GREMLIN Database
Q980X8 - Arsenite transport protein (ArsB)
UniProt: Q980X8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 411 (389)
Sequences: 5048 (3342)
Seq/√Len: 169.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_K86_K4.1331.00
89_E92_K4.0531.00
121_I139_L3.8271.00
362_I372_S3.7711.00
227_L231_V3.6271.00
387_E390_K3.2071.00
47_E292_K3.1801.00
114_S143_V3.0601.00
220_R224_Y3.0301.00
66_F233_T2.9901.00
44_S47_E2.9601.00
224_Y228_T2.9511.00
61_I277_I2.8251.00
349_A353_G2.7541.00
297_Q301_N2.7441.00
101_S117_W2.6471.00
114_S371_I2.6421.00
146_G185_L2.5901.00
72_V267_D2.4991.00
78_F82_K2.4861.00
159_L333_I2.3791.00
389_M393_I2.3671.00
212_E215_K2.3261.00
7_I11_I2.2981.00
136_L371_I2.2381.00
219_D223_G2.2101.00
321_Q360_F2.2011.00
190_F194_R2.1961.00
392_T396_L2.1911.00
221_R225_L2.1861.00
167_K172_T2.1591.00
314_I404_Y2.1591.00
317_I400_A2.1361.00
87_F96_Y2.1241.00
229_L233_T2.1161.00
183_I406_F2.0781.00
172_T175_I1.9991.00
171_I175_I1.9951.00
151_P161_A1.9491.00
226_T229_L1.9361.00
222_L226_T1.9311.00
147_S154_N1.9151.00
118_T136_L1.8401.00
393_I396_L1.8351.00
318_L322_V1.8191.00
231_V235_I1.8181.00
258_L262_T1.7991.00
219_D222_L1.7861.00
226_T230_L1.7831.00
223_G226_T1.7771.00
232_V236_L1.7561.00
70_L75_F1.7341.00
13_Y16_I1.7271.00
343_T346_D1.7231.00
222_L225_L1.7211.00
27_W30_M1.7211.00
401_I405_L1.7161.00
5_A9_M1.6931.00
279_F282_G1.6921.00
109_T112_G1.6901.00
225_L261_L1.6841.00
14_C18_S1.6691.00
72_V271_R1.6471.00
45_P49_L1.6311.00
99_L185_L1.6281.00
365_A368_N1.6161.00
175_I179_L1.6161.00
13_Y19_R1.6141.00
396_L400_A1.5991.00
225_L229_L1.5891.00
91_R193_F1.5891.00
315_V319_L1.5831.00
298_Y301_N1.5821.00
46_E49_L1.5431.00
310_A404_Y1.5391.00
13_Y17_I1.5381.00
247_I250_G1.5331.00
213_E216_V1.5231.00
190_F193_F1.5191.00
187_I402_I1.5051.00
362_I369_V1.4951.00
61_I65_T1.4901.00
184_S399_N1.4851.00
140_A371_I1.4851.00
137_Y141_V1.4811.00
178_T182_I1.4741.00
196_F391_Y1.4731.00
298_Y302_F1.4701.00
131_S199_S1.4591.00
15_L29_S1.4581.00
220_R223_G1.4561.00
8_V36_L1.4531.00
9_M12_T1.4501.00
233_T237_F1.4451.00
314_I318_L1.4381.00
229_L254_T1.4361.00
125_S135_F1.4251.00
62_T251_S1.4101.00
239_S243_F1.4081.00
349_A407_L1.4041.00
148_V181_S1.4031.00
71_E271_R1.4021.00
267_D270_R1.4021.00
13_Y20_S1.4011.00
170_F174_T1.3651.00
133_V387_E1.3611.00
191_I398_P1.3561.00
126_R379_G1.3521.00
393_I397_I1.3481.00
35_I39_I1.3481.00
6_L295_I1.3351.00
388_F392_T1.3321.00
97_I121_I1.3301.00
99_L103_L1.3261.00
98_L138_A1.3201.00
85_E213_E1.3191.00
95_F193_F1.3141.00
45_P48_A1.3121.00
28_A32_F1.3051.00
213_E217_D1.2811.00
248_L251_S1.2811.00
65_T269_V1.2801.00
194_R198_K1.2681.00
82_K85_E1.2661.00
246_D258_L1.2601.00
12_T19_R1.2571.00
156_Q355_T1.2491.00
214_E220_R1.2471.00
103_L107_L1.2301.00
155_P284_F1.2291.00
62_T255_S1.2111.00
384_N387_E1.2101.00
386_V390_K1.2041.00
194_R197_R1.2011.00
15_L18_S1.1981.00
100_Y104_L1.1881.00
223_G229_L1.1801.00
382_G386_V1.1791.00
15_L19_R1.1771.00
254_T258_L1.1761.00
251_S258_L1.1741.00
29_S32_F1.1741.00
263_E266_R1.1711.00
150_M153_G1.1691.00
302_F305_P1.1681.00
248_L258_L1.1671.00
342_I345_V1.1671.00
329_V354_S1.1621.00
56_V64_F1.1571.00
201_S204_S1.1521.00
95_F189_Y1.1481.00
148_V177_L1.1471.00
231_V234_I1.1471.00
351_A354_S1.1471.00
354_S357_A1.1461.00
6_L10_V1.1451.00
316_S350_L1.1441.00
149_I181_S1.1381.00
280_F358_G1.1321.00
164_S347_W1.1311.00
397_I401_I1.1291.00
224_Y227_L1.1261.00
228_T235_I1.1181.00
225_L228_T1.1171.00
47_E50_Q1.1151.00
180_P184_S1.1141.00
12_T29_S1.1091.00
153_G358_G1.1061.00
189_Y193_F1.1031.00
321_Q324_S1.1001.00
316_S354_S1.0931.00
288_D292_K1.0911.00
317_I396_L1.0881.00
251_S254_T1.0851.00
257_I262_T1.0811.00
173_F177_L1.0801.00
360_F396_L1.0791.00
42_I48_A1.0761.00
266_R270_R1.0751.00
17_I20_S1.0691.00
19_R26_P1.0671.00
10_V14_C1.0560.99
246_D249_L1.0470.99
12_T286_F1.0440.99
33_G38_V1.0430.99
134_P192_L1.0410.99
174_T178_T1.0410.99
152_T170_F1.0380.99
141_V395_I1.0310.99
252_L256_S1.0280.99
316_S332_Y1.0280.99
247_I251_S1.0270.99
11_I18_S1.0250.99
111_D154_N1.0220.99
36_L39_I1.0210.99
25_P29_S1.0210.99
368_N371_I1.0210.99
364_G369_V1.0200.99
248_L255_S1.0140.99
111_D147_S1.0130.99
394_P397_I1.0100.99
384_N390_K1.0070.99
16_I19_R0.9990.99
38_V43_I0.9970.99
12_T20_S0.9920.99
68_S71_E0.9900.99
30_M33_G0.9900.99
38_V42_I0.9870.99
51_S288_D0.9860.99
291_L297_Q0.9820.99
247_I255_S0.9820.99
221_R224_Y0.9800.99
35_I256_S0.9770.99
52_I281_I0.9700.99
180_P352_A0.9690.99
229_L237_F0.9680.99
223_G227_L0.9680.99
48_A52_I0.9670.99
118_T371_I0.9650.99
110_N144_T0.9640.99
25_P28_A0.9560.99
228_T232_V0.9500.99
228_T231_V0.9440.99
11_I15_L0.9440.99
353_G357_A0.9420.99
234_I238_F0.9410.99
233_T254_T0.9390.99
66_F258_L0.9360.99
34_G285_I0.9330.99
7_I179_L0.9320.99
36_L40_L0.9270.99
63_L112_G0.9270.99
26_P29_S0.9230.99
358_G368_N0.9210.99
179_L406_F0.9200.99
136_L375_S0.9190.99
101_S139_L0.9170.99
328_L332_Y0.9160.99
81_Y85_E0.9140.99
245_I252_L0.9130.98
303_L311_S0.9110.98
38_V41_G0.9100.98
364_G368_N0.9070.98
57_I277_I0.9050.98
133_V137_Y0.9020.98
193_F197_R0.8900.98
12_T33_G0.8820.98
352_A356_I0.8750.98
247_I262_T0.8730.98
313_M404_Y0.8730.98
230_L234_I0.8710.98
217_D220_R0.8700.98
16_I20_S0.8690.98
109_T147_S0.8680.98
376_E382_G0.8660.98
38_V48_A0.8650.98
320_S325_N0.8650.98
48_A51_S0.8640.98
316_S353_G0.8630.98
35_I38_V0.8590.98
328_L331_I0.8560.98
12_T16_I0.8550.98
137_Y391_Y0.8550.98
15_L20_S0.8510.98
374_A379_G0.8510.98
392_T403_I0.8510.98
229_L232_V0.8500.98
9_M290_V0.8490.98
248_L262_T0.8460.98
100_Y143_V0.8370.97
51_S54_L0.8350.97
367_S371_I0.8290.97
60_L146_G0.8280.97
47_E51_S0.8260.97
142_G185_L0.8250.97
226_T237_F0.8240.97
291_L296_I0.8220.97
156_Q326_V0.8210.97
32_F37_M0.8210.97
211_E215_K0.8190.97
37_M41_G0.8180.97
301_N305_P0.8150.97
172_T176_Y0.8110.97
31_F37_M0.8110.97
237_F240_L0.8100.97
215_K301_N0.8100.97
142_G146_G0.8090.97
155_P358_G0.8060.97
320_S354_S0.8050.97
256_S260_L0.8010.97
385_F392_T0.7970.96
146_G153_G0.7940.96
289_G293_S0.7890.96
137_Y392_T0.7870.96
29_S37_M0.7860.96
389_M396_L0.7860.96
177_L180_P0.7850.96
29_S33_G0.7830.96
44_S48_A0.7820.96
121_I125_S0.7800.96
9_M13_Y0.7770.96
50_Q54_L0.7760.96
8_V40_L0.7750.96
279_F283_L0.7730.96
98_L142_G0.7680.96
229_L234_I0.7670.96
279_F284_F0.7670.96
100_Y117_W0.7660.96
191_I195_L0.7650.96
390_K393_I0.7630.95
289_G292_K0.7600.95
392_T395_I0.7560.95
8_V33_G0.7560.95
7_I14_C0.7550.95
26_P324_S0.7550.95
324_S358_G0.7550.95
60_L64_F0.7540.95
255_S258_L0.7540.95
329_V333_I0.7530.95
122_L381_K0.7500.95
37_M289_G0.7480.95
171_I174_T0.7440.95
390_K394_P0.7430.95
217_D221_R0.7400.95
218_F222_L0.7390.95
257_I261_L0.7370.95
9_M16_I0.7360.94
290_V299_L0.7350.94
359_N362_I0.7350.94
108_V136_L0.7350.94
32_F36_L0.7340.94
319_L322_V0.7330.94
43_I47_E0.7330.94
104_L113_V0.7330.94
276_T373_E0.7290.94
300_S304_P0.7280.94
174_T181_S0.7280.94
319_L328_L0.7270.94
154_N157_N0.7270.94
174_T177_L0.7260.94
385_F396_L0.7250.94
12_T17_I0.7240.94
77_K81_Y0.7240.94
281_I284_F0.7230.94
219_D226_T0.7230.94
42_I45_P0.7210.94
29_S39_I0.7180.94
326_V329_V0.7170.94
142_G153_G0.7170.94
293_S300_S0.7170.94
396_L399_N0.7160.94
342_I346_D0.7160.94
357_A360_F0.7130.94
31_F39_I0.7060.93
235_I239_S0.7050.93
145_I148_V0.7050.93
11_I16_I0.7040.93
232_V235_I0.7020.93
59_F151_P0.7010.93
8_V12_T0.7010.93
218_F301_N0.7000.93
366_A370_I0.6990.93
387_E391_Y0.6980.93
255_S259_L0.6960.93
148_V356_I0.6930.93
219_D237_F0.6920.92
71_E123_E0.6910.92
226_T233_T0.6900.92
359_N368_N0.6890.92
156_Q321_Q0.6870.92
11_I20_S0.6850.92
187_I191_I0.6840.92
247_I252_L0.6840.92
14_C20_S0.6830.92
366_A369_V0.6800.92
141_V188_A0.6800.92
144_T367_S0.6780.92
153_G156_Q0.6770.92
371_I375_S0.6760.92
325_N358_G0.6740.91
45_P51_S0.6740.91
61_I274_W0.6730.91
141_V145_I0.6730.91
150_M155_P0.6710.91
30_M37_M0.6710.91
94_L192_L0.6700.91
51_S291_L0.6690.91
183_I402_I0.6660.91
109_T324_S0.6660.91
110_N367_S0.6660.91
216_V219_D0.6660.91
177_L351_A0.6650.91
246_D262_T0.6650.91
27_W31_F0.6650.91
404_Y408_V0.6650.91
57_I281_I0.6630.91
233_T236_L0.6630.91
280_F326_V0.6620.91
313_M353_G0.6620.91
247_I254_T0.6600.91
34_G282_G0.6600.91
110_N154_N0.6550.90
351_A368_N0.6540.90
68_S268_I0.6520.90
355_T358_G0.6520.90
323_L328_L0.6520.90
30_M34_G0.6510.90
326_V366_A0.6510.90
98_L192_L0.6510.90
8_V17_I0.6500.90
259_L262_T0.6480.90
131_S381_K0.6480.90
264_K267_D0.6470.90
83_I96_Y0.6470.90
389_M392_T0.6470.90
278_L282_G0.6460.90
159_L326_V0.6450.90
40_L43_I0.6440.90
265_R268_I0.6440.90
181_S185_L0.6420.89
11_I17_I0.6420.89
110_N155_P0.6400.89
389_M395_I0.6390.89
28_A38_V0.6390.89
81_Y127_M0.6370.89
65_T255_S0.6350.89
255_S262_T0.6340.89
25_P308_S0.6340.89
108_V113_V0.6330.89
55_D162_L0.6330.89
364_G367_S0.6320.89
170_F173_F0.6320.89
257_I260_L0.6300.89
88_K92_K0.6290.88
386_V389_M0.6280.88
320_S324_S0.6270.88
294_G297_Q0.6260.88
90_P134_P0.6260.88
111_D157_N0.6250.88
155_P160_I0.6240.88
236_L240_L0.6230.88
234_I237_F0.6230.88
110_N325_N0.6230.88
144_T154_N0.6170.87
182_I186_I0.6170.87
112_G279_F0.6170.87
267_D271_R0.6170.87
37_M42_I0.6120.87
365_A369_V0.6110.87
30_M39_I0.6100.87
61_I272_M0.6090.87
30_M35_I0.6060.87
211_E214_E0.6050.86
11_I19_R0.6040.86
250_G258_L0.6030.86
105_S326_V0.6030.86
31_F43_I0.6020.86
140_A144_T0.6000.86
156_Q324_S0.5990.86
34_G37_M0.5950.86
125_S132_E0.5940.85
27_W38_V0.5940.85
34_G48_A0.5920.85
120_V159_L0.5900.85
105_S110_N0.5900.85
214_E217_D0.5900.85
96_Y100_Y0.5900.85
111_D119_P0.5890.85
215_K401_I0.5890.85
7_I214_E0.5890.85
225_L237_F0.5880.85
77_K127_M0.5850.85
372_S376_E0.5850.85
309_V349_A0.5840.84
153_G326_V0.5830.84
70_L226_T0.5820.84
250_G262_T0.5820.84
155_P359_N0.5820.84
235_I238_F0.5800.84
280_F289_G0.5800.84
7_I190_F0.5790.84
147_S331_I0.5790.84
64_F67_A0.5760.84
400_A403_I0.5720.83
355_T368_N0.5720.83
363_L366_A0.5710.83
405_L408_V0.5710.83
33_G48_A0.5700.83
229_L236_L0.5690.83
369_V372_S0.5680.83
7_I15_L0.5680.83
196_F199_S0.5670.83
46_E50_Q0.5670.83
94_L135_F0.5660.83
290_V293_S0.5660.83
361_T364_G0.5660.83
154_N327_P0.5660.83
245_I259_L0.5650.83
110_N327_P0.5630.82
140_A364_G0.5620.82
362_I385_F0.5620.82
201_S205_G0.5610.82
112_G359_N0.5600.82
197_R200_L0.5600.82
148_V355_T0.5600.82
5_A16_I0.5590.82
332_Y350_L0.5580.82
238_F242_F0.5580.82
394_P398_P0.5560.82
140_A143_V0.5550.81
177_L181_S0.5540.81
147_S156_Q0.5530.81
118_T374_A0.5530.81
151_P158_L0.5520.81
217_D222_L0.5520.81
226_T231_V0.5520.81
347_W354_S0.5500.81
360_F364_G0.5490.81
13_Y26_P0.5490.81
78_F81_Y0.5470.80
32_F256_S0.5470.80
325_N364_G0.5470.80
266_R269_V0.5460.80
326_V368_N0.5460.80
290_V300_S0.5450.80
359_N396_L0.5450.80
43_I49_L0.5440.80
114_S360_F0.5440.80
33_G37_M0.5430.80
56_V63_L0.5430.80
333_I347_W0.5410.80
63_L109_T0.5380.79
117_W184_S0.5380.79
330_A366_A0.5370.79
153_G368_N0.5350.79
136_L139_L0.5350.79
30_M38_V0.5340.79
126_R214_E0.5340.79
25_P31_F0.5320.79
350_L357_A0.5310.78
32_F35_I0.5300.78
8_V37_M0.5280.78
56_V328_L0.5270.78
290_V296_I0.5260.78
252_L255_S0.5260.78
303_L315_V0.5260.78
214_E301_N0.5250.78
295_I300_S0.5240.78
224_Y237_F0.5240.78
45_P249_L0.5230.77
280_F284_F0.5220.77
59_F143_V0.5210.77
368_N372_S0.5210.77
114_S140_A0.5210.77
264_K342_I0.5210.77
297_Q338_S0.5200.77
8_V289_G0.5190.77
309_V407_L0.5190.77
67_A140_A0.5190.77
143_V367_S0.5170.77
74_G77_K0.5160.77
222_L229_L0.5150.76
286_F289_G0.5140.76
102_G185_L0.5140.76
355_T365_A0.5130.76
211_E216_V0.5130.76
246_D254_T0.5130.76
216_V238_F0.5110.76
146_G280_F0.5110.76
227_L230_L0.5110.76
217_D223_G0.5100.76
216_V402_I0.5100.76
276_T370_I0.5100.76
122_L380_G0.5080.75
147_S324_S0.5080.75
354_S358_G0.5070.75
180_P183_I0.5040.75
105_S113_V0.5030.75
111_D366_A0.5030.75
246_D256_S0.5020.75
26_P38_V0.5020.75
352_A403_I0.5010.74
159_L330_A0.5010.74
80_A124_L0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.9343 100 0.434 Contact Map
4r1iA 2 0.9781 99.9 0.686 Contact Map
4r0cA 3 0.9611 99.9 0.719 Contact Map
4dx5A 3 0.4039 21.8 0.96 Contact Map
4pd6A 3 0.7956 15 0.963 Contact Map
3qe7A 2 0.4647 14.1 0.964 Contact Map
2cfqA 1 0.854 13.9 0.964 Contact Map
3w9iA 3 0.3844 11.8 0.965 Contact Map
4k0jA 3 0.3625 10.6 0.966 Contact Map
1j4nA 4 0.4501 9.6 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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