GREMLIN Database
ARGB - Acetylglutamate/acetylaminoadipate kinase
UniProt: Q980X0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (243)
Sequences: 3570 (2004)
Seq/√Len: 128.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_I181_L3.9221.00
108_E134_K3.8161.00
65_T68_E3.7041.00
159_D164_T3.5111.00
193_E243_S3.0401.00
66_K129_Y2.9271.00
211_K233_E2.9231.00
105_L173_A2.8311.00
108_E132_K2.7921.00
207_P229_A2.6431.00
106_L135_E2.5921.00
153_V177_I2.5151.00
197_V200_K2.4561.00
185_V240_I2.3811.00
184_N237_N2.3081.00
48_I67_E2.2681.00
105_L136_V2.2561.00
238_K260_V2.2011.00
44_K49_E2.1961.00
212_E216_K2.1431.00
87_L152_V2.1241.00
157_A168_I2.0921.00
211_K215_K2.0901.00
210_A229_A2.0761.00
2_I27_D2.0441.00
107_A157_A2.0371.00
42_Y46_L2.0051.00
206_T209_E1.9591.00
214_S226_L1.9201.00
179_K234_N1.9131.00
43_T50_P1.8211.00
109_R126_E1.8171.00
209_E212_E1.8061.00
161_E164_T1.7911.00
21_D248_R1.7881.00
138_S142_N1.7821.00
23_L92_K1.7721.00
73_I100_V1.7691.00
46_L71_V1.7621.00
143_H147_L1.7531.00
16_D86_K1.7481.00
195_V225_L1.7381.00
42_Y75_A1.7271.00
40_T50_P1.7221.00
217_I225_L1.7181.00
232_V239_V1.6961.00
159_D166_L1.6651.00
41_D44_K1.6611.00
42_Y74_M1.6561.00
69_L72_Y1.6341.00
253_A256_L1.6231.00
20_L90_L1.5901.00
59_I172_Q1.5691.00
205_L210_A1.5631.00
62_R167_N1.5521.00
129_Y164_T1.5211.00
111_K126_E1.5191.00
100_V165_P1.4281.00
109_R166_L1.4251.00
51_V65_T1.4141.00
46_L74_M1.3771.00
72_Y156_I1.3761.00
106_L160_V1.3731.00
196_L201_V1.3681.00
141_I177_I1.3561.00
106_L137_R1.3501.00
225_L229_A1.3451.00
53_V63_Y1.3321.00
228_A239_V1.3311.00
110_K132_K1.3291.00
193_E196_L1.3291.00
28_K146_K1.3251.00
105_L177_I1.3141.00
92_K150_I1.3031.00
142_N146_K1.3011.00
177_I181_L1.2941.00
176_A179_K1.2921.00
69_L156_I1.2911.00
156_I165_P1.2881.00
198_E216_K1.2851.00
107_A166_L1.2651.00
211_K229_A1.2621.00
40_T52_F1.2591.00
41_D45_R1.2521.00
51_V63_Y1.2401.00
204_R260_V1.2401.00
80_N96_G1.2231.00
70_E78_L1.2160.99
77_S96_G1.2150.99
195_V205_L1.2010.99
188_L227_M1.1990.99
141_I153_V1.1920.99
80_N84_T1.1890.99
28_K145_V1.1870.99
9_R37_D1.1850.99
144_L149_D1.1780.99
140_I143_H1.1710.99
16_D82_S1.1590.99
87_L92_K1.1460.99
93_N137_R1.1450.99
211_K226_L1.1290.99
73_I165_P1.1270.99
45_R70_E1.1240.99
104_L140_I1.1080.99
95_I144_L1.1050.99
38_I78_L1.0980.99
43_T48_I1.0950.99
48_I71_V1.0680.99
82_S86_K1.0410.98
179_K232_V1.0410.98
84_T96_G1.0330.98
9_R12_K1.0320.98
221_M224_K1.0220.98
240_I257_N1.0180.98
194_G201_V1.0120.98
186_L239_V1.0110.98
197_V202_I1.0070.98
4_V22_I0.9960.98
109_R125_I0.9940.98
176_A230_E0.9930.98
111_K125_I0.9930.98
185_V238_K0.9920.98
67_E70_E0.9750.98
19_I31_L0.9710.97
189_L242_G0.9700.97
212_E215_K0.9610.97
220_G224_K0.9530.97
54_T126_E0.9380.97
104_L153_V0.9360.97
256_L260_V0.9350.97
69_L129_Y0.9280.97
50_P68_E0.9200.96
138_S180_A0.9160.96
133_V157_A0.9160.96
39_V72_Y0.9130.96
226_L230_E0.9080.96
40_T44_K0.9070.96
175_F179_K0.9040.96
3_V183_A0.9030.96
185_V253_A0.9030.96
35_G76_M0.9020.96
140_I149_D0.8990.96
30_I145_V0.8970.96
111_K127_G0.8880.96
207_P233_E0.8860.96
225_L261_I0.8790.95
40_T43_T0.8770.95
102_G149_D0.8730.95
66_K164_T0.8660.95
27_D185_V0.8640.95
73_I82_S0.8640.95
42_Y45_R0.8640.95
15_L18_I0.8570.95
64_T167_N0.8540.95
81_K98_T0.8540.95
54_T123_R0.8500.95
83_I155_P0.8450.94
169_D220_G0.8430.94
6_I11_V0.8390.94
48_I65_T0.8300.94
3_V177_I0.8290.94
175_F227_M0.8280.94
9_R38_I0.8230.94
107_A133_V0.8210.93
171_D224_K0.8210.93
136_V177_I0.8200.93
19_I87_L0.8140.93
59_I127_G0.8070.93
88_C103_G0.8070.93
95_I149_D0.8070.93
250_I254_L0.8050.93
205_L261_I0.8040.93
207_P228_A0.8040.93
193_E245_V0.8010.93
84_T94_A0.8000.93
104_L141_I0.8000.93
128_G220_G0.7960.92
9_R191_D0.7960.92
176_A180_A0.7810.92
44_K47_G0.7800.92
170_G224_K0.7780.92
134_K160_V0.7780.92
105_L168_I0.7770.91
227_M239_V0.7750.91
157_A173_A0.7740.91
20_L23_L0.7680.91
195_V229_A0.7680.91
140_I144_L0.7640.91
71_V75_A0.7640.91
104_L137_R0.7630.91
80_N154_S0.7620.91
257_N260_V0.7620.91
59_I110_K0.7610.91
111_K124_I0.7610.91
210_A225_L0.7600.91
193_E246_K0.7600.91
168_I173_A0.7590.91
106_L134_K0.7580.90
74_M78_L0.7580.90
204_R238_K0.7560.90
48_I68_E0.7500.90
157_A166_L0.7500.90
12_K41_D0.7420.89
81_K101_D0.7410.89
253_A260_V0.7400.89
7_G33_H0.7380.89
14_S247_D0.7310.89
22_I29_V0.7310.89
249_P253_A0.7260.88
25_I254_L0.7260.88
252_N257_N0.7240.88
43_T68_E0.7220.88
107_A168_I0.7110.87
5_K170_G0.7110.87
110_K172_Q0.7090.87
246_K252_N0.7080.87
14_S17_K0.7070.87
6_I10_V0.7070.87
208_S212_E0.7070.87
130_T169_D0.7060.87
207_P232_V0.7040.87
195_V202_I0.7040.87
74_M77_S0.7020.87
5_K171_D0.7020.87
38_I197_V0.7020.87
74_M99_G0.7000.87
211_K214_S0.7000.87
179_K230_E0.6960.86
169_D223_R0.6940.86
83_I200_K0.6920.86
7_G58_G0.6910.86
108_E160_V0.6900.86
59_I132_K0.6850.85
19_I86_K0.6830.85
135_E160_V0.6800.85
85_S89_S0.6780.85
197_V209_E0.6730.84
18_I38_I0.6710.84
23_L150_I0.6710.84
220_G223_R0.6710.84
169_D224_K0.6700.84
23_L90_L0.6680.84
248_R251_I0.6670.84
230_E233_E0.6670.84
190_S221_M0.6660.84
86_K89_S0.6660.84
69_L165_P0.6610.83
96_G101_D0.6600.83
78_L82_S0.6600.83
2_I254_L0.6570.83
38_I41_D0.6550.83
17_K90_L0.6530.83
68_E71_V0.6520.82
4_V31_L0.6510.82
2_I187_I0.6490.82
88_C93_N0.6460.82
21_D253_A0.6450.82
202_I213_L0.6450.82
205_L213_L0.6420.82
136_V173_A0.6410.81
186_L231_S0.6410.81
102_G140_I0.6410.81
137_R140_I0.6400.81
240_I253_A0.6400.81
7_G224_K0.6310.80
39_V76_M0.6280.80
230_E234_N0.6270.80
172_Q226_L0.6260.80
17_K89_S0.6240.80
218_G225_L0.6160.79
206_T229_A0.6130.78
217_I221_M0.6080.78
77_S163_R0.6080.78
207_P211_K0.6070.78
248_R253_A0.6070.78
46_L67_E0.6050.78
206_T210_A0.6020.77
22_I150_I0.6010.77
127_G130_T0.6000.77
177_I180_A0.5970.77
229_A233_E0.5960.77
30_I141_I0.5960.77
187_I250_I0.5920.76
5_K224_K0.5910.76
135_E180_A0.5910.76
13_N245_V0.5910.76
7_G170_G0.5880.76
103_G106_L0.5860.75
105_L157_A0.5840.75
15_L83_I0.5820.75
141_I145_V0.5800.75
58_G224_K0.5800.75
93_N149_D0.5800.75
197_V216_K0.5780.74
130_T220_G0.5770.74
103_G158_L0.5750.74
6_I9_R0.5740.74
248_R252_N0.5740.74
25_I256_L0.5720.74
7_G220_G0.5690.73
197_V213_L0.5690.73
143_H148_F0.5620.72
74_M81_K0.5580.72
59_I226_L0.5580.72
179_K236_V0.5570.72
229_A232_V0.5530.71
86_K146_K0.5520.71
29_V100_V0.5510.71
89_S160_V0.5510.71
185_V256_L0.5500.71
25_I253_A0.5490.71
172_Q176_A0.5470.70
33_H154_S0.5440.70
218_G222_N0.5440.70
48_I72_Y0.5440.70
36_G171_D0.5430.70
8_G34_G0.5430.70
138_S177_I0.5420.70
28_K92_K0.5370.69
77_S85_S0.5360.69
63_Y125_I0.5360.69
68_E75_A0.5310.68
124_I127_G0.5290.68
242_G249_P0.5290.68
36_G169_D0.5270.67
7_G171_D0.5250.67
210_A217_I0.5250.67
174_A186_L0.5250.67
59_I130_T0.5220.67
52_F130_T0.5210.67
129_Y166_L0.5200.66
128_G169_D0.5200.66
7_G221_M0.5200.66
192_V196_L0.5200.66
73_I155_P0.5190.66
19_I38_I0.5160.66
9_R192_V0.5160.66
172_Q175_F0.5150.66
37_D43_T0.5140.66
35_G221_M0.5130.65
172_Q227_M0.5130.65
184_N238_K0.5130.65
158_L163_R0.5130.65
53_V127_G0.5120.65
25_I251_I0.5100.65
22_I31_L0.5100.65
79_I83_I0.5100.65
205_L211_K0.5090.65
130_T223_R0.5090.65
196_L202_I0.5090.65
4_V212_E0.5080.65
96_G102_G0.5080.65
196_L199_G0.5070.64
87_L90_L0.5060.64
7_G167_N0.5060.64
5_K33_H0.5040.64
73_I81_K0.5040.64
64_T69_L0.5040.64
251_I254_L0.5040.64
38_I42_Y0.5030.64
187_I240_I0.5030.64
169_D221_M0.5020.64
36_G130_T0.5010.64
139_E143_H0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wwnA 2 0.9659 100 0.352 Contact Map
2ap9A 3 0.9545 100 0.354 Contact Map
2bufA 3 0.9697 100 0.364 Contact Map
2btyA 3 0.9356 100 0.372 Contact Map
2v5hA 3 0.9318 100 0.373 Contact Map
2rd5A 3 0.9318 100 0.376 Contact Map
3l86A 1 0.8939 100 0.382 Contact Map
3s6kA 3 0.9167 100 0.383 Contact Map
3s6gA 4 0.9167 100 0.386 Contact Map
1gs5A 2 0.9205 100 0.386 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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