GREMLIN Database
Q980X4 - D-arabino 3-hexulose 6-phosphate formaldehyde lyase (HpS-1)
UniProt: Q980X4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (169)
Sequences: 10628 (7115)
Seq/√Len: 547.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_R132_P3.8361.00
124_S137_S3.3551.00
51_G93_N3.2211.00
116_K138_D3.0341.00
113_E136_I2.9101.00
44_F121_K2.7171.00
114_A117_E2.2781.00
24_R28_A2.2491.00
23_L27_K2.2101.00
169_P172_T2.1701.00
52_K78_N1.9741.00
51_G91_G1.9611.00
98_A112_A1.9001.00
106_K110_T1.8861.00
99_I182_L1.8501.00
56_M96_V1.8081.00
96_V115_A1.7601.00
121_K139_V1.7141.00
55_V65_G1.7111.00
143_I178_T1.7071.00
55_V97_V1.6971.00
121_K138_D1.6521.00
100_S133_L1.6391.00
51_G94_D1.6091.00
65_G99_I1.5901.00
68_F72_L1.5761.00
67_A70_M1.5731.00
95_I123_I1.5481.00
143_I181_F1.5461.00
112_A122_L1.5401.00
112_A133_L1.5351.00
67_A71_R1.5111.00
124_S140_V1.5091.00
10_L13_K1.5041.00
12_L16_Y1.4801.00
141_I181_F1.4771.00
26_A180_I1.4771.00
71_R74_H1.4631.00
36_K39_N1.4041.00
134_A142_E1.3851.00
68_F182_L1.3801.00
99_I178_T1.3781.00
122_L137_S1.3761.00
188_E192_R1.3611.00
91_G94_D1.3531.00
134_A140_V1.3531.00
90_I120_A1.3391.00
41_L123_I1.3381.00
50_N93_N1.3371.00
114_A118_A1.3261.00
16_Y20_E1.3251.00
129_F142_E1.3241.00
24_R27_K1.3181.00
68_F71_R1.3011.00
58_A85_T1.2901.00
60_R169_P1.2871.00
115_A120_A1.2771.00
126_T140_V1.2391.00
23_L30_K1.2351.00
126_T134_A1.2151.00
48_N192_R1.1971.00
69_A73_L1.1931.00
56_M98_A1.1921.00
20_E24_R1.1821.00
11_S39_N1.1791.00
131_S134_A1.1721.00
124_S133_L1.1601.00
53_V97_V1.1581.00
22_I26_A1.1421.00
56_M111_A1.1401.00
23_L26_A1.1391.00
63_L66_R1.1381.00
50_N95_I1.1371.00
98_A108_I1.1291.00
20_E30_K1.1241.00
27_K31_P1.1101.00
44_F139_V1.1031.00
35_I39_N1.1001.00
22_I25_A1.0981.00
20_E23_L1.0931.00
41_L44_F1.0921.00
52_K94_D1.0851.00
55_V68_F1.0811.00
40_E44_F1.0741.00
66_R69_A1.0691.00
19_A22_I1.0621.00
70_M73_L1.0571.00
37_M40_E1.0541.00
19_A26_A1.0521.00
42_E192_R1.0351.00
32_E142_E1.0061.00
64_V67_A1.0041.00
28_A31_P0.9951.00
99_I125_I0.9891.00
13_K16_Y0.9851.00
109_L113_E0.9801.00
96_V120_A0.9731.00
14_T191_I0.9721.00
109_L132_P0.9711.00
143_I177_T0.9671.00
98_A122_L0.9591.00
42_E48_N0.9591.00
56_M108_I0.9561.00
116_K136_I0.9561.00
130_D135_K0.9521.00
43_N192_R0.9481.00
48_N193_L0.9431.00
40_E139_V0.9411.00
27_K30_K0.9311.00
49_R93_N0.9261.00
76_G84_E0.9261.00
66_R70_M0.9221.00
19_A180_I0.9211.00
97_V125_I0.9171.00
17_D21_F0.9171.00
71_R186_V0.9171.00
173_L176_D0.9121.00
28_A32_E0.9111.00
40_E43_N0.9041.00
188_E191_I0.8981.00
49_R95_I0.8871.00
17_D191_I0.8691.00
110_T113_E0.8621.00
37_M44_F0.8581.00
84_E87_V0.8491.00
58_A84_E0.8411.00
81_V84_E0.8391.00
14_T17_D0.8331.00
132_P136_I0.8301.00
52_K91_G0.8261.00
18_I22_I0.8261.00
58_A105_T0.8241.00
64_V179_Q0.8201.00
94_D120_A0.8181.00
19_A23_L0.8031.00
125_I181_F0.8021.00
98_A115_A0.7881.00
21_F171_G0.7881.00
95_I121_K0.7841.00
25_A177_T0.7831.00
12_L15_M0.7811.00
39_N192_R0.7811.00
54_L94_D0.7771.00
39_N43_N0.7761.00
44_F95_I0.7711.00
125_I182_L0.7661.00
145_G177_T0.7651.00
69_A79_S0.7581.00
29_I177_T0.7571.00
68_F183_D0.7531.00
14_T18_I0.7521.00
90_I96_V0.7481.00
16_Y30_K0.7481.00
124_S131_S0.7391.00
80_Y84_E0.7381.00
77_F80_Y0.7361.00
72_L189_L0.7331.00
41_L139_V0.7291.00
36_K40_E0.7261.00
101_G127_S0.7251.00
20_E27_K0.7211.00
22_I176_D0.7191.00
62_G66_R0.7101.00
66_R71_R0.7071.00
37_M139_V0.7021.00
38_V41_L0.7011.00
113_E117_E0.7001.00
18_I170_L0.6971.00
82_L85_T0.6971.00
32_E144_P0.6971.00
11_S15_M0.6951.00
25_A28_A0.6931.00
70_M74_H0.6861.00
14_T188_E0.6851.00
37_M41_L0.6781.00
124_S134_A0.6771.00
127_S145_G0.6771.00
28_A146_R0.6761.00
29_I32_E0.6751.00
132_P135_K0.6741.00
74_H89_A0.6741.00
97_V185_I0.6731.00
100_S105_T0.6681.00
25_A171_G0.6651.00
75_L78_N0.6591.00
82_L87_V0.6551.00
54_L88_P0.6511.00
116_K122_L0.6491.00
61_S178_T0.6471.00
21_F24_R0.6441.00
38_V42_E0.6441.00
53_V95_I0.6431.00
12_L35_I0.6401.00
76_G82_L0.6401.00
12_L33_Q0.6351.00
129_F144_P0.6351.00
77_F84_E0.6301.00
109_L136_I0.6281.00
35_I38_V0.6231.00
187_A190_M0.6231.00
67_A74_H0.6221.00
43_N49_R0.6211.00
127_S143_I0.6201.00
49_R121_K0.6181.00
75_L84_E0.6161.00
92_K119_G0.6131.00
69_A186_V0.6121.00
76_G83_G0.6101.00
21_F28_A0.6031.00
83_G86_I0.5991.00
53_V77_F0.5981.00
40_E121_K0.5981.00
101_G143_I0.5941.00
21_F147_T0.5941.00
45_Y193_L0.5921.00
11_S14_T0.5891.00
61_S99_I0.5841.00
39_N188_E0.5841.00
13_K17_D0.5820.99
76_G79_S0.5780.99
123_I139_V0.5760.99
166_P173_L0.5740.99
186_V190_M0.5650.99
75_L193_L0.5650.99
54_L90_I0.5640.99
37_M123_I0.5640.99
15_M18_I0.5620.99
86_I110_T0.5600.99
69_A77_F0.5530.99
129_F134_A0.5510.99
35_I188_E0.5500.99
123_I141_I0.5500.99
19_A25_A0.5490.99
52_K76_G0.5480.99
68_F74_H0.5400.99
37_M42_E0.5380.99
50_N94_D0.5380.99
42_E188_E0.5360.99
76_G85_T0.5360.99
74_H88_P0.5320.99
137_S140_V0.5310.99
64_V68_F0.5310.99
78_N81_V0.5280.99
80_Y83_G0.5240.99
112_A136_I0.5210.99
110_T114_A0.5190.99
187_A191_I0.5190.99
30_K34_T0.5140.99
109_L133_L0.5110.99
179_Q183_D0.5090.99
104_R128_Y0.5040.99
83_G87_V0.5010.98
43_N139_V0.5000.98
76_G89_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1m3sA 4 0.8852 100 0.332 Contact Map
1vimA 4 0.9091 100 0.353 Contact Map
3fxaA 4 0.89 100 0.371 Contact Map
2xhzA 4 0.8038 100 0.382 Contact Map
3etnA 4 0.8804 100 0.385 Contact Map
4amvA 2 0.9043 100 0.385 Contact Map
2pocA 4 0.866 100 0.393 Contact Map
1moqA 2 0.8804 100 0.397 Contact Map
3tbfA 2 0.8852 100 0.4 Contact Map
1jeoA 4 0.823 100 0.404 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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