Q980Y9 - SULSO - GREMLIN Contacts

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Q980Y9 - Cobalamin biosynthesis protein G (CbiG)

UniProt:	Q980Y9	Sequences: MYVSRILVNGVNKDLVKQIKGLFSELGYWIVYNDPDIIISVNSINNTIRKYFAKFHNKIIINVVPDGSSVIPLTKEHSGGSLISSFLADSLGANLVLTTSTGVKGLYSVEEFSWLNGFSIYGYDRKIVNSLNKKLVTEGKVNVYVDSYKGNYILYDGYSLVDHKTKADLIISENVDSMEDKSSNRLYLIPSGIYIGIRYLESTPLDVLVYSLRMTLKSLYILNDRIDYIVVPSSLKNDKKLHQITKYYYSNIIYGSDVDERSSCEALLKELKVKVLLKDVRRAFGVITCLGVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	293 (266)
Sequences:	1119 (894)
Seq/√Len:	54.8

HALSA - Q9HPN1
SULSO - Q980Y9 Q97WD0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
231_V	252_I	4.404	1.00
69_S	94_N	4.392	1.00
61_I	70_V	3.773	1.00
201_E	237_N	3.311	1.00
44_I	73_L	3.222	1.00
193_I	221_I	3.140	1.00
37_I	83_I	3.082	1.00
208_L	240_K	2.844	1.00
209_V	247_Y	2.800	1.00
208_L	244_I	2.792	1.00
55_F	125_R	2.789	1.00
231_V	254_Y	2.711	1.00
72_P	84_S	2.598	1.00
189_I	222_L	2.506	1.00
195_I	212_L	2.491	1.00
211_S	286_V	2.462	1.00
173_E	192_G	2.311	1.00
216_L	226_I	2.303	1.00
195_I	226_I	2.287	1.00
42_N	47_T	2.217	1.00
212_L	244_I	2.210	1.00
40_S	47_T	2.081	1.00
258_V	267_L	2.048	1.00
200_L	285_G	2.028	1.00
189_I	225_R	1.924	1.00
123_Y	189_I	1.882	0.99
229_I	245_T	1.818	0.99
53_A	125_R	1.812	0.99
193_I	290_L	1.811	0.99
61_I	83_I	1.809	0.99
209_V	248_Y	1.800	0.99
215_T	277_L	1.756	0.99
69_S	96_V	1.750	0.99
131_L	141_V	1.742	0.99
99_T	102_G	1.730	0.99
118_F	188_L	1.699	0.99
215_T	288_T	1.685	0.99
72_P	95_L	1.678	0.99
46_N	50_K	1.669	0.99
63_V	91_L	1.666	0.99
63_V	70_V	1.663	0.99
70_V	87_L	1.658	0.99
228_Y	253_I	1.615	0.98
87_L	91_L	1.612	0.98
194_Y	228_Y	1.609	0.98
236_K	254_Y	1.600	0.98
101_T	132_N	1.595	0.98
211_S	282_R	1.585	0.98
205_L	240_K	1.585	0.98
215_T	219_L	1.563	0.98
55_F	78_S	1.545	0.98
207_V	285_G	1.542	0.98
209_V	213_R	1.541	0.98
195_I	229_I	1.505	0.97
239_K	243_Q	1.479	0.97
202_S	240_K	1.476	0.97
213_R	248_Y	1.472	0.97
244_I	248_Y	1.470	0.97
82_L	115_L	1.465	0.97
211_S	288_T	1.462	0.97
212_L	288_T	1.439	0.97
213_R	223_N	1.439	0.97
199_Y	238_D	1.432	0.97
277_L	290_L	1.427	0.97
37_I	61_I	1.423	0.96
270_E	273_V	1.417	0.96
72_P	87_L	1.402	0.96
214_M	218_S	1.400	0.96
26_L	30_I	1.390	0.96
39_I	63_V	1.380	0.96
242_H	254_Y	1.379	0.96
243_Q	246_K	1.371	0.96
275_V	291_G	1.366	0.96
219_L	277_L	1.359	0.95
53_A	56_H	1.353	0.95
145_V	148_Y	1.348	0.95
205_L	247_Y	1.346	0.95
197_I	241_L	1.335	0.95
235_L	238_D	1.332	0.95
218_S	280_V	1.325	0.95
265_E	279_D	1.323	0.95
22_L	25_E	1.322	0.95
208_L	286_V	1.322	0.95
27_G	40_S	1.318	0.95
29_W	34_D	1.314	0.94
101_T	188_L	1.305	0.94
66_D	103_V	1.285	0.94
39_I	61_I	1.280	0.94
41_V	63_V	1.279	0.94
119_S	191_S	1.278	0.94
222_L	225_R	1.269	0.93
182_S	185_R	1.256	0.93
38_I	146_D	1.250	0.93
216_L	223_N	1.246	0.93
195_I	290_L	1.233	0.92
139_G	166_K	1.232	0.92
270_E	291_G	1.227	0.92
70_V	93_A	1.220	0.92
268_L	291_G	1.212	0.92
201_E	238_D	1.207	0.91
209_V	244_I	1.197	0.91
75_K	78_S	1.194	0.91
241_L	252_I	1.186	0.91
205_L	243_Q	1.184	0.91
124_D	128_V	1.181	0.91
109_V	132_N	1.181	0.91
263_S	266_A	1.174	0.90
109_V	128_V	1.171	0.90
146_D	172_S	1.168	0.90
258_V	266_A	1.167	0.90
208_L	212_L	1.162	0.90
75_K	79_G	1.160	0.90
106_L	135_L	1.154	0.90
200_L	203_T	1.143	0.89
27_G	51_Y	1.134	0.89
231_V	245_T	1.133	0.89
229_I	250_S	1.127	0.88
266_A	285_G	1.103	0.87
197_I	212_L	1.103	0.87
203_T	208_L	1.100	0.87
172_S	187_Y	1.100	0.87
37_I	59_I	1.098	0.87
255_G	258_V	1.077	0.86
226_I	250_S	1.073	0.86
125_R	128_V	1.068	0.86
62_N	71_I	1.058	0.85
195_I	288_T	1.057	0.85
221_I	290_L	1.045	0.84
173_E	225_R	1.041	0.84
118_F	145_V	1.021	0.83
111_E	115_L	1.014	0.82
30_I	38_I	1.012	0.82
59_I	81_S	1.012	0.82
264_C	289_C	1.011	0.82
194_Y	230_V	1.001	0.82
205_L	244_I	0.999	0.81
134_K	139_G	0.996	0.81
128_V	132_N	0.986	0.81
203_T	240_K	0.982	0.80
198_R	235_L	0.981	0.80
64_V	68_S	0.978	0.80
124_D	187_Y	0.977	0.80
168_D	185_R	0.972	0.80
187_Y	222_L	0.960	0.79
39_I	259_D	0.959	0.79
134_K	167_A	0.949	0.78
199_Y	203_T	0.940	0.77
113_S	186_L	0.938	0.77
68_S	94_N	0.937	0.77
244_I	250_S	0.930	0.77
207_V	282_R	0.930	0.77
65_P	104_K	0.923	0.76
101_T	129_N	0.917	0.76
124_D	127_I	0.916	0.75
128_V	136_V	0.912	0.75
42_N	46_N	0.907	0.75
101_T	136_V	0.906	0.75
80_G	101_T	0.904	0.75
120_I	128_V	0.903	0.74
145_V	152_Y	0.902	0.74
207_V	211_S	0.897	0.74
213_R	217_K	0.893	0.74
192_G	225_R	0.892	0.74
84_S	95_L	0.890	0.73
230_V	255_G	0.888	0.73
63_V	87_L	0.887	0.73
198_R	287_I	0.885	0.73
148_Y	152_Y	0.872	0.72
226_I	290_L	0.868	0.71
142_N	168_D	0.867	0.71
78_S	125_R	0.866	0.71
107_Y	266_A	0.859	0.71
195_I	216_L	0.858	0.71
102_G	110_E	0.846	0.70
62_N	72_P	0.843	0.69
245_T	252_I	0.841	0.69
240_K	244_I	0.838	0.69
101_T	113_S	0.837	0.69
169_L	188_L	0.828	0.68
54_K	77_H	0.825	0.68
212_L	226_I	0.817	0.67
46_N	200_L	0.813	0.66
134_K	168_D	0.811	0.66
216_L	290_L	0.809	0.66
143_V	171_I	0.808	0.66
203_T	207_V	0.808	0.66
23_F	50_K	0.806	0.66
112_F	266_A	0.804	0.66
25_E	28_Y	0.804	0.66
183_S	256_S	0.803	0.65
125_R	133_K	0.802	0.65
67_G	93_A	0.801	0.65
123_Y	224_D	0.798	0.65
214_M	282_R	0.798	0.65
65_P	103_V	0.798	0.65
47_T	62_N	0.795	0.65
111_E	143_V	0.795	0.65
241_L	273_V	0.793	0.64
113_S	188_L	0.791	0.64
199_Y	208_L	0.787	0.64
17_K	20_K	0.786	0.64
197_I	229_I	0.786	0.64
245_T	250_S	0.784	0.64
71_I	98_T	0.781	0.63
211_S	215_T	0.777	0.63
62_N	98_T	0.777	0.63
43_S	46_N	0.771	0.62
43_S	99_T	0.769	0.62
206_D	243_Q	0.767	0.62
197_I	244_I	0.766	0.62
199_Y	241_L	0.765	0.62
77_H	198_R	0.758	0.61
231_V	255_G	0.757	0.61
242_H	252_I	0.756	0.61
24_S	50_K	0.755	0.61
146_D	174_N	0.754	0.61
133_K	137_T	0.753	0.60
257_D	260_E	0.753	0.60
129_N	133_K	0.750	0.60
141_V	169_L	0.749	0.60
127_I	186_L	0.749	0.60
30_I	35_P	0.746	0.60
70_V	91_L	0.746	0.60
168_D	182_S	0.744	0.60
23_F	26_L	0.743	0.59
220_Y	223_N	0.740	0.59
277_L	280_V	0.739	0.59
270_E	289_C	0.739	0.59
207_V	284_F	0.738	0.59
275_V	279_D	0.736	0.59
223_N	248_Y	0.735	0.59
46_N	113_S	0.731	0.58
253_I	290_L	0.728	0.58
136_V	266_A	0.724	0.57
279_D	287_I	0.724	0.57
197_I	288_T	0.721	0.57
227_D	251_N	0.716	0.57
64_V	69_S	0.711	0.56
30_I	60_I	0.709	0.56
206_D	218_S	0.705	0.55
72_P	97_L	0.704	0.55
197_I	208_L	0.701	0.55
132_N	188_L	0.697	0.55
181_K	185_R	0.696	0.54
120_I	124_D	0.695	0.54
219_L	288_T	0.695	0.54
201_E	235_L	0.693	0.54
65_P	100_S	0.693	0.54
82_L	85_S	0.692	0.54
231_V	284_F	0.686	0.53
265_E	275_V	0.686	0.53
202_S	205_L	0.684	0.53
240_K	245_T	0.681	0.53
68_S	103_V	0.679	0.53
199_Y	234_S	0.677	0.52
142_N	165_T	0.674	0.52
64_V	81_S	0.671	0.52
229_I	244_I	0.669	0.52
27_G	50_K	0.669	0.52
203_T	286_V	0.668	0.51
189_I	224_D	0.665	0.51
135_L	141_V	0.663	0.51
233_S	236_K	0.662	0.51
205_L	208_L	0.661	0.51
21_G	29_W	0.660	0.51
112_F	116_N	0.658	0.50
77_H	196_G	0.656	0.50
261_R	268_L	0.654	0.50
107_Y	112_F	0.654	0.50
123_Y	222_L	0.652	0.50
43_S	74_T	0.651	0.50
58_K	225_R	0.649	0.49
265_E	289_C	0.648	0.49
27_G	32_Y	0.645	0.49
258_V	261_R	0.643	0.49
202_S	239_K	0.642	0.49
111_E	133_K	0.639	0.48
109_V	143_V	0.637	0.48
234_S	238_D	0.636	0.48
69_S	103_V	0.636	0.48
75_K	81_S	0.635	0.48
268_L	271_L	0.635	0.48
144_Y	170_I	0.634	0.48
57_N	64_V	0.629	0.47
41_V	230_V	0.628	0.47
215_T	290_L	0.627	0.47
129_N	136_V	0.624	0.47
44_I	47_T	0.622	0.47
216_L	221_I	0.622	0.47
229_I	248_Y	0.621	0.46
192_G	290_L	0.619	0.46
48_I	62_N	0.618	0.46
27_G	46_N	0.617	0.46
76_E	102_G	0.616	0.46
141_V	173_E	0.616	0.46
268_L	273_V	0.615	0.46
101_T	169_L	0.614	0.46
47_T	107_Y	0.613	0.46
208_L	241_L	0.611	0.45
76_E	81_S	0.609	0.45
170_I	187_Y	0.609	0.45
75_K	132_N	0.606	0.45
62_N	96_V	0.604	0.45
41_V	46_N	0.603	0.45
66_D	104_K	0.602	0.44
108_S	115_L	0.602	0.44
42_N	65_P	0.601	0.44
81_S	102_G	0.601	0.44
42_N	112_F	0.601	0.44
259_D	262_S	0.601	0.44
206_D	247_Y	0.601	0.44
120_I	188_L	0.600	0.44
100_S	135_L	0.597	0.44
147_S	152_Y	0.596	0.44
109_V	169_L	0.595	0.44
42_N	107_Y	0.593	0.43
215_T	280_V	0.593	0.43
72_P	96_V	0.592	0.43
23_F	40_S	0.591	0.43
147_S	172_S	0.589	0.43
163_H	166_K	0.586	0.43
95_L	172_S	0.584	0.43
71_I	97_L	0.583	0.42
108_S	199_Y	0.582	0.42
202_S	238_D	0.581	0.42
198_R	279_D	0.579	0.42
37_I	87_L	0.579	0.42
93_A	146_D	0.579	0.42
204_P	207_V	0.578	0.42
172_S	222_L	0.578	0.42
70_V	88_A	0.574	0.41
165_T	168_D	0.571	0.41
275_V	289_C	0.571	0.41
196_G	235_L	0.571	0.41
198_R	238_D	0.570	0.41
116_N	186_L	0.569	0.41
211_S	245_T	0.567	0.41
88_A	93_A	0.566	0.41
78_S	114_W	0.564	0.40
81_S	101_T	0.564	0.40
227_D	276_L	0.564	0.40
28_Y	33_N	0.561	0.40
233_S	254_Y	0.560	0.40
110_E	238_D	0.560	0.40
112_F	132_N	0.559	0.40
230_V	269_K	0.559	0.40
61_I	87_L	0.557	0.40
76_E	97_L	0.557	0.40
128_V	133_K	0.556	0.40
258_V	263_S	0.555	0.40
113_S	169_L	0.554	0.39
124_D	132_N	0.553	0.39
65_P	102_G	0.553	0.39
99_T	136_V	0.552	0.39
86_F	89_D	0.552	0.39
64_V	96_V	0.552	0.39
32_Y	102_G	0.552	0.39
199_Y	235_L	0.550	0.39
167_A	184_N	0.549	0.39
26_L	50_K	0.548	0.39
120_I	136_V	0.548	0.39
32_Y	38_I	0.548	0.39
96_V	267_L	0.547	0.39
77_H	235_L	0.546	0.39
124_D	186_L	0.544	0.38
131_L	169_L	0.544	0.38
193_I	277_L	0.543	0.38
25_E	272_K	0.543	0.38
110_E	235_L	0.543	0.38
213_R	247_Y	0.542	0.38
67_G	228_Y	0.541	0.38
75_K	264_C	0.540	0.38
254_Y	267_L	0.539	0.38
57_N	80_G	0.534	0.37
132_N	136_V	0.533	0.37
123_Y	128_V	0.533	0.37
46_N	76_E	0.531	0.37
269_K	291_G	0.527	0.37
46_N	102_G	0.526	0.37
125_R	129_N	0.524	0.36
89_D	214_M	0.524	0.36
51_Y	60_I	0.524	0.36
187_Y	226_I	0.523	0.36
48_I	73_L	0.523	0.36
212_L	216_L	0.522	0.36
61_I	180_D	0.521	0.36
268_L	272_K	0.518	0.36
61_I	105_G	0.517	0.36
30_I	34_D	0.511	0.35
85_S	92_G	0.510	0.35
136_V	168_D	0.508	0.35
195_I	244_I	0.508	0.35
215_T	218_S	0.504	0.34
217_K	257_D	0.502	0.34
190_P	225_R	0.502	0.34
256_S	259_D	0.502	0.34
62_N	284_F	0.501	0.34
105_G	184_N	0.500	0.34
84_S	217_K	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3eeqA	2	0.9044	100	0.228	Contact Map
2w6kA	1	0.3788	100	0.7	Contact Map
3by5A	2	0.3345	99.9	0.723	Contact Map
3lmaA	2	0.4471	13.4	0.97	Contact Map
3a2kA	1	0.3857	11.8	0.971	Contact Map
2fz4A	1	0.314	10.7	0.971	Contact Map
2fz5A	1	0.3891	9.6	0.972	Contact Map
4xltA	3	0.3993	8.9	0.972	Contact Map
3thtA	3	0.314	8.3	0.973	Contact Map
2ecuA	2	0.4403	8.2	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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