GREMLIN Database
Q980Y9 - Cobalamin biosynthesis protein G (CbiG)
UniProt: Q980Y9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (266)
Sequences: 1119 (894)
Seq/√Len: 54.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
231_V252_I4.4041.00
69_S94_N4.3921.00
61_I70_V3.7731.00
201_E237_N3.3111.00
44_I73_L3.2221.00
193_I221_I3.1401.00
37_I83_I3.0821.00
208_L240_K2.8441.00
209_V247_Y2.8001.00
208_L244_I2.7921.00
55_F125_R2.7891.00
231_V254_Y2.7111.00
72_P84_S2.5981.00
189_I222_L2.5061.00
195_I212_L2.4911.00
211_S286_V2.4621.00
173_E192_G2.3111.00
216_L226_I2.3031.00
195_I226_I2.2871.00
42_N47_T2.2171.00
212_L244_I2.2101.00
40_S47_T2.0811.00
258_V267_L2.0481.00
200_L285_G2.0281.00
189_I225_R1.9241.00
123_Y189_I1.8820.99
229_I245_T1.8180.99
53_A125_R1.8120.99
193_I290_L1.8110.99
61_I83_I1.8090.99
209_V248_Y1.8000.99
215_T277_L1.7560.99
69_S96_V1.7500.99
131_L141_V1.7420.99
99_T102_G1.7300.99
118_F188_L1.6990.99
215_T288_T1.6850.99
72_P95_L1.6780.99
46_N50_K1.6690.99
63_V91_L1.6660.99
63_V70_V1.6630.99
70_V87_L1.6580.99
228_Y253_I1.6150.98
87_L91_L1.6120.98
194_Y228_Y1.6090.98
236_K254_Y1.6000.98
101_T132_N1.5950.98
211_S282_R1.5850.98
205_L240_K1.5850.98
215_T219_L1.5630.98
55_F78_S1.5450.98
207_V285_G1.5420.98
209_V213_R1.5410.98
195_I229_I1.5050.97
239_K243_Q1.4790.97
202_S240_K1.4760.97
213_R248_Y1.4720.97
244_I248_Y1.4700.97
82_L115_L1.4650.97
211_S288_T1.4620.97
212_L288_T1.4390.97
213_R223_N1.4390.97
199_Y238_D1.4320.97
277_L290_L1.4270.97
37_I61_I1.4230.96
270_E273_V1.4170.96
72_P87_L1.4020.96
214_M218_S1.4000.96
26_L30_I1.3900.96
39_I63_V1.3800.96
242_H254_Y1.3790.96
243_Q246_K1.3710.96
275_V291_G1.3660.96
219_L277_L1.3590.95
53_A56_H1.3530.95
145_V148_Y1.3480.95
205_L247_Y1.3460.95
197_I241_L1.3350.95
235_L238_D1.3320.95
218_S280_V1.3250.95
265_E279_D1.3230.95
22_L25_E1.3220.95
208_L286_V1.3220.95
27_G40_S1.3180.95
29_W34_D1.3140.94
101_T188_L1.3050.94
66_D103_V1.2850.94
39_I61_I1.2800.94
41_V63_V1.2790.94
119_S191_S1.2780.94
222_L225_R1.2690.93
182_S185_R1.2560.93
38_I146_D1.2500.93
216_L223_N1.2460.93
195_I290_L1.2330.92
139_G166_K1.2320.92
270_E291_G1.2270.92
70_V93_A1.2200.92
268_L291_G1.2120.92
201_E238_D1.2070.91
209_V244_I1.1970.91
75_K78_S1.1940.91
241_L252_I1.1860.91
205_L243_Q1.1840.91
124_D128_V1.1810.91
109_V132_N1.1810.91
263_S266_A1.1740.90
109_V128_V1.1710.90
146_D172_S1.1680.90
258_V266_A1.1670.90
208_L212_L1.1620.90
75_K79_G1.1600.90
106_L135_L1.1540.90
200_L203_T1.1430.89
27_G51_Y1.1340.89
231_V245_T1.1330.89
229_I250_S1.1270.88
266_A285_G1.1030.87
197_I212_L1.1030.87
203_T208_L1.1000.87
172_S187_Y1.1000.87
37_I59_I1.0980.87
255_G258_V1.0770.86
226_I250_S1.0730.86
125_R128_V1.0680.86
62_N71_I1.0580.85
195_I288_T1.0570.85
221_I290_L1.0450.84
173_E225_R1.0410.84
118_F145_V1.0210.83
111_E115_L1.0140.82
30_I38_I1.0120.82
59_I81_S1.0120.82
264_C289_C1.0110.82
194_Y230_V1.0010.82
205_L244_I0.9990.81
134_K139_G0.9960.81
128_V132_N0.9860.81
203_T240_K0.9820.80
198_R235_L0.9810.80
64_V68_S0.9780.80
124_D187_Y0.9770.80
168_D185_R0.9720.80
187_Y222_L0.9600.79
39_I259_D0.9590.79
134_K167_A0.9490.78
199_Y203_T0.9400.77
113_S186_L0.9380.77
68_S94_N0.9370.77
244_I250_S0.9300.77
207_V282_R0.9300.77
65_P104_K0.9230.76
101_T129_N0.9170.76
124_D127_I0.9160.75
128_V136_V0.9120.75
42_N46_N0.9070.75
101_T136_V0.9060.75
80_G101_T0.9040.75
120_I128_V0.9030.74
145_V152_Y0.9020.74
207_V211_S0.8970.74
213_R217_K0.8930.74
192_G225_R0.8920.74
84_S95_L0.8900.73
230_V255_G0.8880.73
63_V87_L0.8870.73
198_R287_I0.8850.73
148_Y152_Y0.8720.72
226_I290_L0.8680.71
142_N168_D0.8670.71
78_S125_R0.8660.71
107_Y266_A0.8590.71
195_I216_L0.8580.71
102_G110_E0.8460.70
62_N72_P0.8430.69
245_T252_I0.8410.69
240_K244_I0.8380.69
101_T113_S0.8370.69
169_L188_L0.8280.68
54_K77_H0.8250.68
212_L226_I0.8170.67
46_N200_L0.8130.66
134_K168_D0.8110.66
216_L290_L0.8090.66
143_V171_I0.8080.66
203_T207_V0.8080.66
23_F50_K0.8060.66
112_F266_A0.8040.66
25_E28_Y0.8040.66
183_S256_S0.8030.65
125_R133_K0.8020.65
67_G93_A0.8010.65
123_Y224_D0.7980.65
214_M282_R0.7980.65
65_P103_V0.7980.65
47_T62_N0.7950.65
111_E143_V0.7950.65
241_L273_V0.7930.64
113_S188_L0.7910.64
199_Y208_L0.7870.64
17_K20_K0.7860.64
197_I229_I0.7860.64
245_T250_S0.7840.64
71_I98_T0.7810.63
211_S215_T0.7770.63
62_N98_T0.7770.63
43_S46_N0.7710.62
43_S99_T0.7690.62
206_D243_Q0.7670.62
197_I244_I0.7660.62
199_Y241_L0.7650.62
77_H198_R0.7580.61
231_V255_G0.7570.61
242_H252_I0.7560.61
24_S50_K0.7550.61
146_D174_N0.7540.61
133_K137_T0.7530.60
257_D260_E0.7530.60
129_N133_K0.7500.60
141_V169_L0.7490.60
127_I186_L0.7490.60
30_I35_P0.7460.60
70_V91_L0.7460.60
168_D182_S0.7440.60
23_F26_L0.7430.59
220_Y223_N0.7400.59
277_L280_V0.7390.59
270_E289_C0.7390.59
207_V284_F0.7380.59
275_V279_D0.7360.59
223_N248_Y0.7350.59
46_N113_S0.7310.58
253_I290_L0.7280.58
136_V266_A0.7240.57
279_D287_I0.7240.57
197_I288_T0.7210.57
227_D251_N0.7160.57
64_V69_S0.7110.56
30_I60_I0.7090.56
206_D218_S0.7050.55
72_P97_L0.7040.55
197_I208_L0.7010.55
132_N188_L0.6970.55
181_K185_R0.6960.54
120_I124_D0.6950.54
219_L288_T0.6950.54
201_E235_L0.6930.54
65_P100_S0.6930.54
82_L85_S0.6920.54
231_V284_F0.6860.53
265_E275_V0.6860.53
202_S205_L0.6840.53
240_K245_T0.6810.53
68_S103_V0.6790.53
199_Y234_S0.6770.52
142_N165_T0.6740.52
64_V81_S0.6710.52
229_I244_I0.6690.52
27_G50_K0.6690.52
203_T286_V0.6680.51
189_I224_D0.6650.51
135_L141_V0.6630.51
233_S236_K0.6620.51
205_L208_L0.6610.51
21_G29_W0.6600.51
112_F116_N0.6580.50
77_H196_G0.6560.50
261_R268_L0.6540.50
107_Y112_F0.6540.50
123_Y222_L0.6520.50
43_S74_T0.6510.50
58_K225_R0.6490.49
265_E289_C0.6480.49
27_G32_Y0.6450.49
258_V261_R0.6430.49
202_S239_K0.6420.49
111_E133_K0.6390.48
109_V143_V0.6370.48
234_S238_D0.6360.48
69_S103_V0.6360.48
75_K81_S0.6350.48
268_L271_L0.6350.48
144_Y170_I0.6340.48
57_N64_V0.6290.47
41_V230_V0.6280.47
215_T290_L0.6270.47
129_N136_V0.6240.47
44_I47_T0.6220.47
216_L221_I0.6220.47
229_I248_Y0.6210.46
192_G290_L0.6190.46
48_I62_N0.6180.46
27_G46_N0.6170.46
76_E102_G0.6160.46
141_V173_E0.6160.46
268_L273_V0.6150.46
101_T169_L0.6140.46
47_T107_Y0.6130.46
208_L241_L0.6110.45
76_E81_S0.6090.45
170_I187_Y0.6090.45
75_K132_N0.6060.45
62_N96_V0.6040.45
41_V46_N0.6030.45
66_D104_K0.6020.44
108_S115_L0.6020.44
42_N65_P0.6010.44
81_S102_G0.6010.44
42_N112_F0.6010.44
259_D262_S0.6010.44
206_D247_Y0.6010.44
120_I188_L0.6000.44
100_S135_L0.5970.44
147_S152_Y0.5960.44
109_V169_L0.5950.44
42_N107_Y0.5930.43
215_T280_V0.5930.43
72_P96_V0.5920.43
23_F40_S0.5910.43
147_S172_S0.5890.43
163_H166_K0.5860.43
95_L172_S0.5840.43
71_I97_L0.5830.42
108_S199_Y0.5820.42
202_S238_D0.5810.42
198_R279_D0.5790.42
37_I87_L0.5790.42
93_A146_D0.5790.42
204_P207_V0.5780.42
172_S222_L0.5780.42
70_V88_A0.5740.41
165_T168_D0.5710.41
275_V289_C0.5710.41
196_G235_L0.5710.41
198_R238_D0.5700.41
116_N186_L0.5690.41
211_S245_T0.5670.41
88_A93_A0.5660.41
78_S114_W0.5640.40
81_S101_T0.5640.40
227_D276_L0.5640.40
28_Y33_N0.5610.40
233_S254_Y0.5600.40
110_E238_D0.5600.40
112_F132_N0.5590.40
230_V269_K0.5590.40
61_I87_L0.5570.40
76_E97_L0.5570.40
128_V133_K0.5560.40
258_V263_S0.5550.40
113_S169_L0.5540.39
124_D132_N0.5530.39
65_P102_G0.5530.39
99_T136_V0.5520.39
86_F89_D0.5520.39
64_V96_V0.5520.39
32_Y102_G0.5520.39
199_Y235_L0.5500.39
167_A184_N0.5490.39
26_L50_K0.5480.39
120_I136_V0.5480.39
32_Y38_I0.5480.39
96_V267_L0.5470.39
77_H235_L0.5460.39
124_D186_L0.5440.38
131_L169_L0.5440.38
193_I277_L0.5430.38
25_E272_K0.5430.38
110_E235_L0.5430.38
213_R247_Y0.5420.38
67_G228_Y0.5410.38
75_K264_C0.5400.38
254_Y267_L0.5390.38
57_N80_G0.5340.37
132_N136_V0.5330.37
123_Y128_V0.5330.37
46_N76_E0.5310.37
269_K291_G0.5270.37
46_N102_G0.5260.37
125_R129_N0.5240.36
89_D214_M0.5240.36
51_Y60_I0.5240.36
187_Y226_I0.5230.36
48_I73_L0.5230.36
212_L216_L0.5220.36
61_I180_D0.5210.36
268_L272_K0.5180.36
61_I105_G0.5170.36
30_I34_D0.5110.35
85_S92_G0.5100.35
136_V168_D0.5080.35
195_I244_I0.5080.35
215_T218_S0.5040.34
217_K257_D0.5020.34
190_P225_R0.5020.34
256_S259_D0.5020.34
62_N284_F0.5010.34
105_G184_N0.5000.34
84_S217_K0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eeqA 2 0.9044 100 0.228 Contact Map
2w6kA 1 0.3788 100 0.7 Contact Map
3by5A 2 0.3345 99.9 0.723 Contact Map
3lmaA 2 0.4471 13.4 0.97 Contact Map
3a2kA 1 0.3857 11.8 0.971 Contact Map
2fz4A 1 0.314 10.7 0.971 Contact Map
2fz5A 1 0.3891 9.6 0.972 Contact Map
4xltA 3 0.3993 8.9 0.972 Contact Map
3thtA 3 0.314 8.3 0.973 Contact Map
2ecuA 2 0.4403 8.2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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