GREMLIN Database
GSA - Glutamate-1-semialdehyde 2,1-aminomutase
UniProt: Q980U5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 418 (373)
Sequences: 20989 (12738)
Seq/√Len: 659.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_V77_E4.3961.00
219_R223_K3.9091.00
380_E412_K3.8031.00
40_Y48_K3.5051.00
325_T404_A3.1591.00
35_R42_Y3.0421.00
95_K308_E2.9711.00
181_L217_G2.9561.00
325_T400_D2.8631.00
242_I248_Y2.8101.00
314_Y317_I2.7781.00
318_I322_A2.6871.00
399_K402_V2.6101.00
67_S312_K2.5231.00
70_R74_E2.4431.00
52_Y406_T2.4121.00
95_K311_E2.4001.00
305_A308_E2.3501.00
67_S309_E2.3111.00
40_Y402_V2.2851.00
217_G220_E2.2621.00
329_E407_I2.2371.00
34_E44_V2.1861.00
220_E224_T2.1811.00
65_P309_E2.1381.00
337_K411_M2.1121.00
42_Y48_K2.1081.00
67_S305_A2.0811.00
329_E404_A2.0681.00
95_K304_I2.0561.00
321_Q400_D2.0451.00
131_K192_D2.0361.00
376_R379_K1.9661.00
69_K73_V1.9531.00
405_D409_K1.9341.00
92_L303_G1.9321.00
185_D224_T1.9301.00
327_V331_E1.8941.00
105_K275_A1.8691.00
43_T47_K1.8411.00
185_D189_R1.8341.00
47_K381_G1.8331.00
376_R380_E1.8251.00
324_K328_E1.8061.00
104_Q275_A1.8031.00
309_E313_E1.7981.00
382_V409_K1.7891.00
329_E332_R1.7611.00
40_Y405_D1.7591.00
275_A279_D1.7491.00
341_N356_V1.7441.00
327_V345_S1.7431.00
197_I230_I1.7241.00
99_H311_E1.7241.00
34_E78_R1.7171.00
87_E91_E1.6771.00
109_V269_G1.6471.00
337_K415_G1.6441.00
116_T257_T1.6191.00
72_I302_A1.6081.00
95_K98_S1.6051.00
184_V218_L1.5991.00
94_R98_S1.5891.00
327_V351_F1.5871.00
91_E304_I1.5801.00
72_I76_L1.5751.00
331_E334_L1.5661.00
376_R413_V1.5591.00
231_F246_Q1.5281.00
37_K66_E1.5271.00
242_I320_N1.5201.00
39_A402_V1.5061.00
263_G268_I1.5051.00
322_A325_T1.4981.00
182_D186_K1.4971.00
258_L270_A1.4871.00
198_L218_L1.4811.00
74_E78_R1.4691.00
322_A403_I1.4651.00
133_L193_I1.4571.00
196_V222_T1.4551.00
126_Y277_I1.4311.00
213_D216_F1.4301.00
333_L411_M1.4271.00
258_L272_A1.4261.00
118_A271_V1.4251.00
188_L227_S1.4211.00
48_K405_D1.4171.00
39_A397_A1.4151.00
242_I247_S1.4131.00
377_L384_I1.4051.00
132_I195_T1.4001.00
185_D217_G1.3971.00
318_I321_Q1.3961.00
219_R222_T1.3911.00
100_I272_A1.3901.00
66_E70_R1.3891.00
219_R229_L1.3821.00
106_I272_A1.3631.00
97_R106_I1.3571.00
380_E413_V1.3561.00
177_E183_C1.3481.00
93_A108_F1.3451.00
322_A400_D1.3431.00
243_G247_S1.3421.00
304_I308_E1.3401.00
126_Y280_N1.3351.00
411_M415_G1.3271.00
248_Y346_M1.3221.00
305_A309_E1.3181.00
317_I321_Q1.3181.00
120_I132_I1.3151.00
131_K174_E1.3041.00
70_R73_V1.3011.00
246_Q256_T1.3001.00
329_E411_M1.2981.00
98_S311_E1.2951.00
198_L215_L1.2901.00
356_V359_Y1.2891.00
135_F214_F1.2871.00
268_I300_M1.2861.00
37_K64_S1.2821.00
325_T329_E1.2681.00
43_T49_F1.2671.00
333_L407_I1.2651.00
329_E408_D1.2641.00
398_H403_I1.2621.00
131_K190_N1.2511.00
255_I273_G1.2471.00
119_A257_T1.2441.00
179_N211_E1.2411.00
64_S69_K1.2411.00
252_Y274_K1.2411.00
65_P313_E1.2391.00
196_V218_L1.2371.00
123_A230_I1.2341.00
69_K77_E1.2331.00
116_T197_I1.2321.00
71_R305_A1.2271.00
308_E312_K1.2141.00
189_R225_Y1.2131.00
262_I268_I1.2121.00
105_K279_D1.2071.00
61_L309_E1.2041.00
168_E172_T1.2041.00
182_D185_D1.2011.00
249_Y346_M1.2001.00
185_D221_L1.1991.00
35_R78_R1.1991.00
320_N324_K1.1981.00
109_V271_V1.1951.00
402_V405_D1.1951.00
216_F220_E1.1941.00
69_K76_L1.1891.00
91_E308_E1.1831.00
268_I303_G1.1821.00
33_V41_I1.1801.00
72_I298_I1.1561.00
408_D412_K1.1541.00
213_D249_Y1.1371.00
180_D183_C1.1331.00
380_E409_K1.1251.00
149_E197_I1.1221.00
183_C186_K1.1211.00
108_F300_M1.1141.00
309_E312_K1.1081.00
216_F250_Q1.1081.00
34_E87_E1.1051.00
244_G258_L1.0981.00
32_Y44_V1.0971.00
377_L409_K1.0931.00
255_I271_V1.0901.00
262_I270_A1.0821.00
405_D408_D1.0821.00
181_L221_L1.0801.00
377_L413_V1.0751.00
73_V76_L1.0741.00
172_T175_I1.0721.00
40_Y50_I1.0641.00
39_A50_I1.0541.00
231_F251_I1.0521.00
382_V406_T1.0331.00
103_A272_A1.0301.00
177_E180_D1.0271.00
168_E171_K1.0271.00
67_S308_E1.0251.00
136_S177_E1.0221.00
400_D404_A1.0211.00
115_A257_T1.0191.00
328_E332_R1.0181.00
37_K42_Y1.0131.00
167_M170_M1.0111.00
377_L382_V1.0071.00
34_E42_Y1.0061.00
404_A408_D1.0041.00
372_K376_R1.0011.00
171_K174_E1.0001.00
95_K99_H0.9971.00
222_T227_S0.9921.00
375_E379_K0.9841.00
212_K216_F0.9811.00
79_G82_F0.9811.00
37_K48_K0.9781.00
92_L304_I0.9771.00
185_D220_E0.9751.00
122_L271_V0.9741.00
113_T146_A0.9721.00
99_H243_G0.9721.00
264_G306_T0.9721.00
241_S247_S0.9701.00
317_I320_N0.9691.00
220_E223_K0.9681.00
70_R77_E0.9671.00
34_E46_G0.9651.00
195_T230_I0.9631.00
238_F310_L0.9561.00
228_L277_I0.9541.00
130_S192_D0.9531.00
129_R226_N0.9531.00
120_I149_E0.9441.00
215_L249_Y0.9441.00
185_D225_Y0.9411.00
209_L346_M0.9331.00
341_N354_D0.9301.00
200_P231_F0.9291.00
60_I261_I0.9281.00
50_I402_V0.9241.00
74_E301_I0.9221.00
176_C187_K0.9181.00
67_S70_R0.9141.00
190_N225_Y0.9131.00
213_D217_G0.9111.00
32_Y90_I0.9101.00
61_L306_T0.9101.00
79_G84_T0.9101.00
135_F210_P0.9091.00
167_M176_C0.9061.00
122_L273_G0.9041.00
316_Y319_A0.8941.00
131_K193_I0.8931.00
167_M171_K0.8921.00
323_A327_V0.8921.00
318_I400_D0.8821.00
134_K197_I0.8811.00
310_L316_Y0.8781.00
119_A230_I0.8781.00
61_L68_V0.8771.00
331_E335_K0.8761.00
401_D404_A0.8761.00
328_E331_E0.8741.00
102_S256_T0.8731.00
176_C179_N0.8721.00
99_H307_I0.8691.00
74_E77_E0.8651.00
188_L193_I0.8621.00
301_I305_A0.8581.00
68_V302_A0.8581.00
243_G316_Y0.8571.00
248_Y320_N0.8551.00
218_L229_L0.8531.00
310_L315_P0.8531.00
126_Y228_L0.8531.00
266_F299_S0.8491.00
223_K252_Y0.8491.00
170_M173_V0.8471.00
123_A195_T0.8441.00
44_V87_E0.8441.00
342_H354_D0.8441.00
334_L340_I0.8421.00
79_G83_G0.8401.00
236_T350_F0.8391.00
371_I375_E0.8371.00
173_V177_E0.8371.00
175_I179_N0.8361.00
39_A399_K0.8361.00
221_L225_Y0.8351.00
173_V178_F0.8331.00
91_E95_K0.8321.00
52_Y398_H0.8281.00
59_L264_G0.8271.00
50_I405_D0.8261.00
316_Y320_N0.8251.00
173_V176_C0.8241.00
88_L301_I0.8211.00
113_T143_H0.8081.00
67_S71_R0.8071.00
398_H406_T0.8061.00
183_C187_K0.8041.00
176_C180_D0.8041.00
123_A228_L0.8031.00
315_P319_A0.8021.00
169_I172_T0.8001.00
344_G354_D0.8001.00
201_V346_M0.7931.00
171_K179_N0.7931.00
325_T328_E0.7921.00
167_M173_V0.7881.00
174_E177_E0.7881.00
170_M174_E0.7871.00
175_I178_F0.7871.00
349_I398_H0.7851.00
321_Q325_T0.7841.00
222_T229_L0.7831.00
171_K175_I0.7811.00
101_P246_Q0.7791.00
81_L84_T0.7791.00
88_L304_I0.7741.00
50_I406_T0.7741.00
201_V350_F0.7721.00
246_Q251_I0.7721.00
332_R335_K0.7681.00
96_I272_A0.7661.00
128_K192_D0.7601.00
200_P215_L0.7571.00
86_S89_E0.7531.00
203_G235_I0.7511.00
244_G256_T0.7501.00
88_L91_E0.7501.00
322_A349_I0.7471.00
178_F210_P0.7461.00
345_S351_F0.7441.00
238_F258_L0.7441.00
97_R103_A0.7371.00
217_G221_L0.7371.00
329_E403_I0.7361.00
92_L300_M0.7361.00
119_A255_I0.7291.00
38_G397_A0.7291.00
122_L281_F0.7281.00
321_Q324_K0.7281.00
125_G285_G0.7271.00
332_R411_M0.7261.00
238_F243_G0.7261.00
106_I270_A0.7261.00
186_K189_R0.7261.00
226_N276_E0.7251.00
196_V227_S0.7241.00
173_V179_N0.7231.00
343_V351_F0.7221.00
193_I227_S0.7211.00
134_K175_I0.7211.00
374_H386_P0.7201.00
238_F307_I0.7181.00
373_F410_L0.7171.00
85_P90_I0.7161.00
291_G294_N0.7151.00
123_A255_I0.7141.00
198_L229_L0.7131.00
246_Q253_P0.7131.00
219_R251_I0.7111.00
243_G311_E0.7101.00
88_L300_M0.7101.00
240_I248_Y0.7051.00
276_E279_D0.7051.00
169_I179_N0.7021.00
71_R302_A0.7001.00
89_E93_A0.6971.00
282_T285_G0.6971.00
319_A323_A0.6951.00
90_I94_R0.6951.00
109_V115_A0.6941.00
188_L221_L0.6931.00
216_F249_Y0.6921.00
172_T176_C0.6871.00
372_K375_E0.6861.00
111_S114_E0.6851.00
337_K414_I0.6811.00
68_V264_G0.6811.00
201_V240_I0.6801.00
52_Y382_V0.6791.00
80_W83_G0.6791.00
184_V196_V0.6781.00
50_I382_V0.6761.00
391_T394_T0.6761.00
120_I197_I0.6741.00
76_L298_I0.6741.00
202_M208_I0.6731.00
116_T146_A0.6721.00
401_D405_D0.6711.00
39_A395_S0.6681.00
53_V385_P0.6681.00
110_N114_E0.6671.00
398_H402_V0.6641.00
78_R87_E0.6621.00
355_E414_I0.6601.00
373_F413_V0.6551.00
406_T409_K0.6541.00
80_W266_F0.6541.00
188_L225_Y0.6511.00
324_K327_V0.6511.00
323_A345_S0.6501.00
78_R88_L0.6491.00
174_E178_F0.6491.00
221_L224_T0.6481.00
41_I383_F0.6481.00
325_T403_I0.6471.00
88_L92_L0.6461.00
258_L262_I0.6461.00
334_L342_H0.6441.00
382_V405_D0.6441.00
39_A398_H0.6421.00
212_K249_Y0.6411.00
71_R74_E0.6401.00
170_M176_C0.6371.00
32_Y85_P0.6371.00
47_K379_K0.6361.00
373_F377_L0.6351.00
100_I256_T0.6351.00
318_I399_K0.6341.00
238_F262_I0.6331.00
229_L251_I0.6331.00
209_L345_S0.6321.00
355_E373_F0.6321.00
103_A256_T0.6311.00
333_L337_K0.6311.00
212_K346_M0.6311.00
33_V36_G0.6311.00
99_H244_G0.6301.00
66_E77_E0.6291.00
75_Q88_L0.6291.00
95_K307_I0.6241.00
121_R289_N0.6231.00
215_L231_F0.6221.00
234_V257_T0.6201.00
75_Q78_R0.6201.00
375_E378_L0.6201.00
133_L184_V0.6201.00
168_E174_E0.6181.00
48_K409_K0.6181.00
102_S252_Y0.6171.00
230_I255_I0.6161.00
259_G269_G0.6151.00
200_P236_T0.6131.00
33_V79_G0.6131.00
118_A289_N0.6121.00
120_I145_Y0.6111.00
122_L255_I0.6101.00
112_G234_V0.6081.00
274_K277_I0.6081.00
54_L395_S0.6071.00
71_R308_E0.6061.00
319_A396_A0.6051.00
202_M205_A0.6041.00
167_M175_I0.6031.00
409_K413_V0.6021.00
149_E173_V0.6021.00
377_L410_L0.6021.00
319_A349_I0.6021.00
181_L185_D0.6001.00
277_I280_N0.5981.00
407_I411_M0.5971.00
210_P213_D0.5971.00
279_D283_P0.5961.00
174_E179_N0.5951.00
100_I244_G0.5951.00
329_E333_L0.5941.00
326_L403_I0.5941.00
64_S76_L0.5941.00
124_R144_D0.5911.00
343_V353_I0.5911.00
409_K412_K0.5911.00
273_G278_I0.5901.00
61_L315_P0.5881.00
322_A398_H0.5861.00
369_Y372_K0.5851.00
326_L407_I0.5851.00
172_T179_N0.5841.00
129_R192_D0.5841.00
168_E179_N0.5841.00
139_Y142_A0.5841.00
31_F34_E0.5831.00
99_H242_I0.5831.00
97_R104_Q0.5831.00
353_I410_L0.5761.00
37_K40_Y0.5751.00
36_G41_I0.5741.00
102_S246_Q0.5721.00
223_K276_E0.5721.00
203_G350_F0.5721.00
223_K229_L0.5721.00
189_R224_T0.5721.00
53_V383_F0.5711.00
69_K266_F0.5711.00
178_F217_G0.5701.00
101_P247_S0.5681.00
216_F219_R0.5681.00
320_N323_A0.5681.00
339_T356_V0.5671.00
60_I396_A0.5671.00
32_Y87_E0.5661.00
170_M179_N0.5651.00
174_E187_K0.5651.00
167_M178_F0.5641.00
340_I414_I0.5641.00
91_E94_R0.5631.00
302_A305_A0.5611.00
326_L351_F0.5601.00
126_Y276_E0.5591.00
80_W84_T0.5551.00
355_E369_Y0.5551.00
74_E305_A0.5541.00
374_H378_L0.5501.00
344_G352_G0.5491.00
333_L408_D0.5451.00
76_L302_A0.5451.00
167_M172_T0.5441.00
238_F244_G0.5431.00
31_F378_L0.5431.00
313_E318_I0.5411.00
92_L108_F0.5411.00
167_M179_N0.5401.00
403_I407_I0.5401.00
184_V188_L0.5401.00
92_L268_I0.5401.00
279_D282_T0.5391.00
60_I310_L0.5391.00
210_P215_L0.5391.00
170_M175_I0.5381.00
334_L343_V0.5371.00
135_F176_C0.5361.00
243_G310_L0.5361.00
181_L184_V0.5361.00
354_D390_E0.5351.00
403_I406_T0.5351.00
171_K176_C0.5331.00
404_A407_I0.5321.00
256_T272_A0.5300.99
129_R227_S0.5300.99
296_N299_S0.5290.99
109_V114_E0.5270.99
135_F198_L0.5260.99
228_L255_I0.5240.99
184_V217_G0.5230.99
406_T410_L0.5220.99
50_I398_H0.5220.99
169_I174_E0.5200.99
137_G205_A0.5200.99
322_A399_K0.5150.99
176_C183_C0.5150.99
34_E37_K0.5150.99
307_I311_E0.5130.99
198_L231_F0.5120.99
405_D412_K0.5100.99
134_K138_N0.5090.99
410_L414_I0.5090.99
127_T194_A0.5080.99
68_V306_T0.5070.99
385_P388_Q0.5070.99
333_L414_I0.5060.99
311_E314_Y0.5060.99
219_R252_Y0.5040.99
378_L383_F0.5040.99
191_E225_Y0.5040.99
184_V221_L0.5020.99
214_F218_L0.5010.99
243_G307_I0.5010.99
354_D391_T0.5010.99
253_P256_T0.5010.99
212_K250_Q0.5000.99
127_T130_S0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2epjA 2 0.9809 100 0.357 Contact Map
4e77A 2 0.9474 100 0.382 Contact Map
3oksA 2 0.9641 100 0.384 Contact Map
4atqA 7 0.9689 100 0.384 Contact Map
2ykyA 4 0.9545 100 0.385 Contact Map
4a0gA 2 0.9689 100 0.387 Contact Map
4uoxA 3 0.9569 100 0.388 Contact Map
4ao9A 2 0.9522 100 0.392 Contact Map
1z7dA 2 0.8756 100 0.396 Contact Map
4ffcA 4 0.9617 100 0.398 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0124 seconds.