GREMLIN Database
Q980Y2 - Primase (Carboxy-end)
UniProt: Q980Y2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 532 (412)
Sequences: 1157 (966)
Seq/√Len: 47.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
380_F408_M4.0581.00
327_W332_F3.9061.00
178_F343_V3.8921.00
62_S67_D3.6471.00
124_I133_L3.5481.00
134_V140_V3.5101.00
180_I195_F3.4111.00
125_P140_V3.3481.00
179_E350_R3.2831.00
121_F341_L3.2581.00
236_F277_K3.2121.00
62_S65_I3.0751.00
202_G310_H3.0301.00
159_C340_I2.8721.00
274_A284_F2.8641.00
192_R310_H2.8421.00
235_R275_D2.8321.00
120_A136_I2.7771.00
361_Q365_E2.7141.00
179_E354_H2.6991.00
181_I344_S2.6271.00
178_F347_A2.5841.00
167_K177_L2.5841.00
92_N96_E2.5411.00
343_V347_A2.4891.00
236_F275_D2.4841.00
156_R160_P2.4341.00
307_A310_H2.4101.00
406_Y426_F2.4011.00
179_E358_D2.3651.00
167_K174_W2.3581.00
342_T345_I2.3061.00
239_A282_I2.2551.00
156_R339_G2.2211.00
196_M294_S2.2131.00
409_Y421_T2.2041.00
181_I212_I2.2011.00
185_L344_S2.1981.00
182_G347_A2.1931.00
168_Q174_W2.1501.00
409_Y413_C2.1231.00
194_A263_L2.1191.00
338_E342_T2.0801.00
123_Y133_L2.0631.00
180_I291_V2.0611.00
125_P142_S2.0551.00
184_T291_V2.0501.00
192_R268_G2.0481.00
175_V350_R2.0411.00
48_Y138_E2.0240.99
427_V451_V1.9700.99
209_I293_A1.9380.99
181_I208_F1.9260.99
183_Y289_K1.9100.99
201_R310_H1.8980.99
276_V282_I1.8870.99
123_Y150_L1.8810.99
64_T145_D1.8410.99
127_K130_L1.8320.99
170_A362_T1.8320.99
159_C211_L1.8170.99
192_R202_G1.8050.99
127_K134_V1.7870.99
122_H149_D1.7680.99
309_W371_L1.7530.99
193_K313_L1.7500.98
157_R336_E1.7390.98
215_L337_L1.7370.98
386_K455_K1.7310.98
236_F278_F1.6860.98
173_K316_E1.6820.98
350_R354_H1.6570.98
91_P97_W1.6540.98
210_N330_K1.6510.98
222_V247_N1.6420.98
151_I338_E1.6280.98
399_Y450_A1.6250.98
427_V431_R1.6100.97
165_V325_T1.6040.97
177_L208_F1.6000.97
168_Q319_N1.5930.97
235_R278_F1.5910.97
395_N398_D1.5840.97
194_A267_T1.5770.97
229_L266_L1.5720.97
271_R283_T1.5680.97
196_M312_W1.5630.97
159_C343_V1.5540.97
383_E412_Y1.5540.97
151_I154_L1.5460.97
348_F352_L1.5350.97
159_C178_F1.5280.96
297_P314_I1.5160.96
186_F289_K1.5150.96
336_E339_G1.5150.96
202_G326_A1.5020.96
246_V291_V1.4990.96
61_I64_T1.4940.96
424_K428_R1.4910.96
271_R285_T1.4800.96
235_R277_K1.4780.96
178_F350_R1.4530.95
88_V96_E1.4520.95
361_Q364_E1.4410.95
376_Y409_Y1.4390.95
161_K165_V1.4350.95
157_R339_G1.4320.95
195_F315_I1.4300.95
253_K259_D1.4240.95
214_K337_L1.4160.95
187_P245_L1.4130.94
304_N307_A1.4120.94
322_E326_A1.3980.94
305_D320_Q1.3910.94
336_E340_I1.3870.94
158_L165_V1.3730.94
405_L426_F1.3730.94
439_V452_V1.3640.93
166_F321_F1.3610.93
191_F351_V1.3520.93
381_V385_L1.3450.93
119_F146_I1.3160.92
409_Y426_F1.3150.92
149_D338_E1.3070.92
197_I317_F1.3030.92
251_E258_D1.3030.92
126_H131_E1.3020.92
61_I136_I1.2850.91
300_I308_F1.2700.91
412_Y416_N1.2650.90
438_V449_R1.2650.90
136_I145_D1.2530.90
178_F340_I1.2460.90
184_T289_K1.2460.90
224_I247_N1.2430.90
247_N292_I1.2260.89
406_Y409_Y1.2250.89
159_C208_F1.2220.89
384_K408_M1.2170.89
275_D278_F1.2040.88
385_L405_L1.1990.88
234_N277_K1.1970.88
151_I342_T1.1920.88
206_S310_H1.1920.88
37_L85_P1.1880.87
148_I338_E1.1840.87
186_F189_I1.1780.87
192_R269_G1.1730.87
203_T321_F1.1690.86
347_A350_R1.1680.86
215_L344_S1.1660.86
300_I309_W1.1600.86
154_L339_G1.1520.86
120_A145_D1.1480.85
350_R358_D1.1480.85
160_P343_V1.1450.85
202_G206_S1.1450.85
214_K334_E1.1420.85
183_Y191_F1.1410.85
166_F317_F1.1390.85
313_L359_F1.1390.85
201_R307_A1.1370.85
241_L247_N1.1350.85
242_Y282_I1.1340.85
150_L154_L1.1340.85
91_P100_S1.1330.85
123_Y149_D1.1310.85
239_A276_V1.1230.84
413_C420_A1.1210.84
322_E325_T1.1200.84
158_L332_F1.1170.84
197_I315_I1.1140.84
206_S210_N1.1110.84
376_Y413_C1.1060.83
238_L274_A1.1020.83
216_L246_V1.1010.83
222_V244_K1.1010.83
360_E363_E1.0980.83
379_K412_Y1.0970.83
164_E174_W1.0960.83
159_C336_E1.0940.83
236_F280_D1.0940.83
175_V179_E1.0940.83
234_N275_D1.0890.82
439_V449_R1.0880.82
321_F326_A1.0850.82
194_A312_W1.0730.81
84_E98_K1.0730.81
173_K360_E1.0700.81
302_D308_F1.0650.81
120_A142_S1.0620.81
192_R307_A1.0600.81
329_D332_F1.0570.80
156_R336_E1.0520.80
117_E129_H1.0460.80
173_K315_I1.0450.80
406_Y410_L1.0390.79
211_L340_I1.0350.79
254_E296_K1.0330.79
96_E99_I1.0150.78
74_K78_L1.0110.77
339_G342_T1.0100.77
122_H147_P1.0080.77
408_M456_I1.0010.77
359_F364_E1.0010.77
240_E283_T0.9990.76
42_R46_E0.9970.76
249_V292_I0.9940.76
157_R340_I0.9940.76
238_L275_D0.9920.76
200_P203_T0.9880.76
162_S166_F0.9870.76
196_M297_P0.9860.75
346_L350_R0.9780.75
154_L342_T0.9740.75
397_D453_G0.9710.74
228_I237_V0.9700.74
61_I138_E0.9520.73
87_R90_F0.9520.73
127_K132_E0.9500.73
342_T346_L0.9490.73
238_L284_F0.9460.72
206_S270_D0.9460.72
121_F148_I0.9410.72
250_S270_D0.9380.72
240_E273_T0.9330.71
351_V357_F0.9310.71
409_Y420_A0.9300.71
405_L454_I0.9300.71
234_N278_F0.9290.71
34_E37_L0.9290.71
186_F348_F0.9220.70
150_L345_I0.9170.70
260_M302_D0.9160.70
442_N447_R0.9150.70
189_I288_A0.9130.70
200_P432_D0.9060.69
133_L150_L0.9060.69
186_F351_V0.9040.69
320_Q326_A0.8930.68
127_K131_E0.8920.68
66_I137_N0.8880.68
441_K447_R0.8870.67
372_S382_K0.8860.67
236_F281_P0.8770.67
229_L290_L0.8720.66
242_Y284_F0.8700.66
273_T283_T0.8660.66
150_L342_T0.8660.66
263_L267_T0.8630.65
194_A292_I0.8550.65
206_S264_K0.8520.64
131_E349_S0.8510.64
167_K173_K0.8500.64
197_I293_A0.8450.64
380_F400_V0.8360.63
340_I343_V0.8360.63
429_R432_D0.8340.63
395_N455_K0.8340.63
192_R336_E0.8320.62
176_T313_L0.8320.62
440_M447_R0.8310.62
410_L417_G0.8310.62
247_N290_L0.8300.62
252_T294_S0.8270.62
172_E361_Q0.8260.62
332_F335_D0.8230.62
184_T246_V0.8220.61
252_T292_I0.8210.61
240_E281_P0.8210.61
120_A144_R0.8190.61
118_H125_P0.8170.61
126_H185_L0.8170.61
93_C98_K0.8170.61
118_H127_K0.8160.61
163_L174_W0.8150.61
424_K427_V0.8110.60
399_Y447_R0.8110.60
440_M449_R0.8090.60
274_A286_P0.8080.60
176_T363_E0.8070.60
316_E370_W0.8040.60
318_P362_T0.8040.60
431_R438_V0.8020.60
115_T129_H0.8010.59
65_I145_D0.8010.59
85_P94_T0.8000.59
88_V93_C0.8000.59
349_S353_L0.7990.59
276_V280_D0.7980.59
120_A125_P0.7930.59
173_K363_E0.7930.59
122_H145_D0.7900.58
253_K261_D0.7870.58
405_L453_G0.7860.58
202_G321_F0.7850.58
155_A160_P0.7840.58
273_T281_P0.7830.58
425_G429_R0.7820.58
178_F346_L0.7780.57
209_I246_V0.7760.57
118_H134_V0.7750.57
197_I208_F0.7720.57
323_D326_A0.7710.57
165_V321_F0.7690.56
373_T428_R0.7690.56
341_L345_I0.7680.56
75_D79_I0.7680.56
250_S268_G0.7670.56
449_R452_V0.7660.56
327_W333_T0.7650.56
385_L454_I0.7640.56
403_K423_Y0.7640.56
166_F203_T0.7630.56
164_E171_N0.7600.55
241_L284_F0.7580.55
320_Q323_D0.7560.55
162_S208_F0.7560.55
95_L98_K0.7510.55
118_H140_V0.7500.54
148_I341_L0.7480.54
348_F351_V0.7480.54
164_E169_W0.7480.54
85_P98_K0.7460.54
343_V346_L0.7440.54
78_L94_T0.7440.54
183_Y357_F0.7430.54
227_H251_E0.7420.54
143_A370_W0.7420.54
182_G344_S0.7400.53
180_I315_I0.7400.53
375_D429_R0.7390.53
205_K311_R0.7380.53
82_P98_K0.7370.53
176_T360_E0.7360.53
94_T98_K0.7340.53
395_N453_G0.7320.53
66_I125_P0.7320.53
408_M412_Y0.7310.53
179_E359_F0.7270.52
122_H146_I0.7240.52
192_R201_R0.7230.52
97_W100_S0.7230.52
235_R281_P0.7220.52
272_I284_F0.7220.52
363_E367_R0.7190.51
123_Y152_E0.7180.51
386_K457_N0.7170.51
107_S112_E0.7150.51
377_V421_T0.7120.51
402_V427_V0.7120.51
90_F93_C0.7110.51
318_P456_I0.7090.50
66_I141_L0.7080.50
93_C119_F0.7050.50
61_I142_S0.7040.50
402_V438_V0.7040.50
84_E87_R0.7020.50
210_N271_R0.7020.50
333_T340_I0.7010.50
30_F43_A0.6990.49
435_N440_M0.6980.49
375_D378_Y0.6980.49
195_F291_V0.6950.49
239_A275_D0.6940.49
95_L99_I0.6910.49
376_Y421_T0.6900.48
266_L286_P0.6890.48
203_T363_E0.6890.48
250_S293_A0.6880.48
30_F33_F0.6870.48
275_D279_K0.6830.48
260_M275_D0.6830.48
345_I348_F0.6810.48
387_H395_N0.6800.47
131_E348_F0.6790.47
380_F384_K0.6780.47
118_H142_S0.6750.47
187_P247_N0.6740.47
227_H261_D0.6740.47
437_T452_V0.6730.47
201_R217_G0.6710.47
159_C347_A0.6710.47
334_E337_L0.6680.46
34_E94_T0.6670.46
226_L252_T0.6660.46
399_Y455_K0.6660.46
354_H358_D0.6660.46
264_K295_N0.6660.46
178_F182_G0.6640.46
147_P214_K0.6610.46
248_A270_D0.6600.46
430_L436_L0.6580.45
225_P265_V0.6580.45
365_E368_G0.6570.45
185_L348_F0.6570.45
188_K289_K0.6540.45
398_D455_K0.6530.45
119_F348_F0.6510.45
334_E340_I0.6510.45
209_I248_A0.6480.44
171_N175_V0.6470.44
189_I286_P0.6460.44
75_D95_L0.6460.44
152_E345_I0.6450.44
206_S209_I0.6430.44
379_K416_N0.6430.44
88_V92_N0.6430.44
126_H348_F0.6400.44
286_P292_I0.6390.43
404_E407_R0.6390.43
310_H320_Q0.6370.43
277_K280_D0.6360.43
148_I344_S0.6360.43
229_L258_D0.6340.43
375_D433_Y0.6330.43
397_D441_K0.6300.43
430_L437_T0.6270.42
238_L272_I0.6260.42
201_R309_W0.6260.42
53_N72_E0.6240.42
166_F319_N0.6230.42
187_P360_E0.6230.42
117_E127_K0.6230.42
76_K169_W0.6230.42
312_W370_W0.6220.42
206_S269_G0.6220.42
172_E362_T0.6210.42
34_E93_C0.6190.41
66_I258_D0.6190.41
206_S304_N0.6180.41
135_K263_L0.6170.41
400_V404_E0.6170.41
288_A292_I0.6150.41
162_S336_E0.6150.41
209_I291_V0.6130.41
57_K68_N0.6110.41
144_R377_V0.6110.41
66_I140_V0.6070.40
205_K295_N0.6050.40
123_Y136_I0.6040.40
117_E352_L0.6040.40
182_G186_F0.6020.40
294_S298_P0.6010.40
421_T429_R0.5990.40
229_L237_V0.5970.39
380_F405_L0.5950.39
165_V319_N0.5900.39
449_R456_I0.5900.39
345_I349_S0.5890.39
381_V435_N0.5890.39
300_I305_D0.5880.39
119_F126_H0.5880.39
156_R343_V0.5870.38
399_Y452_V0.5870.38
176_T180_I0.5870.38
274_A282_I0.5870.38
82_P95_L0.5860.38
119_F128_I0.5830.38
52_A55_E0.5830.38
387_H454_I0.5830.38
89_A92_N0.5820.38
423_Y427_V0.5820.38
89_A93_C0.5820.38
162_S207_T0.5820.38
180_I313_L0.5800.38
268_G271_R0.5800.38
77_T81_L0.5790.38
381_V436_L0.5780.38
226_L277_K0.5770.37
162_S333_T0.5770.37
261_D279_K0.5770.37
214_K397_D0.5760.37
236_F276_V0.5760.37
411_E414_S0.5760.37
419_N422_T0.5750.37
37_L40_K0.5750.37
137_N140_V0.5740.37
145_D383_E0.5740.37
378_Y433_Y0.5720.37
407_R411_E0.5720.37
134_V137_N0.5720.37
316_E366_V0.5710.37
310_H321_F0.5710.37
52_A107_S0.5690.37
258_D290_L0.5670.37
93_C97_W0.5660.36
260_M307_A0.5650.36
180_I289_K0.5650.36
175_V354_H0.5640.36
192_R239_A0.5630.36
81_L377_V0.5620.36
237_V281_P0.5610.36
438_V441_K0.5600.36
202_G320_Q0.5600.36
165_V269_G0.5600.36
184_T209_I0.5600.36
321_F325_T0.5600.36
386_K399_Y0.5590.36
156_R340_I0.5590.36
197_I291_V0.5590.36
338_E345_I0.5590.36
181_I218_R0.5590.36
176_T179_E0.5590.36
61_I65_I0.5580.36
121_F345_I0.5570.36
192_R326_A0.5570.36
170_A173_K0.5570.36
168_Q173_K0.5560.36
251_E294_S0.5560.36
403_K420_A0.5550.35
369_I373_T0.5550.35
264_K302_D0.5550.35
71_D272_I0.5550.35
301_R314_I0.5550.35
407_R415_T0.5540.35
401_R404_E0.5540.35
442_N458_T0.5520.35
157_R161_K0.5520.35
39_K92_N0.5520.35
129_H364_E0.5510.35
267_T270_D0.5510.35
31_E36_R0.5510.35
260_M304_N0.5500.35
158_L336_E0.5500.35
229_L289_K0.5500.35
76_K79_I0.5490.35
183_Y290_L0.5490.35
327_W330_K0.5480.35
48_Y382_K0.5470.35
150_L431_R0.5450.35
192_R267_T0.5440.34
185_L287_Y0.5430.34
121_F149_D0.5420.34
84_E100_S0.5420.34
223_N247_N0.5420.34
82_P101_H0.5410.34
254_E294_S0.5400.34
195_F313_L0.5400.34
314_I367_R0.5390.34
276_V279_K0.5380.34
66_I142_S0.5380.34
341_L360_E0.5380.34
297_P369_I0.5370.34
82_P86_L0.5370.34
229_L292_I0.5360.34
213_K271_R0.5360.34
120_A219_G0.5350.34
112_E141_L0.5350.34
113_E245_L0.5350.34
112_E206_S0.5350.34
173_K362_T0.5330.33
159_C412_Y0.5330.33
247_N286_P0.5330.33
121_F133_L0.5320.33
179_E347_A0.5310.33
121_F126_H0.5310.33
136_I142_S0.5280.33
363_E370_W0.5280.33
159_C163_L0.5280.33
149_D337_L0.5280.33
285_T353_L0.5280.33
121_F124_I0.5260.33
203_T316_E0.5260.33
146_I184_T0.5250.33
122_H150_L0.5240.33
268_G288_A0.5230.33
180_I184_T0.5220.32
175_V272_I0.5210.32
242_Y274_A0.5210.32
275_D282_I0.5200.32
197_I409_Y0.5200.32
385_L453_G0.5200.32
111_A141_L0.5200.32
447_R450_A0.5200.32
304_N308_F0.5190.32
37_L94_T0.5180.32
247_N288_A0.5180.32
123_Y151_I0.5180.32
422_T431_R0.5170.32
45_L253_K0.5170.32
209_I284_F0.5160.32
130_L345_I0.5160.32
126_H133_L0.5150.32
204_G311_R0.5140.32
107_S383_E0.5140.32
162_S183_Y0.5130.32
277_K288_A0.5110.32
165_V346_L0.5100.31
341_L347_A0.5100.31
348_F380_F0.5100.31
107_S397_D0.5090.31
224_I234_N0.5090.31
263_L376_Y0.5090.31
274_A370_W0.5090.31
300_I312_W0.5090.31
310_H375_D0.5090.31
158_L321_F0.5090.31
213_K223_N0.5090.31
379_K383_E0.5090.31
123_Y342_T0.5070.31
72_E79_I0.5070.31
424_K456_I0.5070.31
316_E417_G0.5060.31
74_K79_I0.5060.31
65_I218_R0.5060.31
251_E293_A0.5060.31
302_D374_I0.5050.31
185_L341_L0.5030.31
333_T385_L0.5020.31
298_P370_W0.5010.31
225_P273_T0.5010.31
250_S265_V0.5010.31
179_E344_S0.5010.31
298_P312_W0.5010.31
163_L173_K0.5010.31
217_G342_T0.5010.31
128_I345_I0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u0jA 1 0.4643 99.4 0.873 Contact Map
1tueA 1 0.3571 98.8 0.902 Contact Map
1dp7P 1 0.141 98.4 0.915 Contact Map
2qbyA 1 0.5395 98.3 0.918 Contact Map
4qhsA 3 0.4041 98.2 0.919 Contact Map
2v1uA 1 0.5677 98.2 0.92 Contact Map
1um8A 1 0.4586 98.1 0.922 Contact Map
4qosA 1 0.4135 98.1 0.922 Contact Map
3hwsA 3 0.4756 97.9 0.926 Contact Map
2p65A 1 0.2857 97.7 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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