Q980W0 - SULSO - GREMLIN Contacts

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Q980W0 - Methyl coenzyme M reductase system, component A2 homolog

UniProt:	Q980W0	Sequences: MLIISPKYLNGKIEIEKGERVGLVGKNGSGKTTLILSALCLDQTTSNVTVDDLDFCKEKDYSKISAVLQDVSSQILASTLKDEIELMKRFHSVDDKIARNLMGHYYEVEFNKLSDGYKKRYAIASVLASNPEYILLDEPFANLDDKGVKSVSTIVPKNSLIAEHRIEELRKLVDRVYMIRNNKEINEISKEKLFDIEFLRKEGLRGFSLPKINSELGNEILNVNIDNFTIKIREGEILCLLGRNGSGKTTILRKLSKKIFVIFQEVDLQFFYFTVREIVRSKRVLSLFKLENLADKSPYALSFGQKMRILIASAFSSDSRVIGLDEPSVGMDGEALLSFYEMVKMLKEQKRGLILATHDKDIISLCDTRIVID	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	373 (287)
Sequences:	1663 (1498)
Seq/√Len:	88.4

ECOLI - RBSA PROV LSRA ARAG MALK POTG POTA YCJV MODC UUP FBPC CYSA YHES GSIA YDCT METN UGPC YTFR ALSA XYLG OPPD OPPF DPPF YPHE SAPD MGLA DDPD YADG MACB DPPD CYDD YEHX DDPF MDLB CYDC MDLA MSBA YOJI ETTA FEPC YBHF HISP NIKE MLAF SAPF SSUB TAUB BTUD FECE YECC FHUC GLNQ PHNC YEJF YHDZ ZNUC LPTB SUFC MODF NIKD LIVG PSTB PHNK LIVF GLTL THIQ ARTP FTSE LOLD YDDA FETA
BACSU - YFMM YKPA OPUBA OPUAA YVRA OPUCA RBSA MSMX YURJ TAGH YDIF OPPD METN YFMR YHCH YVFR YKFD YUFO YFIL YCBN DPPD APPF YHEH YXLF SUNT APPD YDBJ YFIC BMRA YHAQ YFIB YKNV YGAD YKOD CYDD YTRB OPPF YHEI YKNU ECFA2 YWJA EXPZ ECFA1 YUSV FHUC YFMF CYDC TCYN YLMA SUFC YCLP SKFE SSUB ECSA ALBC BCEA YXEO YTLC PSTB1 YVCR YXDL YJKB FTSE TCYC PSTB2 NATA MNTB GLNQ ARTM YTHP YYBJ YVRO ZNUC YKNY YCLH
HALSA - Q9HMX3 BTUDA Q9HHQ5 Q9HMW0 Q9HNZ9 Q9HR06 Q9HMT3 Q9HMX2 Q9HMU8 Q9HSQ7 Q9HRJ6 PSTB2 Q9HMG1 Q9HRH8 PHNC Q9HHM2 Q9HR21 Y1631 PSTB1 Q9HMG6 Q9HRV7 Q9HNY3 Q9HRZ9 Y2317 Q9HHR7 Q9HS04 Q9HR96
SULSO - Q980W0 Y1893 Y2030 Q97UJ9 Q97YY4 Q97UF2 Q97ZC0 Q97UY8 Q7LX64 Q97VK9 Q97VF5 Q97VC1 Q97VF4 Q97YP3 Q97VH6 Q97YK2 Q97UH3 Q97X18 Q97VK8 Q97UD4 Q97YP7 Q97YP8 Q97YQ7 Q97Z03 Q97U54 Q97UH4 Q97VM2 Q97W42 Q7LY07 Q97V00 Q7LX80 Q97VY4 Q97V01 PSTB Q7LXM4 Q97UG5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
22_G	173_V	4.088	1.00
72_S	75_I	3.988	1.00
35_I	162_A	3.223	1.00
289_K	292_N	2.941	1.00
37_S	43_Q	2.753	1.00
77_A	111_N	2.735	1.00
78_S	86_L	2.714	1.00
267_D	270_F	2.592	1.00
78_S	82_D	2.518	1.00
286_S	290_L	2.354	1.00
19_E	175_R	2.339	1.00
170_R	191_E	2.318	1.00
94_D	98_A	2.230	1.00
245_G	249_T	2.214	1.00
238_L	245_G	2.214	1.00
22_G	169_L	2.195	1.00
6_P	9_L	2.179	1.00
237_I	244_N	2.120	1.00
238_L	242_G	2.095	1.00
110_F	121_Y	2.072	1.00
241_L	245_G	2.056	1.00
39_L	135_L	2.053	1.00
72_S	76_L	2.036	1.00
248_K	252_L	2.035	1.00
248_K	255_L	2.029	1.00
242_G	245_G	2.026	1.00
83_E	125_S	1.972	1.00
237_I	241_L	1.971	1.00
225_I	228_F	1.938	1.00
273_F	277_E	1.894	1.00
245_G	252_L	1.885	1.00
155_V	159_S	1.882	1.00
230_I	233_R	1.881	1.00
228_F	231_K	1.872	1.00
9_L	183_K	1.795	1.00
235_G	239_C	1.787	1.00
268_L	271_F	1.751	1.00
223_V	226_D	1.746	1.00
92_S	95_D	1.743	1.00
233_R	238_L	1.726	1.00
273_F	276_R	1.723	1.00
245_G	248_K	1.688	1.00
284_V	288_F	1.648	1.00
276_R	279_V	1.641	1.00
81_K	93_V	1.616	1.00
249_T	256_S	1.587	1.00
188_I	192_K	1.578	1.00
91_H	95_D	1.574	1.00
245_G	259_I	1.569	1.00
186_N	193_L	1.567	1.00
237_I	251_I	1.566	1.00
252_L	259_I	1.565	1.00
35_I	135_L	1.557	1.00
282_K	285_L	1.544	1.00
189_S	192_K	1.535	1.00
249_T	255_L	1.535	1.00
105_Y	108_V	1.522	1.00
268_L	275_V	1.521	1.00
88_K	128_A	1.518	1.00
238_L	241_L	1.507	1.00
241_L	244_N	1.496	1.00
251_I	258_K	1.487	1.00
148_V	165_R	1.468	0.99
248_K	256_S	1.453	0.99
37_S	44_T	1.452	0.99
232_I	236_E	1.436	0.99
254_K	258_K	1.435	0.99
15_I	21_V	1.433	0.99
238_L	244_N	1.423	0.99
275_V	278_I	1.420	0.99
232_I	238_L	1.411	0.99
253_R	257_K	1.401	0.99
240_L	247_G	1.394	0.99
236_E	243_R	1.391	0.99
233_R	237_I	1.390	0.99
225_I	231_K	1.389	0.99
269_Q	273_F	1.367	0.99
226_D	231_K	1.366	0.99
255_L	259_I	1.364	0.99
232_I	235_G	1.363	0.99
226_D	233_R	1.352	0.99
37_S	48_V	1.352	0.99
233_R	236_E	1.351	0.99
231_K	234_E	1.342	0.99
249_T	253_R	1.340	0.99
241_L	248_K	1.339	0.99
289_K	293_L	1.338	0.99
138_E	164_H	1.337	0.99
252_L	256_S	1.337	0.99
274_T	281_S	1.336	0.99
252_L	255_L	1.335	0.99
230_I	234_E	1.329	0.99
269_Q	272_Y	1.327	0.99
274_T	292_N	1.323	0.99
292_N	296_K	1.322	0.99
243_R	246_S	1.309	0.99
233_R	240_L	1.276	0.99
236_E	239_C	1.275	0.99
78_S	83_E	1.272	0.98
242_G	249_T	1.269	0.98
244_N	251_I	1.265	0.98
287_L	290_L	1.254	0.98
225_I	233_R	1.248	0.98
65_S	131_P	1.233	0.98
281_S	289_K	1.223	0.98
237_I	245_G	1.222	0.98
21_V	177_Y	1.220	0.98
253_R	259_I	1.216	0.98
228_F	235_G	1.203	0.98
264_Q	268_L	1.196	0.98
204_L	207_F	1.194	0.98
73_S	76_L	1.183	0.98
81_K	85_E	1.177	0.97
225_I	230_I	1.169	0.97
249_T	252_L	1.167	0.97
267_D	274_T	1.164	0.97
247_G	255_L	1.161	0.97
235_G	242_G	1.146	0.97
256_S	259_I	1.143	0.97
169_L	173_V	1.140	0.97
245_G	251_I	1.129	0.97
233_R	239_C	1.125	0.97
240_L	252_L	1.115	0.96
244_N	247_G	1.113	0.96
286_S	289_K	1.106	0.96
234_E	238_L	1.105	0.96
227_N	231_K	1.096	0.96
231_K	238_L	1.093	0.96
232_I	241_L	1.089	0.96
227_N	239_C	1.086	0.96
142_N	148_V	1.084	0.96
236_E	245_G	1.082	0.96
227_N	230_I	1.082	0.96
108_V	112_K	1.070	0.96
16_E	19_E	1.063	0.95
244_N	259_I	1.062	0.95
228_F	233_R	1.056	0.95
24_V	176_V	1.055	0.95
226_D	234_E	1.054	0.95
80_L	113_L	1.049	0.95
268_L	289_K	1.044	0.95
225_I	229_T	1.040	0.95
274_T	277_E	1.039	0.95
234_E	242_G	1.036	0.95
253_R	256_S	1.035	0.95
263_F	271_F	1.035	0.95
230_I	237_I	1.033	0.95
163_E	169_L	1.033	0.95
223_V	230_I	1.026	0.94
97_I	100_N	1.015	0.94
153_T	156_P	1.010	0.94
235_G	241_L	1.001	0.94
281_S	292_N	0.999	0.94
245_G	255_L	0.995	0.93
226_D	232_I	0.987	0.93
224_N	231_K	0.986	0.93
237_I	242_G	0.984	0.93
292_N	295_D	0.981	0.93
226_D	230_I	0.970	0.93
231_K	236_E	0.968	0.92
274_T	282_K	0.967	0.92
220_I	224_N	0.966	0.92
248_K	251_I	0.964	0.92
194_F	197_E	0.961	0.92
258_K	261_V	0.958	0.92
202_E	206_G	0.957	0.92
285_L	290_L	0.953	0.92
230_I	238_L	0.946	0.92
248_K	253_R	0.943	0.91
272_Y	276_R	0.943	0.91
27_N	138_E	0.940	0.91
244_N	248_K	0.937	0.91
31_K	138_E	0.931	0.91
67_V	119_K	0.929	0.91
233_R	241_L	0.929	0.91
232_I	239_C	0.928	0.91
229_T	233_R	0.927	0.91
241_L	246_S	0.908	0.90
261_V	264_Q	0.900	0.89
225_I	232_I	0.899	0.89
243_R	247_G	0.899	0.89
242_G	248_K	0.897	0.89
8_Y	37_S	0.897	0.89
163_E	166_I	0.896	0.89
135_L	160_L	0.894	0.89
285_L	289_K	0.893	0.89
27_N	142_N	0.892	0.89
227_N	232_I	0.891	0.89
230_I	241_L	0.888	0.89
222_N	226_D	0.887	0.89
228_F	232_I	0.886	0.89
244_N	249_T	0.884	0.89
141_A	166_I	0.883	0.89
82_D	86_L	0.879	0.88
203_G	207_F	0.878	0.88
234_E	245_G	0.874	0.88
228_F	234_E	0.874	0.88
251_I	254_K	0.870	0.88
240_L	244_N	0.868	0.88
39_L	66_A	0.859	0.87
13_I	177_Y	0.853	0.87
83_E	110_F	0.853	0.87
36_L	41_L	0.851	0.87
260_F	263_F	0.851	0.87
43_Q	48_V	0.850	0.87
6_P	44_T	0.846	0.86
134_I	143_L	0.843	0.86
201_K	204_L	0.835	0.86
262_I	265_E	0.833	0.86
163_E	168_E	0.831	0.85
268_L	272_Y	0.830	0.85
251_I	255_L	0.826	0.85
263_F	268_L	0.820	0.85
286_S	291_E	0.818	0.84
239_C	244_N	0.818	0.84
115_D	120_R	0.816	0.84
263_F	272_Y	0.815	0.84
220_I	237_I	0.814	0.84
219_E	222_N	0.809	0.84
246_S	256_S	0.804	0.83
282_K	292_N	0.804	0.83
220_I	225_I	0.797	0.83
32_T	36_L	0.797	0.83
242_G	246_S	0.794	0.83
79_T	82_D	0.794	0.83
94_D	106_Y	0.793	0.83
247_G	254_K	0.793	0.83
277_E	280_R	0.791	0.82
221_L	234_E	0.791	0.82
234_E	237_I	0.790	0.82
119_K	142_N	0.790	0.82
265_E	268_L	0.784	0.82
246_S	253_R	0.783	0.82
234_E	241_L	0.781	0.82
75_I	78_S	0.781	0.82
141_A	165_R	0.780	0.82
221_L	228_F	0.780	0.82
222_N	228_F	0.778	0.81
245_G	256_S	0.777	0.81
285_L	288_F	0.776	0.81
229_T	232_I	0.774	0.81
273_F	279_V	0.772	0.81
96_K	124_A	0.772	0.81
214_S	218_N	0.769	0.81
264_Q	267_D	0.768	0.81
267_D	271_F	0.766	0.80
200_R	203_G	0.764	0.80
84_I	87_M	0.762	0.80
251_I	256_S	0.758	0.80
161_I	169_L	0.756	0.79
142_N	154_I	0.756	0.79
243_R	249_T	0.753	0.79
246_S	252_L	0.752	0.79
245_G	258_K	0.751	0.79
92_S	96_K	0.751	0.79
122_A	127_L	0.748	0.79
240_L	255_L	0.746	0.79
224_N	227_N	0.745	0.78
100_N	124_A	0.745	0.78
161_I	173_V	0.744	0.78
228_F	236_E	0.743	0.78
240_L	248_K	0.740	0.78
246_S	249_T	0.740	0.78
271_F	289_K	0.738	0.78
244_N	258_K	0.735	0.78
200_R	204_L	0.733	0.77
76_L	82_D	0.732	0.77
248_K	259_I	0.732	0.77
272_Y	275_V	0.731	0.77
234_E	240_L	0.727	0.77
281_S	284_V	0.726	0.77
104_H	107_E	0.722	0.76
24_V	178_M	0.721	0.76
236_E	240_L	0.721	0.76
268_L	292_N	0.720	0.76
94_D	142_N	0.718	0.76
277_E	281_S	0.712	0.75
211_K	214_S	0.712	0.75
36_L	117_Y	0.711	0.75
246_S	250_T	0.711	0.75
226_D	229_T	0.711	0.75
242_G	252_L	0.710	0.75
203_G	206_G	0.710	0.75
222_N	233_R	0.709	0.75
80_L	121_Y	0.706	0.75
67_V	83_E	0.706	0.75
242_G	247_G	0.697	0.74
197_E	201_K	0.694	0.73
239_C	242_G	0.687	0.73
286_S	292_N	0.686	0.73
84_I	88_K	0.686	0.73
238_L	248_K	0.682	0.72
95_D	99_R	0.682	0.72
218_N	222_N	0.681	0.72
260_F	264_Q	0.680	0.72
224_N	233_R	0.678	0.72
282_K	289_K	0.676	0.71
68_L	71_V	0.671	0.71
83_E	87_M	0.670	0.71
238_L	243_R	0.669	0.71
240_L	246_S	0.667	0.70
221_L	224_N	0.666	0.70
222_N	230_I	0.666	0.70
36_L	66_A	0.665	0.70
225_I	240_L	0.663	0.70
152_S	168_E	0.663	0.70
252_L	258_K	0.663	0.70
279_V	283_R	0.662	0.70
216_L	250_T	0.661	0.70
33_T	115_D	0.658	0.69
27_N	139_P	0.657	0.69
148_V	168_E	0.657	0.69
200_R	207_F	0.656	0.69
288_F	291_E	0.655	0.69
167_E	171_K	0.653	0.69
270_F	274_T	0.648	0.68
10_N	183_K	0.646	0.68
220_I	223_V	0.645	0.68
241_L	249_T	0.640	0.67
99_R	102_M	0.639	0.67
240_L	254_K	0.638	0.67
70_D	83_E	0.638	0.67
120_R	143_L	0.636	0.67
255_L	258_K	0.634	0.67
238_L	246_S	0.630	0.66
141_A	168_E	0.630	0.66
165_R	168_E	0.629	0.66
142_N	168_E	0.623	0.65
278_I	289_K	0.623	0.65
221_L	225_I	0.621	0.65
268_L	279_V	0.616	0.64
263_F	270_F	0.615	0.64
238_L	247_G	0.614	0.64
80_L	83_E	0.614	0.64
223_V	236_E	0.612	0.64
91_H	98_A	0.611	0.64
256_S	260_F	0.609	0.63
217_G	238_L	0.609	0.63
67_V	70_D	0.608	0.63
236_E	244_N	0.606	0.63
87_M	125_S	0.605	0.63
247_G	252_L	0.605	0.63
98_A	154_I	0.604	0.63
93_V	97_I	0.603	0.63
7_K	68_L	0.603	0.63
240_L	258_K	0.603	0.63
27_N	141_A	0.603	0.63
229_T	234_E	0.602	0.63
139_P	164_H	0.602	0.63
232_I	242_G	0.600	0.62
84_I	93_V	0.598	0.62
201_K	205_R	0.595	0.62
27_N	143_L	0.595	0.62
31_K	164_H	0.595	0.62
254_K	257_K	0.594	0.62
210_P	216_L	0.592	0.61
219_E	223_V	0.590	0.61
95_D	98_A	0.588	0.61
294_A	297_S	0.588	0.61
233_R	258_K	0.587	0.61
237_I	291_E	0.586	0.61
31_K	137_D	0.585	0.60
227_N	235_G	0.585	0.60
27_N	110_F	0.584	0.60
245_G	253_R	0.584	0.60
239_C	247_G	0.584	0.60
31_K	69_Q	0.583	0.60
119_K	131_P	0.583	0.60
96_K	101_L	0.580	0.60
237_I	240_L	0.579	0.60
26_K	177_Y	0.578	0.59
117_Y	166_I	0.577	0.59
274_T	278_I	0.577	0.59
247_G	251_I	0.571	0.59
121_Y	136_L	0.569	0.58
35_I	68_L	0.569	0.58
234_E	239_C	0.567	0.58
222_N	225_I	0.567	0.58
36_L	65_S	0.566	0.58
244_N	254_K	0.562	0.57
234_E	248_K	0.560	0.57
39_L	64_I	0.559	0.57
69_Q	115_D	0.559	0.57
250_T	257_K	0.556	0.57
79_T	83_E	0.555	0.56
270_F	273_F	0.554	0.56
139_P	163_E	0.554	0.56
251_I	259_I	0.553	0.56
279_V	282_K	0.551	0.56
266_V	269_Q	0.551	0.56
186_N	196_I	0.551	0.56
283_R	287_L	0.550	0.56
235_G	243_R	0.550	0.56
266_V	270_F	0.548	0.55
236_E	241_L	0.547	0.55
147_G	154_I	0.547	0.55
231_K	241_L	0.545	0.55
35_I	66_A	0.543	0.55
253_R	258_K	0.540	0.54
271_F	274_T	0.539	0.54
223_V	231_K	0.538	0.54
241_L	247_G	0.538	0.54
121_Y	147_G	0.531	0.53
231_K	235_G	0.528	0.53
117_Y	142_N	0.528	0.53
119_K	186_N	0.527	0.53
168_E	190_K	0.526	0.53
254_K	287_L	0.525	0.52
117_Y	126_V	0.524	0.52
269_Q	281_S	0.522	0.52
231_K	251_I	0.522	0.52
212_I	215_E	0.521	0.52
271_F	278_I	0.520	0.52
243_R	255_L	0.516	0.51
242_G	255_L	0.516	0.51
240_L	243_R	0.513	0.51
202_E	205_R	0.513	0.51
216_L	219_E	0.512	0.51
51_D	158_N	0.509	0.50
134_I	138_E	0.508	0.50
285_L	292_N	0.508	0.50
106_Y	154_I	0.507	0.50
229_T	237_I	0.506	0.50
101_L	168_E	0.506	0.50
263_F	266_V	0.504	0.50
239_C	243_R	0.502	0.49
224_N	228_F	0.502	0.49
189_S	193_L	0.502	0.49
217_G	223_V	0.500	0.49
221_L	247_G	0.500	0.49

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4q9hA	1	0.9544	100	0.372	Contact Map
4finA	2	0.9651	100	0.396	Contact Map
4ry2A	2	0.555	100	0.406	Contact Map
4f4cA	1	0.5201	100	0.406	Contact Map
3ux8A	2	0.9088	100	0.414	Contact Map
2iw3A	2	0.9651	100	0.421	Contact Map
4a82A	2	0.5523	100	0.431	Contact Map
4mrsA	2	0.5764	100	0.433	Contact Map
3b5xA	2	0.5523	100	0.433	Contact Map
3b60A	2	0.5523	100	0.434	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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