GREMLIN Database
HEM1 - Glutamyl-tRNA reductase
UniProt: Q980U7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (390)
Sequences: 2451 (1630)
Seq/√Len: 82.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_L303_N6.7591.00
264_I273_F6.5701.00
152_K156_E4.9241.00
268_T272_L4.2241.00
39_L43_I4.1711.00
185_R209_D3.9401.00
153_V302_I3.9301.00
185_R211_T3.7301.00
247_I272_L3.6631.00
48_A143_F3.5361.00
46_E136_G3.5211.00
209_D230_N3.3461.00
39_L42_L3.0991.00
355_D358_A3.0851.00
99_K307_E2.9891.00
15_L90_R2.9731.00
247_I273_F2.9451.00
298_E301_K2.9031.00
334_E337_R2.7811.00
337_R366_T2.7251.00
213_M232_E2.6741.00
152_K309_G2.5531.00
22_G88_Q2.5141.00
175_K205_E2.2801.00
217_I233_K2.2611.00
238_K241_N2.2531.00
217_I231_Y2.2451.00
187_L213_M2.1951.00
340_E343_R2.1801.00
217_I221_K2.1661.00
221_K225_L2.1601.00
101_L122_I2.1421.00
293_K296_E2.1401.00
309_G312_E2.1181.00
333_I373_S2.1081.00
27_H271_P2.0711.00
152_K308_D2.0601.00
200_S226_K2.0471.00
95_K314_L2.0341.00
186_I207_A2.0251.00
232_E238_K1.9741.00
330_M371_K1.9661.00
330_M378_F1.9511.00
103_L109_D1.9381.00
22_G25_N1.9101.00
59_Y143_F1.8981.00
278_V282_E1.8901.00
247_I268_T1.8851.00
334_E338_E1.8601.00
130_K140_Q1.8541.00
264_I276_N1.8331.00
249_I272_L1.8301.00
117_E197_K1.8241.00
60_L70_V1.8201.00
142_F313_L1.8091.00
96_D99_K1.7861.00
158_S161_K1.7481.00
13_S59_Y1.7451.00
211_T232_E1.7301.00
340_E368_S1.7221.00
106_S153_V1.7041.00
40_K44_N1.6981.00
81_H84_P1.6951.00
191_A214_N1.6891.00
25_N88_Q1.6521.00
129_F134_F1.6261.00
345_Y359_K1.6251.00
71_N89_A1.5901.00
147_I150_G1.5781.00
344_A361_I1.5631.00
389_E393_N1.5571.00
72_K76_Y1.5351.00
126_I140_Q1.5341.00
239_L245_A1.5140.99
394_Y401_I1.5050.99
50_L122_I1.4970.99
40_K43_I1.4960.99
16_F29_Y1.4950.99
149_V306_V1.4910.99
119_L150_G1.4720.99
254_L274_T1.4700.99
199_T227_F1.4530.99
46_E61_Y1.4450.99
333_I374_F1.4410.99
163_K169_L1.4240.99
300_A303_N1.4240.99
183_D208_K1.4150.99
98_A310_I1.4070.99
56_V107_G1.4050.99
213_M236_L1.4000.99
104_V109_D1.3990.99
337_R363_D1.3960.99
178_F244_V1.3930.99
196_Q226_K1.3770.99
98_A142_F1.3600.99
340_E372_K1.3510.99
59_Y104_V1.3490.99
163_K168_S1.3450.99
26_L282_E1.3440.99
325_F404_D1.3380.99
325_F399_I1.3260.99
126_I130_K1.3090.98
337_R367_R1.3020.98
170_A267_I1.3010.98
61_Y136_G1.2950.98
185_R241_N1.2730.98
45_A63_D1.2720.98
245_A264_I1.2720.98
72_K82_N1.2710.98
238_K242_F1.2630.98
186_I202_L1.2620.98
257_E260_W1.2580.98
370_I373_S1.2510.98
332_R376_P1.2510.98
213_M234_L1.2510.98
202_L207_A1.2460.98
106_S302_I1.2390.98
359_K363_D1.2350.98
360_E364_L1.2350.98
313_L316_D1.2290.98
177_R277_N1.2200.97
170_A265_V1.2200.97
106_S149_V1.2200.97
350_K358_A1.2020.97
17_T109_D1.2020.97
344_A365_M1.1950.97
150_G162_G1.1890.97
187_L242_F1.1830.97
135_S140_Q1.1790.97
329_I404_D1.1750.97
176_K290_L1.1750.97
90_R109_D1.1750.97
19_K109_D1.1710.97
230_N238_K1.1690.97
259_K275_G1.1680.97
384_L388_G1.1680.97
122_I143_F1.1660.97
107_G113_I1.1630.97
356_Q359_K1.1630.97
376_P403_K1.1590.97
166_I267_I1.1550.96
188_V202_L1.1520.96
364_L368_S1.1490.96
380_N383_S1.1440.96
269_V281_L1.1440.96
42_L47_F1.1430.96
141_I316_D1.1400.96
237_D241_N1.1310.96
253_N274_T1.1260.96
39_L134_F1.1230.96
98_A314_L1.1210.96
187_L238_K1.1170.96
218_E222_Q1.1150.96
349_E359_K1.1150.96
149_V305_L1.1120.96
211_T242_F1.1090.96
16_F89_A1.1090.96
59_Y107_G1.1050.95
285_E289_N1.1040.95
166_I194_M1.1010.95
329_I374_F1.0960.95
39_L44_N1.0930.95
23_I269_V1.0910.95
49_I58_I1.0910.95
29_Y85_I1.0810.95
95_K311_N1.0700.95
211_T238_K1.0690.95
357_Q360_E1.0570.94
195_A223_L1.0540.94
145_R149_V1.0460.94
307_E311_N1.0430.94
251_H272_L1.0420.94
140_Q144_E1.0420.94
211_T230_N1.0420.94
185_R208_K1.0410.94
38_S41_Q1.0340.94
102_F310_I1.0220.93
383_S387_N1.0120.93
43_I134_F1.0110.93
184_R244_V1.0100.93
329_I402_F1.0090.93
215_R270_P1.0080.93
172_D205_E1.0080.93
145_R148_K0.9960.92
35_E78_N0.9910.92
232_E236_L0.9870.92
11_Y138_Y0.9870.92
217_I234_L0.9840.92
344_A366_T0.9810.92
12_C60_L0.9810.92
50_L125_T0.9770.91
180_D183_D0.9760.91
106_S305_L0.9740.91
14_I71_N0.9710.91
127_D131_K0.9690.91
154_R344_A0.9660.91
92_L96_D0.9650.91
178_F277_N0.9640.91
99_K310_I0.9640.91
187_L232_E0.9630.91
145_R309_G0.9630.91
68_K86_G0.9620.91
129_F135_S0.9600.91
393_N396_N0.9590.91
220_A224_A0.9580.91
222_Q225_L0.9570.91
393_N397_F0.9520.90
188_V199_T0.9500.90
362_L365_M0.9490.90
163_K172_D0.9350.90
18_Y111_L0.9330.89
123_R151_R0.9310.89
279_I282_E0.9290.89
112_S286_R0.9290.89
275_G278_V0.9250.89
151_R155_E0.9220.89
320_E323_T0.9160.89
180_D388_G0.9090.88
366_T369_I0.9040.88
338_E363_D0.8970.88
144_E148_K0.8970.88
328_K399_I0.8960.88
197_K201_M0.8930.87
340_E364_L0.8930.87
48_A135_S0.8900.87
20_T90_R0.8900.87
27_H46_E0.8880.87
173_E279_I0.8860.87
208_K230_N0.8830.87
187_L234_L0.8810.87
304_K307_E0.8800.87
278_V281_L0.8700.86
249_I268_T0.8670.86
174_A263_L0.8660.86
166_I284_L0.8640.86
398_L401_I0.8580.85
257_E261_N0.8570.85
37_K132_L0.8570.85
304_K308_D0.8560.85
105_A122_I0.8560.85
341_I362_L0.8550.85
394_Y397_F0.8530.85
210_V229_Y0.8530.85
167_Y198_I0.8510.85
357_Q361_I0.8450.84
216_T220_A0.8430.84
339_N342_L0.8420.84
189_I245_A0.8410.84
316_D319_K0.8370.84
15_L26_L0.8360.84
64_T68_K0.8360.84
128_M131_K0.8350.84
141_I320_E0.8340.83
137_K320_E0.8310.83
71_N86_G0.8290.83
396_N400_D0.8290.83
33_E124_S0.8270.83
179_N183_D0.8230.83
306_V332_R0.8210.83
213_M233_K0.8160.82
116_Y154_R0.8130.82
274_T280_T0.8130.82
127_D130_K0.8110.82
156_E305_L0.8060.81
112_S169_L0.8040.81
28_L84_P0.8030.81
222_Q226_K0.7990.81
348_L361_I0.7980.81
128_M132_L0.7960.81
239_L242_F0.7960.81
11_Y61_Y0.7950.80
177_R244_V0.7950.80
348_L362_L0.7950.80
65_N68_K0.7940.80
184_R243_D0.7940.80
144_E147_I0.7940.80
17_T325_F0.7930.80
264_I278_V0.7930.80
15_L151_R0.7880.80
100_H109_D0.7850.80
107_G160_S0.7840.80
47_F58_I0.7820.79
282_E291_N0.7820.79
279_I283_E0.7800.79
218_E221_K0.7800.79
36_I128_M0.7770.79
199_T229_Y0.7770.79
363_D367_R0.7760.79
341_I363_D0.7750.79
329_I398_L0.7730.79
189_I273_F0.7700.78
325_F328_K0.7690.78
11_Y97_A0.7680.78
245_A262_T0.7650.78
330_M375_Q0.7640.78
48_A125_T0.7620.78
296_E300_A0.7590.77
316_D323_T0.7590.77
380_N400_D0.7580.77
191_A212_I0.7570.77
301_K304_K0.7510.77
243_D260_W0.7490.76
124_S245_A0.7480.76
187_L326_M0.7460.76
129_F348_L0.7460.76
335_T339_N0.7450.76
294_A297_E0.7440.76
166_I281_L0.7440.76
187_L236_L0.7390.75
185_R242_F0.7380.75
385_I388_G0.7380.75
365_M369_I0.7370.75
325_F381_I0.7330.75
198_I246_F0.7300.75
75_Q80_I0.7280.74
183_D186_I0.7280.74
15_L20_T0.7260.74
184_R275_G0.7230.74
82_N86_G0.7210.74
157_T305_L0.7200.73
240_G256_L0.7190.73
282_E295_R0.7180.73
336_I369_I0.7170.73
146_A150_G0.7160.73
257_E277_N0.7160.73
343_R375_Q0.7120.73
157_T302_I0.7120.73
24_S27_H0.7110.73
117_E271_P0.7090.72
378_F382_R0.7090.72
163_K291_N0.7070.72
282_E285_E0.7070.72
96_D307_E0.7060.72
112_S166_I0.7060.72
332_R335_T0.7050.72
35_E41_Q0.7040.72
14_I91_V0.7030.72
153_V305_L0.7020.72
142_F316_D0.6990.71
277_N280_T0.6940.71
343_R368_S0.6940.71
337_R369_I0.6930.71
67_L91_V0.6930.71
116_Y150_G0.6920.71
159_I333_I0.6920.71
271_P283_E0.6910.70
306_V310_I0.6900.70
237_D256_L0.6890.70
214_N220_A0.6870.70
288_S291_N0.6860.70
52_T55_R0.6850.70
261_N277_N0.6850.70
357_Q362_L0.6790.69
17_T113_I0.6790.69
203_H227_F0.6750.69
33_E37_K0.6750.69
26_L167_Y0.6720.68
138_Y316_D0.6710.68
141_I147_I0.6710.68
84_P237_D0.6700.68
263_L277_N0.6700.68
387_N390_N0.6680.68
31_F49_I0.6680.68
179_N250_Y0.6660.68
41_Q76_Y0.6660.68
335_T338_E0.6650.67
102_F329_I0.6630.67
157_T174_A0.6620.67
122_I244_V0.6620.67
137_K140_Q0.6610.67
105_A146_A0.6590.67
10_N94_G0.6570.67
318_K385_I0.6560.66
41_Q44_N0.6550.66
15_L92_L0.6510.66
370_I374_F0.6490.66
17_T90_R0.6490.66
108_A303_N0.6470.65
29_Y80_I0.6460.65
29_Y78_N0.6440.65
329_I377_L0.6430.65
31_F56_V0.6430.65
333_I370_I0.6420.65
295_R298_E0.6420.65
120_S328_K0.6410.65
252_E274_T0.6400.65
280_T358_A0.6400.65
216_T219_K0.6390.64
191_A219_K0.6390.64
397_F401_I0.6370.64
299_L302_I0.6360.64
23_I271_P0.6360.64
336_I365_M0.6350.64
10_N13_S0.6330.64
164_V295_R0.6330.64
59_Y122_I0.6330.64
112_S141_I0.6330.64
58_I70_V0.6320.64
125_T129_F0.6310.63
68_K345_Y0.6300.63
111_L281_L0.6300.63
246_F272_L0.6290.63
26_L269_V0.6280.63
172_D267_I0.6260.63
72_K235_D0.6240.63
248_S267_I0.6230.62
75_Q82_N0.6220.62
38_S77_L0.6210.62
384_L389_E0.6200.62
150_G154_R0.6190.62
30_Y51_Q0.6190.62
27_H281_L0.6190.62
174_A181_F0.6180.62
342_L345_Y0.6180.62
310_I313_L0.6160.62
223_L226_K0.6160.62
325_F329_I0.6150.61
291_N295_R0.6150.61
163_K299_L0.6140.61
33_E36_I0.6130.61
381_I398_L0.6120.61
48_A101_L0.6110.61
100_H104_V0.6110.61
173_E287_I0.6100.61
384_L394_Y0.6090.61
271_P282_E0.6080.61
207_A210_V0.6060.60
189_I236_L0.6050.60
80_I85_I0.6050.60
167_Y267_I0.6020.60
95_K373_S0.6000.60
169_L288_S0.6000.60
394_Y398_L0.5990.59
157_T298_E0.5990.59
119_L147_I0.5980.59
280_T283_E0.5980.59
373_S378_F0.5980.59
149_V302_I0.5970.59
242_F262_T0.5960.59
123_R265_V0.5940.59
49_I73_I0.5940.59
16_F21_I0.5940.59
358_A362_L0.5920.59
348_L358_A0.5910.58
191_A223_L0.5900.58
341_I345_Y0.5890.58
62_S66_T0.5890.58
111_L166_I0.5880.58
365_M368_S0.5880.58
173_E176_K0.5860.58
356_Q360_E0.5860.58
117_E194_M0.5860.58
216_T382_R0.5850.58
221_K233_K0.5850.58
111_L115_E0.5850.58
330_M377_L0.5850.58
247_I281_L0.5850.58
177_R255_R0.5840.58
249_I270_P0.5840.58
130_K144_E0.5840.58
47_F60_L0.5820.57
13_S97_A0.5820.57
360_E363_D0.5810.57
30_Y36_I0.5810.57
380_N401_I0.5810.57
202_L212_I0.5810.57
174_A244_V0.5780.57
34_T124_S0.5760.56
201_M302_I0.5750.56
277_N282_E0.5750.56
196_Q200_S0.5750.56
171_I282_E0.5750.56
290_L294_A0.5740.56
214_N219_K0.5740.56
246_F267_I0.5720.56
331_K335_T0.5720.56
359_K362_L0.5710.56
123_R147_I0.5710.56
212_I229_Y0.5710.56
67_L93_C0.5690.56
251_H268_T0.5690.56
12_C62_S0.5680.55
367_R382_R0.5680.55
363_D366_T0.5660.55
105_A135_S0.5650.55
69_E72_K0.5640.55
166_I305_L0.5640.55
396_N403_K0.5630.55
23_I27_H0.5630.55
196_Q248_S0.5630.55
212_I231_Y0.5610.55
198_I216_T0.5610.55
35_E38_S0.5600.54
260_W356_Q0.5560.54
224_A231_Y0.5560.54
150_G302_I0.5560.54
236_L242_F0.5550.54
49_I77_L0.5540.54
126_I147_I0.5530.53
37_K128_M0.5530.53
366_T373_S0.5530.53
41_Q357_Q0.5520.53
167_Y171_I0.5490.53
85_I97_A0.5480.53
214_N223_L0.5460.53
235_D405_G0.5430.52
76_Y233_K0.5430.52
126_I144_E0.5430.52
14_I347_E0.5430.52
56_V143_F0.5420.52
362_L393_N0.5420.52
36_I43_I0.5410.52
113_I142_F0.5410.52
68_K241_N0.5400.52
179_N184_R0.5400.52
215_R249_I0.5400.52
276_N282_E0.5390.52
252_E272_L0.5380.52
177_R257_E0.5380.52
109_D140_Q0.5360.51
250_Y272_L0.5360.51
238_K370_I0.5360.51
105_A119_L0.5360.51
247_I264_I0.5360.51
337_R344_A0.5350.51
204_N287_I0.5350.51
15_L21_I0.5350.51
154_R381_I0.5350.51
31_F78_N0.5340.51
17_T163_K0.5330.51
87_N237_D0.5330.51
207_A244_V0.5330.51
189_I198_I0.5310.51
123_R327_S0.5310.51
311_N315_Y0.5310.51
230_N241_N0.5290.50
99_K303_N0.5290.50
362_L366_T0.5290.50
102_F111_L0.5280.50
69_E362_L0.5280.50
178_F263_L0.5270.50
101_L143_F0.5250.50
45_A210_V0.5240.50
278_V287_I0.5240.50
102_F137_K0.5210.49
201_M204_N0.5200.49
186_I263_L0.5200.49
239_L257_E0.5200.49
325_F339_N0.5200.49
188_V213_M0.5190.49
376_P380_N0.5170.49
221_K231_Y0.5170.49
15_L197_K0.5160.49
243_D257_E0.5160.49
16_F88_Q0.5150.48
17_T104_V0.5150.48
182_Y189_I0.5150.48
10_N86_G0.5150.48
48_A59_Y0.5140.48
28_L80_I0.5140.48
225_L235_D0.5130.48
177_R258_N0.5130.48
361_I364_L0.5120.48
56_V323_T0.5120.48
167_Y172_D0.5120.48
13_S90_R0.5100.48
212_I402_F0.5090.48
101_L202_L0.5090.48
29_Y51_Q0.5070.47
221_K230_N0.5070.47
258_N331_K0.5070.47
246_F336_I0.5060.47
246_F265_V0.5050.47
202_L206_G0.5050.47
75_Q81_H0.5050.47
305_L309_G0.5040.47
85_I91_V0.5040.47
322_Y382_R0.5030.47
125_T346_K0.5030.47
388_G393_N0.5020.47
267_I368_S0.5020.47
34_T37_K0.5010.47
48_A122_I0.5010.47
37_K42_L0.5000.47
95_K310_I0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n7rA 2 0.8732 100 0.35 Contact Map
1gpjA 2 0.8685 100 0.464 Contact Map
1edzA 2 0.6596 99.9 0.821 Contact Map
3u62A 1 0.5399 99.9 0.825 Contact Map
4ppmA 2 0.1479 99.9 0.825 Contact Map
1p77A 1 0.5798 99.9 0.826 Contact Map
3fbtA 2 0.6009 99.8 0.836 Contact Map
1nytA 6 0.5962 99.8 0.837 Contact Map
2hk9A 1 0.5798 99.7 0.852 Contact Map
3o8qA 2 0.5962 99.7 0.853 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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