FEN - SULSO - GREMLIN Contacts

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FEN - Flap endonuclease 1

UniProt:	Q980U8	Sequences: MDLADLVKDVKRELSFSELKGKRVSIDGYNALYQFLAAIRQPDGTPLMDSQGRVTSHLSGLFYRTINILEEGVIPIYVFDGKPPEQKSEELERRRKAKEEAERKLERAKSEGKIEELRKYSQAILRLSNIMVEESKKLLRAMGIPIVQAPSEGEAEAAYLNKLGLSWAAASQDYDAILFGAKRLVRNLTITGKRKLPNKDVYVEIKPELIETEILLKKLGITREQLIDIGILIGTDYNPDGIRGIGPERALKIIKKYGKIEKAMEYGEISKKDINFNIDEIRGLFLNPQVVKPEEALDLNEPNGEDIINILVYEHNFSEERVKNGIERLTKAIKEAKGASRQTGLDRWF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	349 (306)
Sequences:	1413 (920)
Seq/√Len:	52.6

HALSA - FEN
SULSO - FEN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
25_S	166_S	5.687	1.00
171_S	176_A	4.652	1.00
228_D	282_R	4.419	1.00
161_N	166_S	4.332	1.00
224_E	286_L	4.284	1.00
303_N	306_D	4.138	1.00
113_K	116_E	4.117	1.00
161_N	182_K	4.019	1.00
24_V	168_A	3.949	1.00
227_I	286_L	3.473	1.00
107_R	111_E	3.333	1.00
309_N	313_Y	3.147	1.00
141_A	306_D	2.963	1.00
159_Y	163_L	2.922	1.00
23_R	166_S	2.783	1.00
249_R	252_K	2.777	1.00
225_Q	258_G	2.555	1.00
283_G	287_N	2.518	1.00
136_K	148_Q	2.414	1.00
308_I	323_K	2.371	1.00
141_A	310_I	2.325	1.00
311_L	322_V	2.302	1.00
76_I	166_S	2.201	1.00
304_G	327_E	2.188	1.00
230_G	241_G	2.165	1.00
262_K	265_E	2.151	1.00
222_T	225_Q	2.145	1.00
69_L	144_I	2.141	1.00
24_V	170_A	2.131	1.00
102_E	106_E	2.116	1.00
32_L	135_S	2.111	1.00
61_L	135_S	1.998	1.00
156_E	290_V	1.961	1.00
169_A	181_A	1.920	0.99
229_I	233_I	1.911	0.99
220_G	255_K	1.862	0.99
235_T	285_F	1.807	0.99
159_Y	292_K	1.783	0.99
319_E	323_K	1.758	0.99
35_F	60_G	1.748	0.99
14_L	19_L	1.734	0.99
57_H	134_E	1.709	0.99
238_N	241_G	1.674	0.99
86_Q	284_L	1.673	0.99
137_K	314_E	1.638	0.98
307_I	326_I	1.635	0.98
313_Y	319_E	1.624	0.98
324_N	327_E	1.611	0.98
210_I	215_L	1.609	0.98
263_A	266_Y	1.603	0.98
92_E	96_K	1.601	0.98
34_Q	60_G	1.593	0.98
266_Y	269_I	1.593	0.98
304_G	330_T	1.587	0.98
177_I	184_L	1.585	0.98
25_S	157_A	1.584	0.98
226_L	230_G	1.574	0.98
221_I	229_I	1.549	0.98
233_I	247_P	1.548	0.98
105_L	117_L	1.531	0.97
140_R	146_I	1.530	0.97
104_K	107_R	1.462	0.97
252_K	256_K	1.460	0.97
22_K	167_W	1.459	0.97
178_L	226_L	1.436	0.96
213_E	217_K	1.432	0.96
259_K	262_K	1.418	0.96
299_L	302_P	1.409	0.96
89_E	92_E	1.396	0.96
308_I	313_Y	1.395	0.95
263_A	269_I	1.395	0.95
172_Q	187_N	1.391	0.95
99_E	103_R	1.390	0.95
223_R	286_L	1.381	0.95
84_P	237_Y	1.373	0.95
178_L	230_G	1.369	0.95
65_T	144_I	1.365	0.95
259_K	263_A	1.355	0.95
235_T	281_I	1.340	0.94
179_F	288_P	1.317	0.94
100_E	104_K	1.303	0.94
128_S	131_M	1.299	0.93
105_L	121_S	1.296	0.93
22_K	183_R	1.295	0.93
58_L	138_L	1.284	0.93
159_Y	293_P	1.278	0.93
245_I	250_A	1.274	0.93
108_A	113_K	1.243	0.92
29_Y	132_V	1.231	0.91
235_T	238_N	1.231	0.91
105_L	109_K	1.229	0.91
151_S	284_L	1.222	0.91
74_I	145_P	1.207	0.91
179_F	284_L	1.197	0.90
169_A	176_A	1.186	0.90
157_A	166_S	1.178	0.89
238_N	278_I	1.151	0.88
23_R	74_I	1.149	0.88
232_L	250_A	1.147	0.88
309_N	314_E	1.142	0.88
168_A	185_V	1.139	0.88
171_S	184_L	1.135	0.88
226_L	241_G	1.133	0.88
106_E	109_K	1.128	0.87
156_E	288_P	1.120	0.87
292_K	295_E	1.117	0.87
26_I	77_Y	1.116	0.87
140_R	214_I	1.114	0.87
32_L	116_E	1.111	0.87
231_I	278_I	1.103	0.86
14_L	18_E	1.101	0.86
28_G	35_F	1.091	0.86
228_D	260_I	1.090	0.85
227_I	282_R	1.090	0.85
154_E	157_A	1.088	0.85
65_T	77_Y	1.084	0.85
133_E	137_K	1.075	0.85
307_I	310_I	1.067	0.84
327_E	330_T	1.066	0.84
12_R	214_I	1.065	0.84
253_I	257_Y	1.062	0.84
221_I	251_L	1.062	0.84
171_S	271_K	1.062	0.84
28_G	77_Y	1.059	0.84
245_I	249_R	1.058	0.84
62_F	65_T	1.057	0.84
6_L	9_D	1.056	0.84
121_S	135_S	1.054	0.83
116_E	120_Y	1.049	0.83
164_G	322_V	1.047	0.83
304_G	308_I	1.040	0.83
95_R	99_E	1.039	0.83
232_L	242_I	1.036	0.82
314_E	330_T	1.031	0.82
24_V	73_V	1.018	0.81
74_I	299_L	1.004	0.80
183_R	211_E	1.002	0.80
104_K	116_E	1.002	0.80
254_I	263_A	1.001	0.80
277_N	280_E	0.987	0.79
267_G	270_S	0.986	0.79
138_L	143_G	0.985	0.79
162_K	223_R	0.985	0.79
229_I	251_L	0.984	0.79
161_N	168_A	0.982	0.79
320_E	323_K	0.981	0.79
283_G	286_L	0.967	0.78
228_D	254_I	0.966	0.78
23_R	307_I	0.964	0.78
19_L	209_L	0.964	0.78
31_A	64_R	0.964	0.78
93_R	96_K	0.956	0.77
153_G	174_Y	0.954	0.77
158_A	169_A	0.947	0.76
89_E	240_D	0.946	0.76
8_K	11_K	0.946	0.76
36_L	98_K	0.945	0.76
159_Y	291_V	0.942	0.76
318_S	321_R	0.940	0.76
109_K	117_L	0.940	0.76
108_A	112_G	0.938	0.76
165_L	294_E	0.930	0.75
105_L	124_I	0.914	0.74
268_E	271_K	0.913	0.74
36_L	127_L	0.912	0.74
306_D	309_N	0.911	0.73
127_L	131_M	0.906	0.73
91_L	126_R	0.906	0.73
161_N	230_G	0.904	0.73
29_Y	64_R	0.902	0.73
37_A	184_L	0.897	0.72
32_L	36_L	0.896	0.72
17_S	71_E	0.893	0.72
176_A	181_A	0.890	0.72
78_V	147_V	0.890	0.72
93_R	97_A	0.889	0.72
214_I	218_K	0.887	0.71
31_A	68_I	0.885	0.71
231_I	254_I	0.885	0.71
84_P	288_P	0.880	0.71
19_L	185_V	0.878	0.71
165_L	168_A	0.876	0.71
318_S	322_V	0.875	0.70
89_E	96_K	0.873	0.70
312_V	318_S	0.868	0.70
242_I	256_K	0.862	0.69
268_E	272_K	0.860	0.69
72_G	162_K	0.858	0.69
67_N	71_E	0.843	0.68
150_P	290_V	0.843	0.68
250_A	254_I	0.843	0.68
185_V	188_L	0.843	0.68
137_K	306_D	0.839	0.67
271_K	274_I	0.836	0.67
215_L	227_I	0.836	0.67
142_M	329_L	0.835	0.67
141_A	307_I	0.835	0.67
157_A	186_R	0.833	0.67
62_F	66_I	0.832	0.67
30_N	34_Q	0.831	0.66
66_I	142_M	0.826	0.66
313_Y	329_L	0.825	0.66
149_A	179_F	0.824	0.66
305_E	308_I	0.823	0.66
305_E	309_N	0.822	0.66
25_S	160_L	0.821	0.65
47_L	55_T	0.821	0.65
160_L	165_L	0.821	0.65
254_I	282_R	0.821	0.65
138_L	142_M	0.820	0.65
18_E	190_I	0.819	0.65
231_I	284_L	0.818	0.65
90_E	93_R	0.817	0.65
158_A	161_N	0.813	0.65
5_D	10_V	0.813	0.65
231_I	282_R	0.812	0.65
34_Q	64_R	0.806	0.64
178_L	223_R	0.806	0.64
58_L	134_E	0.806	0.64
140_R	272_K	0.805	0.64
178_L	227_I	0.793	0.63
316_N	325_G	0.792	0.63
47_L	149_A	0.790	0.62
262_K	266_Y	0.788	0.62
101_A	112_G	0.782	0.62
83_P	91_L	0.780	0.61
94_R	285_F	0.777	0.61
139_L	146_I	0.776	0.61
168_A	186_R	0.775	0.61
303_N	312_V	0.771	0.61
181_A	292_K	0.770	0.60
23_R	145_P	0.769	0.60
317_F	328_R	0.767	0.60
82_K	151_S	0.766	0.60
81_G	150_P	0.765	0.60
32_L	156_E	0.760	0.59
311_L	315_H	0.759	0.59
265_E	269_I	0.756	0.59
263_A	270_S	0.755	0.59
248_E	252_K	0.754	0.59
259_K	281_I	0.754	0.59
304_G	323_K	0.754	0.59
29_Y	91_L	0.754	0.59
88_S	99_E	0.751	0.59
76_I	145_P	0.748	0.58
151_S	324_N	0.746	0.58
143_G	219_L	0.745	0.58
66_I	70_E	0.743	0.58
29_Y	153_G	0.739	0.57
138_L	141_A	0.735	0.57
69_L	326_I	0.735	0.57
189_T	193_K	0.734	0.57
280_E	305_E	0.734	0.57
154_E	176_A	0.731	0.57
61_L	77_Y	0.731	0.57
112_G	117_L	0.731	0.57
225_Q	254_I	0.730	0.56
103_R	106_E	0.729	0.56
6_L	11_K	0.728	0.56
7_V	11_K	0.726	0.56
268_E	283_G	0.726	0.56
325_G	329_L	0.725	0.56
300_N	307_I	0.723	0.56
56_S	59_S	0.723	0.56
268_E	275_N	0.722	0.56
130_I	134_E	0.721	0.55
24_V	161_N	0.719	0.55
109_K	121_S	0.719	0.55
36_L	66_I	0.717	0.55
212_T	289_Q	0.715	0.55
315_H	321_R	0.713	0.55
257_Y	260_I	0.713	0.55
84_P	284_L	0.711	0.54
265_E	294_E	0.708	0.54
264_M	270_S	0.702	0.54
17_S	277_N	0.701	0.53
98_K	285_F	0.695	0.53
270_S	274_I	0.693	0.53
172_Q	281_I	0.692	0.52
130_I	140_R	0.692	0.52
133_E	136_K	0.690	0.52
223_R	227_I	0.685	0.52
174_Y	235_T	0.685	0.52
102_E	105_L	0.684	0.52
65_T	142_M	0.680	0.51
323_K	327_E	0.680	0.51
308_I	326_I	0.672	0.50
62_F	142_M	0.672	0.50
301_E	304_G	0.671	0.50
140_R	147_V	0.671	0.50
67_N	131_M	0.670	0.50
19_L	223_R	0.669	0.50
221_I	225_Q	0.669	0.50
109_K	292_K	0.668	0.50
263_A	279_D	0.667	0.50
108_A	116_E	0.663	0.49
24_V	319_E	0.662	0.49
210_I	232_L	0.662	0.49
184_L	298_D	0.659	0.49
229_I	255_K	0.659	0.49
98_K	177_I	0.658	0.49
29_Y	179_F	0.657	0.49
153_G	238_N	0.657	0.49
175_D	234_G	0.655	0.49
212_T	223_R	0.652	0.48
39_I	56_S	0.651	0.48
56_S	321_R	0.651	0.48
158_A	171_S	0.649	0.48
179_F	225_Q	0.648	0.48
314_E	317_F	0.646	0.48
314_E	322_V	0.645	0.48
23_R	203_V	0.644	0.47
33_Y	36_L	0.642	0.47
297_L	302_P	0.641	0.47
77_Y	139_L	0.641	0.47
58_L	64_R	0.641	0.47
48_M	124_I	0.641	0.47
301_E	330_T	0.639	0.47
310_I	315_H	0.635	0.46
24_V	163_L	0.634	0.46
153_G	235_T	0.634	0.46
254_I	259_K	0.632	0.46
245_I	267_G	0.632	0.46
88_S	92_E	0.632	0.46
16_F	71_E	0.630	0.46
30_N	171_S	0.630	0.46
163_L	291_V	0.622	0.45
179_F	223_R	0.622	0.45
323_K	326_I	0.621	0.45
127_L	156_E	0.620	0.45
34_Q	40_R	0.620	0.45
20_K	72_G	0.618	0.45
110_S	292_K	0.618	0.45
17_S	20_K	0.618	0.45
228_D	278_I	0.618	0.45
81_G	87_K	0.617	0.45
33_Y	39_I	0.616	0.44
81_G	152_E	0.615	0.44
59_S	251_L	0.615	0.44
47_L	62_F	0.615	0.44
33_Y	98_K	0.614	0.44
100_E	103_R	0.614	0.44
30_N	157_A	0.614	0.44
107_R	110_S	0.611	0.44
46_P	52_G	0.611	0.44
101_A	124_I	0.608	0.44
166_S	169_A	0.608	0.44
266_Y	272_K	0.607	0.44
223_R	230_G	0.604	0.43
312_V	317_F	0.604	0.43
170_A	324_N	0.602	0.43
321_R	325_G	0.601	0.43
28_G	226_L	0.601	0.43
24_V	185_V	0.599	0.43
270_S	273_D	0.597	0.43
151_S	289_Q	0.596	0.42
32_L	117_L	0.594	0.42
131_M	179_F	0.594	0.42
154_E	186_R	0.593	0.42
38_A	57_H	0.592	0.42
157_A	235_T	0.592	0.42
102_E	171_S	0.592	0.42
69_L	142_M	0.592	0.42
312_V	321_R	0.591	0.42
238_N	281_I	0.586	0.41
279_D	283_G	0.585	0.41
203_V	237_Y	0.585	0.41
62_F	325_G	0.584	0.41
94_R	98_K	0.583	0.41
76_I	147_V	0.582	0.41
222_T	253_I	0.582	0.41
278_I	282_R	0.581	0.41
177_I	317_F	0.580	0.41
114_I	118_R	0.580	0.41
228_D	231_I	0.578	0.41
26_I	89_E	0.576	0.40
29_Y	157_A	0.575	0.40
35_F	38_A	0.574	0.40
171_S	186_R	0.574	0.40
91_L	132_V	0.574	0.40
37_A	40_R	0.573	0.40
282_R	286_L	0.571	0.40
253_I	276_F	0.570	0.40
161_N	169_A	0.570	0.40
319_E	327_E	0.566	0.39
268_E	274_I	0.566	0.39
318_S	324_N	0.566	0.39
41_Q	118_R	0.565	0.39
117_L	121_S	0.565	0.39
314_E	326_I	0.565	0.39
103_R	107_R	0.564	0.39
211_E	214_I	0.563	0.39
20_K	23_R	0.562	0.39
171_S	278_I	0.562	0.39
264_M	267_G	0.562	0.39
35_F	40_R	0.560	0.39
180_G	241_G	0.559	0.39
165_L	295_E	0.558	0.39
154_E	291_V	0.552	0.38
86_Q	302_P	0.552	0.38
82_K	289_Q	0.552	0.38
23_R	167_W	0.552	0.38
167_W	183_R	0.551	0.38
324_N	330_T	0.548	0.38
160_L	292_K	0.548	0.38
167_W	229_I	0.547	0.37
111_E	117_L	0.546	0.37
156_E	291_V	0.545	0.37
324_N	329_L	0.545	0.37
28_G	79_F	0.544	0.37
28_G	61_L	0.541	0.37
312_V	316_N	0.541	0.37
13_E	83_P	0.537	0.37
16_F	24_V	0.536	0.36
164_G	182_K	0.535	0.36
167_W	328_R	0.534	0.36
202_Y	329_L	0.533	0.36
314_E	327_E	0.533	0.36
308_I	319_E	0.533	0.36
316_N	324_N	0.530	0.36
182_K	213_E	0.530	0.36
103_R	114_I	0.530	0.36
104_K	117_L	0.529	0.36
136_K	146_I	0.527	0.36
326_I	330_T	0.527	0.36
21_G	245_I	0.525	0.35
65_T	280_E	0.525	0.35
116_E	169_A	0.524	0.35
57_H	60_G	0.524	0.35
269_I	273_D	0.524	0.35
120_Y	123_A	0.524	0.35
158_A	178_L	0.523	0.35
41_Q	121_S	0.523	0.35
130_I	303_N	0.523	0.35
96_K	100_E	0.520	0.35
156_E	159_Y	0.520	0.35
174_Y	241_G	0.518	0.35
112_G	192_G	0.518	0.35
51_Q	54_V	0.516	0.34
106_E	110_S	0.516	0.34
158_A	186_R	0.514	0.34
76_I	243_R	0.514	0.34
260_I	263_A	0.513	0.34
67_N	70_E	0.513	0.34
190_I	193_K	0.513	0.34
193_K	203_V	0.513	0.34
86_Q	237_Y	0.513	0.34
147_V	163_L	0.512	0.34
261_E	279_D	0.512	0.34
158_A	176_A	0.510	0.34
134_E	315_H	0.507	0.34
163_L	245_I	0.506	0.34
84_P	91_L	0.505	0.33
118_R	215_L	0.505	0.33
305_E	323_K	0.503	0.33
178_L	238_N	0.503	0.33
174_Y	315_H	0.501	0.33
90_E	121_S	0.500	0.33
30_N	153_G	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1b43A	2	0.9599	100	0.287	Contact Map
2izoA	1	0.7679	100	0.295	Contact Map
3oryA	3	0.9599	100	0.297	Contact Map
1ul1X	1	0.8338	100	0.3	Contact Map
1a76A	1	0.8997	100	0.303	Contact Map
4wa8A	1	0.8481	100	0.309	Contact Map
1rxwA	1	0.8739	100	0.313	Contact Map
3q8kA	1	0.9513	100	0.332	Contact Map
4q0wA	1	0.8252	100	0.333	Contact Map
3qe9Y	1	0.8997	100	0.411	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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