GREMLIN Database
FEN - Flap endonuclease 1
UniProt: Q980U8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (306)
Sequences: 1413 (920)
Seq/√Len: 52.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_S166_S5.6871.00
171_S176_A4.6521.00
228_D282_R4.4191.00
161_N166_S4.3321.00
224_E286_L4.2841.00
303_N306_D4.1381.00
113_K116_E4.1171.00
161_N182_K4.0191.00
24_V168_A3.9491.00
227_I286_L3.4731.00
107_R111_E3.3331.00
309_N313_Y3.1471.00
141_A306_D2.9631.00
159_Y163_L2.9221.00
23_R166_S2.7831.00
249_R252_K2.7771.00
225_Q258_G2.5551.00
283_G287_N2.5181.00
136_K148_Q2.4141.00
308_I323_K2.3711.00
141_A310_I2.3251.00
311_L322_V2.3021.00
76_I166_S2.2011.00
304_G327_E2.1881.00
230_G241_G2.1651.00
262_K265_E2.1511.00
222_T225_Q2.1451.00
69_L144_I2.1411.00
24_V170_A2.1311.00
102_E106_E2.1161.00
32_L135_S2.1111.00
61_L135_S1.9981.00
156_E290_V1.9611.00
169_A181_A1.9200.99
229_I233_I1.9110.99
220_G255_K1.8620.99
235_T285_F1.8070.99
159_Y292_K1.7830.99
319_E323_K1.7580.99
35_F60_G1.7480.99
14_L19_L1.7340.99
57_H134_E1.7090.99
238_N241_G1.6740.99
86_Q284_L1.6730.99
137_K314_E1.6380.98
307_I326_I1.6350.98
313_Y319_E1.6240.98
324_N327_E1.6110.98
210_I215_L1.6090.98
263_A266_Y1.6030.98
92_E96_K1.6010.98
34_Q60_G1.5930.98
266_Y269_I1.5930.98
304_G330_T1.5870.98
177_I184_L1.5850.98
25_S157_A1.5840.98
226_L230_G1.5740.98
221_I229_I1.5490.98
233_I247_P1.5480.98
105_L117_L1.5310.97
140_R146_I1.5300.97
104_K107_R1.4620.97
252_K256_K1.4600.97
22_K167_W1.4590.97
178_L226_L1.4360.96
213_E217_K1.4320.96
259_K262_K1.4180.96
299_L302_P1.4090.96
89_E92_E1.3960.96
308_I313_Y1.3950.95
263_A269_I1.3950.95
172_Q187_N1.3910.95
99_E103_R1.3900.95
223_R286_L1.3810.95
84_P237_Y1.3730.95
178_L230_G1.3690.95
65_T144_I1.3650.95
259_K263_A1.3550.95
235_T281_I1.3400.94
179_F288_P1.3170.94
100_E104_K1.3030.94
128_S131_M1.2990.93
105_L121_S1.2960.93
22_K183_R1.2950.93
58_L138_L1.2840.93
159_Y293_P1.2780.93
245_I250_A1.2740.93
108_A113_K1.2430.92
29_Y132_V1.2310.91
235_T238_N1.2310.91
105_L109_K1.2290.91
151_S284_L1.2220.91
74_I145_P1.2070.91
179_F284_L1.1970.90
169_A176_A1.1860.90
157_A166_S1.1780.89
238_N278_I1.1510.88
23_R74_I1.1490.88
232_L250_A1.1470.88
309_N314_E1.1420.88
168_A185_V1.1390.88
171_S184_L1.1350.88
226_L241_G1.1330.88
106_E109_K1.1280.87
156_E288_P1.1200.87
292_K295_E1.1170.87
26_I77_Y1.1160.87
140_R214_I1.1140.87
32_L116_E1.1110.87
231_I278_I1.1030.86
14_L18_E1.1010.86
28_G35_F1.0910.86
228_D260_I1.0900.85
227_I282_R1.0900.85
154_E157_A1.0880.85
65_T77_Y1.0840.85
133_E137_K1.0750.85
307_I310_I1.0670.84
327_E330_T1.0660.84
12_R214_I1.0650.84
253_I257_Y1.0620.84
221_I251_L1.0620.84
171_S271_K1.0620.84
28_G77_Y1.0590.84
245_I249_R1.0580.84
62_F65_T1.0570.84
6_L9_D1.0560.84
121_S135_S1.0540.83
116_E120_Y1.0490.83
164_G322_V1.0470.83
304_G308_I1.0400.83
95_R99_E1.0390.83
232_L242_I1.0360.82
314_E330_T1.0310.82
24_V73_V1.0180.81
74_I299_L1.0040.80
183_R211_E1.0020.80
104_K116_E1.0020.80
254_I263_A1.0010.80
277_N280_E0.9870.79
267_G270_S0.9860.79
138_L143_G0.9850.79
162_K223_R0.9850.79
229_I251_L0.9840.79
161_N168_A0.9820.79
320_E323_K0.9810.79
283_G286_L0.9670.78
228_D254_I0.9660.78
23_R307_I0.9640.78
19_L209_L0.9640.78
31_A64_R0.9640.78
93_R96_K0.9560.77
153_G174_Y0.9540.77
158_A169_A0.9470.76
89_E240_D0.9460.76
8_K11_K0.9460.76
36_L98_K0.9450.76
159_Y291_V0.9420.76
318_S321_R0.9400.76
109_K117_L0.9400.76
108_A112_G0.9380.76
165_L294_E0.9300.75
105_L124_I0.9140.74
268_E271_K0.9130.74
36_L127_L0.9120.74
306_D309_N0.9110.73
127_L131_M0.9060.73
91_L126_R0.9060.73
161_N230_G0.9040.73
29_Y64_R0.9020.73
37_A184_L0.8970.72
32_L36_L0.8960.72
17_S71_E0.8930.72
176_A181_A0.8900.72
78_V147_V0.8900.72
93_R97_A0.8890.72
214_I218_K0.8870.71
31_A68_I0.8850.71
231_I254_I0.8850.71
84_P288_P0.8800.71
19_L185_V0.8780.71
165_L168_A0.8760.71
318_S322_V0.8750.70
89_E96_K0.8730.70
312_V318_S0.8680.70
242_I256_K0.8620.69
268_E272_K0.8600.69
72_G162_K0.8580.69
67_N71_E0.8430.68
150_P290_V0.8430.68
250_A254_I0.8430.68
185_V188_L0.8430.68
137_K306_D0.8390.67
271_K274_I0.8360.67
215_L227_I0.8360.67
142_M329_L0.8350.67
141_A307_I0.8350.67
157_A186_R0.8330.67
62_F66_I0.8320.67
30_N34_Q0.8310.66
66_I142_M0.8260.66
313_Y329_L0.8250.66
149_A179_F0.8240.66
305_E308_I0.8230.66
305_E309_N0.8220.66
25_S160_L0.8210.65
47_L55_T0.8210.65
160_L165_L0.8210.65
254_I282_R0.8210.65
138_L142_M0.8200.65
18_E190_I0.8190.65
231_I284_L0.8180.65
90_E93_R0.8170.65
158_A161_N0.8130.65
5_D10_V0.8130.65
231_I282_R0.8120.65
34_Q64_R0.8060.64
178_L223_R0.8060.64
58_L134_E0.8060.64
140_R272_K0.8050.64
178_L227_I0.7930.63
316_N325_G0.7920.63
47_L149_A0.7900.62
262_K266_Y0.7880.62
101_A112_G0.7820.62
83_P91_L0.7800.61
94_R285_F0.7770.61
139_L146_I0.7760.61
168_A186_R0.7750.61
303_N312_V0.7710.61
181_A292_K0.7700.60
23_R145_P0.7690.60
317_F328_R0.7670.60
82_K151_S0.7660.60
81_G150_P0.7650.60
32_L156_E0.7600.59
311_L315_H0.7590.59
265_E269_I0.7560.59
263_A270_S0.7550.59
248_E252_K0.7540.59
259_K281_I0.7540.59
304_G323_K0.7540.59
29_Y91_L0.7540.59
88_S99_E0.7510.59
76_I145_P0.7480.58
151_S324_N0.7460.58
143_G219_L0.7450.58
66_I70_E0.7430.58
29_Y153_G0.7390.57
138_L141_A0.7350.57
69_L326_I0.7350.57
189_T193_K0.7340.57
280_E305_E0.7340.57
154_E176_A0.7310.57
61_L77_Y0.7310.57
112_G117_L0.7310.57
225_Q254_I0.7300.56
103_R106_E0.7290.56
6_L11_K0.7280.56
7_V11_K0.7260.56
268_E283_G0.7260.56
325_G329_L0.7250.56
300_N307_I0.7230.56
56_S59_S0.7230.56
268_E275_N0.7220.56
130_I134_E0.7210.55
24_V161_N0.7190.55
109_K121_S0.7190.55
36_L66_I0.7170.55
212_T289_Q0.7150.55
315_H321_R0.7130.55
257_Y260_I0.7130.55
84_P284_L0.7110.54
265_E294_E0.7080.54
264_M270_S0.7020.54
17_S277_N0.7010.53
98_K285_F0.6950.53
270_S274_I0.6930.53
172_Q281_I0.6920.52
130_I140_R0.6920.52
133_E136_K0.6900.52
223_R227_I0.6850.52
174_Y235_T0.6850.52
102_E105_L0.6840.52
65_T142_M0.6800.51
323_K327_E0.6800.51
308_I326_I0.6720.50
62_F142_M0.6720.50
301_E304_G0.6710.50
140_R147_V0.6710.50
67_N131_M0.6700.50
19_L223_R0.6690.50
221_I225_Q0.6690.50
109_K292_K0.6680.50
263_A279_D0.6670.50
108_A116_E0.6630.49
24_V319_E0.6620.49
210_I232_L0.6620.49
184_L298_D0.6590.49
229_I255_K0.6590.49
98_K177_I0.6580.49
29_Y179_F0.6570.49
153_G238_N0.6570.49
175_D234_G0.6550.49
212_T223_R0.6520.48
39_I56_S0.6510.48
56_S321_R0.6510.48
158_A171_S0.6490.48
179_F225_Q0.6480.48
314_E317_F0.6460.48
314_E322_V0.6450.48
23_R203_V0.6440.47
33_Y36_L0.6420.47
297_L302_P0.6410.47
77_Y139_L0.6410.47
58_L64_R0.6410.47
48_M124_I0.6410.47
301_E330_T0.6390.47
310_I315_H0.6350.46
24_V163_L0.6340.46
153_G235_T0.6340.46
254_I259_K0.6320.46
245_I267_G0.6320.46
88_S92_E0.6320.46
16_F71_E0.6300.46
30_N171_S0.6300.46
163_L291_V0.6220.45
179_F223_R0.6220.45
323_K326_I0.6210.45
127_L156_E0.6200.45
34_Q40_R0.6200.45
20_K72_G0.6180.45
110_S292_K0.6180.45
17_S20_K0.6180.45
228_D278_I0.6180.45
81_G87_K0.6170.45
33_Y39_I0.6160.44
81_G152_E0.6150.44
59_S251_L0.6150.44
47_L62_F0.6150.44
33_Y98_K0.6140.44
100_E103_R0.6140.44
30_N157_A0.6140.44
107_R110_S0.6110.44
46_P52_G0.6110.44
101_A124_I0.6080.44
166_S169_A0.6080.44
266_Y272_K0.6070.44
223_R230_G0.6040.43
312_V317_F0.6040.43
170_A324_N0.6020.43
321_R325_G0.6010.43
28_G226_L0.6010.43
24_V185_V0.5990.43
270_S273_D0.5970.43
151_S289_Q0.5960.42
32_L117_L0.5940.42
131_M179_F0.5940.42
154_E186_R0.5930.42
38_A57_H0.5920.42
157_A235_T0.5920.42
102_E171_S0.5920.42
69_L142_M0.5920.42
312_V321_R0.5910.42
238_N281_I0.5860.41
279_D283_G0.5850.41
203_V237_Y0.5850.41
62_F325_G0.5840.41
94_R98_K0.5830.41
76_I147_V0.5820.41
222_T253_I0.5820.41
278_I282_R0.5810.41
177_I317_F0.5800.41
114_I118_R0.5800.41
228_D231_I0.5780.41
26_I89_E0.5760.40
29_Y157_A0.5750.40
35_F38_A0.5740.40
171_S186_R0.5740.40
91_L132_V0.5740.40
37_A40_R0.5730.40
282_R286_L0.5710.40
253_I276_F0.5700.40
161_N169_A0.5700.40
319_E327_E0.5660.39
268_E274_I0.5660.39
318_S324_N0.5660.39
41_Q118_R0.5650.39
117_L121_S0.5650.39
314_E326_I0.5650.39
103_R107_R0.5640.39
211_E214_I0.5630.39
20_K23_R0.5620.39
171_S278_I0.5620.39
264_M267_G0.5620.39
35_F40_R0.5600.39
180_G241_G0.5590.39
165_L295_E0.5580.39
154_E291_V0.5520.38
86_Q302_P0.5520.38
82_K289_Q0.5520.38
23_R167_W0.5520.38
167_W183_R0.5510.38
324_N330_T0.5480.38
160_L292_K0.5480.38
167_W229_I0.5470.37
111_E117_L0.5460.37
156_E291_V0.5450.37
324_N329_L0.5450.37
28_G79_F0.5440.37
28_G61_L0.5410.37
312_V316_N0.5410.37
13_E83_P0.5370.37
16_F24_V0.5360.36
164_G182_K0.5350.36
167_W328_R0.5340.36
202_Y329_L0.5330.36
314_E327_E0.5330.36
308_I319_E0.5330.36
316_N324_N0.5300.36
182_K213_E0.5300.36
103_R114_I0.5300.36
104_K117_L0.5290.36
136_K146_I0.5270.36
326_I330_T0.5270.36
21_G245_I0.5250.35
65_T280_E0.5250.35
116_E169_A0.5240.35
57_H60_G0.5240.35
269_I273_D0.5240.35
120_Y123_A0.5240.35
158_A178_L0.5230.35
41_Q121_S0.5230.35
130_I303_N0.5230.35
96_K100_E0.5200.35
156_E159_Y0.5200.35
174_Y241_G0.5180.35
112_G192_G0.5180.35
51_Q54_V0.5160.34
106_E110_S0.5160.34
158_A186_R0.5140.34
76_I243_R0.5140.34
260_I263_A0.5130.34
67_N70_E0.5130.34
190_I193_K0.5130.34
193_K203_V0.5130.34
86_Q237_Y0.5130.34
147_V163_L0.5120.34
261_E279_D0.5120.34
158_A176_A0.5100.34
134_E315_H0.5070.34
163_L245_I0.5060.34
84_P91_L0.5050.33
118_R215_L0.5050.33
305_E323_K0.5030.33
178_L238_N0.5030.33
174_Y315_H0.5010.33
90_E121_S0.5000.33
30_N153_G0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b43A 2 0.9599 100 0.287 Contact Map
2izoA 1 0.7679 100 0.295 Contact Map
3oryA 3 0.9599 100 0.297 Contact Map
1ul1X 1 0.8338 100 0.3 Contact Map
1a76A 1 0.8997 100 0.303 Contact Map
4wa8A 1 0.8481 100 0.309 Contact Map
1rxwA 1 0.8739 100 0.313 Contact Map
3q8kA 1 0.9513 100 0.332 Contact Map
4q0wA 1 0.8252 100 0.333 Contact Map
3qe9Y 1 0.8997 100 0.411 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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