GREMLIN Database
Q980U6 - Delta-aminolevulinic acid dehydratase
UniProt: Q980U6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 341 (319)
Sequences: 2889 (1492)
Seq/√Len: 83.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
239_A271_L3.4811.00
270_R274_D3.4611.00
98_S101_D3.4271.00
246_A272_V3.3741.00
71_Y329_N3.0121.00
94_D134_A2.9681.00
36_D316_K2.9491.00
305_K334_W2.7971.00
125_T166_Q2.7821.00
178_S183_V2.5511.00
250_I279_Y2.5431.00
107_Q165_S2.5051.00
262_A315_I2.5011.00
312_T331_I2.4951.00
246_A257_L2.4081.00
110_V123_V2.4001.00
143_Y146_G2.3841.00
164_L190_A2.2751.00
114_K172_D2.2531.00
168_E196_Y2.2431.00
149_V198_D2.2291.00
28_S235_D2.2231.00
239_A268_V2.2001.00
151_D154_E2.1591.00
294_K304_E2.1521.00
50_P60_Y2.1361.00
100_Y158_I2.0481.00
273_K321_D2.0321.00
73_Q77_E2.0281.00
74_D333_R2.0271.00
52_Q60_Y2.0121.00
303_D306_T1.9891.00
21_K25_D1.9651.00
206_V246_A1.9621.00
308_V334_W1.9611.00
269_I283_A1.9541.00
102_K168_E1.9491.00
295_A301_W1.9321.00
14_P248_L1.9151.00
282_A322_L1.8881.00
51_E61_R1.8801.00
256_I282_A1.8681.00
76_Y117_F1.8331.00
160_A190_A1.8261.00
93_D97_S1.7991.00
110_V125_T1.7741.00
69_I117_F1.7421.00
247_R251_E1.7301.00
67_K70_N1.7271.00
38_V322_L1.7071.00
271_L274_D1.6821.00
240_F273_K1.6781.00
50_P67_K1.6761.00
100_Y161_K1.6611.00
25_D81_R1.6461.00
309_L331_I1.6451.00
64_P112_I1.6141.00
54_A218_D1.6121.00
12_L244_K1.6111.00
140_L158_I1.5971.00
247_R276_F1.5921.00
53_I59_I1.5891.00
69_I116_S1.5861.00
70_N73_Q1.5691.00
82_S124_I1.5671.00
212_M311_I1.5501.00
68_L113_I1.5441.00
263_H285_H1.5301.00
25_D35_N1.4970.99
31_S35_N1.4870.99
240_F271_L1.4860.99
264_T314_A1.4790.99
83_V121_I1.4730.99
73_Q117_F1.4700.99
50_P62_Y1.4660.99
308_V327_Y1.4650.99
49_E63_P1.4610.99
168_E194_A1.4500.99
45_E108_R1.4460.99
34_Q336_K1.4380.99
173_V256_I1.4320.99
48_N67_K1.4140.99
83_V123_V1.4100.99
266_L315_I1.4080.99
74_D329_N1.3980.99
55_S218_D1.3880.99
39_L75_S1.3830.99
129_T162_I1.3810.99
330_D333_R1.3740.99
142_K151_D1.3650.99
262_A283_A1.3630.99
272_V281_L1.3560.99
285_H327_Y1.3530.99
304_E308_V1.3520.99
304_E330_D1.3420.99
125_T171_A1.3420.99
202_L256_I1.3410.99
84_I324_I1.3410.99
84_I175_A1.3400.99
44_K51_E1.3370.99
293_I311_I1.3310.99
17_L27_V1.3070.98
72_L113_I1.3060.98
37_L331_I1.2980.98
69_I112_I1.2960.98
250_I257_L1.2910.98
127_E174_I1.2820.98
72_L117_F1.2690.98
72_L121_I1.2690.98
250_I276_F1.2610.98
173_V200_L1.2580.98
30_T315_I1.2380.98
212_M264_T1.2320.98
38_V124_I1.2310.98
294_K330_D1.2300.98
72_L83_V1.2230.98
205_S246_A1.2120.97
247_R275_H1.2050.97
164_L194_A1.2010.97
302_I307_A1.2000.97
160_A186_A1.1970.97
104_G107_Q1.1950.97
122_I173_V1.1950.97
28_S237_R1.1890.97
240_F321_D1.1690.97
285_H311_I1.1670.97
71_Y75_S1.1660.97
142_K154_E1.1580.97
76_Y121_I1.1480.96
46_N66_D1.1470.96
283_A315_I1.1460.96
264_T311_I1.1460.96
211_V306_T1.1390.96
190_A194_A1.1350.96
73_Q116_S1.1270.96
211_V307_A1.1270.96
62_Y67_K1.1260.96
63_P66_D1.1190.96
297_A302_I1.1150.96
96_A133_M1.1130.96
112_I115_D1.1090.96
39_L59_I1.0970.95
212_M293_I1.0960.95
92_K223_K1.0900.95
22_L122_I1.0870.95
312_T315_I1.0830.95
325_T328_A1.0800.95
263_H311_I1.0770.95
257_L279_Y1.0750.95
263_H314_A1.0710.95
142_K149_V1.0680.95
19_K198_D1.0650.95
297_A308_V1.0600.95
103_N108_R1.0540.94
44_K49_E1.0540.94
208_Y234_M1.0460.94
239_A270_R1.0400.94
19_K149_V1.0360.94
331_I334_W1.0310.94
135_N141_V1.0280.94
75_S329_N1.0260.94
37_L325_T1.0240.93
257_L272_V1.0170.93
114_K123_V1.0160.93
23_V122_I0.9990.93
305_K308_V0.9910.92
128_C138_C0.9880.92
43_I68_L0.9850.92
69_I73_Q0.9810.92
20_S200_L0.9670.91
273_K278_E0.9640.91
237_R313_T0.9630.91
124_I175_A0.9610.91
163_A174_I0.9500.91
243_I246_A0.9490.91
44_K61_R0.9480.90
61_R221_Y0.9470.90
113_I117_F0.9460.90
266_L269_I0.9430.90
311_I314_A0.9430.90
44_K63_P0.9410.90
39_L329_N0.9400.90
56_M291_S0.9380.90
64_P109_A0.9380.90
294_K298_I0.9370.90
309_L334_W0.9320.90
78_N333_R0.9310.90
257_L281_L0.9300.90
159_H178_S0.9250.89
93_D96_A0.9240.89
124_I173_V0.9220.89
127_E166_Q0.9200.89
78_N329_N0.9200.89
185_R189_D0.9180.89
311_I327_Y0.9160.89
293_I327_Y0.9160.89
75_S83_V0.9140.89
80_I332_A0.9100.89
110_V171_A0.9100.89
48_N66_D0.9030.88
316_K323_I0.9030.88
34_Q332_A0.9030.88
100_Y165_S0.9000.88
55_S301_W0.8990.88
19_K23_V0.8980.88
11_V14_P0.8970.88
106_I132_Y0.8960.88
12_L251_E0.8950.88
23_V200_L0.8950.88
247_R278_E0.8950.88
131_E221_Y0.8940.88
184_V201_I0.8850.87
71_Y74_D0.8850.87
293_I302_I0.8820.87
242_A268_V0.8770.87
41_V68_L0.8730.86
269_I315_I0.8730.86
128_C229_R0.8710.86
112_I116_S0.8700.86
129_T158_I0.8680.86
256_I322_L0.8630.86
293_I307_A0.8620.86
95_I100_Y0.8600.86
76_Y119_D0.8590.86
47_I63_P0.8550.85
266_L314_A0.8550.85
138_C229_R0.8540.85
305_K309_L0.8510.85
113_I121_I0.8510.85
91_Y98_S0.8430.85
212_M307_A0.8420.84
202_L322_L0.8420.84
157_K161_K0.8420.84
297_A304_E0.8360.84
34_Q37_L0.8350.84
243_I272_V0.8310.84
158_I162_I0.8300.84
257_L276_F0.8280.83
331_I335_I0.8280.83
269_I320_A0.8210.83
111_R168_E0.8180.83
176_P187_I0.8170.83
156_L186_A0.8130.82
163_A187_I0.8090.82
158_I161_K0.8070.82
38_V324_I0.8020.81
206_V257_L0.8000.81
166_Q174_I0.8000.81
73_Q76_Y0.7990.81
46_N49_E0.7970.81
293_I297_A0.7950.81
72_L112_I0.7950.81
294_K308_V0.7930.81
294_K327_Y0.7890.80
309_L313_T0.7840.80
141_V150_V0.7810.80
304_E334_W0.7790.80
49_E67_K0.7760.79
183_V203_S0.7730.79
11_V189_D0.7720.79
295_A299_N0.7710.79
110_V166_Q0.7680.79
20_S23_V0.7670.78
212_M263_H0.7650.78
285_H293_I0.7550.77
278_E281_L0.7530.77
327_Y334_W0.7520.77
32_I331_I0.7510.77
111_R115_D0.7490.77
127_E178_S0.7470.77
243_I247_R0.7460.77
83_V113_I0.7460.77
32_I37_L0.7430.76
44_K47_I0.7420.76
206_V272_V0.7370.76
64_P105_I0.7350.75
258_M324_I0.7340.75
41_V71_Y0.7330.75
32_I312_T0.7300.75
41_V85_L0.7300.75
242_A246_A0.7280.75
45_E90_S0.7240.74
59_I290_Y0.7230.74
94_D135_N0.7220.74
87_G138_C0.7210.74
20_S122_I0.7190.74
88_I131_E0.7130.73
309_L335_I0.7110.73
328_A332_A0.7090.73
87_G128_C0.7090.73
113_I123_V0.7070.73
159_H183_V0.7030.72
212_M327_Y0.7030.72
292_M296_A0.7020.72
26_L81_R0.7010.72
11_V248_L0.7000.72
51_E221_Y0.7000.72
87_G229_R0.6990.72
62_Y71_Y0.6990.72
128_C131_E0.6940.71
133_M141_V0.6940.71
49_E66_D0.6920.71
64_P69_I0.6910.71
88_I221_Y0.6910.71
85_L110_V0.6850.70
53_I218_D0.6820.70
12_L248_L0.6810.70
243_I275_H0.6800.70
131_E138_C0.6800.70
130_D138_C0.6790.70
43_I109_A0.6740.69
68_L72_L0.6710.69
150_V180_M0.6690.68
307_A311_I0.6660.68
236_P313_T0.6650.68
264_T315_I0.6640.68
127_E183_V0.6590.67
92_K225_A0.6590.67
32_I309_L0.6580.67
304_E327_Y0.6580.67
238_N241_E0.6570.67
164_L167_A0.6560.67
61_R131_E0.6510.66
25_D237_R0.6510.66
220_A224_P0.6500.66
64_P108_R0.6470.66
27_V235_D0.6470.66
167_A199_T0.6450.66
45_E91_Y0.6440.66
131_E229_R0.6410.65
276_F279_Y0.6400.65
78_N332_A0.6370.65
258_M282_A0.6350.64
264_T285_H0.6340.64
282_A324_I0.6340.64
57_P301_W0.6330.64
50_P71_Y0.6320.64
203_S206_V0.6280.64
297_A303_D0.6270.63
42_F216_F0.6250.63
190_A193_S0.6250.63
14_P17_L0.6240.63
155_S159_H0.6230.63
263_H315_I0.6230.63
141_V225_A0.6210.63
294_K297_A0.6210.63
75_S121_I0.6190.62
209_A230_R0.6190.62
80_I329_N0.6180.62
308_V330_D0.6170.62
76_Y118_K0.6170.62
240_F270_R0.6150.62
141_V151_D0.6150.62
130_D220_A0.6140.62
84_I124_I0.6130.62
23_V26_L0.6130.62
167_A200_L0.6070.61
72_L75_S0.6070.61
308_V311_I0.6060.61
240_F278_E0.6040.61
48_N63_P0.6040.61
17_L200_L0.6020.60
107_Q166_Q0.6010.60
130_D229_R0.6010.60
239_A274_D0.5990.60
230_R306_T0.5980.60
55_S291_S0.5970.60
63_P67_K0.5960.60
69_I72_L0.5960.60
154_E157_K0.5950.59
22_L25_D0.5940.59
47_I66_D0.5940.59
14_P244_K0.5920.59
107_Q162_I0.5920.59
41_V83_V0.5880.59
114_K118_K0.5880.59
21_K28_S0.5880.59
84_I87_G0.5850.58
271_L275_H0.5840.58
77_E336_K0.5840.58
273_K279_Y0.5820.58
149_V197_I0.5810.58
30_T239_A0.5800.57
68_L109_A0.5790.57
273_K276_F0.5790.57
149_V231_G0.5790.57
129_T183_V0.5790.57
46_N63_P0.5790.57
58_G330_D0.5780.57
30_T237_R0.5770.57
78_N81_R0.5760.57
208_Y239_A0.5750.57
246_A250_I0.5740.57
285_H312_T0.5730.57
129_T178_S0.5730.57
51_E131_E0.5710.56
37_L124_I0.5710.56
205_S272_V0.5700.56
23_V173_V0.5690.56
150_V232_Y0.5690.56
100_Y162_I0.5680.56
129_T140_L0.5670.56
62_Y72_L0.5670.56
138_C220_A0.5660.56
236_P265_Y0.5660.56
72_L116_S0.5640.55
174_I187_I0.5640.55
31_S36_D0.5610.55
228_D306_T0.5600.55
140_L162_I0.5590.55
103_N111_R0.5590.55
184_V187_I0.5580.55
192_D197_I0.5580.55
186_A190_A0.5560.54
70_N116_S0.5550.54
53_I61_R0.5550.54
117_F121_I0.5540.54
88_I92_K0.5540.54
42_F284_Y0.5530.54
273_K281_L0.5500.54
29_E238_N0.5490.53
262_A269_I0.5490.53
128_C220_A0.5440.53
173_V202_L0.5440.53
98_S162_I0.5440.53
87_G131_E0.5440.53
188_R192_D0.5420.53
38_V82_S0.5390.52
174_I201_I0.5360.52
96_A129_T0.5360.52
315_I320_A0.5350.52
142_K146_G0.5340.51
44_K66_D0.5330.51
150_V231_G0.5320.51
52_Q298_I0.5300.51
154_E158_I0.5290.51
325_T331_I0.5280.51
47_I108_R0.5270.51
311_I315_I0.5260.50
88_I128_C0.5250.50
240_F244_K0.5250.50
99_A162_I0.5240.50
291_S295_A0.5240.50
296_A301_W0.5230.50
220_A229_R0.5230.50
94_D140_L0.5220.50
44_K67_K0.5210.50
140_L154_E0.5190.49
143_Y149_V0.5180.49
26_L322_L0.5170.49
146_G149_V0.5160.49
283_A320_A0.5140.49
166_Q171_A0.5130.49
70_N74_D0.5130.49
56_M301_W0.5120.49
88_I138_C0.5110.48
40_P216_F0.5110.48
270_R273_K0.5110.48
39_L71_Y0.5100.48
64_P67_K0.5090.48
85_L106_I0.5090.48
88_I229_R0.5080.48
17_L20_S0.5080.48
156_L160_A0.5080.48
53_I219_A0.5070.48
220_A225_A0.5070.48
30_T313_T0.5070.48
293_I304_E0.5060.48
327_Y330_D0.5060.48
125_T163_A0.5040.47
32_I313_T0.5030.47
36_D323_I0.5020.47
76_Y116_S0.5020.47
204_Y222_S0.5000.47
41_V72_L0.5000.47
70_N77_E0.5000.47
74_D78_N0.5000.47
250_I278_E0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w1zA 5 0.9355 100 0.022 Contact Map
1w5qA 5 0.9296 100 0.027 Contact Map
3obkA 5 0.9677 100 0.039 Contact Map
1l6sA 5 0.9472 100 0.047 Contact Map
1h7nA 5 0.9648 100 0.06 Contact Map
1pv8A 5 0.827 100 0.067 Contact Map
1wbhA 3 0.5689 96.6 0.954 Contact Map
3i4eA 4 0.827 96.6 0.955 Contact Map
3vcrA 3 0.5836 95.9 0.957 Contact Map
1vhcA 3 0.5689 95.3 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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