GREMLIN Database
ARGC - N-acetyl-gamma-glutamyl-phosphate/N-acetyl-gamma-aminoadipyl-phosphate reductase
UniProt: Q980X1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (296)
Sequences: 7195 (3622)
Seq/√Len: 210.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
262_I311_L3.6741.00
163_A167_A3.6521.00
8_A72_A3.3861.00
6_R31_E3.3211.00
154_N182_V3.1301.00
172_D254_T2.9611.00
150_S331_A2.9501.00
277_R297_F2.9401.00
277_R299_D2.8571.00
97_T335_S2.6211.00
44_P57_S2.5861.00
264_K268_E2.4901.00
204_I239_V2.4671.00
258_E261_E2.4441.00
175_K252_W2.4131.00
74_A332_F2.4071.00
30_T332_F2.3321.00
158_T178_S2.2751.00
184_S200_R2.2581.00
161_A249_A2.1801.00
157_A247_A2.1361.00
27_H333_N2.1331.00
44_P59_N2.1271.00
141_E223_S2.1041.00
23_I329_V2.0621.00
19_E22_R2.0521.00
38_R62_N2.0341.00
76_F332_F2.0201.00
167_A269_F1.9891.00
322_K330_Q1.9721.00
158_T247_A1.9671.00
108_K129_K1.9341.00
179_D248_S1.9191.00
161_A313_T1.9111.00
157_A317_I1.9011.00
148_I335_S1.9001.00
46_S57_S1.8701.00
263_W267_A1.8551.00
6_R33_S1.8431.00
168_T265_K1.8341.00
261_E264_K1.8271.00
20_L76_F1.8171.00
85_L104_D1.8071.00
159_I221_E1.8041.00
154_N180_V1.7951.00
63_F87_Y1.7841.00
5_V336_M1.7791.00
172_D252_W1.7471.00
162_L176_F1.6891.00
165_I253_L1.6811.00
7_V74_A1.6431.00
129_K146_K1.6371.00
267_A280_R1.6311.00
259_E263_W1.6181.00
275_F296_N1.6021.00
189_A193_E1.5971.00
21_L32_I1.5861.00
138_H141_E1.5681.00
241_S289_P1.5671.00
180_V247_A1.5641.00
161_A315_S1.5621.00
24_L30_T1.5541.00
139_Y334_I1.5491.00
263_W281_G1.5451.00
177_I250_H1.5361.00
135_P334_I1.5341.00
12_G35_I1.5251.00
321_M326_G1.5221.00
64_S67_K1.5051.00
249_A315_S1.5041.00
92_L147_L1.4941.00
7_V30_T1.4861.00
193_E196_H1.4841.00
165_I311_L1.4511.00
6_R73_D1.4161.00
165_I266_I1.4111.00
137_L163_A1.4071.00
86_N90_K1.3971.00
263_W280_R1.3951.00
266_I313_T1.3851.00
296_N321_M1.3761.00
90_K93_D1.3711.00
43_K47_L1.3671.00
168_T261_E1.3491.00
253_L311_L1.3481.00
89_P93_D1.3451.00
16_T325_A1.3411.00
158_T218_A1.3381.00
19_E243_R1.3351.00
82_G104_D1.3341.00
10_V77_L1.3141.00
74_A336_M1.3051.00
249_A313_T1.3051.00
259_E304_V1.2911.00
77_L88_A1.2891.00
252_W310_R1.2831.00
201_Q242_I1.2761.00
158_T249_A1.2761.00
264_K267_A1.2621.00
259_E302_F1.2561.00
140_E223_S1.2551.00
87_Y90_K1.2541.00
13_S60_F1.2251.00
8_A75_I1.2131.00
75_I96_L1.2131.00
298_A317_I1.2081.00
260_I264_K1.2001.00
69_S94_L1.1991.00
140_E143_K1.1911.00
266_I278_I1.1751.00
108_K128_D1.1751.00
208_E213_R1.1731.00
178_S249_A1.1611.00
68_I91_L1.1601.00
263_W278_I1.1571.00
97_T148_I1.1561.00
134_L159_I1.1551.00
187_G191_P1.1551.00
44_P47_L1.1531.00
161_A266_I1.1401.00
185_S242_I1.1401.00
97_T146_K1.1371.00
296_N326_G1.1321.00
175_K310_R1.1271.00
246_L316_A1.1211.00
179_D250_H1.1041.00
21_L45_V1.1021.00
181_K239_V1.0991.00
176_F251_T1.0971.00
40_Y43_K1.0971.00
131_V145_A1.0911.00
231_S308_I1.0901.00
162_L251_T1.0871.00
251_T311_L1.0831.00
157_A180_V1.0761.00
107_L216_A1.0661.00
33_S61_T1.0611.00
142_L334_I1.0441.00
321_M329_V1.0441.00
239_V289_P1.0391.00
5_V74_A1.0381.00
279_I299_D1.0341.00
251_T313_T1.0311.00
90_K94_L1.0311.00
288_D291_F1.0261.00
244_G319_N1.0181.00
219_E307_R1.0171.00
192_S196_H1.0141.00
72_A75_I1.0121.00
160_L298_A1.0111.00
298_A315_S1.0091.00
88_A98_V1.0091.00
169_K257_L1.0061.00
279_I291_F1.0021.00
255_N261_E0.9971.00
6_R30_T0.9931.00
278_I302_F0.9901.00
33_S72_A0.9791.00
13_S37_S0.9781.00
136_E322_K0.9771.00
181_K250_H0.9741.00
23_I326_G0.9731.00
191_P195_S0.9581.00
165_I262_I0.9571.00
161_A164_P0.9571.00
246_L314_F0.9571.00
61_T67_K0.9561.00
263_W302_F0.9551.00
136_E330_Q0.9470.99
307_R310_R0.9450.99
32_I58_L0.9450.99
219_E231_S0.9440.99
256_E309_S0.9400.99
138_H221_E0.9360.99
16_T324_A0.9340.99
41_A62_N0.9320.99
66_D94_L0.9290.99
237_H248_S0.9210.99
291_F299_D0.9110.99
256_E304_V0.9080.99
130_A147_L0.9050.99
154_N214_H0.9010.99
99_V332_F0.8990.99
233_S250_H0.8970.99
76_F328_A0.8970.99
65_I90_K0.8940.99
88_A147_L0.8870.99
75_I91_L0.8840.99
83_V86_N0.8790.99
246_L289_P0.8730.99
166_V171_T0.8730.99
162_L249_A0.8720.99
212_H216_A0.8720.99
332_F336_M0.8680.99
203_A288_D0.8680.99
107_L220_Q0.8670.99
295_S299_D0.8660.99
253_L257_L0.8660.99
250_H312_T0.8640.99
91_L98_V0.8580.99
253_L304_V0.8570.99
168_T255_N0.8560.99
227_K230_I0.8530.99
74_A97_T0.8520.99
25_V56_I0.8480.99
196_H242_I0.8460.99
157_A315_S0.8420.99
168_T268_E0.8370.99
170_I254_T0.8310.99
79_L102_S0.8270.99
166_V227_K0.8260.99
260_I263_W0.8250.99
45_V60_F0.8240.99
204_I237_H0.8230.99
8_A34_V0.8160.98
37_S40_Y0.8150.98
281_G285_P0.8090.98
22_R26_T0.8080.98
170_I265_K0.8060.98
150_S324_A0.8040.98
40_Y60_F0.8020.98
300_I313_T0.7940.98
79_L83_V0.7880.98
79_L84_S0.7880.98
260_I281_G0.7870.98
163_A222_L0.7870.98
108_K220_Q0.7860.98
107_L149_A0.7860.98
243_R320_L0.7850.98
10_V63_F0.7810.98
30_T336_M0.7800.98
231_S307_R0.7780.98
256_E265_K0.7740.98
65_I94_L0.7730.98
253_L262_I0.7730.98
279_I285_P0.7730.98
155_A208_E0.7690.98
23_I321_M0.7680.98
36_T40_Y0.7670.98
181_K237_H0.7670.98
205_R288_D0.7640.98
187_G205_R0.7630.98
202_N290_K0.7600.98
179_D237_H0.7560.98
82_G85_L0.7530.97
172_D175_K0.7530.97
12_G17_G0.7520.97
292_V299_D0.7520.97
27_H296_N0.7520.97
253_L256_E0.7490.97
157_A316_A0.7460.97
129_K145_A0.7450.97
204_I289_P0.7400.97
68_I72_A0.7370.97
97_T336_M0.7360.97
156_T327_Q0.7340.97
208_E211_G0.7330.97
137_L160_L0.7290.97
99_V335_S0.7290.97
191_P196_H0.7270.97
305_E310_R0.7260.97
137_L269_F0.7260.97
153_C186_E0.7220.97
248_S312_T0.7200.97
160_L269_F0.7180.97
215_A219_E0.7180.97
178_S247_A0.7160.97
61_T71_K0.7120.96
257_L265_K0.7120.96
163_A166_V0.7120.96
302_F311_L0.7100.96
162_L178_S0.7080.96
169_K254_T0.7070.96
141_E144_N0.7040.96
248_S314_F0.7020.96
91_L102_S0.7020.96
33_S71_K0.6960.96
169_K265_K0.6950.96
184_S198_P0.6950.96
26_T321_M0.6950.96
169_K258_E0.6920.96
257_L262_I0.6910.96
12_G60_F0.6900.96
9_V20_L0.6880.96
101_L327_Q0.6880.96
244_G293_I0.6870.96
259_E262_I0.6860.96
101_L150_S0.6820.95
89_P105_F0.6800.95
223_S227_K0.6780.95
74_A99_V0.6780.95
286_Y314_F0.6780.95
65_I69_S0.6770.95
223_S228_A0.6750.95
133_G331_A0.6740.95
155_A159_I0.6720.95
206_P237_H0.6710.95
181_K204_I0.6710.95
9_V24_L0.6660.95
158_T214_H0.6650.95
62_N67_K0.6640.95
178_S218_A0.6630.95
132_Y155_A0.6610.95
242_I293_I0.6590.95
5_V73_D0.6590.95
167_A268_E0.6580.94
194_G205_R0.6580.94
169_K261_E0.6570.94
89_P98_V0.6570.94
134_L160_L0.6560.94
67_K71_K0.6550.94
192_S195_S0.6540.94
159_I222_L0.6520.94
305_E308_I0.6500.94
223_S230_I0.6490.94
170_I257_L0.6460.94
206_P314_F0.6430.94
206_P246_L0.6430.94
157_A298_A0.6370.93
157_A245_A0.6340.93
165_I251_T0.6330.93
32_I56_I0.6320.93
150_S213_R0.6310.93
81_H103_A0.6300.93
200_R238_A0.6260.93
34_V45_V0.6230.93
89_P92_L0.6230.93
35_I58_L0.6170.92
137_L159_I0.6170.92
269_F276_I0.6140.92
233_S312_T0.6130.92
233_S310_R0.6120.92
134_L327_Q0.6110.92
143_K334_I0.6080.92
77_L98_V0.6040.92
77_L84_S0.6040.92
37_S60_F0.6030.92
21_L34_V0.6030.92
214_H236_P0.6010.91
97_T145_A0.6010.91
66_D69_S0.6010.91
158_T180_V0.6000.91
68_I75_I0.6000.91
206_P288_D0.5940.91
215_A306_K0.5930.91
163_A269_F0.5910.91
247_A315_S0.5910.91
166_V176_F0.5900.91
223_S229_N0.5900.91
287_P301_G0.5890.91
139_Y143_K0.5890.91
161_A298_A0.5890.91
103_A213_R0.5890.91
243_R293_I0.5880.90
177_I252_W0.5860.90
65_I86_N0.5840.90
195_S198_P0.5800.90
194_G198_P0.5780.90
108_K130_A0.5780.90
157_A319_N0.5740.89
151_P156_T0.5730.89
243_R319_N0.5730.89
202_N242_I0.5720.89
24_L329_V0.5710.89
178_S234_I0.5700.89
145_A148_I0.5680.89
311_L314_F0.5680.89
77_L91_L0.5670.89
266_I276_I0.5660.89
91_L94_L0.5660.89
29_K32_I0.5640.89
212_H306_K0.5630.88
46_S56_I0.5630.88
142_L335_S0.5620.88
72_A96_L0.5620.88
290_K293_I0.5610.88
82_G102_S0.5580.88
15_Y192_S0.5570.88
177_I248_S0.5560.88
299_D316_A0.5550.88
76_F329_V0.5540.88
80_P103_A0.5540.88
197_H200_R0.5530.88
178_S232_V0.5530.88
23_I26_T0.5520.88
171_T251_T0.5520.88
13_S40_Y0.5490.87
262_I302_F0.5490.87
183_G243_R0.5490.87
29_K47_L0.5490.87
24_L332_F0.5480.87
327_Q331_A0.5470.87
6_R72_A0.5470.87
29_K58_L0.5450.87
292_V295_S0.5440.87
172_D309_S0.5430.87
282_N285_P0.5430.87
22_R25_V0.5420.87
201_Q204_I0.5420.87
13_S36_T0.5410.86
156_T317_I0.5390.86
170_I253_L0.5370.86
244_G292_V0.5370.86
286_Y303_A0.5360.86
83_V102_S0.5350.86
84_S105_F0.5340.86
88_A91_L0.5330.86
5_V30_T0.5330.86
140_E144_N0.5320.86
10_V79_L0.5310.85
18_G45_V0.5310.85
25_V53_R0.5300.85
212_H215_A0.5290.85
24_L32_I0.5290.85
258_E304_V0.5270.85
152_G213_R0.5220.84
166_V170_I0.5220.84
219_E230_I0.5210.84
215_A232_V0.5210.84
161_A300_I0.5200.84
91_L96_L0.5190.84
286_Y301_G0.5160.84
158_T315_S0.5160.84
106_R186_E0.5160.84
228_A231_S0.5150.84
105_F130_A0.5150.84
85_L108_K0.5150.84
7_V332_F0.5150.84
62_N65_I0.5140.84
239_V242_I0.5140.84
106_R153_C0.5130.83
69_S93_D0.5120.83
85_L89_P0.5120.83
256_E308_I0.5120.83
58_L61_T0.5110.83
279_I301_G0.5100.83
97_T142_L0.5070.83
92_L98_V0.5050.83
193_E197_H0.5030.82
46_S54_G0.5020.82
64_S86_N0.5010.82
36_T60_F0.5000.82
55_L58_L0.5000.82
181_K241_S0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vknA 4 0.9659 100 0.146 Contact Map
1xygA 4 0.9773 100 0.192 Contact Map
2nqtA 4 0.9602 100 0.202 Contact Map
2ozpA 4 0.9659 100 0.225 Contact Map
3dr3A 4 0.9347 100 0.265 Contact Map
2yv3A 2 0.8494 100 0.329 Contact Map
2ep5A 4 0.8835 100 0.333 Contact Map
3uw3A 2 0.8665 100 0.335 Contact Map
1ys4A 4 0.8835 100 0.337 Contact Map
4dplA 4 0.8892 100 0.338 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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