Q980U6 - SULSO - GREMLIN Contacts

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Q980U6 - Delta-aminolevulinic acid dehydratase

UniProt:	Q980U6	Sequences: MIFLKMVTFPVLRPRRLRKSKLVRDLVSETSISQNDLVLPVFIKENINEPEQIASMPGIYRYPPNDKLINYLQDSYENGIRSVILFGIPSYKDDIASSAYDKNGIIQRAVRIIKDSFKDKIIVITDECTDEYMANGHCGLVKYTNGCYVVDNDESLKIHAKIALSQAEAGADVIAPSSMMDGVVRAIRDALDSAGYIDTLILSYSVKYASVMYGPFRDAAYSKPAFGDRRGYQMDPRNAFEAIKEARLDIEEGADILMVKPAHTYLDVIRLVKDHFPEYPLAAYHVSGEYSMIKAAAINGWIDEKTAVLEITTAIKRAGADLIITYYANDIARWIKDGVPF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	341 (319)
Sequences:	2889 (1492)
Seq/√Len:	83.6

ECOLI - HEM2
BACSU - HEM2
HALSA - Q9HMZ1
SULSO - Q980U6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
239_A	271_L	3.481	1.00
270_R	274_D	3.461	1.00
98_S	101_D	3.427	1.00
246_A	272_V	3.374	1.00
71_Y	329_N	3.012	1.00
94_D	134_A	2.968	1.00
36_D	316_K	2.949	1.00
305_K	334_W	2.797	1.00
125_T	166_Q	2.782	1.00
178_S	183_V	2.551	1.00
250_I	279_Y	2.543	1.00
107_Q	165_S	2.505	1.00
262_A	315_I	2.501	1.00
312_T	331_I	2.495	1.00
246_A	257_L	2.408	1.00
110_V	123_V	2.400	1.00
143_Y	146_G	2.384	1.00
164_L	190_A	2.275	1.00
114_K	172_D	2.253	1.00
168_E	196_Y	2.243	1.00
149_V	198_D	2.229	1.00
28_S	235_D	2.223	1.00
239_A	268_V	2.200	1.00
151_D	154_E	2.159	1.00
294_K	304_E	2.152	1.00
50_P	60_Y	2.136	1.00
100_Y	158_I	2.048	1.00
273_K	321_D	2.032	1.00
73_Q	77_E	2.028	1.00
74_D	333_R	2.027	1.00
52_Q	60_Y	2.012	1.00
303_D	306_T	1.989	1.00
21_K	25_D	1.965	1.00
206_V	246_A	1.962	1.00
308_V	334_W	1.961	1.00
269_I	283_A	1.954	1.00
102_K	168_E	1.949	1.00
295_A	301_W	1.932	1.00
14_P	248_L	1.915	1.00
282_A	322_L	1.888	1.00
51_E	61_R	1.880	1.00
256_I	282_A	1.868	1.00
76_Y	117_F	1.833	1.00
160_A	190_A	1.826	1.00
93_D	97_S	1.799	1.00
110_V	125_T	1.774	1.00
69_I	117_F	1.742	1.00
247_R	251_E	1.730	1.00
67_K	70_N	1.727	1.00
38_V	322_L	1.707	1.00
271_L	274_D	1.682	1.00
240_F	273_K	1.678	1.00
50_P	67_K	1.676	1.00
100_Y	161_K	1.661	1.00
25_D	81_R	1.646	1.00
309_L	331_I	1.645	1.00
64_P	112_I	1.614	1.00
54_A	218_D	1.612	1.00
12_L	244_K	1.611	1.00
140_L	158_I	1.597	1.00
247_R	276_F	1.592	1.00
53_I	59_I	1.589	1.00
69_I	116_S	1.586	1.00
70_N	73_Q	1.569	1.00
82_S	124_I	1.567	1.00
212_M	311_I	1.550	1.00
68_L	113_I	1.544	1.00
263_H	285_H	1.530	1.00
25_D	35_N	1.497	0.99
31_S	35_N	1.487	0.99
240_F	271_L	1.486	0.99
264_T	314_A	1.479	0.99
83_V	121_I	1.473	0.99
73_Q	117_F	1.470	0.99
50_P	62_Y	1.466	0.99
308_V	327_Y	1.465	0.99
49_E	63_P	1.461	0.99
168_E	194_A	1.450	0.99
45_E	108_R	1.446	0.99
34_Q	336_K	1.438	0.99
173_V	256_I	1.432	0.99
48_N	67_K	1.414	0.99
83_V	123_V	1.410	0.99
266_L	315_I	1.408	0.99
74_D	329_N	1.398	0.99
55_S	218_D	1.388	0.99
39_L	75_S	1.383	0.99
129_T	162_I	1.381	0.99
330_D	333_R	1.374	0.99
142_K	151_D	1.365	0.99
262_A	283_A	1.363	0.99
272_V	281_L	1.356	0.99
285_H	327_Y	1.353	0.99
304_E	308_V	1.352	0.99
304_E	330_D	1.342	0.99
125_T	171_A	1.342	0.99
202_L	256_I	1.341	0.99
84_I	324_I	1.341	0.99
84_I	175_A	1.340	0.99
44_K	51_E	1.337	0.99
293_I	311_I	1.331	0.99
17_L	27_V	1.307	0.98
72_L	113_I	1.306	0.98
37_L	331_I	1.298	0.98
69_I	112_I	1.296	0.98
250_I	257_L	1.291	0.98
127_E	174_I	1.282	0.98
72_L	117_F	1.269	0.98
72_L	121_I	1.269	0.98
250_I	276_F	1.261	0.98
173_V	200_L	1.258	0.98
30_T	315_I	1.238	0.98
212_M	264_T	1.232	0.98
38_V	124_I	1.231	0.98
294_K	330_D	1.230	0.98
72_L	83_V	1.223	0.98
205_S	246_A	1.212	0.97
247_R	275_H	1.205	0.97
164_L	194_A	1.201	0.97
302_I	307_A	1.200	0.97
160_A	186_A	1.197	0.97
104_G	107_Q	1.195	0.97
122_I	173_V	1.195	0.97
28_S	237_R	1.189	0.97
240_F	321_D	1.169	0.97
285_H	311_I	1.167	0.97
71_Y	75_S	1.166	0.97
142_K	154_E	1.158	0.97
76_Y	121_I	1.148	0.96
46_N	66_D	1.147	0.96
283_A	315_I	1.146	0.96
264_T	311_I	1.146	0.96
211_V	306_T	1.139	0.96
190_A	194_A	1.135	0.96
73_Q	116_S	1.127	0.96
211_V	307_A	1.127	0.96
62_Y	67_K	1.126	0.96
63_P	66_D	1.119	0.96
297_A	302_I	1.115	0.96
96_A	133_M	1.113	0.96
112_I	115_D	1.109	0.96
39_L	59_I	1.097	0.95
212_M	293_I	1.096	0.95
92_K	223_K	1.090	0.95
22_L	122_I	1.087	0.95
312_T	315_I	1.083	0.95
325_T	328_A	1.080	0.95
263_H	311_I	1.077	0.95
257_L	279_Y	1.075	0.95
263_H	314_A	1.071	0.95
142_K	149_V	1.068	0.95
19_K	198_D	1.065	0.95
297_A	308_V	1.060	0.95
103_N	108_R	1.054	0.94
44_K	49_E	1.054	0.94
208_Y	234_M	1.046	0.94
239_A	270_R	1.040	0.94
19_K	149_V	1.036	0.94
331_I	334_W	1.031	0.94
135_N	141_V	1.028	0.94
75_S	329_N	1.026	0.94
37_L	325_T	1.024	0.93
257_L	272_V	1.017	0.93
114_K	123_V	1.016	0.93
23_V	122_I	0.999	0.93
305_K	308_V	0.991	0.92
128_C	138_C	0.988	0.92
43_I	68_L	0.985	0.92
69_I	73_Q	0.981	0.92
20_S	200_L	0.967	0.91
273_K	278_E	0.964	0.91
237_R	313_T	0.963	0.91
124_I	175_A	0.961	0.91
163_A	174_I	0.950	0.91
243_I	246_A	0.949	0.91
44_K	61_R	0.948	0.90
61_R	221_Y	0.947	0.90
113_I	117_F	0.946	0.90
266_L	269_I	0.943	0.90
311_I	314_A	0.943	0.90
44_K	63_P	0.941	0.90
39_L	329_N	0.940	0.90
56_M	291_S	0.938	0.90
64_P	109_A	0.938	0.90
294_K	298_I	0.937	0.90
309_L	334_W	0.932	0.90
78_N	333_R	0.931	0.90
257_L	281_L	0.930	0.90
159_H	178_S	0.925	0.89
93_D	96_A	0.924	0.89
124_I	173_V	0.922	0.89
127_E	166_Q	0.920	0.89
78_N	329_N	0.920	0.89
185_R	189_D	0.918	0.89
311_I	327_Y	0.916	0.89
293_I	327_Y	0.916	0.89
75_S	83_V	0.914	0.89
80_I	332_A	0.910	0.89
110_V	171_A	0.910	0.89
48_N	66_D	0.903	0.88
316_K	323_I	0.903	0.88
34_Q	332_A	0.903	0.88
100_Y	165_S	0.900	0.88
55_S	301_W	0.899	0.88
19_K	23_V	0.898	0.88
11_V	14_P	0.897	0.88
106_I	132_Y	0.896	0.88
12_L	251_E	0.895	0.88
23_V	200_L	0.895	0.88
247_R	278_E	0.895	0.88
131_E	221_Y	0.894	0.88
184_V	201_I	0.885	0.87
71_Y	74_D	0.885	0.87
293_I	302_I	0.882	0.87
242_A	268_V	0.877	0.87
41_V	68_L	0.873	0.86
269_I	315_I	0.873	0.86
128_C	229_R	0.871	0.86
112_I	116_S	0.870	0.86
129_T	158_I	0.868	0.86
256_I	322_L	0.863	0.86
293_I	307_A	0.862	0.86
95_I	100_Y	0.860	0.86
76_Y	119_D	0.859	0.86
47_I	63_P	0.855	0.85
266_L	314_A	0.855	0.85
138_C	229_R	0.854	0.85
305_K	309_L	0.851	0.85
113_I	121_I	0.851	0.85
91_Y	98_S	0.843	0.85
212_M	307_A	0.842	0.84
202_L	322_L	0.842	0.84
157_K	161_K	0.842	0.84
297_A	304_E	0.836	0.84
34_Q	37_L	0.835	0.84
243_I	272_V	0.831	0.84
158_I	162_I	0.830	0.84
257_L	276_F	0.828	0.83
331_I	335_I	0.828	0.83
269_I	320_A	0.821	0.83
111_R	168_E	0.818	0.83
176_P	187_I	0.817	0.83
156_L	186_A	0.813	0.82
163_A	187_I	0.809	0.82
158_I	161_K	0.807	0.82
38_V	324_I	0.802	0.81
206_V	257_L	0.800	0.81
166_Q	174_I	0.800	0.81
73_Q	76_Y	0.799	0.81
46_N	49_E	0.797	0.81
293_I	297_A	0.795	0.81
72_L	112_I	0.795	0.81
294_K	308_V	0.793	0.81
294_K	327_Y	0.789	0.80
309_L	313_T	0.784	0.80
141_V	150_V	0.781	0.80
304_E	334_W	0.779	0.80
49_E	67_K	0.776	0.79
183_V	203_S	0.773	0.79
11_V	189_D	0.772	0.79
295_A	299_N	0.771	0.79
110_V	166_Q	0.768	0.79
20_S	23_V	0.767	0.78
212_M	263_H	0.765	0.78
285_H	293_I	0.755	0.77
278_E	281_L	0.753	0.77
327_Y	334_W	0.752	0.77
32_I	331_I	0.751	0.77
111_R	115_D	0.749	0.77
127_E	178_S	0.747	0.77
243_I	247_R	0.746	0.77
83_V	113_I	0.746	0.77
32_I	37_L	0.743	0.76
44_K	47_I	0.742	0.76
206_V	272_V	0.737	0.76
64_P	105_I	0.735	0.75
258_M	324_I	0.734	0.75
41_V	71_Y	0.733	0.75
32_I	312_T	0.730	0.75
41_V	85_L	0.730	0.75
242_A	246_A	0.728	0.75
45_E	90_S	0.724	0.74
59_I	290_Y	0.723	0.74
94_D	135_N	0.722	0.74
87_G	138_C	0.721	0.74
20_S	122_I	0.719	0.74
88_I	131_E	0.713	0.73
309_L	335_I	0.711	0.73
328_A	332_A	0.709	0.73
87_G	128_C	0.709	0.73
113_I	123_V	0.707	0.73
159_H	183_V	0.703	0.72
212_M	327_Y	0.703	0.72
292_M	296_A	0.702	0.72
26_L	81_R	0.701	0.72
11_V	248_L	0.700	0.72
51_E	221_Y	0.700	0.72
87_G	229_R	0.699	0.72
62_Y	71_Y	0.699	0.72
128_C	131_E	0.694	0.71
133_M	141_V	0.694	0.71
49_E	66_D	0.692	0.71
64_P	69_I	0.691	0.71
88_I	221_Y	0.691	0.71
85_L	110_V	0.685	0.70
53_I	218_D	0.682	0.70
12_L	248_L	0.681	0.70
243_I	275_H	0.680	0.70
131_E	138_C	0.680	0.70
130_D	138_C	0.679	0.70
43_I	109_A	0.674	0.69
68_L	72_L	0.671	0.69
150_V	180_M	0.669	0.68
307_A	311_I	0.666	0.68
236_P	313_T	0.665	0.68
264_T	315_I	0.664	0.68
127_E	183_V	0.659	0.67
92_K	225_A	0.659	0.67
32_I	309_L	0.658	0.67
304_E	327_Y	0.658	0.67
238_N	241_E	0.657	0.67
164_L	167_A	0.656	0.67
61_R	131_E	0.651	0.66
25_D	237_R	0.651	0.66
220_A	224_P	0.650	0.66
64_P	108_R	0.647	0.66
27_V	235_D	0.647	0.66
167_A	199_T	0.645	0.66
45_E	91_Y	0.644	0.66
131_E	229_R	0.641	0.65
276_F	279_Y	0.640	0.65
78_N	332_A	0.637	0.65
258_M	282_A	0.635	0.64
264_T	285_H	0.634	0.64
282_A	324_I	0.634	0.64
57_P	301_W	0.633	0.64
50_P	71_Y	0.632	0.64
203_S	206_V	0.628	0.64
297_A	303_D	0.627	0.63
42_F	216_F	0.625	0.63
190_A	193_S	0.625	0.63
14_P	17_L	0.624	0.63
155_S	159_H	0.623	0.63
263_H	315_I	0.623	0.63
141_V	225_A	0.621	0.63
294_K	297_A	0.621	0.63
75_S	121_I	0.619	0.62
209_A	230_R	0.619	0.62
80_I	329_N	0.618	0.62
308_V	330_D	0.617	0.62
76_Y	118_K	0.617	0.62
240_F	270_R	0.615	0.62
141_V	151_D	0.615	0.62
130_D	220_A	0.614	0.62
84_I	124_I	0.613	0.62
23_V	26_L	0.613	0.62
167_A	200_L	0.607	0.61
72_L	75_S	0.607	0.61
308_V	311_I	0.606	0.61
240_F	278_E	0.604	0.61
48_N	63_P	0.604	0.61
17_L	200_L	0.602	0.60
107_Q	166_Q	0.601	0.60
130_D	229_R	0.601	0.60
239_A	274_D	0.599	0.60
230_R	306_T	0.598	0.60
55_S	291_S	0.597	0.60
63_P	67_K	0.596	0.60
69_I	72_L	0.596	0.60
154_E	157_K	0.595	0.59
22_L	25_D	0.594	0.59
47_I	66_D	0.594	0.59
14_P	244_K	0.592	0.59
107_Q	162_I	0.592	0.59
41_V	83_V	0.588	0.59
114_K	118_K	0.588	0.59
21_K	28_S	0.588	0.59
84_I	87_G	0.585	0.58
271_L	275_H	0.584	0.58
77_E	336_K	0.584	0.58
273_K	279_Y	0.582	0.58
149_V	197_I	0.581	0.58
30_T	239_A	0.580	0.57
68_L	109_A	0.579	0.57
273_K	276_F	0.579	0.57
149_V	231_G	0.579	0.57
129_T	183_V	0.579	0.57
46_N	63_P	0.579	0.57
58_G	330_D	0.578	0.57
30_T	237_R	0.577	0.57
78_N	81_R	0.576	0.57
208_Y	239_A	0.575	0.57
246_A	250_I	0.574	0.57
285_H	312_T	0.573	0.57
129_T	178_S	0.573	0.57
51_E	131_E	0.571	0.56
37_L	124_I	0.571	0.56
205_S	272_V	0.570	0.56
23_V	173_V	0.569	0.56
150_V	232_Y	0.569	0.56
100_Y	162_I	0.568	0.56
129_T	140_L	0.567	0.56
62_Y	72_L	0.567	0.56
138_C	220_A	0.566	0.56
236_P	265_Y	0.566	0.56
72_L	116_S	0.564	0.55
174_I	187_I	0.564	0.55
31_S	36_D	0.561	0.55
228_D	306_T	0.560	0.55
140_L	162_I	0.559	0.55
103_N	111_R	0.559	0.55
184_V	187_I	0.558	0.55
192_D	197_I	0.558	0.55
186_A	190_A	0.556	0.54
70_N	116_S	0.555	0.54
53_I	61_R	0.555	0.54
117_F	121_I	0.554	0.54
88_I	92_K	0.554	0.54
42_F	284_Y	0.553	0.54
273_K	281_L	0.550	0.54
29_E	238_N	0.549	0.53
262_A	269_I	0.549	0.53
128_C	220_A	0.544	0.53
173_V	202_L	0.544	0.53
98_S	162_I	0.544	0.53
87_G	131_E	0.544	0.53
188_R	192_D	0.542	0.53
38_V	82_S	0.539	0.52
174_I	201_I	0.536	0.52
96_A	129_T	0.536	0.52
315_I	320_A	0.535	0.52
142_K	146_G	0.534	0.51
44_K	66_D	0.533	0.51
150_V	231_G	0.532	0.51
52_Q	298_I	0.530	0.51
154_E	158_I	0.529	0.51
325_T	331_I	0.528	0.51
47_I	108_R	0.527	0.51
311_I	315_I	0.526	0.50
88_I	128_C	0.525	0.50
240_F	244_K	0.525	0.50
99_A	162_I	0.524	0.50
291_S	295_A	0.524	0.50
296_A	301_W	0.523	0.50
220_A	229_R	0.523	0.50
94_D	140_L	0.522	0.50
44_K	67_K	0.521	0.50
140_L	154_E	0.519	0.49
143_Y	149_V	0.518	0.49
26_L	322_L	0.517	0.49
146_G	149_V	0.516	0.49
283_A	320_A	0.514	0.49
166_Q	171_A	0.513	0.49
70_N	74_D	0.513	0.49
56_M	301_W	0.512	0.49
88_I	138_C	0.511	0.48
40_P	216_F	0.511	0.48
270_R	273_K	0.511	0.48
39_L	71_Y	0.510	0.48
64_P	67_K	0.509	0.48
85_L	106_I	0.509	0.48
88_I	229_R	0.508	0.48
17_L	20_S	0.508	0.48
156_L	160_A	0.508	0.48
53_I	219_A	0.507	0.48
220_A	225_A	0.507	0.48
30_T	313_T	0.507	0.48
293_I	304_E	0.506	0.48
327_Y	330_D	0.506	0.48
125_T	163_A	0.504	0.47
32_I	313_T	0.503	0.47
36_D	323_I	0.502	0.47
76_Y	116_S	0.502	0.47
204_Y	222_S	0.500	0.47
41_V	72_L	0.500	0.47
70_N	77_E	0.500	0.47
74_D	78_N	0.500	0.47
250_I	278_E	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1w1zA	5	0.9355	100	0.022	Contact Map
1w5qA	5	0.9296	100	0.027	Contact Map
3obkA	5	0.9677	100	0.039	Contact Map
1l6sA	5	0.9472	100	0.047	Contact Map
1h7nA	5	0.9648	100	0.06	Contact Map
1pv8A	5	0.827	100	0.067	Contact Map
1wbhA	3	0.5689	96.6	0.954	Contact Map
3i4eA	4	0.827	96.6	0.955	Contact Map
3vcrA	3	0.5836	95.9	0.957	Contact Map
1vhcA	3	0.5689	95.3	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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