GREMLIN Database
Q980W0 - Methyl coenzyme M reductase system, component A2 homolog
UniProt: Q980W0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (287)
Sequences: 1663 (1498)
Seq/√Len: 88.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_G173_V4.0881.00
72_S75_I3.9881.00
35_I162_A3.2231.00
289_K292_N2.9411.00
37_S43_Q2.7531.00
77_A111_N2.7351.00
78_S86_L2.7141.00
267_D270_F2.5921.00
78_S82_D2.5181.00
286_S290_L2.3541.00
19_E175_R2.3391.00
170_R191_E2.3181.00
94_D98_A2.2301.00
245_G249_T2.2141.00
238_L245_G2.2141.00
22_G169_L2.1951.00
6_P9_L2.1791.00
237_I244_N2.1201.00
238_L242_G2.0951.00
110_F121_Y2.0721.00
241_L245_G2.0561.00
39_L135_L2.0531.00
72_S76_L2.0361.00
248_K252_L2.0351.00
248_K255_L2.0291.00
242_G245_G2.0261.00
83_E125_S1.9721.00
237_I241_L1.9711.00
225_I228_F1.9381.00
273_F277_E1.8941.00
245_G252_L1.8851.00
155_V159_S1.8821.00
230_I233_R1.8811.00
228_F231_K1.8721.00
9_L183_K1.7951.00
235_G239_C1.7871.00
268_L271_F1.7511.00
223_V226_D1.7461.00
92_S95_D1.7431.00
233_R238_L1.7261.00
273_F276_R1.7231.00
245_G248_K1.6881.00
284_V288_F1.6481.00
276_R279_V1.6411.00
81_K93_V1.6161.00
249_T256_S1.5871.00
188_I192_K1.5781.00
91_H95_D1.5741.00
245_G259_I1.5691.00
186_N193_L1.5671.00
237_I251_I1.5661.00
252_L259_I1.5651.00
35_I135_L1.5571.00
282_K285_L1.5441.00
189_S192_K1.5351.00
249_T255_L1.5351.00
105_Y108_V1.5221.00
268_L275_V1.5211.00
88_K128_A1.5181.00
238_L241_L1.5071.00
241_L244_N1.4961.00
251_I258_K1.4871.00
148_V165_R1.4680.99
248_K256_S1.4530.99
37_S44_T1.4520.99
232_I236_E1.4360.99
254_K258_K1.4350.99
15_I21_V1.4330.99
238_L244_N1.4230.99
275_V278_I1.4200.99
232_I238_L1.4110.99
253_R257_K1.4010.99
240_L247_G1.3940.99
236_E243_R1.3910.99
233_R237_I1.3900.99
225_I231_K1.3890.99
269_Q273_F1.3670.99
226_D231_K1.3660.99
255_L259_I1.3640.99
232_I235_G1.3630.99
226_D233_R1.3520.99
37_S48_V1.3520.99
233_R236_E1.3510.99
231_K234_E1.3420.99
249_T253_R1.3400.99
241_L248_K1.3390.99
289_K293_L1.3380.99
138_E164_H1.3370.99
252_L256_S1.3370.99
274_T281_S1.3360.99
252_L255_L1.3350.99
230_I234_E1.3290.99
269_Q272_Y1.3270.99
274_T292_N1.3230.99
292_N296_K1.3220.99
243_R246_S1.3090.99
233_R240_L1.2760.99
236_E239_C1.2750.99
78_S83_E1.2720.98
242_G249_T1.2690.98
244_N251_I1.2650.98
287_L290_L1.2540.98
225_I233_R1.2480.98
65_S131_P1.2330.98
281_S289_K1.2230.98
237_I245_G1.2220.98
21_V177_Y1.2200.98
253_R259_I1.2160.98
228_F235_G1.2030.98
264_Q268_L1.1960.98
204_L207_F1.1940.98
73_S76_L1.1830.98
81_K85_E1.1770.97
225_I230_I1.1690.97
249_T252_L1.1670.97
267_D274_T1.1640.97
247_G255_L1.1610.97
235_G242_G1.1460.97
256_S259_I1.1430.97
169_L173_V1.1400.97
245_G251_I1.1290.97
233_R239_C1.1250.97
240_L252_L1.1150.96
244_N247_G1.1130.96
286_S289_K1.1060.96
234_E238_L1.1050.96
227_N231_K1.0960.96
231_K238_L1.0930.96
232_I241_L1.0890.96
227_N239_C1.0860.96
142_N148_V1.0840.96
236_E245_G1.0820.96
227_N230_I1.0820.96
108_V112_K1.0700.96
16_E19_E1.0630.95
244_N259_I1.0620.95
228_F233_R1.0560.95
24_V176_V1.0550.95
226_D234_E1.0540.95
80_L113_L1.0490.95
268_L289_K1.0440.95
225_I229_T1.0400.95
274_T277_E1.0390.95
234_E242_G1.0360.95
253_R256_S1.0350.95
263_F271_F1.0350.95
230_I237_I1.0330.95
163_E169_L1.0330.95
223_V230_I1.0260.94
97_I100_N1.0150.94
153_T156_P1.0100.94
235_G241_L1.0010.94
281_S292_N0.9990.94
245_G255_L0.9950.93
226_D232_I0.9870.93
224_N231_K0.9860.93
237_I242_G0.9840.93
292_N295_D0.9810.93
226_D230_I0.9700.93
231_K236_E0.9680.92
274_T282_K0.9670.92
220_I224_N0.9660.92
248_K251_I0.9640.92
194_F197_E0.9610.92
258_K261_V0.9580.92
202_E206_G0.9570.92
285_L290_L0.9530.92
230_I238_L0.9460.92
248_K253_R0.9430.91
272_Y276_R0.9430.91
27_N138_E0.9400.91
244_N248_K0.9370.91
31_K138_E0.9310.91
67_V119_K0.9290.91
233_R241_L0.9290.91
232_I239_C0.9280.91
229_T233_R0.9270.91
241_L246_S0.9080.90
261_V264_Q0.9000.89
225_I232_I0.8990.89
243_R247_G0.8990.89
242_G248_K0.8970.89
8_Y37_S0.8970.89
163_E166_I0.8960.89
135_L160_L0.8940.89
285_L289_K0.8930.89
27_N142_N0.8920.89
227_N232_I0.8910.89
230_I241_L0.8880.89
222_N226_D0.8870.89
228_F232_I0.8860.89
244_N249_T0.8840.89
141_A166_I0.8830.89
82_D86_L0.8790.88
203_G207_F0.8780.88
234_E245_G0.8740.88
228_F234_E0.8740.88
251_I254_K0.8700.88
240_L244_N0.8680.88
39_L66_A0.8590.87
13_I177_Y0.8530.87
83_E110_F0.8530.87
36_L41_L0.8510.87
260_F263_F0.8510.87
43_Q48_V0.8500.87
6_P44_T0.8460.86
134_I143_L0.8430.86
201_K204_L0.8350.86
262_I265_E0.8330.86
163_E168_E0.8310.85
268_L272_Y0.8300.85
251_I255_L0.8260.85
263_F268_L0.8200.85
286_S291_E0.8180.84
239_C244_N0.8180.84
115_D120_R0.8160.84
263_F272_Y0.8150.84
220_I237_I0.8140.84
219_E222_N0.8090.84
246_S256_S0.8040.83
282_K292_N0.8040.83
220_I225_I0.7970.83
32_T36_L0.7970.83
242_G246_S0.7940.83
79_T82_D0.7940.83
94_D106_Y0.7930.83
247_G254_K0.7930.83
277_E280_R0.7910.82
221_L234_E0.7910.82
234_E237_I0.7900.82
119_K142_N0.7900.82
265_E268_L0.7840.82
246_S253_R0.7830.82
234_E241_L0.7810.82
75_I78_S0.7810.82
141_A165_R0.7800.82
221_L228_F0.7800.82
222_N228_F0.7780.81
245_G256_S0.7770.81
285_L288_F0.7760.81
229_T232_I0.7740.81
273_F279_V0.7720.81
96_K124_A0.7720.81
214_S218_N0.7690.81
264_Q267_D0.7680.81
267_D271_F0.7660.80
200_R203_G0.7640.80
84_I87_M0.7620.80
251_I256_S0.7580.80
161_I169_L0.7560.79
142_N154_I0.7560.79
243_R249_T0.7530.79
246_S252_L0.7520.79
245_G258_K0.7510.79
92_S96_K0.7510.79
122_A127_L0.7480.79
240_L255_L0.7460.79
224_N227_N0.7450.78
100_N124_A0.7450.78
161_I173_V0.7440.78
228_F236_E0.7430.78
240_L248_K0.7400.78
246_S249_T0.7400.78
271_F289_K0.7380.78
244_N258_K0.7350.78
200_R204_L0.7330.77
76_L82_D0.7320.77
248_K259_I0.7320.77
272_Y275_V0.7310.77
234_E240_L0.7270.77
281_S284_V0.7260.77
104_H107_E0.7220.76
24_V178_M0.7210.76
236_E240_L0.7210.76
268_L292_N0.7200.76
94_D142_N0.7180.76
277_E281_S0.7120.75
211_K214_S0.7120.75
36_L117_Y0.7110.75
246_S250_T0.7110.75
226_D229_T0.7110.75
242_G252_L0.7100.75
203_G206_G0.7100.75
222_N233_R0.7090.75
80_L121_Y0.7060.75
67_V83_E0.7060.75
242_G247_G0.6970.74
197_E201_K0.6940.73
239_C242_G0.6870.73
286_S292_N0.6860.73
84_I88_K0.6860.73
238_L248_K0.6820.72
95_D99_R0.6820.72
218_N222_N0.6810.72
260_F264_Q0.6800.72
224_N233_R0.6780.72
282_K289_K0.6760.71
68_L71_V0.6710.71
83_E87_M0.6700.71
238_L243_R0.6690.71
240_L246_S0.6670.70
221_L224_N0.6660.70
222_N230_I0.6660.70
36_L66_A0.6650.70
225_I240_L0.6630.70
152_S168_E0.6630.70
252_L258_K0.6630.70
279_V283_R0.6620.70
216_L250_T0.6610.70
33_T115_D0.6580.69
27_N139_P0.6570.69
148_V168_E0.6570.69
200_R207_F0.6560.69
288_F291_E0.6550.69
167_E171_K0.6530.69
270_F274_T0.6480.68
10_N183_K0.6460.68
220_I223_V0.6450.68
241_L249_T0.6400.67
99_R102_M0.6390.67
240_L254_K0.6380.67
70_D83_E0.6380.67
120_R143_L0.6360.67
255_L258_K0.6340.67
238_L246_S0.6300.66
141_A168_E0.6300.66
165_R168_E0.6290.66
142_N168_E0.6230.65
278_I289_K0.6230.65
221_L225_I0.6210.65
268_L279_V0.6160.64
263_F270_F0.6150.64
238_L247_G0.6140.64
80_L83_E0.6140.64
223_V236_E0.6120.64
91_H98_A0.6110.64
256_S260_F0.6090.63
217_G238_L0.6090.63
67_V70_D0.6080.63
236_E244_N0.6060.63
87_M125_S0.6050.63
247_G252_L0.6050.63
98_A154_I0.6040.63
93_V97_I0.6030.63
7_K68_L0.6030.63
240_L258_K0.6030.63
27_N141_A0.6030.63
229_T234_E0.6020.63
139_P164_H0.6020.63
232_I242_G0.6000.62
84_I93_V0.5980.62
201_K205_R0.5950.62
27_N143_L0.5950.62
31_K164_H0.5950.62
254_K257_K0.5940.62
210_P216_L0.5920.61
219_E223_V0.5900.61
95_D98_A0.5880.61
294_A297_S0.5880.61
233_R258_K0.5870.61
237_I291_E0.5860.61
31_K137_D0.5850.60
227_N235_G0.5850.60
27_N110_F0.5840.60
245_G253_R0.5840.60
239_C247_G0.5840.60
31_K69_Q0.5830.60
119_K131_P0.5830.60
96_K101_L0.5800.60
237_I240_L0.5790.60
26_K177_Y0.5780.59
117_Y166_I0.5770.59
274_T278_I0.5770.59
247_G251_I0.5710.59
121_Y136_L0.5690.58
35_I68_L0.5690.58
234_E239_C0.5670.58
222_N225_I0.5670.58
36_L65_S0.5660.58
244_N254_K0.5620.57
234_E248_K0.5600.57
39_L64_I0.5590.57
69_Q115_D0.5590.57
250_T257_K0.5560.57
79_T83_E0.5550.56
270_F273_F0.5540.56
139_P163_E0.5540.56
251_I259_I0.5530.56
279_V282_K0.5510.56
266_V269_Q0.5510.56
186_N196_I0.5510.56
283_R287_L0.5500.56
235_G243_R0.5500.56
266_V270_F0.5480.55
236_E241_L0.5470.55
147_G154_I0.5470.55
231_K241_L0.5450.55
35_I66_A0.5430.55
253_R258_K0.5400.54
271_F274_T0.5390.54
223_V231_K0.5380.54
241_L247_G0.5380.54
121_Y147_G0.5310.53
231_K235_G0.5280.53
117_Y142_N0.5280.53
119_K186_N0.5270.53
168_E190_K0.5260.53
254_K287_L0.5250.52
117_Y126_V0.5240.52
269_Q281_S0.5220.52
231_K251_I0.5220.52
212_I215_E0.5210.52
271_F278_I0.5200.52
243_R255_L0.5160.51
242_G255_L0.5160.51
240_L243_R0.5130.51
202_E205_R0.5130.51
216_L219_E0.5120.51
51_D158_N0.5090.50
134_I138_E0.5080.50
285_L292_N0.5080.50
106_Y154_I0.5070.50
229_T237_I0.5060.50
101_L168_E0.5060.50
263_F266_V0.5040.50
239_C243_R0.5020.49
224_N228_F0.5020.49
189_S193_L0.5020.49
217_G223_V0.5000.49
221_L247_G0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q9hA 1 0.9544 100 0.372 Contact Map
4finA 2 0.9651 100 0.396 Contact Map
4ry2A 2 0.555 100 0.406 Contact Map
4f4cA 1 0.5201 100 0.406 Contact Map
3ux8A 2 0.9088 100 0.414 Contact Map
2iw3A 2 0.9651 100 0.421 Contact Map
4a82A 2 0.5523 100 0.431 Contact Map
4mrsA 2 0.5764 100 0.433 Contact Map
3b5xA 2 0.5523 100 0.433 Contact Map
3b60A 2 0.5523 100 0.434 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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