GREMLIN Database
PTH - Peptidyl-tRNA hydrolase
UniProt: Q980V1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (114)
Sequences: 666 (443)
Seq/√Len: 41.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_G91_Q4.1921.00
79_L102_I3.4931.00
32_V50_L2.9471.00
29_T84_I2.7081.00
102_I110_V2.6261.00
30_L101_G2.5881.00
63_S66_E2.5491.00
24_A27_A2.3041.00
62_N66_E2.2101.00
6_I23_V2.0710.99
28_V31_V1.9460.99
31_V46_L1.8750.98
77_M112_S1.8620.98
4_M30_L1.8180.98
55_P89_K1.7490.98
71_A81_F1.7380.98
5_V59_V1.7100.97
72_K76_T1.6980.97
4_M27_A1.6320.96
20_A23_V1.5870.96
29_T82_S1.5720.95
61_V66_E1.5430.95
23_V99_C1.5240.95
70_R100_L1.5130.94
55_P107_E1.4910.94
71_A75_E1.4820.94
85_E97_I1.4760.94
106_P109_L1.4720.94
8_V23_V1.4470.93
77_M113_I1.4320.93
83_I100_L1.4080.92
79_L110_V1.4000.92
79_L113_I1.3610.91
16_K91_Q1.3460.90
107_E111_D1.3090.89
9_R64_L1.3040.89
92_L96_T1.2900.88
64_L97_I1.2700.87
7_V61_V1.2670.87
14_M19_I1.2250.85
8_V19_I1.2230.85
69_S73_K1.2200.85
15_G58_I1.1930.84
85_E95_G1.1910.83
12_I96_T1.1710.82
10_S13_K1.1430.81
6_I99_C1.1300.80
14_M21_A1.1290.80
9_R96_T1.1220.80
2_I107_E1.1160.79
7_V100_L1.0920.78
21_A89_K1.0860.77
105_A109_L1.0580.75
46_L50_L1.0530.75
33_S84_I1.0370.74
58_I108_N1.0290.73
16_K118_K1.0080.72
9_R61_V0.9750.69
79_L105_A0.9720.69
64_L68_I0.9680.69
5_V102_I0.9540.68
11_D103_G0.9420.67
61_V67_I0.9280.65
19_I23_V0.9220.65
34_I80_P0.9180.65
45_W80_P0.9160.64
8_V99_C0.9090.64
4_M82_S0.9050.63
69_S75_E0.9010.63
57_I89_K0.8920.62
30_L80_P0.8790.61
60_K92_L0.8670.60
91_Q118_K0.8520.59
5_V8_V0.8490.58
10_S63_S0.8380.57
32_V46_L0.8350.57
31_V50_L0.8310.57
30_L34_I0.8240.56
10_S62_N0.8170.56
8_V89_K0.8130.55
59_V70_R0.8060.55
68_I97_I0.7940.53
45_W106_P0.7930.53
14_M92_L0.7930.53
18_K90_T0.7900.53
10_S60_K0.7860.53
7_V59_V0.7820.52
46_L99_C0.7820.52
73_K77_M0.7820.52
18_K88_G0.7800.52
58_I105_A0.7750.52
52_Q107_E0.7630.50
13_K94_P0.7500.49
79_L109_L0.7470.49
47_N76_T0.7430.49
92_L95_G0.7430.49
70_R116_D0.7390.48
57_I73_K0.7380.48
102_I114_T0.7270.47
75_E81_F0.7220.47
14_M17_G0.7140.46
24_A43_K0.7050.45
89_K94_P0.7040.45
58_I67_I0.7030.45
33_S82_S0.7020.45
38_N48_E0.7010.45
89_K99_C0.7000.45
73_K76_T0.6970.44
74_A102_I0.6970.44
59_V117_L0.6870.43
10_S84_I0.6840.43
103_G110_V0.6820.43
71_A83_I0.6820.43
11_D64_L0.6750.42
77_M111_D0.6690.42
34_I38_N0.6650.41
76_T81_F0.6640.41
69_S76_T0.6580.41
87_A90_T0.6550.41
47_N108_N0.6470.40
80_P113_I0.6450.40
67_I97_I0.6370.39
7_V114_T0.6350.39
108_N112_S0.6330.39
21_A24_A0.6270.38
8_V58_I0.6260.38
9_R103_G0.6230.38
26_A101_G0.6200.37
2_I27_A0.6180.37
48_E52_Q0.6130.37
88_G91_Q0.6090.36
36_N73_K0.6090.36
53_G87_A0.6030.36
64_L92_L0.6020.36
55_P105_A0.6000.36
66_E101_G0.5990.36
91_Q96_T0.5940.35
45_W109_L0.5940.35
63_S113_I0.5860.34
4_M80_P0.5850.34
64_L85_E0.5760.34
28_V81_F0.5730.33
35_I65_D0.5700.33
106_P118_K0.5690.33
14_M64_L0.5680.33
5_V110_V0.5650.33
77_M109_L0.5650.33
48_E78_N0.5630.33
70_R117_L0.5590.32
11_D63_S0.5560.32
63_S68_I0.5560.32
43_K74_A0.5520.32
7_V113_I0.5490.31
70_R111_D0.5460.31
60_K107_E0.5420.31
4_M99_C0.5410.31
104_P110_V0.5390.31
22_Q88_G0.5380.31
66_E69_S0.5360.30
81_F102_I0.5350.30
54_Q106_P0.5330.30
71_A100_L0.5310.30
34_I45_W0.5270.30
34_I43_K0.5250.30
63_S73_K0.5200.29
53_G95_G0.5130.29
102_I113_I0.5080.28
60_K91_Q0.5070.28
6_I58_I0.5040.28
12_I65_D0.5020.28
58_I95_G0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xtyA 2 1 100 0.144 Contact Map
2zv3A 2 0.9583 100 0.155 Contact Map
1q7sA 2 0.9667 100 0.156 Contact Map
1rlkA 2 0.9667 100 0.162 Contact Map
1wn2A 2 0.9667 100 0.163 Contact Map
1rzwA 1 0.9417 100 0.177 Contact Map
2gaxA 2 0.9083 99.8 0.598 Contact Map
2lndA 1 0.8417 28.6 0.935 Contact Map
1xbiA 1 0.9083 23.2 0.938 Contact Map
4jb1A 1 0.6417 22.8 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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