_K	0.592	0.64
296_R	350_L	0.592	0.64
53_L	411_I	0.592	0.64
64_D	92_Y	0.590	0.63
498_S	526_S	0.589	0.63
425_I	470_L	0.588	0.63
195_E	224_R	0.585	0.63
139_H	151_N	0.585	0.63
251_K	284_M	0.585	0.63
52_T	55_D	0.584	0.63
467_R	530_L	0.584	0.63
36_L	139_H	0.583	0.63
219_I	222_K	0.582	0.62
199_A	225_E	0.581	0.62
129_A	169_V	0.581	0.62
134_K	182_E	0.580	0.62
498_S	506_F	0.580	0.62
233_I	254_A	0.580	0.62
504_I	530_L	0.577	0.62
335_A	343_Y	0.576	0.62
42_D	45_Q	0.576	0.62
362_L	394_K	0.575	0.61
237_N	272_D	0.575	0.61
201_V	230_K	0.574	0.61
458_P	523_V	0.573	0.61
53_L	81_K	0.570	0.61
506_F	534_L	0.569	0.61
83_E	86_F	0.569	0.61
291_G	294_S	0.568	0.61
192_K	227_L	0.567	0.60
369_V	386_L	0.566	0.60
192_K	228_Q	0.565	0.60
210_G	242_A	0.564	0.60
517_G	528_M	0.564	0.60
272_D	317_Q	0.563	0.60
189_E	192_K	0.562	0.60
227_L	230_K	0.561	0.60
482_L	489_L	0.559	0.59
305_V	308_I	0.559	0.59
83_E	119_N	0.558	0.59
134_K	137_S	0.557	0.59
458_P	517_G	0.557	0.59
100_A	103_G	0.556	0.59
195_E	227_L	0.556	0.59
112_V	119_N	0.555	0.59
346_V	350_L	0.553	0.59
151_N	154_I	0.551	0.58
104_S	132_F	0.550	0.58
485_Y	522_V	0.550	0.58
78_S	106_K	0.549	0.58
372_L	377_I	0.549	0.58
425_I	538_L	0.548	0.58
78_S	87_R	0.548	0.58
188_L	227_L	0.547	0.58
379_V	389_A	0.547	0.58
99_I	104_S	0.547	0.58
133_G	372_L	0.546	0.58
121_I	165_H	0.546	0.58
271_A	339_V	0.545	0.57
138_L	339_V	0.545	0.57
441_I	454_E	0.545	0.57
439_L	454_E	0.544	0.57
462_I	465_A	0.544	0.57
103_G	109_D	0.543	0.57
49_I	308_I	0.543	0.57
453_A	468_M	0.541	0.57
180_F	215_E	0.541	0.57
55_D	307_E	0.540	0.57
209_G	245_N	0.540	0.57
337_M	369_V	0.539	0.57
524_E	528_M	0.538	0.56
273_L	298_L	0.538	0.56
504_I	533_G	0.538	0.56
299_R	303_R	0.538	0.56
281_I	284_M	0.537	0.56
201_V	357_F	0.537	0.56
109_D	112_V	0.536	0.56
377_I	499_V	0.536	0.56
301_V	305_V	0.536	0.56
344_E	355_R	0.536	0.56
107_R	112_V	0.535	0.56
139_H	181_K	0.534	0.56
127_D	167_L	0.533	0.56
237_N	297_K	0.533	0.56
501_R	505_E	0.533	0.56
128_V	201_V	0.532	0.56
359_I	393_I	0.532	0.56
108_K	112_V	0.531	0.55
184_P	187_A	0.531	0.55
261_I	301_V	0.530	0.55
299_R	322_D	0.528	0.55
58_K	308_I	0.528	0.55
180_F	184_P	0.527	0.55
377_I	417_E	0.527	0.55
74_G	179_G	0.527	0.55
410_A	413_I	0.526	0.55
68_V	301_V	0.526	0.55
194_A	202_I	0.526	0.55
366_A	487_V	0.526	0.55
359_I	371_Y	0.524	0.55
299_R	325_F	0.524	0.55
371_Y	504_I	0.523	0.54
212_P	248_M	0.522	0.54
38_T	102_F	0.521	0.54
185_E	222_K	0.520	0.54
38_T	179_G	0.520	0.54
433_I	441_I	0.520	0.54
180_F	216_V	0.520	0.54
190_V	193_T	0.520	0.54
239_I	319_Y	0.518	0.54
150_D	154_I	0.518	0.54
146_V	186_Y	0.518	0.54
415_L	419_N	0.518	0.54
145_K	334_D	0.518	0.54
363_S	367_N	0.517	0.54
457_G	487_V	0.516	0.53
247_L	287_N	0.516	0.53
98_K	103_G	0.515	0.53
357_F	370_S	0.514	0.53
423_N	535_D	0.513	0.53
493_I	498_S	0.513	0.53
66_L	261_I	0.513	0.53
166_G	173_A	0.511	0.53
147_T	186_Y	0.511	0.53
38_T	42_D	0.511	0.53
379_V	414_T	0.509	0.52
353_N	356_K	0.509	0.52
36_L	256_H	0.509	0.52
312_P	315_P	0.509	0.52
257_V	271_A	0.509	0.52
260_T	273_L	0.509	0.52
105_T	133_G	0.508	0.52
220_T	224_R	0.508	0.52
77_G	111_S	0.507	0.52
320_V	325_F	0.507	0.52
457_G	496_T	0.507	0.52
386_L	389_A	0.507	0.52
212_P	264_I	0.507	0.52
372_L	378_A	0.506	0.52
429_Y	445_K	0.504	0.52
389_A	418_L	0.504	0.52
216_V	249_A	0.503	0.52
425_I	446_V	0.503	0.52
237_N	316_Y	0.503	0.52
436_N	444_V	0.501	0.51
216_V	220_T	0.501	0.51
70_Y	128_V	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hq1A	2	0.9078	100	0.297	Contact Map
4ov4A	2	0.6618	100	0.444	Contact Map
2ztjA	2	0.5515	100	0.458	Contact Map
3rmjA	2	0.5443	100	0.465	Contact Map
3ivsA	2	0.651	100	0.472	Contact Map
3bleA	2	0.5425	100	0.538	Contact Map
3eegA	2	0.481	100	0.574	Contact Map
2qf7A	4	0.9168	100	0.622	Contact Map
4qshA	4	0.8716	100	0.643	Contact Map
2nx9A	2	0.736	100	0.645	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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