GREMLIN Database
Q980W1 - UDP-glucose 4-epimerase (GalE-2)
UniProt: Q980W1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (287)
Sequences: 61429 (42509)
Seq/√Len: 2509.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_G28_V3.2421.00
243_I293_R2.8091.00
212_A229_I2.7191.00
18_Y211_E2.7101.00
225_D279_K2.5831.00
57_V102_R2.5751.00
227_F283_E2.5101.00
87_E91_K2.4911.00
65_I217_E2.3741.00
246_D293_R2.3201.00
29_I47_F2.2721.00
291_S294_E2.2651.00
107_K158_K2.1931.00
111_T213_F2.1831.00
51_Q55_E2.1801.00
81_N84_E2.1611.00
18_Y22_K2.1511.00
281_S287_S2.1261.00
126_P129_E2.1091.00
5_T68_H2.0781.00
68_H110_F2.0511.00
4_V16_V2.0491.00
211_E289_K2.0391.00
3_I63_N2.0201.00
18_Y214_V2.0171.00
67_Y217_E2.0131.00
47_F55_E1.9561.00
22_K218_K1.9401.00
238_D242_K1.9381.00
168_T295_V1.9341.00
247_E297_R1.9061.00
27_I43_K1.9031.00
27_I63_N1.8841.00
211_E215_M1.8401.00
243_I246_D1.8371.00
148_V159_S1.8101.00
207_D298_Q1.8041.00
25_E43_K1.8011.00
236_T239_E1.7631.00
164_L213_F1.7511.00
52_N98_E1.7141.00
50_R87_E1.6791.00
27_I45_V1.6791.00
232_N281_S1.6771.00
162_T216_L1.6661.00
94_L147_I1.6441.00
15_L210_I1.6231.00
182_K186_D1.6161.00
57_V99_L1.6091.00
94_L98_E1.6081.00
15_L67_Y1.6061.00
127_E279_K1.5761.00
205_Y298_Q1.5761.00
86_F143_L1.5441.00
18_Y21_S1.5431.00
214_V218_K1.5201.00
32_L44_F1.5171.00
280_I284_V1.5111.00
64_P106_E1.5101.00
91_K94_L1.5061.00
22_K214_V1.5031.00
239_E242_K1.5031.00
27_I61_E1.5031.00
243_I247_E1.4921.00
101_R155_Y1.4881.00
11_I167_I1.4551.00
142_L146_N1.4471.00
68_H93_T1.4461.00
83_E87_E1.4461.00
15_L69_L1.4431.00
183_K188_P1.4311.00
66_I100_A1.4301.00
277_I281_S1.4281.00
117_Y228_N1.4241.00
55_E58_E1.4201.00
18_Y210_I1.4151.00
16_V28_V1.4091.00
131_L142_L1.4041.00
107_K160_I1.4031.00
164_L209_L1.4011.00
190_L255_T1.3971.00
162_T213_F1.3961.00
206_I210_I1.3791.00
137_Y141_K1.3761.00
215_M219_K1.3741.00
24_L218_K1.3731.00
93_T144_C1.3611.00
205_Y295_V1.3561.00
52_N95_N1.3481.00
67_Y213_F1.3461.00
17_D171_R1.3301.00
96_V108_V1.3281.00
57_V103_V1.3191.00
49_L92_V1.3191.00
89_D140_F1.3181.00
112_S116_V1.3131.00
69_L111_T1.3081.00
146_N149_K1.3081.00
294_E297_R1.2981.00
165_A275_L1.2651.00
97_M151_Y1.2601.00
192_E255_T1.2491.00
294_E298_Q1.2361.00
98_E101_R1.2271.00
20_I42_A1.2201.00
204_L209_L1.2171.00
126_P276_D1.2161.00
111_T164_L1.2121.00
52_N57_V1.1941.00
7_G16_V1.1741.00
277_I288_P1.1661.00
19_L214_V1.1621.00
110_F148_V1.1601.00
60_L66_I1.1541.00
100_A108_V1.1531.00
125_T129_E1.1441.00
149_K161_S1.1421.00
163_R226_V1.1401.00
8_A30_D1.1391.00
200_R234_S1.1381.00
51_Q54_G1.1301.00
149_K226_V1.1251.00
110_F144_C1.1251.00
98_E102_R1.1171.00
211_E286_W1.1021.00
3_I29_I1.1001.00
17_D21_S1.0991.00
152_A159_S1.0991.00
139_L143_L1.0971.00
225_D283_E1.0951.00
238_D256_Y1.0891.00
279_K283_E1.0881.00
202_S232_N1.0781.00
128_S279_K1.0781.00
235_I292_S1.0741.00
14_H207_D1.0681.00
176_V180_F1.0621.00
212_A280_I1.0581.00
49_L70_A1.0531.00
10_Y169_G1.0521.00
43_K61_E1.0481.00
20_I41_K1.0461.00
198_K238_D1.0451.00
147_I150_Y1.0401.00
28_V42_A1.0361.00
100_A105_A1.0351.00
18_Y207_D1.0351.00
245_I251_S1.0251.00
227_F279_K1.0221.00
60_L63_N1.0201.00
56_L99_L1.0181.00
293_R297_R1.0171.00
13_G171_R1.0161.00
97_M108_V1.0101.00
242_K245_I1.0101.00
149_K159_S1.0101.00
88_R92_V1.0031.00
109_I162_T1.0001.00
2_Y24_L0.9981.00
54_G58_E0.9971.00
205_Y208_D0.9851.00
230_G275_L0.9821.00
190_L253_R0.9811.00
145_E163_R0.9801.00
247_E300_V0.9781.00
168_T205_Y0.9701.00
69_L213_F0.9691.00
234_S272_L0.9681.00
54_G57_V0.9671.00
99_L103_V0.9661.00
29_I59_K0.9631.00
29_I56_L0.9621.00
215_M284_V0.9591.00
24_L64_P0.9591.00
108_V148_V0.9471.00
72_N88_R0.9431.00
163_R228_N0.9431.00
110_F161_S0.9411.00
10_Y206_I0.9391.00
158_K223_I0.9371.00
122_K126_P0.9361.00
97_M147_I0.9341.00
208_D231_N0.9341.00
248_M300_V0.9331.00
167_I209_L0.9311.00
101_R157_I0.9301.00
245_I252_P0.9281.00
95_N98_E0.9251.00
45_V59_K0.9221.00
5_T70_A0.9181.00
60_L99_L0.9141.00
247_E296_I0.9121.00
32_L35_G0.9091.00
65_I107_K0.9081.00
198_K236_T0.9061.00
91_K95_N0.9061.00
5_T96_V0.9051.00
27_I62_K0.9051.00
235_I239_E0.9041.00
16_V26_V0.9001.00
112_S145_E0.8991.00
14_H206_I0.8981.00
55_E59_K0.8951.00
20_I26_V0.8881.00
150_Y154_Q0.8871.00
234_S274_L0.8831.00
200_R236_T0.8791.00
149_K153_E0.8761.00
161_S226_V0.8741.00
85_H140_F0.8741.00
162_T229_I0.8631.00
31_D48_D0.8621.00
97_M148_V0.8621.00
212_A286_W0.8611.00
60_L103_V0.8581.00
230_G277_I0.8571.00
86_F90_V0.8561.00
160_I216_L0.8531.00
29_I55_E0.8521.00
167_I204_L0.8501.00
122_K129_E0.8471.00
216_L284_V0.8441.00
52_N102_R0.8421.00
99_L102_R0.8381.00
14_H18_Y0.8361.00
15_L19_L0.8351.00
77_T81_N0.8341.00
215_M218_K0.8321.00
222_R225_D0.8321.00
127_E280_I0.8311.00
33_S46_M0.8301.00
235_I240_I0.8301.00
30_D44_F0.8291.00
14_H17_D0.8271.00
143_L146_N0.8271.00
245_I250_L0.8261.00
86_F91_K0.8191.00
50_R88_R0.8081.00
247_E293_R0.8041.00
90_V143_L0.8031.00
216_L280_I0.7971.00
32_L46_M0.7961.00
95_N99_L0.7951.00
229_I280_I0.7891.00
254_I258_N0.7871.00
179_D182_K0.7821.00
215_M285_G0.7811.00
48_D51_Q0.7801.00
60_L100_A0.7791.00
211_E214_V0.7741.00
232_N277_I0.7741.00
86_F140_F0.7741.00
123_I129_E0.7731.00
51_Q56_L0.7721.00
56_L95_N0.7691.00
179_D183_K0.7691.00
79_M136_N0.7611.00
165_A230_G0.7541.00
182_K185_K0.7481.00
66_I96_V0.7471.00
215_M286_W0.7451.00
15_L213_F0.7431.00
200_R272_L0.7421.00
106_E158_K0.7421.00
72_N84_E0.7371.00
98_E151_Y0.7361.00
25_E41_K0.7361.00
151_Y155_Y0.7311.00
242_K246_D0.7291.00
197_G238_D0.7251.00
175_G178_I0.7241.00
170_G298_Q0.7221.00
93_T148_V0.7221.00
14_H210_I0.7161.00
116_V145_E0.7141.00
66_I108_V0.7141.00
144_C148_V0.7121.00
3_I47_F0.7111.00
92_V95_N0.7111.00
278_S281_S0.7081.00
84_E87_E0.7071.00
93_T97_M0.7061.00
2_Y65_I0.7061.00
219_K222_R0.7051.00
11_I209_L0.7051.00
82_V139_L0.6931.00
146_N150_Y0.6881.00
68_H96_V0.6861.00
114_S165_A0.6851.00
101_R156_G0.6851.00
233_D291_S0.6851.00
181_I185_K0.6821.00
222_R283_E0.6811.00
121_S129_E0.6801.00
243_I292_S0.6791.00
13_G17_D0.6771.00
3_I66_I0.6771.00
208_D211_E0.6761.00
185_K188_P0.6751.00
143_L147_I0.6751.00
114_S275_L0.6741.00
281_S288_P0.6741.00
27_I59_K0.6711.00
239_E243_I0.6681.00
32_L37_Y0.6681.00
135_S138_G0.6661.00
170_G205_Y0.6651.00
72_N85_H0.6641.00
120_T125_T0.6621.00
127_E228_N0.6611.00
240_I292_S0.6581.00
133_P138_G0.6571.00
184_L245_I0.6561.00
192_E257_K0.6531.00
45_V61_E0.6461.00
181_I244_V0.6431.00
139_L146_N0.6391.00
72_N89_D0.6381.00
84_E88_R0.6371.00
24_L65_I0.6361.00
124_P276_D0.6351.00
208_D289_K0.6281.00
181_I300_V0.6271.00
210_I214_V0.6271.00
56_L60_L0.6261.00
82_V136_N0.6261.00
86_F139_L0.6251.00
101_R151_Y0.6251.00
71_A89_D0.6241.00
59_K63_N0.6201.00
45_V55_E0.6201.00
4_V19_L0.6191.00
19_L217_E0.6141.00
233_D293_R0.6141.00
280_I283_E0.6071.00
65_I106_E0.6061.00
255_T258_N0.6021.00
162_T212_A0.6011.00
180_F183_K0.6001.00
65_I109_I0.6001.00
115_T138_G0.6001.00
68_H108_V0.5981.00
109_I217_E0.5951.00
289_K294_E0.5951.00
159_S224_Y0.5921.00
136_N139_L0.5901.00
223_I227_F0.5901.00
22_K215_M0.5891.00
221_N225_D0.5871.00
37_Y46_M0.5861.00
202_S231_N0.5841.00
118_G132_K0.5821.00
199_Q237_V0.5811.00
245_I248_M0.5791.00
100_A103_V0.5791.00
166_N201_K0.5781.00
136_N140_F0.5781.00
3_I59_K0.5761.00
180_F184_L0.5741.00
187_N250_L0.5741.00
16_V20_I0.5741.00
140_F144_C0.5731.00
14_H171_R0.5721.00
184_L191_L0.5701.00
97_M101_R0.5681.00
270_V273_M0.5681.00
221_N224_Y0.5681.00
35_G39_N0.5621.00
23_N26_V0.5621.00
200_R274_L0.5611.00
148_V161_S0.5611.00
4_V28_V0.5601.00
116_V131_L0.5591.00
19_L67_Y0.5591.00
109_I216_L0.5581.00
8_A32_L0.5581.00
22_K211_E0.5571.00
202_S234_S0.5571.00
111_T162_T0.5561.00
93_T110_F0.5561.00
124_P274_L0.5551.00
113_S141_K0.5541.00
254_I257_K0.5541.00
110_F113_S0.5521.00
150_Y153_E0.5511.00
266_W269_D0.5491.00
241_A245_I0.5481.00
131_L146_N0.5481.00
243_I296_I0.5471.00
183_K186_D0.5461.00
175_G179_D0.5401.00
126_P278_S0.5391.00
139_L150_Y0.5391.00
3_I60_L0.5371.00
209_L229_I0.5361.00
94_L150_Y0.5361.00
62_K103_V0.5351.00
15_L214_V0.5341.00
137_Y140_F0.5341.00
109_I213_F0.5331.00
183_K192_E0.5311.00
170_G207_D0.5311.00
17_D207_D0.5311.00
235_I243_I0.5291.00
214_V217_E0.5281.00
52_N99_L0.5271.00
28_V44_F0.5231.00
10_Y14_H0.5231.00
176_V183_K0.5191.00
245_I254_I0.5171.00
133_P142_L0.5171.00
100_A104_D0.5161.00
147_I151_Y0.5161.00
47_F56_L0.5161.00
252_P255_T0.5141.00
61_E103_V0.5141.00
113_S116_V0.5131.00
244_V300_V0.5121.00
66_I105_A0.5101.00
205_Y299_A0.5091.00
164_L167_I0.5091.00
58_E61_E0.5091.00
4_V7_G0.5081.00
227_F280_I0.5081.00
67_Y214_V0.5081.00
184_L244_V0.5071.00
89_D137_Y0.5051.00
8_A28_V0.5031.00
178_I182_K0.5011.00
244_V296_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sb8A 2 0.9807 100 0.169 Contact Map
3rufA 2 0.9646 100 0.173 Contact Map
1rkxA 3 0.9582 100 0.195 Contact Map
2q1sA 2 0.9357 100 0.196 Contact Map
3ko8A 2 0.9357 100 0.197 Contact Map
3m2pA 2 0.9421 100 0.199 Contact Map
1orrA 3 0.9582 100 0.199 Contact Map
4wkgA 5 0.9904 100 0.2 Contact Map
2c20A 2 0.9775 100 0.2 Contact Map
1gy8A 2 0.9743 100 0.201 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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