GREMLIN Database
SYDND - Aspartate--tRNA(Asp/Asn) ligase
UniProt: Q980V3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (407)
Sequences: 9419 (4840)
Seq/√Len: 239.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_H244_Q4.5671.00
72_N91_D3.9411.00
14_L17_S3.8031.00
48_I89_A3.7571.00
149_Y203_F3.6671.00
18_E72_N3.5711.00
20_K72_N3.5611.00
142_K146_E3.5121.00
147_T244_Q3.4641.00
18_E90_K3.2821.00
142_K149_Y3.2451.00
146_E150_K3.2131.00
70_V93_E2.9521.00
143_S252_D2.9301.00
192_K202_V2.8931.00
143_S248_N2.7731.00
233_A237_D2.7531.00
358_S395_A2.7241.00
285_E289_S2.5841.00
263_I276_K2.5081.00
321_D334_K2.4391.00
136_I409_T2.4251.00
160_K209_W2.3931.00
48_I71_V2.2541.00
195_L394_H2.2331.00
144_F226_M2.2321.00
22_A70_V2.2141.00
12_P84_G2.2141.00
99_R388_D2.2001.00
140_A405_M2.1631.00
46_G87_V2.1101.00
141_V401_L2.0871.00
145_R155_E2.0841.00
348_F353_I2.0741.00
146_E149_Y2.0531.00
160_K206_A2.0441.00
18_E74_V2.0141.00
367_E371_K2.0121.00
371_K377_P2.0071.00
138_S149_Y1.9921.00
305_L309_Y1.9901.00
74_V90_K1.9501.00
301_G304_E1.9491.00
248_N252_D1.9421.00
16_G74_V1.9151.00
230_M233_A1.9071.00
19_V87_V1.9021.00
133_V411_L1.8991.00
147_T248_N1.8931.00
147_T245_I1.8601.00
271_V315_D1.8501.00
147_T151_H1.8321.00
146_E252_D1.8281.00
238_I395_A1.8271.00
174_P181_E1.8261.00
240_A244_Q1.8211.00
144_F245_I1.8141.00
235_Y342_E1.8111.00
228_V397_F1.8021.00
282_D285_E1.8011.00
76_K88_H1.7981.00
258_E262_K1.7891.00
318_F346_L1.7831.00
332_K361_H1.7791.00
285_E288_K1.7741.00
363_K367_E1.7601.00
368_N372_V1.7491.00
131_Q135_K1.7401.00
21_V46_G1.7311.00
143_S249_M1.7051.00
334_K342_E1.7031.00
335_K342_E1.6981.00
150_K248_N1.6761.00
246_I346_L1.6501.00
367_E384_L1.6481.00
135_K154_V1.6151.00
234_D237_D1.6121.00
40_R45_I1.5881.00
302_T305_L1.5791.00
301_G305_L1.5731.00
368_N371_K1.5401.00
20_K70_V1.5391.00
153_F230_M1.5311.00
332_K362_V1.5271.00
132_A136_I1.5191.00
38_L45_I1.5181.00
367_E377_P1.5151.00
25_V69_I1.5111.00
363_K388_D1.5021.00
74_V88_H1.4971.00
25_V63_I1.4841.00
139_V142_K1.4801.00
300_I304_E1.4761.00
333_Q365_V1.4671.00
117_R124_D1.4541.00
152_G201_R1.4531.00
25_V37_I1.4471.00
128_L132_A1.4291.00
230_M241_L1.4281.00
279_S282_D1.4231.00
280_Y284_I1.4211.00
208_A225_S1.3961.00
274_P277_K1.3931.00
251_N255_R1.3691.00
304_E308_L1.3641.00
129_E411_L1.3601.00
250_I408_L1.3541.00
372_V375_L1.3501.00
89_A92_I1.3461.00
156_V195_L1.3421.00
15_D77_A1.3421.00
376_N379_S1.3351.00
308_L312_L1.3301.00
367_E381_E1.3301.00
140_A249_M1.3201.00
143_S146_E1.3161.00
286_L289_S1.3141.00
139_V252_D1.3121.00
358_S361_H1.3081.00
134_L199_I1.3011.00
233_A395_A1.2831.00
148_L226_M1.2801.00
143_S253_V1.2731.00
236_N240_A1.2591.00
63_I69_I1.2551.00
43_S46_G1.2491.00
306_R309_Y1.2441.00
226_M401_L1.2441.00
35_I57_Y1.2441.00
346_L354_V1.2421.00
365_V368_N1.2381.00
385_K388_D1.2361.00
134_L419_P1.2321.00
70_V95_L1.2211.00
332_K335_K1.2181.00
337_N340_L1.2151.00
201_R230_M1.2101.00
362_V365_V1.2051.00
148_L228_V1.1981.00
324_W333_Q1.1961.00
334_K340_L1.1961.00
21_V39_L1.1951.00
324_W369_S1.1951.00
132_A135_K1.1941.00
146_E248_N1.1891.00
75_V85_V1.1881.00
71_V89_A1.1881.00
104_L107_T1.1861.00
120_E385_K1.1841.00
139_V257_C1.1841.00
306_R310_N1.1731.00
188_P208_A1.1651.00
298_D301_G1.1621.00
259_N262_K1.1591.00
257_C261_L1.1451.00
265_N270_N1.1441.00
331_T357_S1.1401.00
12_P15_D1.1401.00
135_K139_V1.1381.00
240_A277_K1.1371.00
278_V283_A1.1351.00
369_S372_V1.1121.00
244_Q247_Y1.1031.00
144_F401_L1.1031.00
190_L382_F1.0991.00
75_V87_V1.0971.00
302_T306_R1.0951.00
301_G308_L1.0951.00
27_N38_L1.0941.00
12_P77_A1.0921.00
309_Y313_K1.0911.00
64_G67_S1.0851.00
148_L245_I1.0741.00
156_V199_I1.0731.00
144_F249_M1.0731.00
63_I92_I1.0721.00
242_I399_M1.0711.00
266_Y270_N1.0711.00
188_P225_S1.0701.00
213_E424_K1.0691.00
155_E203_F1.0591.00
271_V274_P1.0581.00
50_V89_A1.0561.00
246_I404_V1.0551.00
310_N314_E1.0521.00
256_E259_N1.0521.00
139_V149_Y1.0521.00
54_N88_H1.0481.00
272_R275_I1.0461.00
289_S292_V1.0441.00
140_A408_L1.0421.00
33_G52_K1.0391.00
136_I253_V1.0351.00
151_H241_L1.0261.00
41_D44_G1.0231.00
249_M253_V1.0211.00
284_I287_L1.0201.00
131_Q199_I1.0171.00
194_L420_F1.0161.00
271_V317_Y1.0141.00
43_S200_E1.0131.00
316_L348_F1.0121.00
259_N263_I1.0111.00
369_S373_R1.0091.00
37_I48_I1.0061.00
26_H40_R1.0061.00
21_V87_V1.0021.00
39_L69_I1.0001.00
58_D61_I0.9981.00
278_V282_D0.9921.00
243_E247_Y0.9911.00
157_F207_P0.9891.00
176_L181_E0.9891.00
51_E88_H0.9881.00
140_A401_L0.9771.00
297_G301_G0.9771.00
295_K298_D0.9761.00
145_R203_F0.9761.00
288_K293_N0.9721.00
40_R66_E0.9711.00
105_D108_G0.9671.00
301_G307_V0.9641.00
233_A238_I0.9601.00
269_P272_R0.9541.00
307_V311_E0.9481.00
34_K49_V0.9471.00
63_I94_I0.9471.00
136_I139_V0.9401.00
301_G309_Y0.9361.00
51_E54_N0.9361.00
305_L308_L0.9321.00
308_L313_K0.9311.00
161_I182_A0.9281.00
258_E340_L0.9281.00
188_P191_Y0.9261.00
56_A59_K0.9241.00
301_G306_R0.9221.00
411_L416_E0.9191.00
281_S296_F0.9181.00
188_P206_A0.9111.00
235_Y239_M0.9071.00
411_L417_V0.9071.00
247_Y268_P0.9041.00
21_V71_V0.9021.00
391_M394_H0.9021.00
367_E388_D0.9021.00
136_I140_A0.8981.00
245_I249_M0.8951.00
177_Y426_R0.8880.99
305_L314_E0.8880.99
258_E261_L0.8840.99
96_S391_M0.8830.99
196_A391_M0.8810.99
256_E321_D0.8800.99
290_K307_V0.8800.99
162_I191_Y0.8760.99
147_T241_L0.8750.99
68_T96_S0.8710.99
242_I397_F0.8710.99
125_L134_L0.8690.99
244_Q248_N0.8690.99
286_L290_K0.8680.99
19_V75_V0.8670.99
42_K135_K0.8660.99
305_L326_S0.8630.99
62_N97_Y0.8630.99
238_I397_F0.8620.99
105_D109_K0.8600.99
138_S142_K0.8590.99
31_L34_K0.8580.99
237_D240_A0.8580.99
141_V155_E0.8570.99
292_V311_E0.8560.99
265_N269_P0.8550.99
258_E263_I0.8540.99
30_N35_I0.8510.99
252_D255_R0.8490.99
273_I319_V0.8480.99
46_G75_V0.8450.99
287_L292_V0.8410.99
281_S284_I0.8380.99
228_V242_I0.8320.99
267_T270_N0.8300.99
307_V310_N0.8290.99
304_E307_V0.8260.99
21_V48_I0.8230.99
129_E133_V0.8220.99
54_N90_K0.8210.99
78_D82_P0.8130.99
67_S97_Y0.8110.99
113_D116_T0.8110.99
180_K425_K0.8100.99
260_E266_Y0.8070.99
375_L380_F0.8070.99
57_Y61_I0.8070.99
363_K384_L0.8020.99
321_D340_L0.8010.99
332_K365_V0.8000.99
381_E385_K0.7990.99
370_L380_F0.7990.99
136_I254_K0.7980.99
309_Y312_L0.7960.99
37_I69_I0.7940.99
194_L386_W0.7940.99
26_H45_I0.7940.99
261_L410_G0.7930.99
287_L291_G0.7920.99
64_G97_Y0.7920.99
73_G87_V0.7900.99
309_Y314_E0.7880.99
280_Y283_A0.7880.99
298_D302_T0.7880.99
351_L407_M0.7860.99
332_K342_E0.7840.99
243_E277_K0.7810.99
50_V60_V0.7790.99
122_L385_K0.7760.99
166_T187_S0.7750.99
242_I354_V0.7750.99
303_P308_L0.7730.99
37_I50_V0.7730.99
196_A387_F0.7720.99
257_C260_E0.7720.99
71_V87_V0.7720.99
294_I298_D0.7710.99
297_G305_L0.7690.99
143_S147_T0.7680.99
228_V238_I0.7670.99
249_M252_D0.7650.99
288_K295_K0.7640.98
360_N365_V0.7630.98
151_H201_R0.7610.98
282_D286_L0.7580.98
265_N268_P0.7570.98
353_I404_V0.7550.98
102_L105_D0.7490.98
77_A84_G0.7480.98
305_L313_K0.7460.98
153_F201_R0.7430.98
253_V408_L0.7400.98
399_M404_V0.7390.98
272_R277_K0.7380.98
335_K362_V0.7370.98
298_D306_R0.7360.98
104_L108_G0.7350.98
364_E367_E0.7330.98
55_N58_D0.7320.98
24_W232_F0.7310.98
299_D304_E0.7310.98
321_D342_E0.7300.98
133_V409_T0.7300.98
233_A241_L0.7300.98
37_I89_A0.7290.98
58_D62_N0.7270.98
68_T392_P0.7240.98
138_S203_F0.7240.98
406_L414_V0.7240.98
252_D256_E0.7230.98
59_K92_I0.7230.98
235_Y321_D0.7210.98
160_K207_P0.7170.98
141_V226_M0.7160.98
343_S355_S0.7160.98
360_N369_S0.7140.98
160_K188_P0.7110.98
176_L183_F0.7100.98
344_F356_G0.7100.98
78_D84_G0.7060.97
31_L35_I0.7050.97
261_L266_Y0.7050.97
40_R128_L0.7040.97
294_I297_G0.7040.97
264_L276_K0.7030.97
104_L112_A0.7030.97
273_I277_K0.7020.97
336_D339_Q0.6970.97
381_E384_L0.6960.97
27_N65_L0.6930.97
228_V241_L0.6910.97
327_R343_S0.6880.97
302_T309_Y0.6880.97
248_N251_N0.6870.97
15_D85_V0.6850.97
59_K62_N0.6840.97
302_T308_L0.6840.97
68_T232_F0.6810.97
102_L106_V0.6790.97
176_L179_G0.6760.97
308_L311_E0.6750.97
375_L378_E0.6740.97
127_R130_M0.6690.97
288_K294_I0.6680.96
334_K339_Q0.6680.96
39_L48_I0.6670.96
276_K315_D0.6670.96
299_D302_T0.6660.96
364_E368_N0.6640.96
279_S321_D0.6640.96
32_G35_I0.6640.96
25_V28_V0.6630.96
264_L267_T0.6630.96
319_V347_I0.6610.96
28_V35_I0.6610.96
52_K57_Y0.6600.96
233_A358_S0.6590.96
106_V109_K0.6590.96
217_P351_L0.6590.96
239_M318_F0.6580.96
94_I97_Y0.6570.96
216_T413_S0.6540.96
405_M409_T0.6520.96
239_M320_T0.6520.96
138_S154_V0.6510.96
288_K291_G0.6500.96
365_V369_S0.6450.96
324_W341_S0.6420.96
78_D83_N0.6390.95
136_I405_M0.6390.95
100_S388_D0.6380.95
195_L391_M0.6370.95
304_E309_Y0.6360.95
300_I303_P0.6320.95
346_L399_M0.6300.95
236_N239_M0.6300.95
60_V92_I0.6290.95
16_G77_A0.6280.95
97_Y362_V0.6270.95
161_I175_V0.6270.95
266_Y269_P0.6270.95
50_V92_I0.6250.95
67_S94_I0.6240.95
205_I401_L0.6230.95
37_I60_V0.6220.95
342_E358_S0.6210.95
72_N90_K0.6210.95
409_T417_V0.6200.95
264_L270_N0.6190.95
263_I267_T0.6190.95
247_Y251_N0.6170.95
242_I344_F0.6170.95
118_L416_E0.6160.95
375_L379_S0.6140.94
263_I266_Y0.6130.94
55_N59_K0.6130.94
266_Y272_R0.6120.94
251_N254_K0.6120.94
48_I69_I0.6110.94
122_L389_Y0.6070.94
121_R125_L0.6070.94
334_K337_N0.6060.94
116_T120_E0.6050.94
42_K200_E0.6040.94
214_S423_D0.6030.94
267_T272_R0.6010.94
241_L244_Q0.6010.94
43_S135_K0.6000.94
303_P307_V0.6000.94
298_D305_L0.6000.94
311_E314_E0.6000.94
327_R357_S0.5990.94
260_E410_G0.5960.94
165_A422_R0.5960.94
130_M133_V0.5940.93
283_A287_L0.5940.93
265_N271_V0.5930.93
290_K311_E0.5930.93
124_D127_R0.5920.93
28_V37_I0.5910.93
197_G392_P0.5910.93
270_N275_I0.5900.93
103_P389_Y0.5900.93
385_K426_R0.5870.93
104_L109_K0.5860.93
137_Q157_F0.5860.93
234_D358_S0.5850.93
158_T204_E0.5840.93
140_A253_V0.5840.93
130_M416_E0.5840.93
51_E76_K0.5840.93
146_E256_E0.5810.93
303_P306_R0.5810.93
246_I399_M0.5790.93
238_I241_L0.5790.93
294_I303_P0.5790.93
286_L293_N0.5780.92
148_L241_L0.5780.92
297_G300_I0.5770.92
141_V157_F0.5760.92
165_A191_Y0.5760.92
271_V275_I0.5760.92
238_I242_I0.5750.92
299_D303_P0.5750.92
17_S75_V0.5730.92
274_P321_D0.5700.92
305_L312_L0.5700.92
306_R313_K0.5690.92
157_F224_I0.5690.92
125_L197_G0.5690.92
123_L385_K0.5680.92
279_S320_T0.5680.92
345_D355_S0.5680.92
286_L312_L0.5680.92
57_Y60_V0.5680.92
423_D426_R0.5650.92
322_W347_I0.5650.92
266_Y271_V0.5650.92
354_V399_M0.5640.92
28_V65_L0.5640.92
56_A92_I0.5640.92
331_T334_K0.5640.92
196_A383_F0.5620.91
54_N74_V0.5600.91
271_V277_K0.5600.91
297_G304_E0.5590.91
235_Y334_K0.5590.91
137_Q402_A0.5580.91
254_K408_L0.5580.91
301_G312_L0.5570.91
148_L203_F0.5570.91
235_Y320_T0.5560.91
151_H248_N0.5550.91
351_L413_S0.5530.91
103_P107_T0.5530.91
262_K266_Y0.5530.91
158_T188_P0.5530.91
411_L414_V0.5510.91
230_M237_D0.5500.90
158_T192_K0.5500.90
46_G85_V0.5480.90
230_M238_I0.5470.90
29_R38_L0.5470.90
141_V205_I0.5470.90
148_L397_F0.5460.90
281_S285_E0.5460.90
361_H391_M0.5460.90
129_E132_A0.5450.90
327_R331_T0.5440.90
383_F387_F0.5430.90
308_L319_V0.5420.90
299_D325_L0.5410.90
333_Q360_N0.5400.90
261_L264_L0.5390.90
295_K305_L0.5390.90
103_P106_V0.5390.90
284_I288_K0.5390.90
305_L310_N0.5390.90
166_T183_F0.5380.90
286_L292_V0.5360.89
297_G302_T0.5350.89
333_Q368_N0.5350.89
128_L131_Q0.5350.89
102_L107_T0.5350.89
190_L383_F0.5340.89
53_G88_H0.5340.89
385_K389_Y0.5340.89
299_D305_L0.5330.89
154_V199_I0.5300.89
153_F188_P0.5290.89
238_I344_F0.5280.89
192_K195_L0.5280.89
35_I60_V0.5270.89
257_C266_Y0.5270.89
295_K304_E0.5270.89
153_F238_I0.5260.88
79_A82_P0.5250.88
304_E313_K0.5250.88
298_D303_P0.5240.88
30_N33_G0.5240.88
75_V86_E0.5220.88
256_E261_L0.5210.88
97_Y364_E0.5200.88
167_E183_F0.5200.88
239_M277_K0.5200.88
278_V313_K0.5190.88
193_E382_F0.5180.88
102_L126_R0.5180.88
104_L116_T0.5170.88
366_L387_F0.5170.88
147_T249_M0.5160.88
30_N61_I0.5150.87
325_L328_P0.5150.87
304_E312_L0.5140.87
114_I118_L0.5140.87
133_V416_E0.5140.87
180_K422_R0.5130.87
278_V319_V0.5110.87
288_K292_V0.5100.87
296_F301_G0.5100.87
43_S152_G0.5100.87
125_L199_I0.5100.87
257_C262_K0.5090.87
298_D304_E0.5080.87
23_G48_I0.5080.87
286_L291_G0.5080.87
306_R314_E0.5070.87
297_G309_Y0.5070.87
31_L79_A0.5050.86
12_P17_S0.5050.86
261_L267_T0.5040.86
302_T307_V0.5040.86
177_Y182_A0.5030.86
238_I356_G0.5030.86
188_P205_I0.5030.86
378_E381_E0.5030.86
320_T334_K0.5020.86
287_L293_N0.5010.86
129_E416_E0.5010.86
267_T271_V0.5010.86
295_K309_Y0.5000.86
354_V397_F0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i7fA 2 0.9557 100 0.138 Contact Map
1eovA 2 1 100 0.15 Contact Map
4j15A 2 0.9044 100 0.164 Contact Map
2xgtA 2 0.9837 100 0.177 Contact Map
3nemA 2 1 100 0.179 Contact Map
1wydA 2 0.9953 100 0.186 Contact Map
1l0wA 2 0.9907 100 0.188 Contact Map
4wj4A 2 0.9907 100 0.189 Contact Map
1x54A 2 0.9883 100 0.196 Contact Map
1c0aA 1 0.986 100 0.196 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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