Q980W1 - SULSO - GREMLIN Contacts

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Q980W1 - UDP-glucose 4-epimerase (GalE-2)

UniProt:	Q980W1	Sequences: MYIVTGGAGYIGGHLVDYLISKNLEVIVIDDLSYGKYRNEKAKFVMFDLRQNMGELVEKLEKNPIIYHLAANPDVRTSMINVEEHFERDVKVTLNVMELARRVDAEKVIFTSSSTVYGETSKIPTPESEELKPISNYGLFKLLCENIVKYYAEQYGIKSISTRLANITGGRVSHGVVIDFIKKLKDNPNLLEILGNGKQRKSYLYIDDLIEAFVMLEKKVNRIYDVFNIGNNDSITVDEIAKIVIDEMKLSPRITYKNPTADGRGWPGDVRLMLLDISKISREVGWSPKMSSREVIRQAVKDLLYGYKSVY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	311 (287)
Sequences:	61429 (42509)
Seq/√Len:	2509.2

ECOLI - GALE RMLB2 GM4D HLDD RMLB1 YBJS FCL YFCH RMLD YEEZ QOR2 ARNA YBJT YRAR
BACSU - RMLB YFNG YTCB GALE YFHF SPSK YTBQ YESF YWNB YHFK YHEG EPSC
HALSA - Q9HSU9 Q9HSV1 Q9HRD1 Q9HML4 Q9HSE7 Q9HS50 Q9HNV3 Q9HSQ3 Q9HPF1 Q9HR86
SULSO - Q980W1 Q97VN5 Q7LXG5 Q97XJ9 Q97XG1 Q7LXE8 Q97UM3 Q7LX44 Q7LXE6 Q97XF9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
7_G	28_V	3.242	1.00
243_I	293_R	2.809	1.00
212_A	229_I	2.719	1.00
18_Y	211_E	2.710	1.00
225_D	279_K	2.583	1.00
57_V	102_R	2.575	1.00
227_F	283_E	2.510	1.00
87_E	91_K	2.491	1.00
65_I	217_E	2.374	1.00
246_D	293_R	2.320	1.00
29_I	47_F	2.272	1.00
291_S	294_E	2.265	1.00
107_K	158_K	2.193	1.00
111_T	213_F	2.183	1.00
51_Q	55_E	2.180	1.00
81_N	84_E	2.161	1.00
18_Y	22_K	2.151	1.00
281_S	287_S	2.126	1.00
126_P	129_E	2.109	1.00
5_T	68_H	2.078	1.00
68_H	110_F	2.051	1.00
4_V	16_V	2.049	1.00
211_E	289_K	2.039	1.00
3_I	63_N	2.020	1.00
18_Y	214_V	2.017	1.00
67_Y	217_E	2.013	1.00
47_F	55_E	1.956	1.00
22_K	218_K	1.940	1.00
238_D	242_K	1.938	1.00
168_T	295_V	1.934	1.00
247_E	297_R	1.906	1.00
27_I	43_K	1.903	1.00
27_I	63_N	1.884	1.00
211_E	215_M	1.840	1.00
243_I	246_D	1.837	1.00
148_V	159_S	1.810	1.00
207_D	298_Q	1.804	1.00
25_E	43_K	1.801	1.00
236_T	239_E	1.763	1.00
164_L	213_F	1.751	1.00
52_N	98_E	1.714	1.00
50_R	87_E	1.679	1.00
27_I	45_V	1.679	1.00
232_N	281_S	1.677	1.00
162_T	216_L	1.666	1.00
94_L	147_I	1.644	1.00
15_L	210_I	1.623	1.00
182_K	186_D	1.616	1.00
57_V	99_L	1.609	1.00
94_L	98_E	1.608	1.00
15_L	67_Y	1.606	1.00
127_E	279_K	1.576	1.00
205_Y	298_Q	1.576	1.00
86_F	143_L	1.544	1.00
18_Y	21_S	1.543	1.00
214_V	218_K	1.520	1.00
32_L	44_F	1.517	1.00
280_I	284_V	1.511	1.00
64_P	106_E	1.510	1.00
91_K	94_L	1.506	1.00
22_K	214_V	1.503	1.00
239_E	242_K	1.503	1.00
27_I	61_E	1.503	1.00
243_I	247_E	1.492	1.00
101_R	155_Y	1.488	1.00
11_I	167_I	1.455	1.00
142_L	146_N	1.447	1.00
68_H	93_T	1.446	1.00
83_E	87_E	1.446	1.00
15_L	69_L	1.443	1.00
183_K	188_P	1.431	1.00
66_I	100_A	1.430	1.00
277_I	281_S	1.428	1.00
117_Y	228_N	1.424	1.00
55_E	58_E	1.420	1.00
18_Y	210_I	1.415	1.00
16_V	28_V	1.409	1.00
131_L	142_L	1.404	1.00
107_K	160_I	1.403	1.00
164_L	209_L	1.401	1.00
190_L	255_T	1.397	1.00
162_T	213_F	1.396	1.00
206_I	210_I	1.379	1.00
137_Y	141_K	1.376	1.00
215_M	219_K	1.374	1.00
24_L	218_K	1.373	1.00
93_T	144_C	1.361	1.00
205_Y	295_V	1.356	1.00
52_N	95_N	1.348	1.00
67_Y	213_F	1.346	1.00
17_D	171_R	1.330	1.00
96_V	108_V	1.328	1.00
57_V	103_V	1.319	1.00
49_L	92_V	1.319	1.00
89_D	140_F	1.318	1.00
112_S	116_V	1.313	1.00
69_L	111_T	1.308	1.00
146_N	149_K	1.308	1.00
294_E	297_R	1.298	1.00
165_A	275_L	1.265	1.00
97_M	151_Y	1.260	1.00
192_E	255_T	1.249	1.00
294_E	298_Q	1.236	1.00
98_E	101_R	1.227	1.00
20_I	42_A	1.220	1.00
204_L	209_L	1.217	1.00
126_P	276_D	1.216	1.00
111_T	164_L	1.212	1.00
52_N	57_V	1.194	1.00
7_G	16_V	1.174	1.00
277_I	288_P	1.166	1.00
19_L	214_V	1.162	1.00
110_F	148_V	1.160	1.00
60_L	66_I	1.154	1.00
100_A	108_V	1.153	1.00
125_T	129_E	1.144	1.00
149_K	161_S	1.142	1.00
163_R	226_V	1.140	1.00
8_A	30_D	1.139	1.00
200_R	234_S	1.138	1.00
51_Q	54_G	1.130	1.00
149_K	226_V	1.125	1.00
110_F	144_C	1.125	1.00
98_E	102_R	1.117	1.00
211_E	286_W	1.102	1.00
3_I	29_I	1.100	1.00
17_D	21_S	1.099	1.00
152_A	159_S	1.099	1.00
139_L	143_L	1.097	1.00
225_D	283_E	1.095	1.00
238_D	256_Y	1.089	1.00
279_K	283_E	1.088	1.00
202_S	232_N	1.078	1.00
128_S	279_K	1.078	1.00
235_I	292_S	1.074	1.00
14_H	207_D	1.068	1.00
176_V	180_F	1.062	1.00
212_A	280_I	1.058	1.00
49_L	70_A	1.053	1.00
10_Y	169_G	1.052	1.00
43_K	61_E	1.048	1.00
20_I	41_K	1.046	1.00
198_K	238_D	1.045	1.00
147_I	150_Y	1.040	1.00
28_V	42_A	1.036	1.00
100_A	105_A	1.035	1.00
18_Y	207_D	1.035	1.00
245_I	251_S	1.025	1.00
227_F	279_K	1.022	1.00
60_L	63_N	1.020	1.00
56_L	99_L	1.018	1.00
293_R	297_R	1.017	1.00
13_G	171_R	1.016	1.00
97_M	108_V	1.010	1.00
242_K	245_I	1.010	1.00
149_K	159_S	1.010	1.00
88_R	92_V	1.003	1.00
109_I	162_T	1.000	1.00
2_Y	24_L	0.998	1.00
54_G	58_E	0.997	1.00
205_Y	208_D	0.985	1.00
230_G	275_L	0.982	1.00
190_L	253_R	0.981	1.00
145_E	163_R	0.980	1.00
247_E	300_V	0.978	1.00
168_T	205_Y	0.970	1.00
69_L	213_F	0.969	1.00
234_S	272_L	0.968	1.00
54_G	57_V	0.967	1.00
99_L	103_V	0.966	1.00
29_I	59_K	0.963	1.00
29_I	56_L	0.962	1.00
215_M	284_V	0.959	1.00
24_L	64_P	0.959	1.00
108_V	148_V	0.947	1.00
72_N	88_R	0.943	1.00
163_R	228_N	0.943	1.00
110_F	161_S	0.941	1.00
10_Y	206_I	0.939	1.00
158_K	223_I	0.937	1.00
122_K	126_P	0.936	1.00
97_M	147_I	0.934	1.00
208_D	231_N	0.934	1.00
248_M	300_V	0.933	1.00
167_I	209_L	0.931	1.00
101_R	157_I	0.930	1.00
245_I	252_P	0.928	1.00
95_N	98_E	0.925	1.00
45_V	59_K	0.922	1.00
5_T	70_A	0.918	1.00
60_L	99_L	0.914	1.00
247_E	296_I	0.912	1.00
32_L	35_G	0.909	1.00
65_I	107_K	0.908	1.00
198_K	236_T	0.906	1.00
91_K	95_N	0.906	1.00
5_T	96_V	0.905	1.00
27_I	62_K	0.905	1.00
235_I	239_E	0.904	1.00
16_V	26_V	0.900	1.00
112_S	145_E	0.899	1.00
14_H	206_I	0.898	1.00
55_E	59_K	0.895	1.00
20_I	26_V	0.888	1.00
150_Y	154_Q	0.887	1.00
234_S	274_L	0.883	1.00
200_R	236_T	0.879	1.00
149_K	153_E	0.876	1.00
161_S	226_V	0.874	1.00
85_H	140_F	0.874	1.00
162_T	229_I	0.863	1.00
31_D	48_D	0.862	1.00
97_M	148_V	0.862	1.00
212_A	286_W	0.861	1.00
60_L	103_V	0.858	1.00
230_G	277_I	0.857	1.00
86_F	90_V	0.856	1.00
160_I	216_L	0.853	1.00
29_I	55_E	0.852	1.00
167_I	204_L	0.850	1.00
122_K	129_E	0.847	1.00
216_L	284_V	0.844	1.00
52_N	102_R	0.842	1.00
99_L	102_R	0.838	1.00
14_H	18_Y	0.836	1.00
15_L	19_L	0.835	1.00
77_T	81_N	0.834	1.00
215_M	218_K	0.832	1.00
222_R	225_D	0.832	1.00
127_E	280_I	0.831	1.00
33_S	46_M	0.830	1.00
235_I	240_I	0.830	1.00
30_D	44_F	0.829	1.00
14_H	17_D	0.827	1.00
143_L	146_N	0.827	1.00
245_I	250_L	0.826	1.00
86_F	91_K	0.819	1.00
50_R	88_R	0.808	1.00
247_E	293_R	0.804	1.00
90_V	143_L	0.803	1.00
216_L	280_I	0.797	1.00
32_L	46_M	0.796	1.00
95_N	99_L	0.795	1.00
229_I	280_I	0.789	1.00
254_I	258_N	0.787	1.00
179_D	182_K	0.782	1.00
215_M	285_G	0.781	1.00
48_D	51_Q	0.780	1.00
60_L	100_A	0.779	1.00
211_E	214_V	0.774	1.00
232_N	277_I	0.774	1.00
86_F	140_F	0.774	1.00
123_I	129_E	0.773	1.00
51_Q	56_L	0.772	1.00
56_L	95_N	0.769	1.00
179_D	183_K	0.769	1.00
79_M	136_N	0.761	1.00
165_A	230_G	0.754	1.00
182_K	185_K	0.748	1.00
66_I	96_V	0.747	1.00
215_M	286_W	0.745	1.00
15_L	213_F	0.743	1.00
200_R	272_L	0.742	1.00
106_E	158_K	0.742	1.00
72_N	84_E	0.737	1.00
98_E	151_Y	0.736	1.00
25_E	41_K	0.736	1.00
151_Y	155_Y	0.731	1.00
242_K	246_D	0.729	1.00
197_G	238_D	0.725	1.00
175_G	178_I	0.724	1.00
170_G	298_Q	0.722	1.00
93_T	148_V	0.722	1.00
14_H	210_I	0.716	1.00
116_V	145_E	0.714	1.00
66_I	108_V	0.714	1.00
144_C	148_V	0.712	1.00
3_I	47_F	0.711	1.00
92_V	95_N	0.711	1.00
278_S	281_S	0.708	1.00
84_E	87_E	0.707	1.00
93_T	97_M	0.706	1.00
2_Y	65_I	0.706	1.00
219_K	222_R	0.705	1.00
11_I	209_L	0.705	1.00
82_V	139_L	0.693	1.00
146_N	150_Y	0.688	1.00
68_H	96_V	0.686	1.00
114_S	165_A	0.685	1.00
101_R	156_G	0.685	1.00
233_D	291_S	0.685	1.00
181_I	185_K	0.682	1.00
222_R	283_E	0.681	1.00
121_S	129_E	0.680	1.00
243_I	292_S	0.679	1.00
13_G	17_D	0.677	1.00
3_I	66_I	0.677	1.00
208_D	211_E	0.676	1.00
185_K	188_P	0.675	1.00
143_L	147_I	0.675	1.00
114_S	275_L	0.674	1.00
281_S	288_P	0.674	1.00
27_I	59_K	0.671	1.00
239_E	243_I	0.668	1.00
32_L	37_Y	0.668	1.00
135_S	138_G	0.666	1.00
170_G	205_Y	0.665	1.00
72_N	85_H	0.664	1.00
120_T	125_T	0.662	1.00
127_E	228_N	0.661	1.00
240_I	292_S	0.658	1.00
133_P	138_G	0.657	1.00
184_L	245_I	0.656	1.00
192_E	257_K	0.653	1.00
45_V	61_E	0.646	1.00
181_I	244_V	0.643	1.00
139_L	146_N	0.639	1.00
72_N	89_D	0.638	1.00
84_E	88_R	0.637	1.00
24_L	65_I	0.636	1.00
124_P	276_D	0.635	1.00
208_D	289_K	0.628	1.00
181_I	300_V	0.627	1.00
210_I	214_V	0.627	1.00
56_L	60_L	0.626	1.00
82_V	136_N	0.626	1.00
86_F	139_L	0.625	1.00
101_R	151_Y	0.625	1.00
71_A	89_D	0.624	1.00
59_K	63_N	0.620	1.00
45_V	55_E	0.620	1.00
4_V	19_L	0.619	1.00
19_L	217_E	0.614	1.00
233_D	293_R	0.614	1.00
280_I	283_E	0.607	1.00
65_I	106_E	0.606	1.00
255_T	258_N	0.602	1.00
162_T	212_A	0.601	1.00
180_F	183_K	0.600	1.00
65_I	109_I	0.600	1.00
115_T	138_G	0.600	1.00
68_H	108_V	0.598	1.00
109_I	217_E	0.595	1.00
289_K	294_E	0.595	1.00
159_S	224_Y	0.592	1.00
136_N	139_L	0.590	1.00
223_I	227_F	0.590	1.00
22_K	215_M	0.589	1.00
221_N	225_D	0.587	1.00
37_Y	46_M	0.586	1.00
202_S	231_N	0.584	1.00
118_G	132_K	0.582	1.00
199_Q	237_V	0.581	1.00
245_I	248_M	0.579	1.00
100_A	103_V	0.579	1.00
166_N	201_K	0.578	1.00
136_N	140_F	0.578	1.00
3_I	59_K	0.576	1.00
180_F	184_L	0.574	1.00
187_N	250_L	0.574	1.00
16_V	20_I	0.574	1.00
140_F	144_C	0.573	1.00
14_H	171_R	0.572	1.00
184_L	191_L	0.570	1.00
97_M	101_R	0.568	1.00
270_V	273_M	0.568	1.00
221_N	224_Y	0.568	1.00
35_G	39_N	0.562	1.00
23_N	26_V	0.562	1.00
200_R	274_L	0.561	1.00
148_V	161_S	0.561	1.00
4_V	28_V	0.560	1.00
116_V	131_L	0.559	1.00
19_L	67_Y	0.559	1.00
109_I	216_L	0.558	1.00
8_A	32_L	0.558	1.00
22_K	211_E	0.557	1.00
202_S	234_S	0.557	1.00
111_T	162_T	0.556	1.00
93_T	110_F	0.556	1.00
124_P	274_L	0.555	1.00
113_S	141_K	0.554	1.00
254_I	257_K	0.554	1.00
110_F	113_S	0.552	1.00
150_Y	153_E	0.551	1.00
266_W	269_D	0.549	1.00
241_A	245_I	0.548	1.00
131_L	146_N	0.548	1.00
243_I	296_I	0.547	1.00
183_K	186_D	0.546	1.00
175_G	179_D	0.540	1.00
126_P	278_S	0.539	1.00
139_L	150_Y	0.539	1.00
3_I	60_L	0.537	1.00
209_L	229_I	0.536	1.00
94_L	150_Y	0.536	1.00
62_K	103_V	0.535	1.00
15_L	214_V	0.534	1.00
137_Y	140_F	0.534	1.00
109_I	213_F	0.533	1.00
183_K	192_E	0.531	1.00
170_G	207_D	0.531	1.00
17_D	207_D	0.531	1.00
235_I	243_I	0.529	1.00
214_V	217_E	0.528	1.00
52_N	99_L	0.527	1.00
28_V	44_F	0.523	1.00
10_Y	14_H	0.523	1.00
176_V	183_K	0.519	1.00
245_I	254_I	0.517	1.00
133_P	142_L	0.517	1.00
100_A	104_D	0.516	1.00
147_I	151_Y	0.516	1.00
47_F	56_L	0.516	1.00
252_P	255_T	0.514	1.00
61_E	103_V	0.514	1.00
113_S	116_V	0.513	1.00
244_V	300_V	0.512	1.00
66_I	105_A	0.510	1.00
205_Y	299_A	0.509	1.00
164_L	167_I	0.509	1.00
58_E	61_E	0.509	1.00
4_V	7_G	0.508	1.00
227_F	280_I	0.508	1.00
67_Y	214_V	0.508	1.00
184_L	244_V	0.507	1.00
89_D	137_Y	0.505	1.00
8_A	28_V	0.503	1.00
178_I	182_K	0.501	1.00
244_V	296_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sb8A	2	0.9807	100	0.169	Contact Map
3rufA	2	0.9646	100	0.173	Contact Map
1rkxA	3	0.9582	100	0.195	Contact Map
2q1sA	2	0.9357	100	0.196	Contact Map
3ko8A	2	0.9357	100	0.197	Contact Map
3m2pA	2	0.9421	100	0.199	Contact Map
1orrA	3	0.9582	100	0.199	Contact Map
4wkgA	5	0.9904	100	0.2	Contact Map
2c20A	2	0.9775	100	0.2	Contact Map
1gy8A	2	0.9743	100	0.201	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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