ARGB - SULSO - GREMLIN Contacts

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ARGB - Acetylglutamate/acetylaminoadipate kinase

UniProt:	Q980X0	Sequences: MIVVKIGGRVVKNSLDKIILDILNINDKVILVHGGGDIVTDYTKRLGIEPVFVTSPEGIRSRYTTKEELEVYIMAMSLINKSITSKLCSLGKNAIGITGVDGGLLLAERKKRIVVIDERGKKRIIEGGYTGKVKEVRSEIINHLVKLFDIIVVSPIALDVEERTPLNIDGDQAAFAISKALRANVLILLSDVEGVLVEGKVINRLTPSEAKELSKKIGPGMNRKLLMAAESVENGVNKVIIGSGVKDRPIINALELNGTVIANG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	264 (243)
Sequences:	3570 (2004)
Seq/√Len:	128.6

ECOLI - ARGB ARGA
BACSU - ARGB
SULSO - ARGB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
30_I	181_L	3.922	1.00
108_E	134_K	3.816	1.00
65_T	68_E	3.704	1.00
159_D	164_T	3.511	1.00
193_E	243_S	3.040	1.00
66_K	129_Y	2.927	1.00
211_K	233_E	2.923	1.00
105_L	173_A	2.831	1.00
108_E	132_K	2.792	1.00
207_P	229_A	2.643	1.00
106_L	135_E	2.592	1.00
153_V	177_I	2.515	1.00
197_V	200_K	2.456	1.00
185_V	240_I	2.381	1.00
184_N	237_N	2.308	1.00
48_I	67_E	2.268	1.00
105_L	136_V	2.256	1.00
238_K	260_V	2.201	1.00
44_K	49_E	2.196	1.00
212_E	216_K	2.143	1.00
87_L	152_V	2.124	1.00
157_A	168_I	2.092	1.00
211_K	215_K	2.090	1.00
210_A	229_A	2.076	1.00
2_I	27_D	2.044	1.00
107_A	157_A	2.037	1.00
42_Y	46_L	2.005	1.00
206_T	209_E	1.959	1.00
214_S	226_L	1.920	1.00
179_K	234_N	1.913	1.00
43_T	50_P	1.821	1.00
109_R	126_E	1.817	1.00
209_E	212_E	1.806	1.00
161_E	164_T	1.791	1.00
21_D	248_R	1.788	1.00
138_S	142_N	1.782	1.00
23_L	92_K	1.772	1.00
73_I	100_V	1.769	1.00
46_L	71_V	1.762	1.00
143_H	147_L	1.753	1.00
16_D	86_K	1.748	1.00
195_V	225_L	1.738	1.00
42_Y	75_A	1.727	1.00
40_T	50_P	1.722	1.00
217_I	225_L	1.718	1.00
232_V	239_V	1.696	1.00
159_D	166_L	1.665	1.00
41_D	44_K	1.661	1.00
42_Y	74_M	1.656	1.00
69_L	72_Y	1.634	1.00
253_A	256_L	1.623	1.00
20_L	90_L	1.590	1.00
59_I	172_Q	1.569	1.00
205_L	210_A	1.563	1.00
62_R	167_N	1.552	1.00
129_Y	164_T	1.521	1.00
111_K	126_E	1.519	1.00
100_V	165_P	1.428	1.00
109_R	166_L	1.425	1.00
51_V	65_T	1.414	1.00
46_L	74_M	1.377	1.00
72_Y	156_I	1.376	1.00
106_L	160_V	1.373	1.00
196_L	201_V	1.368	1.00
141_I	177_I	1.356	1.00
106_L	137_R	1.350	1.00
225_L	229_A	1.345	1.00
53_V	63_Y	1.332	1.00
228_A	239_V	1.331	1.00
110_K	132_K	1.329	1.00
193_E	196_L	1.329	1.00
28_K	146_K	1.325	1.00
105_L	177_I	1.314	1.00
92_K	150_I	1.303	1.00
142_N	146_K	1.301	1.00
177_I	181_L	1.294	1.00
176_A	179_K	1.292	1.00
69_L	156_I	1.291	1.00
156_I	165_P	1.288	1.00
198_E	216_K	1.285	1.00
107_A	166_L	1.265	1.00
211_K	229_A	1.262	1.00
40_T	52_F	1.259	1.00
41_D	45_R	1.252	1.00
51_V	63_Y	1.240	1.00
204_R	260_V	1.240	1.00
80_N	96_G	1.223	1.00
70_E	78_L	1.216	0.99
77_S	96_G	1.215	0.99
195_V	205_L	1.201	0.99
188_L	227_M	1.199	0.99
141_I	153_V	1.192	0.99
80_N	84_T	1.189	0.99
28_K	145_V	1.187	0.99
9_R	37_D	1.185	0.99
144_L	149_D	1.178	0.99
140_I	143_H	1.171	0.99
16_D	82_S	1.159	0.99
87_L	92_K	1.146	0.99
93_N	137_R	1.145	0.99
211_K	226_L	1.129	0.99
73_I	165_P	1.127	0.99
45_R	70_E	1.124	0.99
104_L	140_I	1.108	0.99
95_I	144_L	1.105	0.99
38_I	78_L	1.098	0.99
43_T	48_I	1.095	0.99
48_I	71_V	1.068	0.99
82_S	86_K	1.041	0.98
179_K	232_V	1.041	0.98
84_T	96_G	1.033	0.98
9_R	12_K	1.032	0.98
221_M	224_K	1.022	0.98
240_I	257_N	1.018	0.98
194_G	201_V	1.012	0.98
186_L	239_V	1.011	0.98
197_V	202_I	1.007	0.98
4_V	22_I	0.996	0.98
109_R	125_I	0.994	0.98
176_A	230_E	0.993	0.98
111_K	125_I	0.993	0.98
185_V	238_K	0.992	0.98
67_E	70_E	0.975	0.98
19_I	31_L	0.971	0.97
189_L	242_G	0.970	0.97
212_E	215_K	0.961	0.97
220_G	224_K	0.953	0.97
54_T	126_E	0.938	0.97
104_L	153_V	0.936	0.97
256_L	260_V	0.935	0.97
69_L	129_Y	0.928	0.97
50_P	68_E	0.920	0.96
138_S	180_A	0.916	0.96
133_V	157_A	0.916	0.96
39_V	72_Y	0.913	0.96
226_L	230_E	0.908	0.96
40_T	44_K	0.907	0.96
175_F	179_K	0.904	0.96
3_V	183_A	0.903	0.96
185_V	253_A	0.903	0.96
35_G	76_M	0.902	0.96
140_I	149_D	0.899	0.96
30_I	145_V	0.897	0.96
111_K	127_G	0.888	0.96
207_P	233_E	0.886	0.96
225_L	261_I	0.879	0.95
40_T	43_T	0.877	0.95
102_G	149_D	0.873	0.95
66_K	164_T	0.866	0.95
27_D	185_V	0.864	0.95
73_I	82_S	0.864	0.95
42_Y	45_R	0.864	0.95
15_L	18_I	0.857	0.95
64_T	167_N	0.854	0.95
81_K	98_T	0.854	0.95
54_T	123_R	0.850	0.95
83_I	155_P	0.845	0.94
169_D	220_G	0.843	0.94
6_I	11_V	0.839	0.94
48_I	65_T	0.830	0.94
3_V	177_I	0.829	0.94
175_F	227_M	0.828	0.94
9_R	38_I	0.823	0.94
107_A	133_V	0.821	0.93
171_D	224_K	0.821	0.93
136_V	177_I	0.820	0.93
19_I	87_L	0.814	0.93
59_I	127_G	0.807	0.93
88_C	103_G	0.807	0.93
95_I	149_D	0.807	0.93
250_I	254_L	0.805	0.93
205_L	261_I	0.804	0.93
207_P	228_A	0.804	0.93
193_E	245_V	0.801	0.93
84_T	94_A	0.800	0.93
104_L	141_I	0.800	0.93
128_G	220_G	0.796	0.92
9_R	191_D	0.796	0.92
176_A	180_A	0.781	0.92
44_K	47_G	0.780	0.92
170_G	224_K	0.778	0.92
134_K	160_V	0.778	0.92
105_L	168_I	0.777	0.91
227_M	239_V	0.775	0.91
157_A	173_A	0.774	0.91
20_L	23_L	0.768	0.91
195_V	229_A	0.768	0.91
140_I	144_L	0.764	0.91
71_V	75_A	0.764	0.91
104_L	137_R	0.763	0.91
80_N	154_S	0.762	0.91
257_N	260_V	0.762	0.91
59_I	110_K	0.761	0.91
111_K	124_I	0.761	0.91
210_A	225_L	0.760	0.91
193_E	246_K	0.760	0.91
168_I	173_A	0.759	0.91
106_L	134_K	0.758	0.90
74_M	78_L	0.758	0.90
204_R	238_K	0.756	0.90
48_I	68_E	0.750	0.90
157_A	166_L	0.750	0.90
12_K	41_D	0.742	0.89
81_K	101_D	0.741	0.89
253_A	260_V	0.740	0.89
7_G	33_H	0.738	0.89
14_S	247_D	0.731	0.89
22_I	29_V	0.731	0.89
249_P	253_A	0.726	0.88
25_I	254_L	0.726	0.88
252_N	257_N	0.724	0.88
43_T	68_E	0.722	0.88
107_A	168_I	0.711	0.87
5_K	170_G	0.711	0.87
110_K	172_Q	0.709	0.87
246_K	252_N	0.708	0.87
14_S	17_K	0.707	0.87
6_I	10_V	0.707	0.87
208_S	212_E	0.707	0.87
130_T	169_D	0.706	0.87
207_P	232_V	0.704	0.87
195_V	202_I	0.704	0.87
74_M	77_S	0.702	0.87
5_K	171_D	0.702	0.87
38_I	197_V	0.702	0.87
74_M	99_G	0.700	0.87
211_K	214_S	0.700	0.87
179_K	230_E	0.696	0.86
169_D	223_R	0.694	0.86
83_I	200_K	0.692	0.86
7_G	58_G	0.691	0.86
108_E	160_V	0.690	0.86
59_I	132_K	0.685	0.85
19_I	86_K	0.683	0.85
135_E	160_V	0.680	0.85
85_S	89_S	0.678	0.85
197_V	209_E	0.673	0.84
18_I	38_I	0.671	0.84
23_L	150_I	0.671	0.84
220_G	223_R	0.671	0.84
169_D	224_K	0.670	0.84
23_L	90_L	0.668	0.84
248_R	251_I	0.667	0.84
230_E	233_E	0.667	0.84
190_S	221_M	0.666	0.84
86_K	89_S	0.666	0.84
69_L	165_P	0.661	0.83
96_G	101_D	0.660	0.83
78_L	82_S	0.660	0.83
2_I	254_L	0.657	0.83
38_I	41_D	0.655	0.83
17_K	90_L	0.653	0.83
68_E	71_V	0.652	0.82
4_V	31_L	0.651	0.82
2_I	187_I	0.649	0.82
88_C	93_N	0.646	0.82
21_D	253_A	0.645	0.82
202_I	213_L	0.645	0.82
205_L	213_L	0.642	0.82
136_V	173_A	0.641	0.81
186_L	231_S	0.641	0.81
102_G	140_I	0.641	0.81
137_R	140_I	0.640	0.81
240_I	253_A	0.640	0.81
7_G	224_K	0.631	0.80
39_V	76_M	0.628	0.80
230_E	234_N	0.627	0.80
172_Q	226_L	0.626	0.80
17_K	89_S	0.624	0.80
218_G	225_L	0.616	0.79
206_T	229_A	0.613	0.78
217_I	221_M	0.608	0.78
77_S	163_R	0.608	0.78
207_P	211_K	0.607	0.78
248_R	253_A	0.607	0.78
46_L	67_E	0.605	0.78
206_T	210_A	0.602	0.77
22_I	150_I	0.601	0.77
127_G	130_T	0.600	0.77
177_I	180_A	0.597	0.77
229_A	233_E	0.596	0.77
30_I	141_I	0.596	0.77
187_I	250_I	0.592	0.76
5_K	224_K	0.591	0.76
135_E	180_A	0.591	0.76
13_N	245_V	0.591	0.76
7_G	170_G	0.588	0.76
103_G	106_L	0.586	0.75
105_L	157_A	0.584	0.75
15_L	83_I	0.582	0.75
141_I	145_V	0.580	0.75
58_G	224_K	0.580	0.75
93_N	149_D	0.580	0.75
197_V	216_K	0.578	0.74
130_T	220_G	0.577	0.74
103_G	158_L	0.575	0.74
6_I	9_R	0.574	0.74
248_R	252_N	0.574	0.74
25_I	256_L	0.572	0.74
7_G	220_G	0.569	0.73
197_V	213_L	0.569	0.73
143_H	148_F	0.562	0.72
74_M	81_K	0.558	0.72
59_I	226_L	0.558	0.72
179_K	236_V	0.557	0.72
229_A	232_V	0.553	0.71
86_K	146_K	0.552	0.71
29_V	100_V	0.551	0.71
89_S	160_V	0.551	0.71
185_V	256_L	0.550	0.71
25_I	253_A	0.549	0.71
172_Q	176_A	0.547	0.70
33_H	154_S	0.544	0.70
218_G	222_N	0.544	0.70
48_I	72_Y	0.544	0.70
36_G	171_D	0.543	0.70
8_G	34_G	0.543	0.70
138_S	177_I	0.542	0.70
28_K	92_K	0.537	0.69
77_S	85_S	0.536	0.69
63_Y	125_I	0.536	0.69
68_E	75_A	0.531	0.68
124_I	127_G	0.529	0.68
242_G	249_P	0.529	0.68
36_G	169_D	0.527	0.67
7_G	171_D	0.525	0.67
210_A	217_I	0.525	0.67
174_A	186_L	0.525	0.67
59_I	130_T	0.522	0.67
52_F	130_T	0.521	0.67
129_Y	166_L	0.520	0.66
128_G	169_D	0.520	0.66
7_G	221_M	0.520	0.66
192_V	196_L	0.520	0.66
73_I	155_P	0.519	0.66
19_I	38_I	0.516	0.66
9_R	192_V	0.516	0.66
172_Q	175_F	0.515	0.66
37_D	43_T	0.514	0.66
35_G	221_M	0.513	0.65
172_Q	227_M	0.513	0.65
184_N	238_K	0.513	0.65
158_L	163_R	0.513	0.65
53_V	127_G	0.512	0.65
25_I	251_I	0.510	0.65
22_I	31_L	0.510	0.65
79_I	83_I	0.510	0.65
205_L	211_K	0.509	0.65
130_T	223_R	0.509	0.65
196_L	202_I	0.509	0.65
4_V	212_E	0.508	0.65
96_G	102_G	0.508	0.65
196_L	199_G	0.507	0.64
87_L	90_L	0.506	0.64
7_G	167_N	0.506	0.64
5_K	33_H	0.504	0.64
73_I	81_K	0.504	0.64
64_T	69_L	0.504	0.64
251_I	254_L	0.504	0.64
38_I	42_Y	0.503	0.64
187_I	240_I	0.503	0.64
169_D	221_M	0.502	0.64
36_G	130_T	0.501	0.64
139_E	143_H	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wwnA	2	0.9659	100	0.352	Contact Map
2ap9A	3	0.9545	100	0.354	Contact Map
2bufA	3	0.9697	100	0.364	Contact Map
2btyA	3	0.9356	100	0.372	Contact Map
2v5hA	3	0.9318	100	0.373	Contact Map
2rd5A	3	0.9318	100	0.376	Contact Map
3l86A	1	0.8939	100	0.382	Contact Map
3s6kA	3	0.9167	100	0.383	Contact Map
3s6gA	4	0.9167	100	0.386	Contact Map
1gs5A	2	0.9205	100	0.386	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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