GREMLIN Database
Q980X6 - Uncharacterized protein
UniProt: Q980X6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (232)
Sequences: 21926 (16503)
Seq/√Len: 1083.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_G233_A3.2661.00
10_K109_D2.8031.00
194_D200_N2.5951.00
47_K67_E2.5441.00
112_L132_A2.5301.00
201_V245_A2.4841.00
234_L239_L2.3671.00
10_K45_I2.2511.00
199_F227_L2.2181.00
240_E243_E2.1151.00
23_Q26_I2.0811.00
209_Y242_I2.0471.00
169_R194_D2.0451.00
183_F202_Y2.0251.00
234_L247_I2.0011.00
13_I36_S1.9361.00
132_A232_F1.8921.00
39_V44_G1.8671.00
166_H228_L1.8481.00
130_P163_M1.8221.00
200_N210_T1.8141.00
226_F251_L1.7831.00
201_V209_Y1.7791.00
12_L108_V1.7661.00
110_G130_P1.7581.00
176_K208_K1.7371.00
38_G229_G1.7361.00
11_I39_V1.7241.00
239_L243_E1.7211.00
179_L202_Y1.6931.00
199_F249_G1.6871.00
164_V189_E1.6821.00
252_T256_S1.6651.00
118_K121_D1.6511.00
62_F65_D1.6131.00
214_S250_K1.6001.00
194_D210_T1.5861.00
163_M188_K1.5731.00
110_G132_A1.5691.00
189_E203_T1.5691.00
230_A251_L1.5661.00
54_R74_E1.5641.00
191_I231_Y1.5451.00
231_Y244_A1.5421.00
242_I246_T1.5311.00
64_S68_K1.5221.00
201_V241_I1.5181.00
17_F50_G1.5111.00
194_D197_N1.5081.00
181_D184_K1.5071.00
61_D65_D1.5051.00
223_T256_S1.4971.00
39_V233_A1.4881.00
10_K47_K1.4751.00
211_Y245_A1.4651.00
230_A247_I1.4591.00
130_P164_V1.4191.00
176_K180_S1.4011.00
214_S246_T1.3911.00
211_Y249_G1.3891.00
181_D185_V1.3771.00
203_T206_L1.3701.00
110_G232_F1.3681.00
59_E72_Y1.3631.00
54_R59_E1.3561.00
77_I82_D1.3481.00
61_D64_S1.3481.00
233_A237_G1.3361.00
134_D193_S1.2881.00
189_E241_I1.2781.00
189_E235_R1.2601.00
37_L41_R1.2571.00
94_K97_K1.2511.00
45_I67_E1.2501.00
78_R82_D1.2471.00
202_Y208_K1.2431.00
78_R83_L1.2411.00
54_R72_Y1.2351.00
87_G90_L1.2311.00
122_N126_Q1.2281.00
135_I167_G1.2261.00
194_D198_G1.2231.00
69_Q72_Y1.2151.00
89_K92_L1.2121.00
216_I257_N1.2071.00
199_F245_A1.2071.00
162_Y165_M1.2031.00
28_P62_F1.2001.00
189_E231_Y1.1841.00
76_T80_K1.1831.00
183_F204_N1.1821.00
180_S184_K1.1801.00
214_S253_E1.1781.00
106_N127_S1.1751.00
156_F185_V1.1741.00
44_G237_G1.1741.00
254_E257_N1.1601.00
180_S202_Y1.1411.00
230_A248_A1.1361.00
123_M126_Q1.1351.00
166_H193_S1.1331.00
231_Y235_R1.1291.00
77_I81_I1.1261.00
80_K83_L1.1231.00
21_E57_D1.1171.00
234_L244_A1.1151.00
243_E246_T1.1101.00
17_F48_L1.1051.00
56_F59_E1.1051.00
121_D125_I1.1031.00
234_L237_G1.0951.00
164_V235_R1.0921.00
189_E201_V1.0881.00
180_S208_K1.0871.00
130_P188_K1.0851.00
69_Q73_D1.0771.00
214_S249_G1.0751.00
104_S108_V1.0711.00
36_S46_P1.0691.00
164_V231_Y1.0681.00
19_I60_I1.0611.00
172_L192_V1.0611.00
44_G236_L1.0591.00
193_S227_L1.0581.00
39_V46_P1.0561.00
35_S112_L1.0501.00
79_F83_L1.0441.00
231_Y248_A1.0391.00
88_R92_L1.0391.00
216_I256_S1.0351.00
177_L181_D1.0291.00
231_Y241_I1.0221.00
103_I106_N1.0211.00
51_L73_D1.0131.00
57_D60_I1.0071.00
38_G226_F1.0051.00
226_F255_F1.0041.00
69_Q75_Y1.0031.00
77_I80_K1.0011.00
76_T81_I1.0001.00
42_G230_A0.9951.00
72_Y75_Y0.9941.00
40_M66_L0.9921.00
79_F82_D0.9921.00
177_L180_S0.9801.00
246_T250_K0.9801.00
42_G251_L0.9781.00
111_I129_I0.9741.00
33_I63_I0.9721.00
133_V162_Y0.9711.00
69_Q74_E0.9651.00
244_A248_A0.9651.00
169_R197_N0.9641.00
112_L232_F0.9631.00
213_P249_G0.9621.00
188_K204_N0.9591.00
113_V131_I0.9581.00
17_F33_I0.9521.00
166_H231_Y0.9481.00
76_T79_F0.9481.00
84_T87_G0.9471.00
206_L209_Y0.9471.00
249_G252_T0.9421.00
239_L247_I0.9381.00
119_E122_N0.9371.00
14_V111_I0.9341.00
104_S107_T0.9311.00
211_Y246_T0.9231.00
169_R173_E0.9231.00
200_N208_K0.9141.00
112_L228_L0.9131.00
122_N125_I0.9121.00
12_L49_Y0.9111.00
152_M156_F0.9101.00
35_S228_L0.9101.00
233_A247_I0.8981.00
51_L71_I0.8971.00
54_R73_D0.8941.00
22_I27_R0.8901.00
47_K104_S0.8851.00
172_L178_E0.8851.00
168_N171_E0.8801.00
216_I253_E0.8801.00
39_V229_G0.8781.00
88_R91_I0.8681.00
167_G172_L0.8671.00
175_S178_E0.8571.00
121_D124_S0.8571.00
240_E244_A0.8511.00
40_M45_I0.8401.00
13_I32_L0.8351.00
102_V127_S0.8301.00
71_I75_Y0.8291.00
10_K107_T0.8291.00
203_T241_I0.8221.00
28_P60_I0.8211.00
211_Y242_I0.8171.00
230_A234_L0.8171.00
159_N162_Y0.8121.00
235_R244_A0.8101.00
206_L242_I0.8091.00
36_S48_L0.8071.00
52_I58_F0.8061.00
87_G91_I0.8031.00
12_L47_K0.8011.00
250_K254_E0.7981.00
180_S183_F0.7951.00
197_N210_T0.7951.00
198_G213_P0.7911.00
40_M46_P0.7891.00
134_D166_H0.7881.00
11_I236_L0.7821.00
209_Y245_A0.7801.00
179_L192_V0.7751.00
47_K108_V0.7711.00
84_T90_L0.7671.00
71_I74_E0.7621.00
120_V123_M0.7571.00
102_V106_N0.7511.00
227_L249_G0.7511.00
203_T209_Y0.7481.00
119_E123_M0.7481.00
252_T255_F0.7441.00
179_L183_F0.7441.00
42_G247_I0.7411.00
11_I110_G0.7391.00
77_I83_L0.7391.00
119_E125_I0.7321.00
226_F252_T0.7251.00
179_L190_I0.7241.00
105_D108_V0.7211.00
19_I57_D0.7191.00
126_Q157_P0.7101.00
226_F230_A0.7091.00
117_C120_V0.7061.00
120_V125_I0.7051.00
85_N89_K0.7041.00
120_V124_S0.7011.00
76_T83_L0.7001.00
126_Q161_N0.6981.00
87_G92_L0.6951.00
110_G236_L0.6921.00
198_G210_T0.6911.00
153_G156_F0.6901.00
86_E89_K0.6891.00
249_G253_E0.6891.00
55_D58_F0.6861.00
84_T92_L0.6811.00
157_P160_S0.6721.00
84_T88_R0.6641.00
33_I48_L0.6611.00
20_D29_G0.6551.00
36_S66_L0.6521.00
176_K179_L0.6481.00
175_S194_D0.6461.00
115_P133_V0.6421.00
89_K93_L0.6411.00
178_E181_D0.6371.00
132_A164_V0.6371.00
93_L97_K0.6351.00
176_K210_T0.6351.00
217_G257_N0.6341.00
191_I201_V0.6321.00
42_G233_A0.6321.00
176_K202_Y0.6301.00
90_L93_L0.6281.00
160_S186_G0.6281.00
109_D129_I0.6231.00
84_T89_K0.6231.00
239_L244_A0.6221.00
120_V126_Q0.6211.00
152_M155_R0.6201.00
227_L245_A0.6201.00
94_K98_N0.6201.00
176_K200_N0.6201.00
131_I162_Y0.6151.00
93_L96_P0.6141.00
243_E247_I0.6131.00
108_V129_I0.6121.00
102_V105_D0.6111.00
196_H215_K0.6081.00
227_L252_T0.6071.00
183_F203_T0.6041.00
245_A249_G0.5951.00
117_C121_D0.5941.00
103_I107_T0.5911.00
31_P136_Q0.5911.00
227_L248_A0.5881.00
163_M189_E0.5871.00
118_K122_N0.5871.00
132_A166_H0.5831.00
134_D167_G0.5771.00
191_I227_L0.5741.00
13_I39_V0.5731.00
172_L175_S0.5721.00
102_V108_V0.5691.00
211_Y214_S0.5671.00
229_G233_A0.5671.00
132_A228_L0.5661.00
11_I44_G0.5661.00
95_K98_N0.5621.00
78_R81_I0.5611.00
178_E182_L0.5601.00
56_F60_I0.5541.00
52_I72_Y0.5531.00
13_I46_P0.5531.00
158_F162_Y0.5521.00
175_S179_L0.5521.00
29_G34_Y0.5521.00
156_F160_S0.5511.00
118_K124_S0.5461.00
191_I245_A0.5451.00
166_H191_I0.5431.00
179_L208_K0.5421.00
241_I244_A0.5421.00
86_E91_I0.5411.00
55_D76_T0.5391.00
159_N187_F0.5371.00
33_I37_L0.5361.00
199_F211_Y0.5321.00
170_E174_S0.5321.00
241_I245_A0.5321.00
151_E154_F0.5301.00
175_S200_N0.5301.00
19_I28_P0.5281.00
247_I251_L0.5271.00
157_P161_N0.5271.00
214_S254_E0.5241.00
21_E78_R0.5241.00
179_L182_L0.5231.00
235_R238_G0.5181.00
45_I236_L0.5171.00
42_G229_G0.5171.00
97_K101_K0.5161.00
169_R195_G0.5161.00
238_G244_A0.5161.00
14_V49_Y0.5121.00
13_I48_L0.5111.00
183_F190_I0.5091.00
183_F187_F0.5081.00
12_L104_S0.5081.00
105_D129_I0.5061.00
172_L182_L0.5051.00
59_E71_I0.5041.00
47_K69_Q0.5031.00
153_G157_P0.5021.00
35_S232_F0.5011.00
134_D225_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qcvA 3 0.9733 100 0.343 Contact Map
3hj6A 2 0.9084 100 0.349 Contact Map
1tyyA 2 0.9275 100 0.349 Contact Map
3pl2A 2 0.9618 100 0.349 Contact Map
4du5A 2 0.916 100 0.35 Contact Map
3ljsA 2 0.9504 100 0.35 Contact Map
3iq0A 2 0.9504 100 0.353 Contact Map
4wjmA 2 0.9695 100 0.36 Contact Map
3lhxA 2 0.9427 100 0.365 Contact Map
2c4eA 2 0.9427 100 0.366 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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