ARGC - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

ARGC - N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase

UniProt:	Q980X1	Sequences: MKDKVRVAVVGGSGYTGGELLRILVTHPKTEISVITSREYAGKPVSLIHPNLRGLISLNFTNFSIDKISDKADAIFLALPHGVSLNYAPKLLDLGLTVVDLSADFRLKNPELYKIWYNYEHPYPDLLDKAVYGLPELHYEELKNAKLIASPGCNATATILALAPIVATKITDEKKFISDVKVGSSEGGAKPSEGSHHPERQNAIRPYEAEGHRHAAEAEQELSRIAKANISVSIVPHAVSSIRGALASAHTWLTNELEEIEIWKKIAEFYRGKRFIRIIRGNIHPYPDPKFVIGSNFADIGFAVEKRISRLTTFSAIDNLMKGAAGQAVQAFNISMGFNEDDGLKLVPLRPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	352 (296)
Sequences:	7195 (3622)
Seq/√Len:	210.5

ECOLI - ARGC USG DHAS
BACSU - ARGC DHAS
HALSA - Q9HPX0
SULSO - ARGC Q97WN3 Q97ZL8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
262_I	311_L	3.674	1.00
163_A	167_A	3.652	1.00
8_A	72_A	3.386	1.00
6_R	31_E	3.321	1.00
154_N	182_V	3.130	1.00
172_D	254_T	2.961	1.00
150_S	331_A	2.950	1.00
277_R	297_F	2.940	1.00
277_R	299_D	2.857	1.00
97_T	335_S	2.621	1.00
44_P	57_S	2.586	1.00
264_K	268_E	2.490	1.00
204_I	239_V	2.467	1.00
258_E	261_E	2.444	1.00
175_K	252_W	2.413	1.00
74_A	332_F	2.407	1.00
30_T	332_F	2.332	1.00
158_T	178_S	2.275	1.00
184_S	200_R	2.258	1.00
161_A	249_A	2.180	1.00
157_A	247_A	2.136	1.00
27_H	333_N	2.133	1.00
44_P	59_N	2.127	1.00
141_E	223_S	2.104	1.00
23_I	329_V	2.062	1.00
19_E	22_R	2.052	1.00
38_R	62_N	2.034	1.00
76_F	332_F	2.020	1.00
167_A	269_F	1.989	1.00
322_K	330_Q	1.972	1.00
158_T	247_A	1.967	1.00
108_K	129_K	1.934	1.00
179_D	248_S	1.919	1.00
161_A	313_T	1.911	1.00
157_A	317_I	1.901	1.00
148_I	335_S	1.900	1.00
46_S	57_S	1.870	1.00
263_W	267_A	1.855	1.00
6_R	33_S	1.843	1.00
168_T	265_K	1.834	1.00
261_E	264_K	1.827	1.00
20_L	76_F	1.817	1.00
85_L	104_D	1.807	1.00
159_I	221_E	1.804	1.00
154_N	180_V	1.795	1.00
63_F	87_Y	1.784	1.00
5_V	336_M	1.779	1.00
172_D	252_W	1.747	1.00
162_L	176_F	1.689	1.00
165_I	253_L	1.681	1.00
7_V	74_A	1.643	1.00
129_K	146_K	1.637	1.00
267_A	280_R	1.631	1.00
259_E	263_W	1.618	1.00
275_F	296_N	1.602	1.00
189_A	193_E	1.597	1.00
21_L	32_I	1.586	1.00
138_H	141_E	1.568	1.00
241_S	289_P	1.567	1.00
180_V	247_A	1.564	1.00
161_A	315_S	1.562	1.00
24_L	30_T	1.554	1.00
139_Y	334_I	1.549	1.00
263_W	281_G	1.545	1.00
177_I	250_H	1.536	1.00
135_P	334_I	1.534	1.00
12_G	35_I	1.525	1.00
321_M	326_G	1.522	1.00
64_S	67_K	1.505	1.00
249_A	315_S	1.504	1.00
92_L	147_L	1.494	1.00
7_V	30_T	1.486	1.00
193_E	196_H	1.484	1.00
165_I	311_L	1.451	1.00
6_R	73_D	1.416	1.00
165_I	266_I	1.411	1.00
137_L	163_A	1.407	1.00
86_N	90_K	1.397	1.00
263_W	280_R	1.395	1.00
266_I	313_T	1.385	1.00
296_N	321_M	1.376	1.00
90_K	93_D	1.371	1.00
43_K	47_L	1.367	1.00
168_T	261_E	1.349	1.00
253_L	311_L	1.348	1.00
89_P	93_D	1.345	1.00
16_T	325_A	1.341	1.00
158_T	218_A	1.338	1.00
19_E	243_R	1.335	1.00
82_G	104_D	1.334	1.00
10_V	77_L	1.314	1.00
74_A	336_M	1.305	1.00
249_A	313_T	1.305	1.00
259_E	304_V	1.291	1.00
77_L	88_A	1.289	1.00
252_W	310_R	1.283	1.00
201_Q	242_I	1.276	1.00
158_T	249_A	1.276	1.00
264_K	267_A	1.262	1.00
259_E	302_F	1.256	1.00
140_E	223_S	1.255	1.00
87_Y	90_K	1.254	1.00
13_S	60_F	1.225	1.00
8_A	75_I	1.213	1.00
75_I	96_L	1.213	1.00
298_A	317_I	1.208	1.00
260_I	264_K	1.200	1.00
69_S	94_L	1.199	1.00
140_E	143_K	1.191	1.00
266_I	278_I	1.175	1.00
108_K	128_D	1.175	1.00
208_E	213_R	1.173	1.00
178_S	249_A	1.161	1.00
68_I	91_L	1.160	1.00
263_W	278_I	1.157	1.00
97_T	148_I	1.156	1.00
134_L	159_I	1.155	1.00
187_G	191_P	1.155	1.00
44_P	47_L	1.153	1.00
161_A	266_I	1.140	1.00
185_S	242_I	1.140	1.00
97_T	146_K	1.137	1.00
296_N	326_G	1.132	1.00
175_K	310_R	1.127	1.00
246_L	316_A	1.121	1.00
179_D	250_H	1.104	1.00
21_L	45_V	1.102	1.00
181_K	239_V	1.099	1.00
176_F	251_T	1.097	1.00
40_Y	43_K	1.097	1.00
131_V	145_A	1.091	1.00
231_S	308_I	1.090	1.00
162_L	251_T	1.087	1.00
251_T	311_L	1.083	1.00
157_A	180_V	1.076	1.00
107_L	216_A	1.066	1.00
33_S	61_T	1.061	1.00
142_L	334_I	1.044	1.00
321_M	329_V	1.044	1.00
239_V	289_P	1.039	1.00
5_V	74_A	1.038	1.00
279_I	299_D	1.034	1.00
251_T	313_T	1.031	1.00
90_K	94_L	1.031	1.00
288_D	291_F	1.026	1.00
244_G	319_N	1.018	1.00
219_E	307_R	1.017	1.00
192_S	196_H	1.014	1.00
72_A	75_I	1.012	1.00
160_L	298_A	1.011	1.00
298_A	315_S	1.009	1.00
88_A	98_V	1.009	1.00
169_K	257_L	1.006	1.00
279_I	291_F	1.002	1.00
255_N	261_E	0.997	1.00
6_R	30_T	0.993	1.00
278_I	302_F	0.990	1.00
33_S	72_A	0.979	1.00
13_S	37_S	0.978	1.00
136_E	322_K	0.977	1.00
181_K	250_H	0.974	1.00
23_I	326_G	0.973	1.00
191_P	195_S	0.958	1.00
165_I	262_I	0.957	1.00
161_A	164_P	0.957	1.00
246_L	314_F	0.957	1.00
61_T	67_K	0.956	1.00
263_W	302_F	0.955	1.00
136_E	330_Q	0.947	0.99
307_R	310_R	0.945	0.99
32_I	58_L	0.945	0.99
219_E	231_S	0.944	0.99
256_E	309_S	0.940	0.99
138_H	221_E	0.936	0.99
16_T	324_A	0.934	0.99
41_A	62_N	0.932	0.99
66_D	94_L	0.929	0.99
237_H	248_S	0.921	0.99
291_F	299_D	0.911	0.99
256_E	304_V	0.908	0.99
130_A	147_L	0.905	0.99
154_N	214_H	0.901	0.99
99_V	332_F	0.899	0.99
233_S	250_H	0.897	0.99
76_F	328_A	0.897	0.99
65_I	90_K	0.894	0.99
88_A	147_L	0.887	0.99
75_I	91_L	0.884	0.99
83_V	86_N	0.879	0.99
246_L	289_P	0.873	0.99
166_V	171_T	0.873	0.99
162_L	249_A	0.872	0.99
212_H	216_A	0.872	0.99
332_F	336_M	0.868	0.99
203_A	288_D	0.868	0.99
107_L	220_Q	0.867	0.99
295_S	299_D	0.866	0.99
253_L	257_L	0.866	0.99
250_H	312_T	0.864	0.99
91_L	98_V	0.858	0.99
253_L	304_V	0.857	0.99
168_T	255_N	0.856	0.99
227_K	230_I	0.853	0.99
74_A	97_T	0.852	0.99
25_V	56_I	0.848	0.99
196_H	242_I	0.846	0.99
157_A	315_S	0.842	0.99
168_T	268_E	0.837	0.99
170_I	254_T	0.831	0.99
79_L	102_S	0.827	0.99
166_V	227_K	0.826	0.99
260_I	263_W	0.825	0.99
45_V	60_F	0.824	0.99
204_I	237_H	0.823	0.99
8_A	34_V	0.816	0.98
37_S	40_Y	0.815	0.98
281_G	285_P	0.809	0.98
22_R	26_T	0.808	0.98
170_I	265_K	0.806	0.98
150_S	324_A	0.804	0.98
40_Y	60_F	0.802	0.98
300_I	313_T	0.794	0.98
79_L	83_V	0.788	0.98
79_L	84_S	0.788	0.98
260_I	281_G	0.787	0.98
163_A	222_L	0.787	0.98
108_K	220_Q	0.786	0.98
107_L	149_A	0.786	0.98
243_R	320_L	0.785	0.98
10_V	63_F	0.781	0.98
30_T	336_M	0.780	0.98
231_S	307_R	0.778	0.98
256_E	265_K	0.774	0.98
65_I	94_L	0.773	0.98
253_L	262_I	0.773	0.98
279_I	285_P	0.773	0.98
155_A	208_E	0.769	0.98
23_I	321_M	0.768	0.98
36_T	40_Y	0.767	0.98
181_K	237_H	0.767	0.98
205_R	288_D	0.764	0.98
187_G	205_R	0.763	0.98
202_N	290_K	0.760	0.98
179_D	237_H	0.756	0.98
82_G	85_L	0.753	0.97
172_D	175_K	0.753	0.97
12_G	17_G	0.752	0.97
292_V	299_D	0.752	0.97
27_H	296_N	0.752	0.97
253_L	256_E	0.749	0.97
157_A	316_A	0.746	0.97
129_K	145_A	0.745	0.97
204_I	289_P	0.740	0.97
68_I	72_A	0.737	0.97
97_T	336_M	0.736	0.97
156_T	327_Q	0.734	0.97
208_E	211_G	0.733	0.97
137_L	160_L	0.729	0.97
99_V	335_S	0.729	0.97
191_P	196_H	0.727	0.97
305_E	310_R	0.726	0.97
137_L	269_F	0.726	0.97
153_C	186_E	0.722	0.97
248_S	312_T	0.720	0.97
160_L	269_F	0.718	0.97
215_A	219_E	0.718	0.97
178_S	247_A	0.716	0.97
61_T	71_K	0.712	0.96
257_L	265_K	0.712	0.96
163_A	166_V	0.712	0.96
302_F	311_L	0.710	0.96
162_L	178_S	0.708	0.96
169_K	254_T	0.707	0.96
141_E	144_N	0.704	0.96
248_S	314_F	0.702	0.96
91_L	102_S	0.702	0.96
33_S	71_K	0.696	0.96
169_K	265_K	0.695	0.96
184_S	198_P	0.695	0.96
26_T	321_M	0.695	0.96
169_K	258_E	0.692	0.96
257_L	262_I	0.691	0.96
12_G	60_F	0.690	0.96
9_V	20_L	0.688	0.96
101_L	327_Q	0.688	0.96
244_G	293_I	0.687	0.96
259_E	262_I	0.686	0.96
101_L	150_S	0.682	0.95
89_P	105_F	0.680	0.95
223_S	227_K	0.678	0.95
74_A	99_V	0.678	0.95
286_Y	314_F	0.678	0.95
65_I	69_S	0.677	0.95
223_S	228_A	0.675	0.95
133_G	331_A	0.674	0.95
155_A	159_I	0.672	0.95
206_P	237_H	0.671	0.95
181_K	204_I	0.671	0.95
9_V	24_L	0.666	0.95
158_T	214_H	0.665	0.95
62_N	67_K	0.664	0.95
178_S	218_A	0.663	0.95
132_Y	155_A	0.661	0.95
242_I	293_I	0.659	0.95
5_V	73_D	0.659	0.95
167_A	268_E	0.658	0.94
194_G	205_R	0.658	0.94
169_K	261_E	0.657	0.94
89_P	98_V	0.657	0.94
134_L	160_L	0.656	0.94
67_K	71_K	0.655	0.94
192_S	195_S	0.654	0.94
159_I	222_L	0.652	0.94
305_E	308_I	0.650	0.94
223_S	230_I	0.649	0.94
170_I	257_L	0.646	0.94
206_P	314_F	0.643	0.94
206_P	246_L	0.643	0.94
157_A	298_A	0.637	0.93
157_A	245_A	0.634	0.93
165_I	251_T	0.633	0.93
32_I	56_I	0.632	0.93
150_S	213_R	0.631	0.93
81_H	103_A	0.630	0.93
200_R	238_A	0.626	0.93
34_V	45_V	0.623	0.93
89_P	92_L	0.623	0.93
35_I	58_L	0.617	0.92
137_L	159_I	0.617	0.92
269_F	276_I	0.614	0.92
233_S	312_T	0.613	0.92
233_S	310_R	0.612	0.92
134_L	327_Q	0.611	0.92
143_K	334_I	0.608	0.92
77_L	98_V	0.604	0.92
77_L	84_S	0.604	0.92
37_S	60_F	0.603	0.92
21_L	34_V	0.603	0.92
214_H	236_P	0.601	0.91
97_T	145_A	0.601	0.91
66_D	69_S	0.601	0.91
158_T	180_V	0.600	0.91
68_I	75_I	0.600	0.91
206_P	288_D	0.594	0.91
215_A	306_K	0.593	0.91
163_A	269_F	0.591	0.91
247_A	315_S	0.591	0.91
166_V	176_F	0.590	0.91
223_S	229_N	0.590	0.91
287_P	301_G	0.589	0.91
139_Y	143_K	0.589	0.91
161_A	298_A	0.589	0.91
103_A	213_R	0.589	0.91
243_R	293_I	0.588	0.90
177_I	252_W	0.586	0.90
65_I	86_N	0.584	0.90
195_S	198_P	0.580	0.90
194_G	198_P	0.578	0.90
108_K	130_A	0.578	0.90
157_A	319_N	0.574	0.89
151_P	156_T	0.573	0.89
243_R	319_N	0.573	0.89
202_N	242_I	0.572	0.89
24_L	329_V	0.571	0.89
178_S	234_I	0.570	0.89
145_A	148_I	0.568	0.89
311_L	314_F	0.568	0.89
77_L	91_L	0.567	0.89
266_I	276_I	0.566	0.89
91_L	94_L	0.566	0.89
29_K	32_I	0.564	0.89
212_H	306_K	0.563	0.88
46_S	56_I	0.563	0.88
142_L	335_S	0.562	0.88
72_A	96_L	0.562	0.88
290_K	293_I	0.561	0.88
82_G	102_S	0.558	0.88
15_Y	192_S	0.557	0.88
177_I	248_S	0.556	0.88
299_D	316_A	0.555	0.88
76_F	329_V	0.554	0.88
80_P	103_A	0.554	0.88
197_H	200_R	0.553	0.88
178_S	232_V	0.553	0.88
23_I	26_T	0.552	0.88
171_T	251_T	0.552	0.88
13_S	40_Y	0.549	0.87
262_I	302_F	0.549	0.87
183_G	243_R	0.549	0.87
29_K	47_L	0.549	0.87
24_L	332_F	0.548	0.87
327_Q	331_A	0.547	0.87
6_R	72_A	0.547	0.87
29_K	58_L	0.545	0.87
292_V	295_S	0.544	0.87
172_D	309_S	0.543	0.87
282_N	285_P	0.543	0.87
22_R	25_V	0.542	0.87
201_Q	204_I	0.542	0.87
13_S	36_T	0.541	0.86
156_T	317_I	0.539	0.86
170_I	253_L	0.537	0.86
244_G	292_V	0.537	0.86
286_Y	303_A	0.536	0.86
83_V	102_S	0.535	0.86
84_S	105_F	0.534	0.86
88_A	91_L	0.533	0.86
5_V	30_T	0.533	0.86
140_E	144_N	0.532	0.86
10_V	79_L	0.531	0.85
18_G	45_V	0.531	0.85
25_V	53_R	0.530	0.85
212_H	215_A	0.529	0.85
24_L	32_I	0.529	0.85
258_E	304_V	0.527	0.85
152_G	213_R	0.522	0.84
166_V	170_I	0.522	0.84
219_E	230_I	0.521	0.84
215_A	232_V	0.521	0.84
161_A	300_I	0.520	0.84
91_L	96_L	0.519	0.84
286_Y	301_G	0.516	0.84
158_T	315_S	0.516	0.84
106_R	186_E	0.516	0.84
228_A	231_S	0.515	0.84
105_F	130_A	0.515	0.84
85_L	108_K	0.515	0.84
7_V	332_F	0.515	0.84
62_N	65_I	0.514	0.84
239_V	242_I	0.514	0.84
106_R	153_C	0.513	0.83
69_S	93_D	0.512	0.83
85_L	89_P	0.512	0.83
256_E	308_I	0.512	0.83
58_L	61_T	0.511	0.83
279_I	301_G	0.510	0.83
97_T	142_L	0.507	0.83
92_L	98_V	0.505	0.83
193_E	197_H	0.503	0.82
46_S	54_G	0.502	0.82
64_S	86_N	0.501	0.82
36_T	60_F	0.500	0.82
55_L	58_L	0.500	0.82
181_K	241_S	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vknA	4	0.9659	100	0.146	Contact Map
1xygA	4	0.9773	100	0.192	Contact Map
2nqtA	4	0.9602	100	0.202	Contact Map
2ozpA	4	0.9659	100	0.225	Contact Map
3dr3A	4	0.9347	100	0.265	Contact Map
2yv3A	2	0.8494	100	0.329	Contact Map
2ep5A	4	0.8835	100	0.333	Contact Map
3uw3A	2	0.8665	100	0.335	Contact Map
1ys4A	4	0.8835	100	0.337	Contact Map
4dplA	4	0.8892	100	0.338	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.